Project name: 8bb37dd640ea92d

Chain sequence(s)	A: IQLTQSPSFLSASVGDRVTITCKASQNVDTNVAWYQQKPGKAPKALIYSASYRYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYNNYPFTFGQGTKLEIKGGGGSGGGGSGGGGSEVQLVESGGGLVQPGGSLRLSCAASGFTFSSFGMHWVRQAPGKGLEWVAYISSDSSAIYYADTVKGRFTISRDNAKNSLYLQMNSLRDEDTAVYYCGRGRENIYYGSRLDYWGQGTTVTVSS
Selected Chain(s)	A
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with A chain(s) selected             (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:02:44)
[INFO]       Main:     Simulation completed successfully.                                          (00:02:46)

• Minimal score value: -3.5794
• Maximal score value: 1.717
• Average score: -0.629
• Total score value: -152.8485

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	I	A	-0.7205
2	Q	A	-1.5615
3	L	A	0.0000
4	T	A	-1.1927
5	Q	A	0.0000
6	S	A	-0.2849
7	P	A	0.1987
8	S	A	0.3935
9	F	A	1.3402
10	L	A	0.3951
11	S	A	-0.5278
12	A	A	0.0000
13	S	A	-0.7389
14	V	A	-0.0550
15	G	A	-0.8521
16	D	A	-1.5122
17	R	A	-2.2069
18	V	A	0.0000
19	T	A	-0.5927
20	I	A	0.0000
21	T	A	-0.7424
22	C	A	0.0000
23	K	A	-2.3826
24	A	A	0.0000
25	S	A	-1.7306
26	Q	A	-2.4442
27	N	A	-2.7910
28	V	A	0.0000
29	D	A	-2.7327
30	T	A	-1.4404
31	N	A	-1.2755
32	V	A	0.0000
33	A	A	0.0000
34	W	A	0.0000
35	Y	A	0.0000
36	Q	A	0.0000
37	Q	A	0.0000
38	K	A	-1.3670
39	P	A	-1.0529
40	G	A	-1.2529
41	K	A	-1.7461
42	A	A	-1.2024
43	P	A	0.0000
44	K	A	-1.2489
45	A	A	0.0000
46	L	A	0.0000
47	I	A	0.0000
48	Y	A	-0.0536
49	S	A	-0.4260
50	A	A	0.0000
51	S	A	-0.0574
52	Y	A	0.5359
53	R	A	-0.9430
54	Y	A	-0.5769
55	S	A	-0.5724
56	G	A	-0.7791
57	V	A	0.0000
58	P	A	-0.6524
59	S	A	-0.7469
60	R	A	-0.9365
61	F	A	0.0000
62	S	A	-0.5179
63	G	A	-0.3369
64	S	A	-0.4990
65	G	A	-1.2664
66	S	A	-1.7485
67	G	A	-2.2738
68	T	A	-2.2820
69	D	A	-2.3989
70	F	A	0.0000
71	T	A	-0.7150
72	L	A	0.0000
73	T	A	-0.5877
74	I	A	0.0000
75	S	A	-1.2787
76	S	A	-1.1981
77	L	A	0.0000
78	Q	A	-0.8970
79	P	A	-0.8704
80	E	A	-1.5418
81	D	A	0.0000
82	F	A	-0.5498
83	A	A	0.0000
84	T	A	-0.4573
85	Y	A	0.0000
86	Y	A	0.0000
87	C	A	0.0000
88	Q	A	0.0000
89	Q	A	0.0000
90	Y	A	-0.1389
91	N	A	-1.0006
92	N	A	-0.3106
93	Y	A	0.4512
94	P	A	-0.0551
95	F	A	0.0000
96	T	A	-0.4742
97	F	A	0.0000
98	G	A	0.0000
99	Q	A	-1.4763
100	G	A	0.0000
101	T	A	0.0000
102	K	A	-0.4032
103	L	A	0.0000
104	E	A	-0.8876
105	I	A	-0.4911
106	K	A	-1.7629
107	G	A	-1.2929
108	G	A	-1.2454
109	G	A	-1.1887
110	G	A	-1.0014
111	S	A	-0.8530
112	G	A	-1.0979
113	G	A	-1.5089
114	G	A	-1.3568
115	G	A	-1.1755
116	S	A	-1.2677
117	G	A	-1.1413
118	G	A	-1.2778
119	G	A	-1.4456
120	G	A	-1.4438
121	S	A	-1.7456
122	E	A	-2.3159
123	V	A	0.0000
124	Q	A	-0.8098
125	L	A	0.2818
126	V	A	1.2524
127	E	A	0.1540
128	S	A	-0.3685
129	G	A	-1.0412
130	G	A	-0.4262
131	G	A	0.2595
132	L	A	1.1980
133	V	A	-0.2141
134	Q	A	-1.6309
135	P	A	-2.3271
136	G	A	-1.8086
137	G	A	-1.1733
138	S	A	-1.4833
139	L	A	-1.0756
140	R	A	-2.2436
141	L	A	0.0000
142	S	A	-0.4038
143	C	A	0.0000
144	A	A	0.0035
145	A	A	0.0000
146	S	A	-0.8290
147	G	A	-1.1326
148	F	A	-0.4692
149	T	A	-0.2306
150	F	A	0.0000
151	S	A	-0.9579
152	S	A	-0.2749
153	F	A	-0.1238
154	G	A	0.2437
155	M	A	0.0000
156	H	A	0.0000
157	W	A	0.0000
158	V	A	0.0000
159	R	A	0.0000
160	Q	A	-0.8614
161	A	A	-1.2191
162	P	A	-0.9921
163	G	A	-1.4953
164	K	A	-2.3278
165	G	A	-1.5671
166	L	A	0.0000
167	E	A	-1.1649
168	W	A	0.0000
169	V	A	0.0000
170	A	A	0.0000
171	Y	A	0.0000
172	I	A	0.0000
173	S	A	0.1681
174	S	A	-0.6682
175	D	A	-2.1034
176	S	A	-1.0277
177	S	A	-0.5772
178	A	A	0.2564
179	I	A	1.3645
180	Y	A	0.8022
181	Y	A	-0.2487
182	A	A	0.0000
183	D	A	-2.2374
184	T	A	-1.6521
185	V	A	0.0000
186	K	A	-2.4792
187	G	A	-1.7894
188	R	A	-1.5822
189	F	A	0.0000
190	T	A	-0.8093
191	I	A	0.0000
192	S	A	-0.1376
193	R	A	0.0000
194	D	A	-1.5411
195	N	A	-1.8462
196	A	A	-1.3344
197	K	A	-2.2861
198	N	A	-1.7915
199	S	A	0.0000
200	L	A	0.0000
201	Y	A	-0.5543
202	L	A	0.0000
203	Q	A	-1.7422
204	M	A	0.0000
205	N	A	-2.2146
206	S	A	-1.6006
207	L	A	0.0000
208	R	A	-3.2689
209	D	A	-3.5794
210	E	A	-3.1244
211	D	A	0.0000
212	T	A	-1.1890
213	A	A	0.0000
214	V	A	0.0055
215	Y	A	0.0000
216	Y	A	0.0000
217	C	A	0.0000
218	G	A	0.0000
219	R	A	0.0000
220	G	A	0.0000
221	R	A	-0.9637
222	E	A	-1.9756
223	N	A	-0.7848
224	I	A	1.7170
225	Y	A	1.6626
226	Y	A	1.3860
227	G	A	0.0000
228	S	A	0.0000
229	R	A	0.0000
230	L	A	0.0000
231	D	A	-0.5339
232	Y	A	-0.5043
233	W	A	-0.3414
234	G	A	0.0000
235	Q	A	-1.2111
236	G	A	-0.6710
237	T	A	-0.3067
238	T	A	0.0759
239	V	A	0.0000
240	T	A	-0.3721
241	V	A	0.0000
242	S	A	-1.3689
243	S	A	-0.7470