| Chain sequence(s) |
A: YLPPTTPVAKVQSTDEYVYPTSLFCHAHTDRLLTVGHPFKDIVVNGKVLVPKVSGYQWRVFRLKFPDPNKFALPQKDFYDPEKERLVWRLRGLEIGRGGPLGKGSVGHPLFNKLGDTENPTAPQHCGADDRVAFSFDPKQTQLFIVGCEPPTGEHWDIAEPCPGLPPGACPPIQLVNSVIEDGDMCDIGFGNMNFKELQQDRSGVPLDIVSTRCKWPDFLKMTNEAYGDKMFFFGRREQVYARHFYVRCGPVGHPLPDAPPPSPLYTPPPPSSPYAVRPPYDYFGTPSGSLVSSDGQLFNRPFWLQRAQGNNNGVCWHNELFVTVVDNTRNTNFTISQQLCTPLPNVYDPSCFKNYLRHVEQFELSLIAQLCKVPLDPGVLAHINTMNPTILENWNLGFVPPKEREDPYKGLIFWEVDLTERFSQDLDQFALGRKFLYQ
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:01)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:07)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Y | A | 1.9440 | |
| 2 | L | A | 1.9638 | |
| 3 | P | A | 0.8364 | |
| 4 | P | A | 0.3756 | |
| 5 | T | A | 0.1305 | |
| 6 | T | A | 0.1355 | |
| 7 | P | A | 0.1959 | |
| 8 | V | A | 1.2113 | |
| 9 | A | A | 0.0961 | |
| 10 | K | A | -1.0168 | |
| 11 | V | A | -0.1523 | |
| 12 | Q | A | -1.4044 | |
| 13 | S | A | -1.5609 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.4474 | |
| 16 | E | A | -2.4528 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | Y | A | 0.4552 | |
| 20 | P | A | 0.1236 | |
| 21 | T | A | 0.1591 | |
| 22 | S | A | -0.0951 | |
| 23 | L | A | 0.1183 | |
| 24 | F | A | -0.0285 | |
| 25 | C | A | 0.0000 | |
| 26 | H | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | H | A | -1.2792 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -2.8920 | |
| 31 | R | A | -2.6784 | |
| 32 | L | A | -0.7970 | |
| 33 | L | A | 1.1596 | |
| 34 | T | A | 1.3637 | |
| 35 | V | A | 1.8109 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -0.2443 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | -0.6174 | |
| 40 | K | A | -1.6629 | |
| 41 | D | A | -0.6856 | |
| 42 | I | A | 1.2672 | |
| 43 | V | A | 2.2027 | |
| 44 | V | A | 1.6534 | |
| 45 | N | A | -0.5390 | |
| 46 | G | A | -0.3718 | |
| 47 | K | A | -0.1411 | |
| 48 | V | A | 2.0150 | |
| 49 | L | A | 2.5241 | |
| 50 | V | A | 1.4361 | |
| 51 | P | A | 0.3330 | |
| 52 | K | A | -0.6847 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | G | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | R | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.1425 | |
| 65 | F | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.3750 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.2336 | |
| 70 | K | A | -1.7848 | |
| 71 | F | A | -0.6327 | |
| 72 | A | A | -0.5759 | |
| 73 | L | A | -0.8660 | |
| 74 | P | A | -1.2751 | |
| 75 | Q | A | -2.5062 | |
| 76 | K | A | -3.1091 | |
| 77 | D | A | -2.9921 | |
| 78 | F | A | -1.6625 | |
| 79 | Y | A | -1.8901 | |
| 80 | D | A | -2.6870 | |
| 81 | P | A | -2.3048 | |
| 82 | E | A | -3.0512 | |
| 83 | K | A | -3.3941 | |
| 84 | E | A | -2.4602 | |
| 85 | R | A | -1.2910 | |
| 86 | L | A | 0.0000 | |
| 87 | V | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.6573 | |
| 92 | G | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | E | A | -0.9719 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | -1.3591 | |
