| Chain sequence(s) |
A: GALPLNPEPEPRPTSEYVTPTDLYVIAETDLLTETGHPFEDIVVDGKVVVPRVSAYDWKVFLLKLPDPNTFPLPSSDFLDPSTQIRIWQLKAYKIKRFGPLGKGSIGHPNFNRLGDVDNPTAPLHEGADDTVNLSFRPKRLQSYIIGDEPPLVKYTAPAPPEPGLPPGALPPTTVVTDVLQHGDRADIGFGAKDYKALEPRKNDVPDDILNTKTKVPDLDGMKAEPYGNRMFDYDSYSSSHDVKRYVRSGPDLIPLPDAPPPSKLYVRPPPSSPYAVRPSTDYFTIPDGGEITEDDLLFNKPFYFEKAPGKNNFVLWGNRLYVTVLDNTRAEIETIETRISTPAINVYDPSNYVTSRRYTEEYQLSLILQLCTIPLTPETLAYLARLDPSILVDAKLPFIPPVERPDPLAGLKFREIDLTDKLSTDLSKYELGQEFLNR
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:04)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | G | A | -0.0494 | |
| 2 | A | A | 0.7352 | |
| 3 | L | A | 1.5421 | |
| 4 | P | A | 0.7826 | |
| 5 | L | A | 0.9008 | |
| 6 | N | A | -1.0079 | |
| 7 | P | A | -1.7314 | |
| 8 | E | A | -2.6440 | |
| 9 | P | A | -2.5599 | |
| 10 | E | A | -2.7139 | |
| 11 | P | A | -1.6946 | |
| 12 | R | A | -1.7869 | |
| 13 | P | A | -1.5433 | |
| 14 | T | A | 0.0000 | |
| 15 | S | A | -1.6063 | |
| 16 | E | A | -2.1820 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | T | A | -0.5934 | |
| 20 | P | A | -0.6723 | |
| 21 | T | A | -0.6482 | |
| 22 | D | A | -1.6389 | |
| 23 | L | A | -0.3171 | |
| 24 | Y | A | -0.1048 | |
| 25 | V | A | 0.0000 | |
| 26 | I | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | E | A | -0.8644 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -1.3629 | |
| 31 | L | A | 0.2073 | |
| 32 | L | A | 0.0364 | |
| 33 | T | A | -0.1367 | |
| 34 | E | A | -0.3590 | |
| 35 | T | A | -0.6370 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -1.8221 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | -1.4444 | |
| 40 | E | A | -1.9806 | |
| 41 | D | A | -0.6558 | |
| 42 | I | A | 1.5096 | |
| 43 | V | A | 2.3080 | |
| 44 | V | A | 1.7151 | |
| 45 | D | A | -0.9568 | |
| 46 | G | A | -0.5384 | |
| 47 | K | A | -0.1611 | |
| 48 | V | A | 2.0097 | |
| 49 | V | A | 2.6557 | |
| 50 | V | A | 1.4391 | |
| 51 | P | A | 0.0566 | |
| 52 | R | A | -1.2780 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | A | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | D | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | K | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | L | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.1827 | |
| 65 | L | A | 0.0000 | |
| 66 | P | A | -1.1641 | |
| 67 | D | A | -0.8708 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -0.8871 | |
| 70 | T | A | -0.3035 | |
| 71 | F | A | -0.0682 | |
| 72 | P | A | -0.1953 | |
| 73 | L | A | 0.0464 | |
| 74 | P | A | -0.2749 | |
| 75 | S | A | -0.4280 | |
| 76 | S | A | -0.7621 | |
| 77 | D | A | -1.1966 | |
| 78 | F | A | 0.5237 | |
| 79 | L | A | -0.4116 | |
| 80 | D | A | -1.5949 | |
| 81 | P | A | -1.0276 | |
| 82 | S | A | -0.9364 | |
| 83 | T | A | -0.7691 | |
| 84 | Q | A | -0.6252 | |
| 85 | I | A | 0.0000 | |
| 86 | R | A | -0.3421 | |
| 87 | I | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | Q | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | K | A | -0.6053 | |
| 92 | A | A | 0.0000 | |
| 93 | Y | A | 0.0000 | |
| 94 | K | A | 0.0000 | |
| 95 | I | A | 0.0000 | |
| 96 | K | A | -0.4758 | |
