| Chain sequence(s) |
A: ASFNVPIIMDNGTGYSKLGYAGNDAPSYVFPTVIATRATEDLDFFIGNDALKKASAGYSLDYPIRHGQIENWDHMERFWQQSLFKYLRCEPEDHYFLLTEPPLNPPENRENTAEIMFESFNCAGLYIAVQAVLALAASWTSSKVTDRSLTGTVVDSGDGVTHIIPVAEGYVIGSSIKTMPLAGRDVTYFVQSLLRLKTAERIKEECCYVCPDIVKEFSRFDRLKYASIDVGFERFLAPEIFFNPEIASSDFLTPLPELVDNVVQSSPIDVRKGLYKNIVLSGGSTLFKNFGNRLQRDLKRIVDERIHRSEMLSGAKSGGVDVNVISHKRQRNAVWFGGSLLAQTPEFGSYCHTKADYEEYGASIARRYQI
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:04:50)
[INFO] Main: Simulation completed successfully. (00:04:52)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 2 | A | A | -0.0031 | |
| 3 | S | A | 0.5614 | |
| 4 | F | A | 1.6287 | |
| 5 | N | A | 0.6044 | |
| 6 | V | A | 0.9266 | |
| 7 | P | A | 0.3913 | |
| 8 | I | A | 0.0000 | |
| 9 | I | A | 0.0000 | |
| 10 | M | A | 0.0253 | |
| 11 | D | A | 0.0000 | |
| 12 | N | A | -0.0727 | |
| 13 | G | A | -0.4031 | |
| 14 | T | A | -0.5578 | |
| 15 | G | A | -0.0472 | |
| 16 | Y | A | 1.3914 | |
| 17 | S | A | 0.0000 | |
| 18 | K | A | 0.5229 | |
| 19 | L | A | 0.0000 | |
| 20 | G | A | 0.0052 | |
| 21 | Y | A | -0.0244 | |
| 22 | A | A | 0.0000 | |
| 23 | G | A | -1.2779 | |
| 24 | N | A | -2.1853 | |
| 25 | D | A | -2.6428 | |
| 26 | A | A | -1.3662 | |
| 27 | P | A | -0.1748 | |
| 28 | S | A | 0.1761 | |
| 29 | Y | A | 1.4244 | |
| 30 | V | A | 2.0943 | |
| 31 | F | A | 0.0000 | |
| 32 | P | A | 0.7957 | |
| 33 | T | A | 0.0000 | |
| 34 | V | A | 0.0000 | |
| 35 | I | A | 0.0000 | |
| 36 | A | A | 0.0000 | |
| 37 | T | A | -0.9759 | |
| 38 | R | A | -1.7751 | |
| 68 | A | A | -0.6761 | |
| 69 | T | A | -1.2888 | |
| 70 | E | A | -2.6189 | |
| 71 | D | A | -2.7103 | |
| 72 | L | A | -1.0600 | |
| 73 | D | A | -2.0966 | |
| 74 | F | A | -0.9823 | |
| 75 | F | A | -0.6302 | |
| 76 | I | A | 0.0000 | |
| 77 | G | A | 0.0000 | |
| 78 | N | A | -1.6403 | |
| 79 | D | A | -2.1747 | |
| 80 | A | A | 0.0000 | |
| 81 | L | A | -0.9395 | |
| 82 | K | A | -2.5444 | |
| 83 | K | A | -2.1301 | |
| 84 | A | A | -0.8668 | |
| 85 | S | A | -0.5959 | |
| 86 | A | A | -0.4515 | |
| 87 | G | A | 0.0000 | |
| 88 | Y | A | 0.3498 | |
| 89 | S | A | -0.1779 | |
| 90 | L | A | -0.3290 | |
| 91 | D | A | -1.0968 | |
| 92 | Y | A | -0.1889 | |
| 93 | P | A | 0.0000 | |
| 94 | I | A | 0.0000 | |
| 95 | R | A | -1.7381 | |
| 96 | H | A | -1.9556 | |
| 97 | G | A | -1.6327 | |
| 98 | Q | A | -2.1483 | |
| 99 | I | A | -1.8041 | |
| 100 | E | A | -2.7906 | |
| 101 | N | A | -2.1192 | |
| 102 | W | A | -1.8239 | |
| 103 | D | A | -2.6294 | |
| 104 | H | A | -2.0017 | |
| 105 | M | A | 0.0000 | |
| 106 | E | A | -1.7888 | |
| 107 | R | A | -1.6475 | |
| 108 | F | A | 0.0000 | |
| 109 | W | A | 0.0000 | |
| 110 | Q | A | -0.9471 | |
| 111 | Q | A | 0.0000 | |
| 112 | S | A | 0.0000 | |
| 113 | L | A | 0.0000 | |
| 114 | F | A | -0.9760 | |
| 115 | K | A | -1.7132 | |
| 116 | Y | A | -0.7177 | |
| 117 | L | A | -0.9969 | |
| 118 | R | A | -2.2368 | |
| 119 | C | A | -1.9907 | |
| 120 | E | A | -2.8463 | |
| 121 | P | A | -2.2830 | |
| 122 | E | A | -2.8946 | |
| 123 | D | A | -1.9072 | |
| 124 | H | A | 0.0000 | |
| 125 | Y | A | 0.0170 | |
| 126 | F | A | 0.0000 | |
| 127 | L | A | 0.0000 | |
| 128 | L | A | 0.0000 | |
| 129 | T | A | -0.0319 | |
| 130 | E | A | 0.0000 | |
| 131 | P | A | -0.0848 | |
| 132 | P | A | 0.5642 | |
| 133 | L | A | 1.5262 | |
| 134 | N | A | 0.0000 | |
| 135 | P | A | -0.8969 | |
| 136 | P | A | -1.8539 | |
| 137 | E | A | -2.5477 | |
| 138 | N | A | -2.0298 | |
| 139 | R | A | -1.8814 | |
| 140 | E | A | -2.3569 | |
| 141 | N | A | -1.8350 | |
| 142 | T | A | 0.0000 | |
| 143 | A | A | 0.0000 | |
| 144 | E | A | -2.7232 | |
| 145 | I | A | -1.7489 | |
| 146 | M | A | 0.0000 | |
| 147 | F | A | 0.0000 | |
| 148 | E | A | -2.9307 | |
| 149 | S | A | -1.7135 | |
| 150 | F | A | 0.0000 | |
| 151 | N | A | -2.2982 | |
| 152 | C | A | 0.0000 | |
| 153 | A | A | -1.1988 | |
| 154 | G | A | 0.0000 | |
| 155 | L | A | 0.0000 | |
| 156 | Y | A | 0.1032 | |
| 157 | I | A | -0.1600 | |
| 158 | A | A | 0.2829 | |
| 159 | V | A | 0.6683 | |
| 160 | Q | A | 0.1427 | |
| 161 | A | A | 0.0000 | |
| 162 | V | A | 0.5027 | |
| 163 | L | A | 0.0000 | |
| 164 | A | A | 0.0000 | |
| 165 | L | A | 0.0000 | |
| 166 | A | A | 0.0000 | |
| 167 | A | A | 0.0000 | |
| 168 | S | A | 0.0000 | |
| 169 | W | A | -0.8939 | |
| 170 | T | A | -0.5615 | |
| 171 | S | A | -0.8487 | |
| 172 | S | A | -0.8548 | |
| 173 | K | A | -1.2869 | |
| 174 | V | A | -1.1911 | |
| 175 | T | A | -1.5121 | |
| 176 | D | A | -2.7688 | |
| 177 | R | A | -2.6349 | |
| 178 | S | A | -1.6704 | |
| 179 | L | A | -0.7302 | |
| 180 | T | A | -0.7593 | |
| 181 | G | A | 0.0000 | |
| 182 | T | A | 0.0000 | |
| 183 | V | A | 0.0000 | |
| 184 | V | A | 0.0367 | |
| 185 | D | A | -0.2780 | |
| 186 | S | A | 0.0000 | |
| 187 | G | A | -0.7324 | |
| 188 | D | A | -1.8245 | |
| 189 | G | A | -0.7056 | |
| 190 | V | A | 0.8308 | |
| 191 | T | A | 0.0000 | |
| 192 | H | A | 0.0813 | |
| 193 | I | A | 0.0000 | |
| 194 | I | A | 0.0000 | |
| 195 | P | A | 0.0000 | |
| 196 | V | A | 0.0000 | |
| 197 | A | A | -0.2963 | |
| 198 | E | A | -1.3203 | |
| 199 | G | A | 0.0716 | |
| 200 | Y | A | 1.0512 | |
| 201 | V | A | 0.8617 | |
| 202 | I | A | 0.6547 | |
| 203 | G | A | 0.4850 | |
| 204 | S | A | -0.0672 | |
| 205 | S | A | -0.1836 | |
| 206 | I | A | 0.2239 | |
| 207 | K | A | -0.3736 | |
| 208 | T | A | 0.0354 | |
| 209 | M | A | 0.0000 | |
| 210 | P | A | 0.2733 | |
| 211 | L | A | 0.0000 | |
| 212 | A | A | 0.0000 | |
| 213 | G | A | -0.9310 | |
| 214 | R | A | -0.9122 | |
| 215 | D | A | -0.1842 | |
| 216 | V | A | 0.0000 | |
| 217 | T | A | 0.3204 | |
| 218 | Y | A | 1.2441 | |
| 219 | F | A | 0.9375 | |
| 220 | V | A | 0.4724 | |
| 221 | Q | A | 0.5015 | |
| 222 | S | A | 0.2735 | |
| 223 | L | A | 0.7229 | |
| 224 | L | A | 0.7260 | |
| 225 | R | A | -1.1007 | |
| 234 | L | A | 0.2799 | |
| 235 | K | A | -1.8136 | |
| 236 | T | A | -1.5662 | |
| 237 | A | A | 0.0000 | |
| 238 | E | A | -3.0175 | |
| 239 | R | A | -3.5490 | |
| 240 | I | A | -1.7627 | |
| 241 | K | A | -2.5574 | |
| 242 | E | A | -3.4515 | |
| 243 | E | A | -3.1018 | |
| 244 | C | A | -1.3949 | |
| 245 | C | A | -0.5535 | |
| 246 | Y | A | 0.4156 | |
| 247 | V | A | 0.0000 | |
| 248 | C | A | -0.5328 | |
| 249 | P | A | -1.2335 | |
| 250 | D | A | -0.8235 | |
| 251 | I | A | 0.3543 | |
| 252 | V | A | 0.8944 | |
| 253 | K | A | -1.1077 | |
| 254 | E | A | 0.0000 | |
| 255 | F | A | 0.3380 | |
| 256 | S | A | -1.2136 | |
| 257 | R | A | -2.4959 | |
| 258 | F | A | -1.3367 | |
| 259 | D | A | -2.7020 | |
| 260 | R | A | -2.9610 | |
| 266 | L | A | 0.9078 | |
| 267 | K | A | -0.1697 | |
| 268 | Y | A | 0.9472 | |
| 269 | A | A | 0.3270 | |
| 270 | S | A | 0.1806 | |
| 280 | I | A | 1.5653 | |
| 281 | D | A | -0.1683 | |
| 282 | V | A | 0.4442 | |
| 283 | G | A | 0.3094 | |
| 284 | F | A | 1.1693 | |
| 285 | E | A | 0.5131 | |
| 286 | R | A | 0.3756 | |
| 287 | F | A | 0.0000 | |
| 288 | L | A | 0.0000 | |
| 289 | A | A | 0.0000 | |
| 290 | P | A | 0.0000 | |
| 291 | E | A | -0.5179 | |
| 292 | I | A | 0.0000 | |
| 293 | F | A | 0.0000 | |
| 294 | F | A | 0.0000 | |
| 295 | N | A | -0.3739 | |
| 296 | P | A | 0.0000 | |
| 297 | E | A | -1.1161 | |
| 298 | I | A | -0.1220 | |
| 299 | A | A | -0.0533 | |
| 300 | S | A | -0.5012 | |
| 301 | S | A | -0.7163 | |
| 302 | D | A | -0.9769 | |
| 303 | F | A | 1.0393 | |
| 304 | L | A | 1.1283 | |
| 305 | T | A | 0.3133 | |
| 306 | P | A | 0.0031 | |
| 307 | L | A | 0.0000 | |
| 308 | P | A | 0.0000 | |
| 309 | E | A | -0.9323 | |
| 310 | L | A | 0.0000 | |
| 311 | V | A | -0.4893 | |
| 312 | D | A | -1.0213 | |
| 313 | N | A | -1.0711 | |
| 314 | V | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | Q | A | -1.1524 | |
| 317 | S | A | -0.5205 | |
| 318 | S | A | -0.5086 | |
| 319 | P | A | -0.3472 | |
| 320 | I | A | 0.2342 | |
| 321 | D | A | -1.3511 | |
| 322 | V | A | -1.0730 | |
| 323 | R | A | -1.2181 | |
| 324 | K | A | -2.3374 | |
| 325 | G | A | -1.6708 | |
| 326 | L | A | 0.0000 | |
| 327 | Y | A | -1.1945 | |
| 328 | K | A | -1.7943 | |
| 329 | N | A | -0.8697 | |
| 330 | I | A | 0.0837 | |
| 331 | V | A | 0.0000 | |
| 332 | L | A | 0.2890 | |
| 333 | S | A | 0.0000 | |
| 334 | G | A | -1.2996 | |
| 335 | G | A | -1.8534 | |
| 336 | S | A | -0.8737 | |
| 337 | T | A | -0.3954 | |
| 338 | L | A | -0.7220 | |
| 339 | F | A | -0.4539 | |
| 340 | K | A | -1.7792 | |
| 341 | N | A | -1.9159 | |
| 342 | F | A | 0.0000 | |
| 343 | G | A | -0.9854 | |
| 344 | N | A | -1.7532 | |
| 345 | R | A | -1.9013 | |
| 346 | L | A | -1.2783 | |
| 347 | Q | A | -1.8813 | |
| 348 | R | A | -3.0254 | |
| 349 | D | A | -2.3026 | |
| 350 | L | A | 0.0000 | |
| 351 | K | A | -2.8849 | |
| 352 | R | A | -3.4283 | |
| 353 | I | A | -2.2083 | |
| 354 | V | A | -2.6324 | |
| 355 | D | A | -3.1589 | |
| 356 | E | A | -3.8489 | |
| 357 | R | A | -3.4417 | |
| 358 | I | A | -2.0378 | |
| 359 | H | A | -2.4867 | |
| 360 | R | A | -2.2252 | |
| 361 | S | A | -1.4134 | |
| 362 | E | A | -1.1763 | |
| 363 | M | A | 0.6395 | |
| 364 | L | A | 1.3085 | |
| 365 | S | A | 0.1675 | |
| 366 | G | A | -0.3380 | |
| 367 | A | A | -0.8379 | |
| 368 | K | A | -2.0994 | |
| 369 | S | A | -1.3234 | |
| 370 | G | A | -1.0570 | |
| 371 | G | A | -0.9657 | |
| 372 | V | A | 0.1280 | |
| 373 | D | A | -1.7997 | |
| 374 | V | A | 0.0000 | |
| 375 | N | A | -1.6145 | |
| 376 | V | A | -0.5652 | |
| 377 | I | A | -0.2992 | |
| 378 | S | A | -0.7071 | |
| 379 | H | A | -1.6945 | |
| 380 | K | A | -2.8654 | |
| 381 | R | A | -3.4607 | |
| 382 | Q | A | 0.0000 | |
| 383 | R | A | -2.7861 | |
| 384 | N | A | -1.4610 | |
| 385 | A | A | 0.0000 | |
| 386 | V | A | 0.0000 | |
| 387 | W | A | 0.0000 | |
| 388 | F | A | -0.4979 | |
| 389 | G | A | 0.0000 | |
| 390 | G | A | 0.0000 | |
| 391 | S | A | 0.0000 | |
| 392 | L | A | 0.1159 | |
| 393 | L | A | 0.0095 | |
| 394 | A | A | 0.0000 | |
| 395 | Q | A | -1.1931 | |
| 396 | T | A | -1.1131 | |
| 397 | P | A | -1.2323 | |
| 398 | E | A | -1.8618 | |
| 399 | F | A | -0.8840 | |
| 400 | G | A | -0.7170 | |
| 401 | S | A | -0.6894 | |
| 402 | Y | A | -0.0595 | |
| 403 | C | A | -0.3634 | |
| 404 | H | A | -0.3297 | |
| 405 | T | A | -0.8240 | |
| 406 | K | A | -1.6472 | |
| 407 | A | A | -1.3345 | |
| 408 | D | A | -1.5047 | |
| 409 | Y | A | 0.0000 | |
| 410 | E | A | -2.9107 | |
| 411 | E | A | -2.4036 | |
| 412 | Y | A | -0.5148 | |
| 413 | G | A | -1.1073 | |
| 414 | A | A | -1.1529 | |
| 415 | S | A | -0.6218 | |
| 416 | I | A | -0.6312 | |
| 417 | A | A | -1.7898 | |
| 418 | R | A | -2.8891 | |
| 419 | R | A | -2.5575 | |
| 420 | Y | A | -0.7025 | |
| 421 | Q | A | -0.0155 | |
| 422 | I | A | 1.6005 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine