| Chain sequence(s) |
A: FNAEQAAVEAGEVLKGLEKDFKRYGDALKPDTSVPGKSKDIRTTKDFLNGYKNDHAKEIVDGFRSDMSIKQLVDLFVKGNWSAEQKGALAWEIESRALKVTFQNKSEKYNRLFREIASAGVVDAKATEQLAPQLMLLNLSNDGFGGRCDPLSKLVLVAKQLENDGQVGVARQLLEKMYSAAAVLSNPTLYSDSEKANASKLLSSLAAIHAKNPMHDTSMKVWQEKLEGKQALTVNGVVEKITDASANGKPVLLELDAPGHAMAAWAKGSGDDRVYGFYDPNAGIVEFSSAEKFGDYLTRFFGKSDLNMAQSYKLGKNDAGEAIFNRVVVMDGNTLASYKPTFGDKTTMQGILDLPVFDATPIKKPTGGVASDLEAL
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:06:05)
[INFO] Main: Simulation completed successfully. (00:06:07)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 63 | F | A | 0.8925 | |
| 64 | N | A | -1.1755 | |
| 65 | A | A | -1.0609 | |
| 66 | E | A | -2.1634 | |
| 67 | Q | A | -1.7687 | |
| 68 | A | A | -1.0956 | |
| 69 | A | A | -1.0493 | |
| 70 | V | A | -0.1814 | |
| 71 | E | A | -1.8892 | |
| 72 | A | A | -1.0663 | |
| 73 | G | A | -0.9916 | |
| 74 | E | A | -1.9132 | |
| 75 | V | A | -0.3287 | |
| 76 | L | A | -1.2392 | |
| 77 | K | A | -2.9610 | |
| 78 | G | A | -2.0378 | |
| 79 | L | A | -2.3191 | |
| 80 | E | A | -3.3695 | |
| 81 | K | A | -3.7293 | |
| 82 | D | A | 0.0000 | |
| 83 | F | A | -2.2140 | |
| 84 | K | A | -3.1540 | |
| 85 | R | A | -2.2613 | |
| 86 | Y | A | 0.0000 | |
| 87 | G | A | -1.8051 | |
| 88 | D | A | -1.9133 | |
| 89 | A | A | -1.4568 | |
| 90 | L | A | -1.5798 | |
| 91 | K | A | -2.7549 | |
| 92 | P | A | -2.8870 | |
| 93 | D | A | -3.0658 | |
| 94 | T | A | -2.0208 | |
| 95 | S | A | -1.0430 | |
| 96 | V | A | -0.7924 | |
| 97 | P | A | -0.9400 | |
| 98 | G | A | -1.5127 | |
| 99 | K | A | -2.7912 | |
| 100 | S | A | -2.8144 | |
| 101 | K | A | -3.2243 | |
| 102 | D | A | -2.3352 | |
| 103 | I | A | -1.5819 | |
| 104 | R | A | -1.1675 | |
| 105 | T | A | -1.0187 | |
| 106 | T | A | -1.6395 | |
| 107 | K | A | -2.4387 | |
| 108 | D | A | -2.4377 | |
| 109 | F | A | 0.0000 | |
| 110 | L | A | -1.3941 | |
| 111 | N | A | -1.8335 | |
| 112 | G | A | 0.0000 | |
| 113 | Y | A | 0.0000 | |
| 114 | K | A | -1.8063 | |
| 115 | N | A | -2.3815 | |
| 116 | D | A | -3.2884 | |
| 117 | H | A | -2.7026 | |
| 118 | A | A | 0.0000 | |
| 119 | K | A | -3.9528 | |
| 120 | E | A | -3.1156 | |
| 121 | I | A | -1.8151 | |
| 122 | V | A | 0.0000 | |
| 123 | D | A | -2.7233 | |
| 124 | G | A | -1.9708 | |
| 125 | F | A | 0.0000 | |
| 126 | R | A | -3.3705 | |
| 127 | S | A | -2.6478 | |
| 128 | D | A | -2.6064 | |
| 129 | M | A | -2.1084 | |
| 130 | S | A | -1.7903 | |
| 131 | I | A | 0.0000 | |
| 132 | K | A | -2.3949 | |
| 133 | Q | A | -2.3582 | |
| 134 | L | A | 0.0000 | |
| 135 | V | A | 0.0000 | |
| 136 | D | A | -1.5632 | |
| 137 | L | A | -1.3509 | |
| 138 | F | A | 0.0000 | |
| 139 | V | A | -0.8854 | |
| 140 | K | A | -1.8058 | |
| 141 | G | A | -1.7119 | |
| 142 | N | A | -1.6388 | |
| 143 | W | A | -1.1402 | |
| 144 | S | A | -0.8543 | |
| 145 | A | A | -1.2616 | |
| 146 | E | A | -1.5946 | |
| 147 | Q | A | -1.3721 | |
| 148 | K | A | -0.7999 | |
| 149 | G | A | 0.0000 | |
| 150 | A | A | 0.0000 | |
| 151 | L | A | 0.0000 | |
| 152 | A | A | 0.0000 | |
| 153 | W | A | -0.8724 | |
| 154 | E | A | -0.9436 | |
| 155 | I | A | 0.0000 | |
| 156 | E | A | -0.4137 | |
| 157 | S | A | -0.6935 | |
| 158 | R | A | -0.8042 | |
| 159 | A | A | -0.3821 | |
| 160 | L | A | 0.0000 | |
| 161 | K | A | -1.6325 | |
| 162 | V | A | -0.4551 | |
| 163 | T | A | 0.0000 | |
| 164 | F | A | -0.6776 | |
| 165 | Q | A | -1.9278 | |
| 166 | N | A | -1.8603 | |
| 167 | K | A | -1.9967 | |
| 168 | S | A | -1.9615 | |
| 169 | E | A | -2.9462 | |
| 170 | K | A | -3.2873 | |
| 171 | Y | A | 0.0000 | |
| 172 | N | A | -2.8725 | |
| 173 | R | A | -3.9553 | |
| 174 | L | A | 0.0000 | |
| 175 | F | A | 0.0000 | |
| 176 | R | A | -3.3216 | |
| 177 | E | A | -3.1671 | |
| 178 | I | A | 0.0000 | |
| 179 | A | A | -1.2762 | |
| 180 | S | A | -0.2638 | |
| 181 | A | A | -0.3602 | |
| 182 | G | A | 0.6327 | |
| 183 | V | A | 2.3777 | |
| 184 | V | A | 1.8080 | |
| 185 | D | A | 0.0000 | |
| 186 | A | A | -0.0589 | |
| 187 | K | A | -1.6075 | |
| 188 | A | A | -0.8745 | |
| 189 | T | A | -0.8466 | |
| 190 | E | A | -0.6607 | |
| 191 | Q | A | -0.4858 | |
| 192 | L | A | -0.0172 | |
| 193 | A | A | 0.0000 | |
| 194 | P | A | -0.0001 | |
| 195 | Q | A | 0.0684 | |
| 196 | L | A | 0.3278 | |
| 197 | M | A | 0.2167 | |
| 198 | L | A | 0.0000 | |
| 199 | L | A | 0.0000 | |
| 200 | N | A | -0.1843 | |
| 201 | L | A | 0.1417 | |
| 202 | S | A | -0.1484 | |
| 203 | N | A | -0.5846 | |
| 204 | D | A | -0.3909 | |
| 205 | G | A | 0.0000 | |
| 206 | F | A | -0.2842 | |
| 207 | G | A | -0.4113 | |
| 208 | G | A | -0.6261 | |
| 209 | R | A | 0.0000 | |
| 210 | C | A | -0.4105 | |
| 211 | D | A | -0.5680 | |
| 212 | P | A | 0.0000 | |
| 213 | L | A | 0.0000 | |
| 214 | S | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | L | A | 0.0000 | |
| 217 | V | A | 0.0000 | |
| 218 | L | A | 0.0000 | |
| 219 | V | A | 0.0000 | |
| 220 | A | A | 0.0000 | |
| 221 | K | A | 0.0000 | |
| 222 | Q | A | 0.0000 | |
| 223 | L | A | -1.1126 | |
| 224 | E | A | 0.0000 | |
| 225 | N | A | -1.5867 | |
| 226 | D | A | -2.4001 | |
| 227 | G | A | -1.6049 | |
| 228 | Q | A | -1.0655 | |
| 229 | V | A | 0.5865 | |
| 230 | G | A | -0.0301 | |
| 231 | V | A | -0.5496 | |
| 232 | A | A | 0.0000 | |
| 233 | R | A | -1.5524 | |
| 234 | Q | A | -1.9184 | |
| 235 | L | A | 0.0000 | |
| 236 | L | A | 0.0000 | |
| 237 | E | A | -2.2523 | |
| 238 | K | A | -1.3360 | |
| 239 | M | A | 0.0000 | |
| 240 | Y | A | -0.3759 | |
| 241 | S | A | -0.1048 | |
| 242 | A | A | 0.0000 | |
| 243 | A | A | 0.0000 | |
| 244 | A | A | 0.1274 | |
| 245 | V | A | 0.0000 | |
| 246 | L | A | 0.0440 | |
| 247 | S | A | -0.3854 | |
| 248 | N | A | -0.4177 | |
| 249 | P | A | -0.3493 | |
| 250 | T | A | 0.1855 | |
| 251 | L | A | 1.1283 | |
| 252 | Y | A | 0.3358 | |
| 253 | S | A | -0.7954 | |
| 254 | D | A | -1.9533 | |
| 255 | S | A | -1.3515 | |
| 256 | E | A | -0.9519 | |
| 257 | K | A | -1.1265 | |
| 258 | A | A | -1.0529 | |
| 259 | N | A | -1.0902 | |
| 260 | A | A | 0.0000 | |
| 261 | S | A | -0.8058 | |
| 262 | K | A | -1.1958 | |
| 263 | L | A | 0.0000 | |
| 264 | L | A | 0.0000 | |
| 265 | S | A | -0.6086 | |
| 266 | S | A | 0.0000 | |
| 267 | L | A | 0.0000 | |
| 268 | A | A | -0.3939 | |
| 269 | A | A | -0.3500 | |
| 270 | I | A | 0.0000 | |
| 271 | H | A | -0.8703 | |
| 272 | A | A | -0.8165 | |
| 273 | K | A | -1.4456 | |
| 274 | N | A | -1.3589 | |
| 275 | P | A | 0.0000 | |
| 276 | M | A | -1.0046 | |
| 277 | H | A | -1.6226 | |
| 278 | D | A | -1.4761 | |
| 279 | T | A | -0.9208 | |
| 280 | S | A | -0.7417 | |
| 281 | M | A | -0.8737 | |
| 282 | K | A | -1.9831 | |
| 283 | V | A | 0.0000 | |
| 284 | W | A | -1.5695 | |
| 285 | Q | A | -2.0241 | |
| 286 | E | A | -2.2739 | |
| 287 | K | A | -2.3109 | |
| 288 | L | A | 0.0000 | |
| 289 | E | A | -3.3981 | |
| 290 | G | A | -2.8173 | |
| 291 | K | A | -2.9085 | |
| 292 | Q | A | -2.9317 | |
| 293 | A | A | -2.5408 | |
| 294 | L | A | -1.5542 | |
| 295 | T | A | -1.2529 | |
| 296 | V | A | -0.8957 | |
| 297 | N | A | -2.0164 | |
| 298 | G | A | -1.2569 | |
| 299 | V | A | 0.0000 | |
| 300 | V | A | -1.9572 | |
| 301 | E | A | -2.7040 | |
| 302 | K | A | -2.0394 | |
| 303 | I | A | 0.0000 | |
| 304 | T | A | -1.6236 | |
| 305 | D | A | -2.1298 | |
| 306 | A | A | -1.4427 | |
| 307 | S | A | -1.2222 | |
| 308 | A | A | -1.5394 | |
| 309 | N | A | -2.0004 | |
| 310 | G | A | -1.8245 | |
| 311 | K | A | -1.7425 | |
| 312 | P | A | -1.2442 | |
| 313 | V | A | 0.0000 | |
| 314 | L | A | 0.0000 | |
| 315 | L | A | 0.0000 | |
| 316 | E | A | 0.0000 | |
| 317 | L | A | 0.0000 | |
| 318 | D | A | -1.1788 | |
| 319 | A | A | 0.0000 | |
| 320 | P | A | -1.2906 | |
| 321 | G | A | -1.0859 | |
| 322 | H | A | -0.9174 | |
| 323 | A | A | 0.0000 | |
| 324 | M | A | 0.0000 | |
| 325 | A | A | 0.0000 | |
| 326 | A | A | 0.0000 | |
| 327 | W | A | 0.0000 | |
| 328 | A | A | 0.0000 | |
| 329 | K | A | -1.1658 | |
| 330 | G | A | -2.0051 | |
| 331 | S | A | -2.1333 | |
| 332 | G | A | -2.3028 | |
| 333 | D | A | -2.9855 | |
| 334 | D | A | -3.1678 | |
| 335 | R | A | -2.0093 | |
| 336 | V | A | -0.9557 | |
| 337 | Y | A | -0.2590 | |
| 338 | G | A | 0.0000 | |
| 339 | F | A | 0.0000 | |
| 340 | Y | A | 0.0000 | |
| 341 | D | A | 0.0000 | |
| 342 | P | A | 0.0000 | |
| 343 | N | A | -0.4716 | |
| 344 | A | A | 0.0000 | |
| 345 | G | A | 0.0000 | |
| 346 | I | A | 0.0000 | |
| 347 | V | A | 0.0000 | |
| 348 | E | A | 0.0000 | |
| 349 | F | A | 0.0000 | |
| 350 | S | A | -1.3749 | |
| 351 | S | A | -1.3050 | |
| 352 | A | A | -1.5111 | |
| 353 | E | A | -2.3746 | |
| 354 | K | A | -1.6461 | |
| 355 | F | A | 0.0000 | |
| 356 | G | A | -2.1141 | |
| 357 | D | A | -2.5942 | |
| 358 | Y | A | 0.0000 | |
| 359 | L | A | 0.0000 | |
| 360 | T | A | -1.4342 | |
| 361 | R | A | -1.5815 | |
| 362 | F | A | 0.0000 | |
| 363 | F | A | 0.0000 | |
| 364 | G | A | -1.6790 | |
| 365 | K | A | -2.5377 | |
| 366 | S | A | -1.6381 | |
| 367 | D | A | -1.8898 | |
| 368 | L | A | -1.5067 | |
| 369 | N | A | -2.0412 | |
| 370 | M | A | 0.0000 | |
| 371 | A | A | -1.8257 | |
| 372 | Q | A | -2.3269 | |
| 373 | S | A | -1.3122 | |
| 374 | Y | A | -1.4252 | |
| 375 | K | A | -2.6695 | |
| 376 | L | A | 0.0000 | |
| 377 | G | A | -2.2470 | |
| 378 | K | A | -3.3192 | |
| 379 | N | A | -2.9149 | |
| 380 | D | A | -2.7520 | |
| 381 | A | A | -1.9442 | |
| 382 | G | A | -2.4358 | |
| 383 | E | A | -2.7861 | |
| 384 | A | A | -2.3254 | |
| 385 | I | A | -1.8747 | |
| 386 | F | A | 0.0000 | |
| 387 | N | A | -2.6645 | |
| 388 | R | A | -2.2699 | |
| 389 | V | A | 0.0000 | |
| 390 | V | A | 0.0000 | |
| 391 | V | A | 0.0000 | |
| 392 | M | A | 0.0000 | |
| 393 | D | A | -1.5307 | |
| 394 | G | A | 0.0000 | |
| 395 | N | A | -1.7150 | |
| 396 | T | A | -1.0975 | |
| 397 | L | A | 0.0000 | |
| 398 | A | A | 0.0000 | |
| 399 | S | A | -1.0530 | |
| 400 | Y | A | 0.0000 | |
| 401 | K | A | -1.5061 | |
| 402 | P | A | 0.0000 | |
| 403 | T | A | -0.1561 | |
| 404 | F | A | 0.9579 | |
| 405 | G | A | -0.2498 | |
| 406 | D | A | -1.0282 | |
| 407 | K | A | -1.9759 | |
| 408 | T | A | -1.4793 | |
| 409 | T | A | -1.5137 | |
| 410 | M | A | 0.0000 | |
| 411 | Q | A | -1.5313 | |
| 412 | G | A | -1.5172 | |
| 413 | I | A | 0.0000 | |
| 414 | L | A | 0.0000 | |
| 415 | D | A | -2.0680 | |
| 416 | L | A | -0.9414 | |
| 417 | P | A | -0.6429 | |
| 418 | V | A | 0.0000 | |
| 419 | F | A | 0.6458 | |
| 420 | D | A | -0.7380 | |
| 421 | A | A | -0.1919 | |
| 422 | T | A | -0.1965 | |
| 423 | P | A | -0.1494 | |
| 424 | I | A | 0.3216 | |
| 425 | K | A | -1.7198 | |
| 426 | K | A | -2.2040 | |
| 427 | P | A | -1.2556 | |
| 428 | T | A | -1.1321 | |
| 429 | G | A | -0.6278 | |
| 430 | G | A | -0.1734 | |
| 431 | V | A | 0.9009 | |
| 432 | A | A | 0.1475 | |
| 433 | S | A | -0.4409 | |
| 434 | D | A | -0.8943 | |
| 435 | L | A | 0.5639 | |
| 436 | E | A | -0.9756 | |
| 437 | A | A | -0.1722 | |
| 438 | L | A | 1.1064 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine