Project name: 8acd0a5a7306d19

Chain sequence(s)	H: QVTLKESGPTLVKPTETLTLTCTLSGFSLNNARMGVSWIRQPPGKCLEWLAHIFSNDEKSYSTSLKNRLTISKDSSKTQVVLTMTNVDPVDTATYYCARIVGYGSGWYGFFDYWGQGTLVTVSS; L: DIQMTQSPSSLSASVGDRVTITCRASQGIRNDLGWYQQKPGKAPKRLIYAASTLQSGVPSRFSGSGSGTEFTLTISSLQPEDFATYYCLQHNSYPLTFGCGTKVEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:01)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:01)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:01)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:01)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:01)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:01:52)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:54)

• Minimal score value: -2.8475
• Maximal score value: 1.2113
• Average score: -0.6003
• Total score value: -138.6778

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	Q	H	-1.2453
2	V	H	-0.4115
3	T	H	-0.6990
4	L	H	0.0000
5	K	H	-1.8565
6	E	H	0.0000
7	S	H	-0.6493
8	G	H	-0.3382
9	P	H	-0.0423
11	T	H	0.3544
12	L	H	0.5215
13	V	H	0.0000
14	K	H	-1.7657
15	P	H	-1.4938
16	T	H	-1.7996
17	E	H	-1.9633
18	T	H	-1.2688
19	L	H	0.0000
20	T	H	-0.1926
21	L	H	0.0000
22	T	H	-0.3233
23	C	H	0.0000
24	T	H	-0.9705
25	L	H	0.0000
26	S	H	-0.7568
27	G	H	-0.7800
28	F	H	-0.6196
29	S	H	-1.1532
30	L	H	0.0000
31	N	H	-2.5289
34	N	H	-2.4162
35	A	H	-1.9648
36	R	H	-2.2670
37	M	H	-1.4031
38	G	H	0.0000
39	V	H	0.0000
40	S	H	0.0000
41	W	H	0.0000
42	I	H	0.0000
43	R	H	0.0000
44	Q	H	-0.6759
45	P	H	-0.4751
46	P	H	-0.7400
47	G	H	-1.3605
48	K	H	-1.7991
49	C	H	-0.5132
50	L	H	0.0000
51	E	H	-0.6035
52	W	H	0.0000
53	L	H	0.0000
54	A	H	0.0000
55	H	H	0.0000
56	I	H	0.0000
57	F	H	0.0000
58	S	H	-2.4591
59	N	H	-2.8475
63	D	H	-2.7016
64	E	H	-2.3694
65	K	H	-1.8602
66	S	H	-0.8257
67	Y	H	-0.7163
68	S	H	0.0000
69	T	H	-1.0058
70	S	H	-1.1172
71	L	H	0.0000
72	K	H	-2.4454
74	N	H	-2.2764
75	R	H	-1.7590
76	L	H	0.0000
77	T	H	-0.6749
78	I	H	0.0000
79	S	H	-0.7151
80	K	H	-1.0840
81	D	H	-1.5278
82	S	H	-1.6151
83	S	H	-1.5056
84	K	H	-2.1574
85	T	H	-1.5205
86	Q	H	-1.2783
87	V	H	0.0000
88	V	H	0.1921
89	L	H	0.0000
90	T	H	-0.0118
91	M	H	0.0000
92	T	H	-1.3746
93	N	H	-2.1585
94	V	H	0.0000
95	D	H	-1.3949
96	P	H	-0.2139
97	V	H	1.2113
98	D	H	0.0000
99	T	H	0.4234
100	A	H	0.0000
101	T	H	0.0489
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	A	H	0.0000
106	R	H	0.1140
107	I	H	0.0000
108	V	H	0.0235
109	G	H	0.0000
110	Y	H	0.1227
111	G	H	-0.5019
111A	S	H	-0.3015
112B	G	H	-0.2575
112A	W	H	0.2977
112	Y	H	0.5449
113	G	H	0.0000
114	F	H	0.0000
115	F	H	0.0000
116	D	H	-0.0828
117	Y	H	0.5042
118	W	H	-0.4782
119	G	H	-1.1219
120	Q	H	-1.9502
121	G	H	-1.1024
122	T	H	-0.2926
123	L	H	0.5743
124	V	H	0.0000
125	T	H	0.2363
126	V	H	0.0000
127	S	H	-0.7896
128	S	H	-0.6019
1	D	L	-2.0817
2	I	L	0.0000
3	Q	L	-1.9276
4	M	L	0.0000
5	T	L	-0.6643
6	Q	L	0.0000
7	S	L	-0.3618
8	P	L	-0.3474
9	S	L	-0.4366
10	S	L	-0.7728
11	L	L	-0.6140
12	S	L	-0.9631
13	A	L	0.0000
14	S	L	-0.8273
15	V	L	0.1292
16	G	L	-0.8247
17	D	L	-1.8873
18	R	L	-2.3626
19	V	L	0.0000
20	T	L	-0.6485
21	I	L	0.0000
22	T	L	-0.5093
23	C	L	0.0000
24	R	L	-1.6976
25	A	L	0.0000
26	S	L	-1.7105
27	Q	L	-2.1147
28	G	L	-1.8856
29	I	L	0.0000
36	R	L	-2.4570
37	N	L	-1.6209
38	D	L	0.0000
39	L	L	0.0000
40	G	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	Q	L	0.0000
44	Q	L	-1.1267
45	K	L	-1.4680
46	P	L	-1.0842
47	G	L	-1.6694
48	K	L	-2.5680
49	A	L	-1.5853
50	P	L	0.0000
51	K	L	-1.2529
52	R	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	Y	L	0.1339
56	A	L	-0.2515
57	A	L	0.0000
65	S	L	-0.3006
66	T	L	0.0665
67	L	L	0.2304
68	Q	L	-0.3435
69	S	L	-0.4360
70	G	L	-0.5956
71	V	L	0.0000
72	P	L	-0.4381
74	S	L	-0.4978
75	R	L	-0.8601
76	F	L	0.0000
77	S	L	-0.3552
78	G	L	-0.2467
79	S	L	-0.6552
80	G	L	-1.1484
83	S	L	-1.5593
84	G	L	-1.8402
85	T	L	-1.7447
86	E	L	-1.6364
87	F	L	0.0000
88	T	L	-0.5510
89	L	L	0.0000
90	T	L	-0.6438
91	I	L	0.0000
92	S	L	-1.4585
93	S	L	-1.2445
94	L	L	0.0000
95	Q	L	-0.6301
96	P	L	-0.8874
97	E	L	-1.5534
98	D	L	0.0000
99	F	L	-0.0814
100	A	L	0.0000
101	T	L	-0.4531
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	L	L	0.0000
106	Q	L	0.0000
107	H	L	0.0000
108	N	L	-0.4790
109	S	L	0.0446
114	Y	L	0.4434
115	P	L	0.0000
116	L	L	0.0000
117	T	L	-0.4629
118	F	L	0.0000
119	G	L	0.0000
120	C	L	0.2250
121	G	L	0.0000
122	T	L	0.0000
123	K	L	-1.0915
124	V	L	0.0000
125	E	L	-0.9786
126	I	L	-0.5284
127	K	L	-1.5242