| Chain sequence(s) |
A: GPLPTNPEPEVKSTDEYVTPTDLLYIAETDKITEIGHPEADIVVNGKVLVPKVSAYQWRVFKLTLPDPNTLPLPSKDFLDKTTEIAIWRLLAFKIKVFGPLGYGSVGHPNFNAFGDVDNPTAYQHCGADDTQDLSFRPVLKQMYIIGDEPPIGKYTAPAPPEPGLPPGARPPLKTVSTIIEHGDMADIGFGARDFAALEPDKDRVPLDILNTVTKVPDFDGMKAEKYGTRMFTYDRYEKSRSVRNLVRCGPDLDPLPSSPPPSPLYTPPPPSSPYAVPPPYDYFTLPDRGEITEEDELFNKPIFLTKTEGKNNGILWYNQLYITVLDNRRAEIKTIKTRISTPAIDVYDPANYVESRLYEREYQLELILQLCKIPLTPETLEYIRRLDPRILEDANLPFIPPVERPDPLAGKKFINIDLTNKLSRNLSLYELGREYLNR
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:04)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | G | A | -0.2186 | |
| 2 | P | A | 0.1728 | |
| 3 | L | A | 0.9877 | |
| 4 | P | A | -0.0487 | |
| 5 | T | A | -0.7092 | |
| 6 | N | A | -1.7804 | |
| 7 | P | A | -2.1873 | |
| 8 | E | A | -2.8124 | |
| 9 | P | A | -2.3080 | |
| 10 | E | A | -2.5397 | |
| 11 | V | A | -1.7851 | |
| 12 | K | A | -2.5133 | |
| 13 | S | A | -2.2886 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -3.2399 | |
| 16 | E | A | -3.0268 | |
| 17 | Y | A | -1.7602 | |
| 18 | V | A | 0.0000 | |
| 19 | T | A | -0.9221 | |
| 20 | P | A | -1.0422 | |
| 21 | T | A | -1.0067 | |
| 22 | D | A | -1.8031 | |
| 23 | L | A | 0.0000 | |
| 24 | L | A | -0.8758 | |
| 25 | Y | A | 0.0000 | |
| 26 | I | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | E | A | -1.2763 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -2.7550 | |
| 31 | K | A | -2.6624 | |
| 32 | I | A | -1.2170 | |
| 33 | T | A | -0.5906 | |
| 34 | E | A | -0.0162 | |
| 35 | I | A | 0.9575 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -0.4779 | |
| 38 | P | A | 0.0000 | |
| 39 | E | A | -0.4288 | |
| 40 | A | A | -0.1658 | |
| 41 | D | A | 0.0326 | |
| 42 | I | A | 1.9446 | |
| 43 | V | A | 2.6244 | |
| 44 | V | A | 1.7389 | |
| 45 | N | A | -0.5282 | |
| 46 | G | A | -0.3316 | |
| 47 | K | A | -0.0551 | |
| 48 | V | A | 2.3354 | |
| 49 | L | A | 2.7374 | |
| 50 | V | A | 2.0348 | |
| 51 | P | A | 0.6533 | |
| 52 | K | A | -0.1723 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | A | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | K | A | -1.0742 | |
| 63 | L | A | 0.0000 | |
| 64 | T | A | -1.1087 | |
| 65 | L | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -0.8091 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -0.8257 | |
| 70 | T | A | -0.2073 | |
| 71 | L | A | -0.0021 | |
| 72 | P | A | -0.3034 | |
| 73 | L | A | -0.4905 | |
| 74 | P | A | -0.7346 | |
| 75 | S | A | -1.5002 | |
| 76 | K | A | -2.7414 | |
| 77 | D | A | -2.9769 | |
| 78 | F | A | -1.6871 | |
| 79 | L | A | 0.0000 | |
| 80 | D | A | -2.9166 | |
| 81 | K | A | -2.7360 | |
| 82 | T | A | -1.2911 | |
| 83 | T | A | -1.2391 | |
| 84 | E | A | -1.5243 | |
| 85 | I | A | 0.0000 | |
| 86 | A | A | 0.0000 | |
| 87 | I | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | -0.2769 | |
| 90 | L | A | 0.0000 | |
| 91 | L | A | 0.1191 | |
| 92 | A | A | 0.0000 | |
| 93 | F | A | 0.0000 | |
| 94 | K | A | 0.0000 | |
| 95 | I | A | 0.0000 | |
| 96 | K | A | -0.8708 | |
| 97 | V | A | 0.0000 | |
| 98 | F | A | -0.2025 | |
| 99 | G | A | -0.4762 | |
| 100 | P | A | -0.1738 | |
| 101 | L | A | 0.0974 | |
| 102 | G | A | 0.2320 | |
| 103 | Y | A | 0.4779 | |
| 104 | G | A | 0.0000 | |
| 105 | S | A | -0.2944 | |
| 106 | V | A | 0.0000 | |
| 107 | G | A | -0.6180 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | -1.8990 | |
| 110 | N | A | -2.9273 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | 0.0000 | |
| 113 | A | A | 0.0000 | |
| 114 | F | A | -0.6651 | |
| 115 | G | A | -0.7859 | |
| 116 | D | A | -1.5727 | |
| 117 | V | A | -1.0300 | |
| 118 | D | A | -2.4523 | |
| 119 | N | A | -2.3321 | |
| 120 | P | A | -1.2437 | |
| 121 | T | A | -0.6707 | |
| 122 | A | A | -0.3082 | |
| 123 | Y | A | 0.2625 | |
| 124 | Q | A | -0.8549 | |
| 125 | H | A | -0.8435 | |
| 126 | C | A | -0.9677 | |
| 127 | G | A | -1.2785 | |
| 128 | A | A | -1.0912 | |
| 129 | D | A | -2.3689 | |
| 130 | D | A | -1.8841 | |
| 131 | T | A | -2.3080 | |
| 132 | Q | A | -2.8539 | |
| 133 | D | A | -2.8270 | |
| 134 | L | A | -1.3983 | |
| 135 | S | A | -0.7548 | |
| 136 | F | A | 0.0000 | |
| 137 | R | A | -0.5369 | |
| 138 | P | A | 0.0000 | |
| 139 | V | A | 0.0000 | |
| 140 | L | A | 0.0000 | |
| 141 | K | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | M | A | 0.0000 | |
| 144 | Y | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | I | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | D | A | 0.0000 | |
| 149 | E | A | -0.3747 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | I | A | 0.1839 | |
| 153 | G | A | 0.0000 | |
| 154 | K | A | -0.4753 | |
| 155 | Y | A | -0.5554 | |
| 156 | T | A | -0.3162 | |
| 157 | A | A | 0.0000 | |
| 158 | P | A | -0.1625 | |
| 159 | A | A | -0.3012 | |
| 160 | P | A | -0.8143 | |
| 161 | P | A | -1.3296 | |
| 162 | E | A | -2.0889 | |
| 163 | P | A | -1.2958 | |
| 164 | G | A | -0.8134 | |
| 165 | L | A | -0.5536 | |
| 166 | P | A | -0.4924 | |
| 167 | P | A | -0.7229 | |
| 168 | G | A | -0.7975 | |
| 169 | A | A | -0.8395 | |
| 170 | R | A | -1.5175 | |
| 171 | P | A | -1.0814 | |
| 172 | P | A | -0.4880 | |
| 173 | L | A | 0.5805 | |
| 174 | K | A | -0.4476 | |
| 175 | T | A | -0.3994 | |
| 176 | V | A | -0.2554 | |
| 177 | S | A | -0.3177 | |
| 178 | T | A | 0.0345 | |
| 179 | I | A | -0.1513 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | -1.0373 | |
| 182 | H | A | -1.1233 | |
| 183 | G | A | -0.7157 | |
| 184 | D | A | -0.6103 | |
| 185 | M | A | 0.0000 | |
| 186 | A | A | 0.0000 | |
| 187 | D | A | -0.2331 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | -0.5227 | |
| 190 | F | A | -0.2524 | |
| 191 | G | A | -0.3674 | |
| 192 | A | A | -0.4287 | |
| 193 | R | A | -0.6026 | |
| 194 | D | A | -0.4337 | |
| 195 | F | A | 0.0000 | |
| 196 | A | A | -0.7877 | |
| 197 | A | A | -0.1588 | |
| 198 | L | A | -0.4030 | |
| 199 | E | A | 0.0000 | |
| 200 | P | A | -1.5510 | |
| 201 | D | A | -2.3972 | |
| 202 | K | A | -2.6542 | |
| 203 | D | A | -2.2160 | |
| 204 | R | A | -1.7094 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | L | A | -0.0854 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | L | A | -0.5465 | |
| 211 | N | A | -1.0004 | |
| 212 | T | A | -0.3667 | |
| 213 | V | A | -0.1582 | |
| 214 | T | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | V | A | 0.0315 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | -0.9812 | |
| 219 | F | A | -1.3010 | |
| 220 | D | A | -2.4618 | |
| 221 | G | A | -1.7611 | |
| 222 | M | A | 0.0000 | |
| 223 | K | A | -2.9645 | |
| 224 | A | A | -2.0960 | |
| 225 | E | A | -2.2101 | |
| 226 | K | A | -2.2774 | |
| 227 | Y | A | -1.5848 | |
| 228 | G | A | 0.0000 | |
| 229 | T | A | 0.0000 | |
| 230 | R | A | -0.5758 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | T | A | -0.9369 | |
| 234 | Y | A | -0.7913 | |
| 235 | D | A | -1.4914 | |
| 236 | R | A | -2.3112 | |
| 237 | Y | A | -1.7060 | |
| 238 | E | A | -2.2083 | |
| 239 | K | A | -2.2068 | |
| 240 | S | A | -2.0258 | |
| 241 | R | A | -2.1270 | |
| 242 | S | A | -1.1403 | |
| 243 | V | A | -0.6558 | |
| 244 | R | A | -2.1389 | |
| 245 | N | A | -1.4388 | |
| 246 | L | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | R | A | 0.0000 | |
| 249 | C | A | -0.5052 | |
| 250 | G | A | -0.6996 | |
| 251 | P | A | -0.6534 | |
| 252 | D | A | -0.9093 | |
| 253 | L | A | -0.1859 | |
| 254 | D | A | -1.3590 | |
| 255 | P | A | -0.8095 | |
| 256 | L | A | 0.1529 | |
| 257 | P | A | -0.1108 | |
| 258 | S | A | -0.0074 | |
| 259 | S | A | -0.5118 | |
| 260 | P | A | -0.6077 | |
| 261 | P | A | -0.6470 | |
| 262 | P | A | -0.3539 | |
| 263 | S | A | 0.1391 | |
| 264 | P | A | 0.4838 | |
| 265 | L | A | 1.6097 | |
| 266 | Y | A | 0.9981 | |
| 267 | T | A | 0.1711 | |
| 268 | P | A | 0.2467 | |
| 269 | P | A | 0.1712 | |
| 270 | P | A | -0.1841 | |
| 271 | P | A | -0.1134 | |
| 272 | S | A | -0.3274 | |
| 273 | S | A | 0.2179 | |
| 274 | P | A | 0.4582 | |
| 275 | Y | A | 1.3871 | |
| 276 | A | A | 1.0809 | |
| 277 | V | A | 1.7703 | |
| 278 | P | A | 0.8958 | |
| 279 | P | A | 0.1951 | |
| 280 | P | A | -0.1906 | |
| 281 | Y | A | 0.2402 | |
| 282 | D | A | -0.1649 | |
| 283 | Y | A | 1.0476 | |
| 284 | F | A | 0.3091 | |
| 285 | T | A | -0.4379 | |
| 286 | L | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | D | A | 0.0000 | |
| 289 | R | A | 0.0000 | |
| 290 | G | A | 0.0000 | |
| 291 | E | A | -1.7104 | |
| 292 | I | A | -1.2797 | |
| 293 | T | A | -1.9699 | |
| 294 | E | A | -2.8316 | |
| 295 | E | A | -3.0293 | |
| 296 | D | A | -2.1671 | |
| 297 | E | A | -1.7195 | |
| 298 | L | A | -1.2982 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.1862 | |
| 301 | K | A | -1.5683 | |
| 302 | P | A | -0.6782 | |
| 303 | I | A | 0.2654 | |
| 304 | F | A | 0.1805 | |
| 305 | L | A | 0.0000 | |
| 306 | T | A | -0.7079 | |
| 307 | K | A | -2.4242 | |
| 308 | T | A | 0.0000 | |
| 309 | E | A | -2.7465 | |
| 310 | G | A | -2.5299 | |
| 311 | K | A | -2.7814 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | I | A | 0.0000 | |
| 316 | L | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | Y | A | -0.5101 | |
| 319 | N | A | -0.6188 | |
| 320 | Q | A | -0.6179 | |
| 321 | L | A | 0.0000 | |
| 322 | Y | A | 0.0000 | |
| 323 | I | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | L | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | R | A | 0.0000 | |
| 330 | R | A | 0.0000 | |
| 331 | A | A | 0.0000 | |
| 332 | E | A | -1.1429 | |
| 333 | I | A | -0.8375 | |
| 334 | K | A | -1.3527 | |
| 335 | T | A | -1.1668 | |
| 336 | I | A | -0.1124 | |
| 337 | K | A | -1.2701 | |
| 338 | T | A | -0.2113 | |
| 339 | R | A | 0.2288 | |
| 340 | I | A | 1.8654 | |
| 341 | S | A | 0.7379 | |
| 342 | T | A | 0.1667 | |
| 343 | P | A | -0.1478 | |
| 344 | A | A | -0.0039 | |
| 345 | I | A | 0.5072 | |
| 346 | D | A | -0.3677 | |
| 347 | V | A | 1.5618 | |
| 348 | Y | A | 1.4678 | |
| 349 | D | A | -0.0329 | |
| 350 | P | A | -0.3146 | |
| 351 | A | A | 0.3267 | |
| 352 | N | A | 0.5769 | |
| 353 | Y | A | 0.6300 | |
| 354 | V | A | 0.7146 | |
| 355 | E | A | -1.6456 | |
| 356 | S | A | -1.2185 | |
| 357 | R | A | -1.5423 | |
| 358 | L | A | -0.3395 | |
| 359 | Y | A | 0.0000 | |
| 360 | E | A | -0.2855 | |
| 361 | R | A | 0.0000 | |
| 362 | E | A | -0.7031 | |
| 363 | Y | A | 0.0000 | |
| 364 | Q | A | -1.3828 | |
| 365 | L | A | 0.0000 | |
| 366 | E | A | 0.0000 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | L | A | 0.0000 | |
| 370 | Q | A | -0.4873 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.5836 | |
| 374 | I | A | 0.0000 | |
| 375 | P | A | -0.7867 | |
| 376 | L | A | -0.8230 | |
| 377 | T | A | -0.8437 | |
| 378 | P | A | -1.3234 | |
| 379 | E | A | -2.3799 | |
| 380 | T | A | -1.7575 | |
| 381 | L | A | -1.6243 | |
| 382 | E | A | -2.6615 | |
| 383 | Y | A | 0.0000 | |
| 384 | I | A | 0.0000 | |
| 385 | R | A | -3.3010 | |
| 386 | R | A | -2.7929 | |
| 387 | L | A | -1.6290 | |
| 388 | D | A | -1.6265 | |
| 389 | P | A | -2.0373 | |
| 390 | R | A | -1.6048 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | 0.0000 | |
| 393 | E | A | -1.6788 | |
| 394 | D | A | -2.5540 | |
| 395 | A | A | -1.7692 | |
| 396 | N | A | -1.5932 | |
| 397 | L | A | 0.0000 | |
| 398 | P | A | 0.2075 | |
| 399 | F | A | 1.6968 | |
| 400 | I | A | 0.7871 | |
| 401 | P | A | 0.0517 | |
| 402 | P | A | -0.4770 | |
| 403 | V | A | -0.0482 | |
| 404 | E | A | -2.0274 | |
| 405 | R | A | -2.1207 | |
| 406 | P | A | -1.7590 | |
| 407 | D | A | -2.2009 | |
| 408 | P | A | -1.2620 | |
| 409 | L | A | -1.0153 | |
| 410 | A | A | -1.2092 | |
| 411 | G | A | -1.4195 | |
| 412 | K | A | -1.8307 | |
| 413 | K | A | -2.3986 | |
| 414 | F | A | -1.2933 | |
| 415 | I | A | -0.8815 | |
| 416 | N | A | -1.7458 | |
| 417 | I | A | -1.4825 | |
| 418 | D | A | -2.3611 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.4054 | |
| 421 | N | A | -1.8351 | |
| 422 | K | A | -1.7279 | |
| 423 | L | A | -1.0350 | |
| 424 | S | A | -1.2940 | |
| 425 | R | A | -2.1578 | |
| 426 | N | A | -1.8292 | |
| 427 | L | A | 0.0000 | |
| 428 | S | A | -0.5093 | |
| 429 | L | A | 0.5697 | |
| 430 | Y | A | -0.0796 | |
| 431 | E | A | -0.8764 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -1.6179 | |
| 435 | E | A | -1.7460 | |
| 436 | Y | A | -0.6125 | |
| 437 | L | A | -0.2018 | |
| 438 | N | A | -1.8994 | |
| 439 | R | A | -2.1351 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine