Project name: 8ab283874a10801

Chain sequence(s)	H: EVKLEESGGGLVQPGGSMKLSCVASGFIFSNHWMNWVRQSPEKGLEWVAEIRSKSINSATHYAESVKGRFTISRDDSKSAVYLQMTDLRTEDTGVYYCSRNYYGSTYDYWGQGTTLTVSS; L: DILLTQSPAILSVSPGERVSFSCRASQFVGSSIHWYQQRTNGSPRLLIKYASESMSGIPSRFSGSGSGTDFTLSINTVESEDIADYYCQQSHSWPFTFGSGTNLEVK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:01)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:02:04)
[INFO]       Main:     Simulation completed successfully.                                          (00:02:05)

• Minimal score value: -3.1521
• Maximal score value: 1.9129
• Average score: -0.575
• Total score value: -130.5351

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-2.1459
2	V	H	-1.3240
3	K	H	-2.0599
4	L	H	0.0000
5	E	H	-2.1398
6	E	H	-1.2265
7	S	H	-1.0733
8	G	H	-1.0341
9	G	H	-0.4448
11	G	H	0.4215
12	L	H	1.1968
13	V	H	-0.0387
14	Q	H	-1.4411
15	P	H	-1.7409
16	G	H	-1.6467
17	G	H	-1.1013
18	S	H	-1.2929
19	M	H	-0.9403
20	K	H	-1.9796
21	L	H	0.0000
22	S	H	-0.6437
23	C	H	0.0000
24	V	H	0.1014
25	A	H	0.0000
26	S	H	-0.8232
27	G	H	-0.8415
28	F	H	0.3796
29	I	H	1.5899
30	F	H	0.0000
35	S	H	-0.6546
36	N	H	-0.8088
37	H	H	0.1547
38	W	H	0.0680
39	M	H	0.0000
40	N	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	R	H	0.0000
44	Q	H	-0.5626
45	S	H	0.0000
46	P	H	-1.3546
47	E	H	-2.5437
48	K	H	-1.9850
49	G	H	-1.1191
50	L	H	0.0000
51	E	H	-0.5212
52	W	H	0.0000
53	V	H	0.0000
54	A	H	0.0000
55	E	H	0.0000
56	I	H	0.0000
57	R	H	-0.6609
58	S	H	0.0000
59	K	H	-2.2092
60	S	H	-1.0181
61	I	H	-0.0590
62	N	H	-1.4258
63	S	H	-1.1636
64	A	H	-0.5836
65	T	H	-0.2348
66	H	H	-0.6283
67	Y	H	-1.0172
68	A	H	-1.3755
69	E	H	-2.5456
70	S	H	-1.8312
71	V	H	0.0000
72	K	H	-2.5932
74	G	H	-1.7227
75	R	H	-1.6766
76	F	H	0.0000
77	T	H	-0.8680
78	I	H	0.0000
79	S	H	-0.3769
80	R	H	-0.8790
81	D	H	-1.1789
82	D	H	-1.4019
83	S	H	-1.4421
84	K	H	-1.8665
85	S	H	-0.5534
86	A	H	0.0000
87	V	H	0.0000
88	Y	H	-0.3266
89	L	H	0.0000
90	Q	H	-1.3688
91	M	H	0.0000
92	T	H	-1.3439
93	D	H	-1.7564
94	L	H	0.0000
95	R	H	-2.4973
96	T	H	-1.8458
97	E	H	-2.6259
98	D	H	0.0000
99	T	H	-0.6694
100	G	H	-0.5622
101	V	H	0.1868
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	S	H	0.0000
106	R	H	0.0000
107	N	H	0.0000
108	Y	H	1.9129
109	Y	H	1.7187
110	G	H	0.8106
113	S	H	0.0000
114	T	H	0.0000
115	Y	H	0.0000
116	D	H	0.1184
117	Y	H	0.2142
118	W	H	-0.7305
119	G	H	0.0000
120	Q	H	-2.0538
121	G	H	-1.0188
122	T	H	-0.6923
123	T	H	0.1092
124	L	H	0.0000
125	T	H	-0.0229
126	V	H	0.0000
127	S	H	-0.7536
128	S	H	-0.5685
1	D	L	-1.4973
2	I	L	0.0000
3	L	L	0.6787
4	L	L	0.0000
5	T	L	-0.2517
6	Q	L	0.0000
7	S	L	-0.1792
8	P	L	0.2612
9	A	L	0.5087
10	I	L	1.0651
11	L	L	0.4225
12	S	L	-0.4899
13	V	L	0.0000
14	S	L	-2.0016
15	P	L	-2.0213
16	G	L	-2.3081
17	E	L	-3.1334
18	R	L	-3.1521
19	V	L	0.0000
20	S	L	-0.8431
21	F	L	0.0000
22	S	L	-0.6322
23	C	L	0.0000
24	R	L	-1.3446
25	A	L	0.0000
26	S	L	-0.4142
27	Q	L	-0.4190
28	F	L	0.9545
29	V	L	0.0000
36	G	L	0.0961
37	S	L	-0.0905
38	S	L	0.0626
39	I	L	0.0000
40	H	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	Q	L	0.0000
44	Q	L	-1.2582
45	R	L	-1.5449
46	T	L	-0.9882
47	N	L	-1.7187
48	G	L	-1.5616
49	S	L	-1.2659
50	P	L	0.0000
51	R	L	-1.7777
52	L	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	K	L	-0.5197
56	Y	L	-0.0050
57	A	L	0.0000
65	S	L	-0.8051
66	E	L	-1.1848
67	S	L	-0.7914
68	M	L	-0.4369
69	S	L	-0.4640
70	G	L	-0.4744
71	I	L	-0.3741
72	P	L	-0.4076
74	S	L	-0.6389
75	R	L	-1.2829
76	F	L	0.0000
77	S	L	-0.7426
78	G	L	-0.5562
79	S	L	-0.6637
80	G	L	-0.8281
83	S	L	-0.4984
84	G	L	-0.1956
85	T	L	-0.7271
86	D	L	-1.5414
87	F	L	0.0000
88	T	L	-0.6437
89	L	L	0.0000
90	S	L	0.0000
91	I	L	0.0000
92	N	L	-2.4419
93	T	L	-2.3928
94	V	L	0.0000
95	E	L	-2.6895
96	S	L	-1.9415
97	E	L	-2.1580
98	D	L	0.0000
99	I	L	-0.4826
100	A	L	0.0000
101	D	L	-0.6498
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	Q	L	0.0000
106	Q	L	0.0000
107	S	L	-0.1844
108	H	L	-0.2527
109	S	L	-0.3113
114	W	L	-0.1525
115	P	L	-0.5713
116	F	L	0.0000
117	T	L	-0.0356
118	F	L	0.3164
119	G	L	0.0000
120	S	L	-0.4792
121	G	L	0.0000
122	T	L	0.0000
123	N	L	-0.3471
124	L	L	0.0000
125	E	L	-1.0395
126	V	L	-1.4762
127	K	L	-1.9662