| 97 | R | A | 0.0000 | |
| 98 | F | A | 0.4203 | |
| 99 | G | A | -0.3122 | |
| 100 | P | A | -0.3683 | |
| 101 | L | A | -0.2692 | |
| 102 | G | A | -1.0101 | |
| 103 | K | A | -1.5700 | |
| 104 | G | A | 0.0000 | |
| 105 | S | A | -0.8736 | |
| 106 | I | A | 0.0000 | |
| 107 | G | A | -0.9123 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | -1.4519 | |
| 110 | N | A | -2.2427 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | 0.0000 | |
| 113 | R | A | -0.8840 | |
| 114 | L | A | -0.7327 | |
| 115 | G | A | 0.0000 | |
| 116 | D | A | -1.2812 | |
| 117 | V | A | -1.0428 | |
| 118 | D | A | -2.1686 | |
| 119 | N | A | -2.1603 | |
| 120 | P | A | -1.0816 | |
| 121 | T | A | -0.5725 | |
| 122 | A | A | -0.3169 | |
| 123 | P | A | 0.2069 | |
| 124 | L | A | -0.2285 | |
| 125 | H | A | -1.1774 | |
| 126 | E | A | -1.9747 | |
| 127 | G | A | -1.8328 | |
| 128 | A | A | -1.3460 | |
| 129 | D | A | -2.3688 | |
| 130 | D | A | -1.8000 | |
| 131 | T | A | -1.3745 | |
| 132 | V | A | -1.0104 | |
| 133 | N | A | -1.5731 | |
| 134 | L | A | -0.8030 | |
| 135 | S | A | -0.6478 | |
| 136 | F | A | 0.0000 | |
| 137 | R | A | -0.8799 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | -1.0224 | |
| 140 | R | A | 0.0000 | |
| 141 | L | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | S | A | 0.0000 | |
| 144 | Y | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | I | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | D | A | 0.0000 | |
| 149 | E | A | -0.6040 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | L | A | -0.3230 | |
| 153 | V | A | 0.0000 | |
| 154 | K | A | -0.1636 | |
| 155 | Y | A | 0.0000 | |
| 156 | T | A | 0.3211 | |
| 157 | A | A | -0.0587 | |
| 158 | P | A | -0.0085 | |
| 159 | A | A | -0.2933 | |
| 160 | P | A | -0.9224 | |
| 161 | P | A | -1.3523 | |
| 162 | E | A | -2.1106 | |
| 163 | P | A | -1.3178 | |
| 164 | G | A | -0.8403 | |
| 165 | L | A | -0.1264 | |
| 166 | P | A | -0.1202 | |
| 167 | P | A | -0.2952 | |
| 168 | G | A | 0.1064 | |
| 169 | A | A | 0.7647 | |
| 170 | L | A | 1.8849 | |
| 171 | P | A | 0.2319 | |
| 172 | P | A | -0.1237 | |
| 173 | T | A | 0.3699 | |
| 174 | T | A | 0.8009 | |
| 175 | V | A | 1.6714 | |
| 176 | V | A | 0.8592 | |
| 177 | T | A | 0.0906 | |
| 178 | D | A | -0.3377 | |
| 179 | V | A | -0.2983 | |
| 180 | L | A | 0.0000 | |
| 181 | Q | A | -0.8150 | |
| 182 | H | A | -1.0552 | |
| 183 | G | A | -0.7054 | |
| 184 | D | A | -0.7494 | |
| 185 | R | A | 0.0000 | |
| 186 | A | A | 0.0000 | |
| 187 | D | A | -0.4449 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | -0.7617 | |
| 190 | F | A | -0.0341 | |
| 191 | G | A | -0.2575 | |
| 192 | A | A | -0.3707 | |
| 193 | K | A | -0.7278 | |
| 194 | D | A | -1.3449 | |
| 195 | Y | A | 0.0000 | |
| 196 | K | A | -2.7716 | |
| 197 | A | A | -1.2005 | |
| 198 | L | A | -0.9422 | |
| 199 | E | A | -1.7749 | |
| 200 | P | A | -2.0301 | |
| 201 | R | A | -2.6644 | |
| 202 | K | A | -3.1138 | |
| 203 | N | A | -1.9303 | |
| 204 | D | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | D | A | -1.4629 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | L | A | -1.4139 | |
| 211 | N | A | -2.1116 | |
| 212 | T | A | -1.5001 | |
| 213 | K | A | -1.6551 | |
| 214 | T | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | V | A | -0.0177 | |
| 217 | P | A | -0.2887 | |
| 218 | D | A | -1.0167 | |
| 219 | L | A | -1.1740 | |
| 220 | D | A | -2.3791 | |
| 221 | G | A | -1.6831 | |
| 222 | M | A | 0.0000 | |
| 223 | K | A | -2.5312 | |
| 224 | A | A | -1.5106 | |
| 225 | E | A | -1.3510 | |
| 226 | P | A | -1.1442 | |
| 227 | Y | A | -0.7771 | |
| 228 | G | A | -1.0480 | |
| 229 | N | A | -0.7979 | |
| 230 | R | A | -0.7537 | |
| 231 | M | A | -0.5433 | |
| 232 | F | A | 0.0000 | |
| 233 | D | A | -0.3687 | |
| 234 | Y | A | -0.1566 | |
| 235 | D | A | -0.5446 | |
| 236 | S | A | -0.1789 | |
| 237 | Y | A | 0.1034 | |
| 238 | S | A | -0.1147 | |
| 239 | S | A | -0.6767 | |
| 240 | S | A | -1.2042 | |
| 241 | H | A | -1.9127 | |
| 242 | D | A | -2.2723 | |
| 243 | V | A | -0.7275 | |
| 244 | K | A | -1.9711 | |
| 245 | R | A | -2.1328 | |
| 246 | Y | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | R | A | 0.0000 | |
| 249 | S | A | -1.0853 | |
| 250 | G | A | -0.7924 | |
| 251 | P | A | -0.1584 | |
| 252 | D | A | 0.6083 | |
| 253 | L | A | 2.3059 | |
| 254 | I | A | 2.7060 | |
| 255 | P | A | 0.7542 | |
| 256 | L | A | 0.5647 | |
| 257 | P | A | -0.5106 | |
| 258 | D | A | -1.9761 | |
| 259 | A | A | -1.1698 | |
| 260 | P | A | -1.1664 | |
| 261 | P | A | -0.9683 | |
| 262 | P | A | -0.5375 | |
| 263 | S | A | -0.6863 | |
| 264 | K | A | -0.7024 | |
| 265 | L | A | 0.8336 | |
| 266 | Y | A | 0.7578 | |
| 267 | V | A | 0.8742 | |
| 268 | R | A | -0.9288 | |
| 269 | P | A | -0.2378 | |
| 270 | P | A | -0.5491 | |
| 271 | P | A | -0.3352 | |
| 272 | S | A | -0.1105 | |
| 273 | S | A | 0.1014 | |
| 274 | P | A | 0.4461 | |
| 275 | Y | A | 1.1696 | |
| 276 | A | A | 0.7274 | |
| 277 | V | A | 1.3505 | |
| 278 | R | A | 0.1930 | |
| 279 | P | A | -0.4486 | |
| 280 | S | A | 0.0000 | |
| 281 | T | A | -0.1266 | |
| 282 | D | A | -0.3757 | |
| 283 | Y | A | 0.5667 | |
| 284 | F | A | -0.1250 | |
| 285 | T | A | -0.9223 | |
| 286 | I | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | D | A | -1.4089 | |
| 289 | G | A | 0.0000 | |
| 290 | G | A | -1.4826 | |
| 291 | E | A | -1.9324 | |
| 292 | I | A | -1.4438 | |
| 293 | T | A | -1.9117 | |
| 294 | E | A | -2.7170 | |
| 295 | D | A | -2.9000 | |
| 296 | D | A | -2.0742 | |
| 297 | L | A | -1.2968 | |
| 298 | L | A | -0.8629 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.1892 | |
| 301 | K | A | -1.5230 | |
| 302 | P | A | -0.8227 | |
| 303 | F | A | 0.0388 | |
| 304 | Y | A | -0.5212 | |
| 305 | F | A | 0.0000 | |
| 306 | E | A | -2.7088 | |
| 307 | K | A | -2.8225 | |
| 308 | A | A | 0.0000 | |
| 309 | P | A | -1.3374 | |
| 310 | G | A | -1.2761 | |
| 311 | K | A | -1.3988 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | -1.4464 | |
| 314 | F | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | L | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | G | A | -1.0060 | |
| 319 | N | A | -1.0364 | |
| 320 | R | A | -1.2368 | |
| 321 | L | A | 0.0000 | |
| 322 | Y | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | L | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | 0.0000 | |
| 331 | A | A | 0.0000 | |
| 332 | E | A | -2.5849 | |
| 333 | I | A | -2.2896 | |
| 334 | E | A | -3.1112 | |
| 335 | T | A | -2.0794 | |
| 336 | I | A | -1.1420 | |
| 337 | E | A | -1.6854 | |
| 338 | T | A | -0.8156 | |
| 339 | R | A | -1.0130 | |
| 340 | I | A | 1.0885 | |
| 341 | S | A | 0.1985 | |
| 342 | T | A | -0.1723 | |
| 343 | P | A | -0.5428 | |
| 344 | A | A | -0.2161 | |
| 345 | I | A | 0.2142 | |
| 346 | N | A | -0.0165 | |
| 347 | V | A | 1.6853 | |
| 348 | Y | A | 1.4978 | |
| 349 | D | A | -0.0236 | |
| 350 | P | A | -0.2454 | |
| 351 | S | A | -0.1232 | |
| 352 | N | A | 0.0792 | |
| 353 | Y | A | 0.0871 | |
| 354 | V | A | 0.7498 | |
| 355 | T | A | -0.5337 | |
| 356 | S | A | -1.2833 | |
| 357 | R | A | -2.5520 | |
| 358 | R | A | -2.8668 | |
| 359 | Y | A | 0.0000 | |
| 360 | T | A | -1.0525 | |
| 361 | E | A | 0.0000 | |
| 362 | E | A | -0.0916 | |
| 363 | Y | A | 0.0000 | |
| 364 | Q | A | -0.3647 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | 0.0000 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | L | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | T | A | 0.0000 | |
| 374 | I | A | 0.0000 | |
| 375 | P | A | -0.4383 | |
| 376 | L | A | -0.3316 | |
| 377 | T | A | -0.6680 | |
| 378 | P | A | -1.0170 | |
| 379 | E | A | -1.8092 | |
| 380 | T | A | 0.0000 | |
| 381 | L | A | -0.5626 | |
| 382 | A | A | -0.8801 | |
| 383 | Y | A | -1.0786 | |
| 384 | L | A | 0.0000 | |
| 385 | A | A | -0.9385 | |
| 386 | R | A | -1.8961 | |
| 387 | L | A | -1.0103 | |
| 388 | D | A | -1.1849 | |
| 389 | P | A | -0.9795 | |
| 390 | S | A | -0.9201 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | 0.0000 | |
| 393 | V | A | -0.7456 | |
| 394 | D | A | -1.5126 | |
| 395 | A | A | -1.4848 | |
| 396 | K | A | -1.7784 | |
| 397 | L | A | 0.0000 | |
| 398 | P | A | 0.2824 | |
| 399 | F | A | 1.6956 | |
| 400 | I | A | 0.9111 | |
| 401 | P | A | 0.3105 | |
| 402 | P | A | -0.2438 | |
| 403 | V | A | 0.3403 | |
| 404 | E | A | -1.9155 | |
| 405 | R | A | -2.2667 | |
| 406 | P | A | -1.9879 | |
| 407 | D | A | -2.5678 | |
| 408 | P | A | -1.2992 | |
| 409 | L | A | -0.7901 | |
| 410 | A | A | -0.9665 | |
| 411 | G | A | -0.8423 | |
| 412 | L | A | -0.5833 | |
| 413 | K | A | -1.9081 | |
| 414 | F | A | -1.3453 | |
| 415 | R | A | -1.7041 | |
| 416 | E | A | -2.7411 | |
| 417 | I | A | 0.0000 | |
| 418 | D | A | -3.0286 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.8119 | |
| 421 | D | A | -2.3366 | |
| 422 | K | A | -1.9138 | |
| 423 | L | A | -0.7136 | |
| 424 | S | A | -0.7504 | |
| 425 | T | A | -0.4114 | |
| 426 | D | A | -1.1519 | |
| 427 | L | A | -0.8344 | |
| 428 | S | A | -1.5277 | |
| 429 | K | A | -2.2701 | |
| 430 | Y | A | -1.6676 | |
| 431 | E | A | -1.9604 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | Q | A | -1.9811 | |
| 435 | E | A | -1.5404 | |
| 436 | F | A | -0.6160 | |
| 437 | L | A | -0.0386 | |
| 438 | N | A | -1.7826 | |
| 439 | R | A | -2.0893 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine