Project name: 5GGQ

Chain sequence(s)	H: QVQLVESGGGVVQPGRSLRLDCKASGITFSNSGMHWVRQAPGKGLEWVAVIWYDGSKRYYADSVKGRFTISRDNSKNTLFLQMNSLRAEDTAVYYCATNDDYWGQGTLVTVSS; L: EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQSSNWPRTFGQGTKVEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:00:59)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:00)

• Minimal score value: -2.5728
• Maximal score value: 1.7662
• Average score: -0.6035
• Total score value: -132.7805

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	Q	H	-1.2708
2	V	H	-0.3932
3	Q	H	-0.6631
4	L	H	0.0000
5	V	H	0.2732
6	E	H	0.0000
7	S	H	-0.5411
8	G	H	-0.6941
9	G	H	0.2159
11	G	H	0.9397
12	V	H	1.7662
13	V	H	-0.0096
14	Q	H	-1.1581
15	P	H	-1.7589
16	G	H	-2.0259
17	R	H	-2.5728
18	S	H	-1.8193
19	L	H	-1.0226
20	R	H	-1.6695
21	L	H	0.0000
22	D	H	-0.9593
23	C	H	0.0000
24	K	H	-1.5358
25	A	H	0.0000
26	S	H	-0.8902
27	G	H	-0.7445
28	I	H	-0.2110
29	T	H	-0.3374
30	F	H	0.0000
35	S	H	-1.2138
36	N	H	-1.2321
37	S	H	-1.0183
38	G	H	-0.8908
39	M	H	0.0000
40	H	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	R	H	0.0000
44	Q	H	-0.6191
45	A	H	-1.0030
46	P	H	-0.8000
47	G	H	-1.4842
48	K	H	-2.3760
49	G	H	-1.5691
50	L	H	0.0000
51	E	H	-1.0217
52	W	H	0.0000
53	V	H	0.0000
54	A	H	0.0000
55	V	H	0.0000
56	I	H	0.0000
57	W	H	-0.6269
58	Y	H	-0.4621
59	D	H	-1.8099
62	G	H	-1.2027
63	S	H	-1.1810
64	K	H	-1.4253
65	R	H	-1.0074
66	Y	H	-0.2627
67	Y	H	-0.6111
68	A	H	-1.2942
69	D	H	-2.4620
70	S	H	-1.6293
71	V	H	0.0000
72	K	H	-2.1345
74	G	H	-1.5271
75	R	H	-1.3251
76	F	H	0.0000
77	T	H	-0.7534
78	I	H	0.0000
79	S	H	-0.4308
80	R	H	-1.0659
81	D	H	-1.7931
82	N	H	-1.8515
83	S	H	-1.5377
84	K	H	-2.5577
85	N	H	-2.0035
86	T	H	0.0000
87	L	H	0.0000
88	F	H	-0.6050
89	L	H	0.0000
90	Q	H	-1.0892
91	M	H	0.0000
92	N	H	-1.6849
93	S	H	-1.6245
94	L	H	0.0000
95	R	H	-2.2821
96	A	H	-1.5528
97	E	H	-2.1876
98	D	H	0.0000
99	T	H	-0.2948
100	A	H	0.0000
101	V	H	0.8464
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	A	H	0.0000
106	T	H	0.0000
107	N	H	-1.4991
115	D	H	-1.8091
116	D	H	-0.8244
117	Y	H	0.1954
118	W	H	-0.0519
119	G	H	0.0000
120	Q	H	-1.0800
121	G	H	-0.1071
122	T	H	0.0000
123	L	H	1.7493
124	V	H	0.0000
125	T	H	0.5511
126	V	H	0.0000
127	S	H	-0.4297
128	S	H	-0.3288
1	E	L	-1.8877
2	I	L	0.0000
3	V	L	0.6118
4	L	L	0.0000
5	T	L	-0.7149
6	Q	L	0.0000
7	S	L	-0.7837
8	P	L	-0.3540
9	A	L	-0.4439
10	T	L	-0.4228
11	L	L	-0.1202
12	S	L	-0.2606
13	L	L	-0.5041
14	S	L	-0.8227
15	P	L	-1.1821
16	G	L	-1.5628
17	E	L	-1.9598
18	R	L	-2.4655
19	A	L	0.0000
20	T	L	-0.6528
21	L	L	0.0000
22	S	L	-0.8660
23	C	L	0.0000
24	R	L	-2.3185
25	A	L	0.0000
26	S	L	-1.0431
27	Q	L	-1.7310
28	S	L	-1.1906
29	V	L	0.0000
36	S	L	-0.3629
37	S	L	-0.1083
38	Y	L	0.7268
39	L	L	0.0000
40	A	L	0.0763
41	W	L	0.0000
42	Y	L	0.0000
43	Q	L	0.0000
44	Q	L	0.0000
45	K	L	-0.8813
46	P	L	-0.7770
47	G	L	-1.0577
48	Q	L	-1.2137
49	A	L	-0.7180
50	P	L	0.0000
51	R	L	-0.4041
52	L	L	-0.1345
53	L	L	0.0000
54	I	L	0.0000
55	Y	L	-0.3079
56	D	L	-0.8193
57	A	L	0.0000
65	S	L	-1.0736
66	N	L	-1.6024
67	R	L	-1.4082
68	A	L	-0.9292
69	T	L	-0.5222
70	G	L	-0.5382
71	I	L	-0.3418
72	P	L	-0.2822
74	A	L	-0.2716
75	R	L	-0.5792
76	F	L	0.0000
77	S	L	-0.6401
78	G	L	-0.7415
79	S	L	-0.8668
80	G	L	-1.1314
83	S	L	-0.9228
84	G	L	-0.9885
85	T	L	-1.7196
86	D	L	-2.0816
87	F	L	0.0000
88	T	L	-0.7549
89	L	L	0.0000
90	T	L	-0.5992
91	I	L	0.0000
92	S	L	-1.2077
93	S	L	-1.5594
94	L	L	0.0000
95	E	L	-1.7861
96	P	L	-0.9340
97	E	L	-1.4149
98	D	L	0.0000
99	F	L	-0.0845
100	A	L	0.0000
101	V	L	-0.1910
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	Q	L	0.0000
106	Q	L	0.0000
107	S	L	-0.1990
108	S	L	-0.2394
109	N	L	-1.1308
114	W	L	-0.4517
115	P	L	-0.7814
116	R	L	-0.4612
117	T	L	-0.3322
118	F	L	-0.0091
119	G	L	0.0000
120	Q	L	-1.3059
121	G	L	0.0000
122	T	L	0.0000
123	K	L	-0.7314
124	V	L	0.0000
125	E	L	0.0005
126	I	L	0.8962
127	K	L	-0.8319