| 97 | R | A | 0.0000 | |
| 98 | G | A | -0.6943 | |
| 99 | G | A | -0.5380 | |
| 100 | P | A | -0.4049 | |
| 101 | L | A | 0.0425 | |
| 102 | G | A | -0.1986 | |
| 103 | K | A | -0.5984 | |
| 104 | G | A | -0.4647 | |
| 105 | S | A | -0.5151 | |
| 106 | V | A | 0.0000 | |
| 107 | G | A | 0.1306 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | 0.4438 | |
| 110 | L | A | 0.3943 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -1.0769 | |
| 113 | K | A | -0.3527 | |
| 114 | L | A | -0.8009 | |
| 115 | G | A | -0.8165 | |
| 116 | D | A | -1.2196 | |
| 117 | T | A | -0.9179 | |
| 118 | E | A | -1.9069 | |
| 119 | N | A | -1.9963 | |
| 120 | P | A | -1.4542 | |
| 121 | T | A | -0.7549 | |
| 122 | A | A | -0.4969 | |
| 123 | P | A | -0.1548 | |
| 124 | Q | A | -0.4518 | |
| 125 | H | A | -0.4810 | |
| 126 | C | A | -0.7518 | |
| 127 | G | A | -1.2403 | |
| 128 | A | A | -1.1907 | |
| 129 | D | A | -2.1891 | |
| 130 | D | A | -1.7034 | |
| 131 | R | A | -1.1085 | |
| 132 | V | A | 0.2714 | |
| 133 | A | A | 0.4739 | |
| 134 | F | A | 0.2917 | |
| 135 | S | A | -0.0947 | |
| 136 | F | A | 0.0000 | |
| 137 | D | A | -0.4533 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | Q | A | 0.0000 | |
| 141 | T | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | C | A | 0.0000 | |
| 149 | E | A | -0.5547 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | 0.0000 | |
| 153 | G | A | 0.0000 | |
| 154 | E | A | -0.2154 | |
| 155 | H | A | 0.0000 | |
| 156 | W | A | 1.1121 | |
| 157 | D | A | 0.2779 | |
| 158 | I | A | 0.8272 | |
| 159 | A | A | 0.1121 | |
| 160 | E | A | -1.4804 | |
| 161 | P | A | -0.2258 | |
| 162 | C | A | 0.1912 | |
| 163 | P | A | -0.1645 | |
| 164 | G | A | -0.0656 | |
| 165 | L | A | 0.6151 | |
| 166 | P | A | -0.0983 | |
| 167 | P | A | -0.3324 | |
| 168 | G | A | -0.4159 | |
| 169 | A | A | -0.0168 | |
| 170 | C | A | 0.7474 | |
| 171 | P | A | 0.5554 | |
| 172 | P | A | 0.8169 | |
| 173 | I | A | 2.0422 | |
| 174 | Q | A | 0.8431 | |
| 175 | L | A | 1.4474 | |
| 176 | V | A | 0.8266 | |
| 177 | N | A | -0.3018 | |
| 178 | S | A | -0.0816 | |
| 179 | V | A | 0.4353 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | 0.3826 | |
| 182 | D | A | 0.0839 | |
| 183 | G | A | -0.1606 | |
| 184 | D | A | -0.5498 | |
| 185 | M | A | 0.0000 | |
| 186 | C | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | 0.1324 | |
| 190 | F | A | 0.0679 | |
| 191 | G | A | -0.1024 | |
| 192 | N | A | -0.2740 | |
| 193 | M | A | -0.1460 | |
| 194 | N | A | 0.0000 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -3.3928 | |
| 197 | E | A | -2.6114 | |
| 198 | L | A | -1.2214 | |
| 199 | Q | A | -2.5439 | |
| 200 | Q | A | -3.3161 | |
| 201 | D | A | -3.5882 | |
| 202 | R | A | -3.3174 | |
| 203 | S | A | 0.0000 | |
| 204 | G | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | L | A | 0.1872 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | V | A | -1.3563 | |
| 211 | S | A | -1.8820 | |
| 212 | T | A | -1.4512 | |
| 213 | R | A | -2.1205 | |
| 214 | C | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | W | A | -0.1640 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | F | A | 0.3301 | |
| 220 | L | A | 0.5895 | |
| 221 | K | A | -1.1340 | |
| 222 | M | A | 0.0000 | |
| 223 | T | A | -0.8235 | |
| 224 | N | A | -1.5006 | |
| 225 | E | A | -1.2415 | |
| 226 | A | A | -0.5960 | |
| 227 | Y | A | -0.3543 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | K | A | -0.6605 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | F | A | 0.0682 | |
| 234 | F | A | 0.2471 | |
| 235 | G | A | -0.8296 | |
| 236 | R | A | -2.6195 | |
| 237 | R | A | -2.9013 | |
| 238 | E | A | -2.1600 | |
| 239 | Q | A | -0.1978 | |
| 240 | V | A | 1.4659 | |
| 241 | Y | A | 1.2304 | |
| 242 | A | A | 0.3708 | |
| 243 | R | A | -0.6688 | |
| 244 | H | A | -0.6960 | |
| 245 | F | A | 0.0718 | |
| 246 | Y | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | R | A | -0.3202 | |
| 249 | C | A | -0.7237 | |
| 250 | G | A | -0.8413 | |
| 251 | P | A | -0.5122 | |
| 252 | V | A | -0.6460 | |
| 253 | G | A | -0.9359 | |
| 254 | H | A | -1.1634 | |
| 255 | P | A | -0.9453 | |
| 256 | L | A | -0.2541 | |
| 257 | P | A | -0.8587 | |
| 258 | D | A | -1.8894 | |
| 259 | A | A | -0.8892 | |
| 260 | P | A | -0.9249 | |
| 261 | P | A | -0.6254 | |
| 262 | P | A | -0.3245 | |
| 263 | S | A | -0.1788 | |
| 264 | P | A | 0.3971 | |
| 265 | L | A | 1.4941 | |
| 266 | Y | A | 0.6040 | |
| 267 | T | A | 0.0554 | |
| 268 | P | A | -0.3855 | |
| 269 | P | A | -0.0274 | |
| 270 | P | A | -0.4002 | |
| 271 | P | A | -0.1571 | |
| 272 | S | A | -0.1576 | |
| 273 | S | A | 0.1846 | |
| 274 | P | A | 0.2548 | |
| 275 | Y | A | 0.9486 | |
| 276 | A | A | 0.8130 | |
| 277 | V | A | 1.4317 | |
| 278 | R | A | 0.2108 | |
| 279 | P | A | -0.1010 | |
| 280 | P | A | 0.0000 | |
| 281 | Y | A | 0.0654 | |
| 282 | D | A | -0.3756 | |
| 283 | Y | A | 1.0586 | |
| 284 | F | A | 0.7756 | |
| 285 | G | A | 0.2978 | |
| 286 | T | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | S | A | 0.0000 | |
| 289 | G | A | 0.0000 | |
| 290 | S | A | 0.9810 | |
| 291 | L | A | 1.6314 | |
| 292 | V | A | 0.6452 | |
| 293 | S | A | -0.1599 | |
| 294 | S | A | -0.9648 | |
| 295 | D | A | -1.8432 | |
| 296 | G | A | 0.0000 | |
| 297 | Q | A | 0.0000 | |
| 298 | L | A | -1.1121 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.6495 | |
| 301 | R | A | -1.8725 | |
| 302 | P | A | -0.9918 | |
| 303 | F | A | -0.1971 | |
| 304 | W | A | -0.5651 | |
| 305 | L | A | 0.0000 | |
| 306 | Q | A | -2.0828 | |
| 307 | R | A | -2.8378 | |
| 308 | A | A | 0.0000 | |
| 309 | Q | A | -1.2655 | |
| 310 | G | A | -1.2325 | |
| 311 | N | A | -1.2835 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | C | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.7722 | |
| 319 | N | A | -0.9093 | |
| 320 | E | A | -1.0263 | |
| 321 | L | A | 0.0000 | |
| 322 | F | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.3340 | |
| 331 | N | A | 0.0000 | |
| 332 | T | A | -0.0773 | |
| 333 | N | A | 0.5542 | |
| 334 | F | A | 1.7825 | |
| 335 | T | A | 0.8764 | |
| 336 | I | A | 0.4454 | |
| 337 | S | A | -0.9430 | |
| 338 | Q | A | -1.7098 | |
| 339 | Q | A | -1.1618 | |
| 340 | L | A | 0.6971 | |
| 341 | C | A | 0.5823 | |
| 342 | T | A | 0.4104 | |
| 343 | P | A | 0.1937 | |
| 344 | L | A | 1.1148 | |
| 345 | P | A | 0.5700 | |
| 346 | N | A | -0.0158 | |
| 347 | V | A | 1.7122 | |
| 348 | Y | A | 1.6053 | |
| 349 | D | A | 0.2432 | |
| 350 | P | A | -0.3850 | |
| 351 | S | A | -0.3411 | |
| 352 | C | A | 0.0000 | |
| 353 | F | A | -0.7249 | |
| 354 | K | A | -1.8007 | |
| 355 | N | A | -1.7673 | |
| 356 | Y | A | -0.0828 | |
| 357 | L | A | 0.6478 | |
| 358 | R | A | 0.9694 | |
| 359 | H | A | 0.0000 | |
| 360 | V | A | 1.3947 | |
| 361 | E | A | 0.0000 | |
| 362 | Q | A | -0.0769 | |
| 363 | F | A | 0.0000 | |
| 364 | E | A | -2.0356 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | -0.6868 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | A | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.2733 | |
| 374 | V | A | 0.0000 | |
| 375 | P | A | -1.3068 | |
| 376 | L | A | -1.7039 | |
| 377 | D | A | -1.9792 | |
| 378 | P | A | -1.0340 | |
| 379 | G | A | -1.0105 | |
| 380 | V | A | -0.9309 | |
| 381 | L | A | -0.5310 | |
| 382 | A | A | -0.6551 | |
| 383 | H | A | -0.8057 | |
| 384 | I | A | 0.0000 | |
| 385 | N | A | -1.4090 | |
| 386 | T | A | -0.5485 | |
| 387 | M | A | -0.2938 | |
| 388 | N | A | -0.8632 | |
| 389 | P | A | -1.2347 | |
| 390 | T | A | -1.4034 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | -1.3859 | |
| 393 | E | A | -2.7102 | |
| 394 | N | A | -2.2766 | |
| 395 | W | A | -1.2817 | |
| 396 | N | A | -0.9883 | |
| 397 | L | A | -0.1550 | |
| 398 | G | A | 0.5694 | |
| 399 | F | A | 2.4351 | |
| 400 | V | A | 1.8449 | |
| 401 | P | A | 0.0525 | |
| 402 | P | A | -1.7698 | |
| 403 | K | A | -3.3094 | |
| 404 | E | A | -3.7420 | |
| 405 | R | A | -3.8325 | |
| 406 | E | A | -3.7461 | |
| 407 | D | A | -2.8447 | |
| 408 | P | A | -1.7521 | |
| 409 | Y | A | -0.9835 | |
| 410 | K | A | -2.1062 | |
| 411 | G | A | -0.6371 | |
| 412 | L | A | 0.6735 | |
| 413 | I | A | 1.5859 | |
| 414 | F | A | 0.0000 | |
| 415 | W | A | -0.3937 | |
| 416 | E | A | -1.6864 | |
| 417 | V | A | 0.0000 | |
| 418 | D | A | -2.9440 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -2.0382 | |
| 421 | E | A | -2.7653 | |
| 422 | R | A | -2.5338 | |
| 423 | F | A | -1.2614 | |
| 424 | S | A | -1.4550 | |
| 425 | Q | A | -1.7444 | |
| 426 | D | A | -2.9636 | |
| 427 | L | A | -2.1604 | |
| 428 | D | A | -3.0226 | |
| 429 | Q | A | -2.7513 | |
| 430 | F | A | -1.6108 | |
| 431 | A | A | -1.1393 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -2.2829 | |
| 435 | K | A | -1.0896 | |
| 436 | F | A | -0.1040 | |
| 437 | L | A | 0.7840 | |
| 438 | Y | A | 0.6283 | |
| 439 | Q | A | -0.3891 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine