| Chain sequence(s) |
A: GLPPLNPEPPPRPTTEFVTPTDLLYIAETDLLTRTGHPTADIVVDGKVLVPKVSAYQYRVFKLTLPDPNTLPLPSADFLDPSTEIRIWRLLAYYIKRFGPLGKGSYGHPNYNALGDVDNPTEPVHEGEDDTVSLSWTPKLRQEYIIGDRPPTGVYTDIAPPAPGLPPGAIPPTVKVSDIIEDGDMADIGFGAKDFAKLYPRKDEVPDDILNTSTKVPDYEGMKAEPYGRSMFDYDSYEKSKDIKNLRLDGPDLIPLPDAEPPSPLYVKPPPSSPYAELPSYRYFTLPDAGEITEEDLLFNRPRWLTKTAGLNDGILWNNQLYVTIVDNTRAEIETIQTQVSTPVPNVYDPANYVTSRRYTEEYQLALIVQLCKIPLTPETLEYIRRLDPRILVNANLPDIPPVEEPDPYAGKKFIEIDLTDKLSTDLSKYPLGRAYLNR
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:05)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | G | A | 0.1582 | |
| 2 | L | A | 1.4002 | |
| 3 | P | A | 0.3719 | |
| 4 | P | A | -0.0523 | |
| 5 | L | A | 0.7487 | |
| 6 | N | A | -1.3102 | |
| 7 | P | A | -1.6414 | |
| 8 | E | A | -2.3532 | |
| 9 | P | A | -1.5612 | |
| 10 | P | A | -1.0237 | |
| 11 | P | A | -0.7426 | |
| 12 | R | A | -0.7060 | |
| 13 | P | A | -0.6490 | |
| 14 | T | A | 0.0000 | |
| 15 | T | A | -1.0420 | |
| 16 | E | A | -1.8952 | |
| 17 | F | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | T | A | -0.5745 | |
| 20 | P | A | -0.7094 | |
| 21 | T | A | 0.0000 | |
| 22 | D | A | -1.6698 | |
| 23 | L | A | -0.5723 | |
| 24 | L | A | -0.1667 | |
| 25 | Y | A | -0.0230 | |
| 26 | I | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | E | A | -0.6372 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -1.2617 | |
| 31 | L | A | 0.3082 | |
| 32 | L | A | 0.1465 | |
| 33 | T | A | -0.2454 | |
| 34 | R | A | -0.5865 | |
| 35 | T | A | -0.5317 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -0.6704 | |
| 38 | P | A | 0.0000 | |
| 39 | T | A | -0.5086 | |
| 40 | A | A | -0.2120 | |
| 41 | D | A | 0.0931 | |
| 42 | I | A | 1.8993 | |
| 43 | V | A | 2.4506 | |
| 44 | V | A | 1.5377 | |
| 45 | D | A | -1.0188 | |
| 46 | G | A | -0.5786 | |
| 47 | K | A | -0.2659 | |
| 48 | V | A | 2.0775 | |
| 49 | L | A | 2.4859 | |
| 50 | V | A | 1.4930 | |
| 51 | P | A | 0.3587 | |
| 52 | K | A | -0.3855 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | A | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | Y | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | K | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | T | A | -1.1519 | |
| 65 | L | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -0.7433 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -0.7017 | |
| 70 | T | A | -0.3279 | |
| 71 | L | A | 0.0355 | |
| 72 | P | A | -0.0531 | |
| 73 | L | A | 0.0765 | |
| 74 | P | A | -0.2686 | |
| 75 | S | A | -0.5162 | |
| 76 | A | A | -0.8070 | |
| 77 | D | A | -1.6624 | |
| 78 | F | A | -0.6117 | |
| 79 | L | A | -0.9021 | |
| 80 | D | A | -1.7248 | |
| 81 | P | A | -1.1987 | |
| 82 | S | A | -0.9007 | |
| 83 | T | A | -0.8363 | |
| 84 | E | A | -0.9541 | |
| 85 | I | A | 0.0000 | |
| 86 | R | A | 0.0000 | |
| 87 | I | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | -0.3635 | |
| 90 | L | A | 0.0000 | |
| 91 | L | A | -0.0563 | |
| 92 | A | A | 0.0000 | |
| 93 | Y | A | 0.0000 | |
| 94 | Y | A | -0.5138 | |
| 95 | I | A | 0.0000 | |
| 96 | K | A | -0.3028 | |
| 97 | R | A | 0.0000 | |
| 98 | F | A | 0.5495 | |
| 99 | G | A | -0.3045 | |
| 100 | P | A | -0.4151 | |
| 101 | L | A | -0.3171 | |
| 102 | G | A | -1.2138 | |
| 103 | K | A | -1.8389 | |
| 104 | G | A | 0.0000 | |
| 105 | S | A | -0.7009 | |
| 106 | Y | A | 0.0000 | |
| 107 | G | A | -0.6031 | |
| 108 | H | A | -0.8832 | |
| 109 | P | A | -0.8608 | |
| 110 | N | A | -1.6357 | |
| 111 | Y | A | 0.0000 | |
| 112 | N | A | 0.0000 | |
| 113 | A | A | 0.0000 | |
| 114 | L | A | 0.0000 | |
| 115 | G | A | -1.0947 | |
| 116 | D | A | -1.8128 | |
| 117 | V | A | -1.4541 | |
| 118 | D | A | -2.6026 | |
| 119 | N | A | -2.6476 | |
| 120 | P | A | -1.9518 | |
| 121 | T | A | -1.5963 | |
| 122 | E | A | -2.0506 | |
| 123 | P | A | -1.0270 | |
| 124 | V | A | -1.0880 | |
| 125 | H | A | -1.8224 | |
| 126 | E | A | -2.6067 | |
| 127 | G | A | -2.7151 | |
| 128 | E | A | -3.1971 | |
| 129 | D | A | -3.1606 | |
| 130 | D | A | -2.0491 | |
| 131 | T | A | -1.0412 | |
| 132 | V | A | 0.0398 | |
| 133 | S | A | -0.2750 | |
| 134 | L | A | -0.0822 | |
| 135 | S | A | -0.2376 | |
| 136 | W | A | 0.0000 | |
| 137 | T | A | -0.5481 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | -1.5619 | |
| 140 | L | A | 0.0000 | |
| 141 | R | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | E | A | 0.0000 | |
| 144 | Y | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | I | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | D | A | 0.0000 | |
| 149 | R | A | -0.4017 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | -0.1672 | |
| 153 | G | A | 0.0000 | |
| 154 | V | A | -0.1164 | |
| 155 | Y | A | -0.2684 | |
| 156 | T | A | -0.5171 | |
| 157 | D | A | -0.3756 | |
| 158 | I | A | 0.2008 | |
| 159 | A | A | 0.0581 | |
| 160 | P | A | -0.2157 | |
| 161 | P | A | -0.0736 | |
| 162 | A | A | -0.2176 | |
| 163 | P | A | -0.3700 | |
| 164 | G | A | -0.3302 | |
| 165 | L | A | 0.4683 | |
| 166 | P | A | -0.0142 | |
| 167 | P | A | -0.2036 | |
| 168 | G | A | 0.1766 | |
| 169 | A | A | 0.9258 | |
| 170 | I | A | 2.1584 | |
| 171 | P | A | 0.8733 | |
| 172 | P | A | 0.5299 | |
| 173 | T | A | 0.3286 | |
| 174 | V | A | 0.1450 | |
| 175 | K | A | -1.0796 | |
| 176 | V | A | -0.3208 | |
| 177 | S | A | -0.4116 | |
| 178 | D | A | -0.5539 | |
| 179 | I | A | -0.4552 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | -1.1211 | |
| 182 | D | A | -1.0932 | |
| 183 | G | A | -0.6695 | |
| 184 | D | A | -0.6363 | |
| 185 | M | A | 0.0000 | |
| 186 | A | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | -0.5611 | |
| 190 | F | A | 0.0000 | |
| 191 | G | A | -0.2653 | |
| 192 | A | A | -0.2747 | |
| 193 | K | A | -0.6026 | |
| 194 | D | A | 0.0000 | |
| 195 | F | A | 0.0000 | |
| 196 | A | A | -1.6177 | |
| 197 | K | A | -1.8550 | |
| 198 | L | A | -0.6537 | |
| 199 | Y | A | -1.1913 | |
| 200 | P | A | -1.5304 | |
| 201 | R | A | -1.8559 | |
| 202 | K | A | -2.3367 | |
| 203 | D | A | 0.0000 | |
| 204 | E | A | -0.9426 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | D | A | -1.0850 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | L | A | -0.9020 | |
| 211 | N | A | -1.6810 | |
| 212 | T | A | -0.9622 | |
| 213 | S | A | -0.6588 | |
| 214 | T | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | V | A | 0.3855 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | -0.9333 | |
| 219 | Y | A | -1.1545 | |
| 220 | E | A | -2.4011 | |
| 221 | G | A | -1.6173 | |
| 222 | M | A | 0.0000 | |
| 223 | K | A | -2.0344 | |
| 224 | A | A | -1.3896 | |
| 225 | E | A | -1.1310 | |
| 226 | P | A | -0.5825 | |
| 227 | Y | A | -0.1472 | |
| 228 | G | A | 0.0000 | |
| 229 | R | A | 0.0000 | |
| 230 | S | A | 0.0000 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | D | A | -0.6042 | |
| 234 | Y | A | -0.0706 | |
| 235 | D | A | -0.4070 | |
| 236 | S | A | -0.5500 | |
| 237 | Y | A | -0.9037 | |
| 238 | E | A | -2.0615 | |
| 239 | K | A | -2.1097 | |
| 240 | S | A | -2.3432 | |
| 241 | K | A | -2.9933 | |
| 242 | D | A | -2.6064 | |
| 243 | I | A | -1.0395 | |
| 244 | K | A | -1.9940 | |
| 245 | N | A | -1.4383 | |
| 246 | L | A | 0.0000 | |
| 247 | R | A | -0.0713 | |
| 248 | L | A | -0.0045 | |
| 249 | D | A | 0.0000 | |
| 250 | G | A | -0.5320 | |
| 251 | P | A | 0.0994 | |
| 252 | D | A | 0.9815 | |
| 253 | L | A | 2.5364 | |
| 254 | I | A | 2.5847 | |
| 255 | P | A | 0.9767 | |
| 256 | L | A | 0.8415 | |
| 257 | P | A | -0.6263 | |
| 258 | D | A | -2.5031 | |
| 259 | A | A | 0.0000 | |
| 260 | E | A | -2.6167 | |
| 261 | P | A | -1.5242 | |
| 262 | P | A | -0.6358 | |
| 263 | S | A | -0.4106 | |
| 264 | P | A | 0.5233 | |
| 265 | L | A | 1.7074 | |
| 266 | Y | A | 1.1353 | |
| 267 | V | A | 0.9574 | |
| 268 | K | A | -1.3145 | |
| 269 | P | A | -0.5281 | |
| 270 | P | A | -0.7000 | |
| 271 | P | A | -0.8454 | |
| 272 | S | A | -0.4911 | |
| 273 | S | A | -0.4421 | |
| 274 | P | A | -0.4083 | |
| 275 | Y | A | 0.0042 | |
| 276 | A | A | -0.7441 | |
| 277 | E | A | -1.7017 | |
| 278 | L | A | -0.5417 | |
| 279 | P | A | -0.4250 | |
| 280 | S | A | 0.0000 | |
| 281 | Y | A | 0.6456 | |
| 282 | R | A | 0.3912 | |
| 283 | Y | A | 1.1910 | |
| 284 | F | A | 0.5475 | |
| 285 | T | A | -0.6338 | |
| 286 | L | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | D | A | -1.8103 | |
| 289 | A | A | 0.0000 | |
| 290 | G | A | -1.8523 | |
| 291 | E | A | -2.3405 | |
| 292 | I | A | -1.4848 | |
| 293 | T | A | -1.8628 | |
| 294 | E | A | -2.8456 | |
| 295 | E | A | -2.8404 | |
| 296 | D | A | -2.0101 | |
| 297 | L | A | -1.2194 | |
| 298 | L | A | -0.7843 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.0472 | |
| 301 | R | A | -1.5353 | |
| 302 | P | A | -0.8744 | |
| 303 | R | A | -0.6218 | |
| 304 | W | A | -0.4489 | |
| 305 | L | A | 0.0000 | |
| 306 | T | A | -0.8951 | |
| 307 | K | A | -1.7380 | |
| 308 | T | A | 0.0000 | |
| 309 | A | A | -0.6840 | |
| 310 | G | A | -0.6403 | |
| 311 | L | A | -0.2854 | |
| 312 | N | A | 0.0000 | |
| 313 | D | A | -0.5141 | |
| 314 | G | A | 0.0000 | |
| 315 | I | A | 0.0000 | |
| 316 | L | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | N | A | -0.6284 | |
| 319 | N | A | -0.5944 | |
| 320 | Q | A | -0.6405 | |
| 321 | L | A | 0.0000 | |
| 322 | Y | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | I | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.7565 | |
| 331 | A | A | 0.0000 | |
| 332 | E | A | -2.5604 | |
| 333 | I | A | -1.8070 | |
| 334 | E | A | -2.1879 | |
| 335 | T | A | -1.0381 | |
| 336 | I | A | 0.3017 | |
| 337 | Q | A | -0.2668 | |
| 338 | T | A | 0.3141 | |
| 339 | Q | A | 0.4130 | |
| 340 | V | A | 1.7442 | |
| 341 | S | A | 0.7151 | |
| 342 | T | A | 0.3055 | |
| 343 | P | A | 0.1654 | |
| 344 | V | A | 1.0871 | |
| 345 | P | A | 0.3895 | |
| 346 | N | A | -0.0121 | |
| 347 | V | A | 1.6844 | |
| 348 | Y | A | 1.5126 | |
| 349 | D | A | 0.0201 | |
| 350 | P | A | 0.0640 | |
| 351 | A | A | 0.3424 | |
| 352 | N | A | 0.8135 | |
| 353 | Y | A | 1.2040 | |
| 354 | V | A | 1.8504 | |
| 355 | T | A | 0.4715 | |
| 356 | S | A | -0.1820 | |
| 357 | R | A | -1.1706 | |
| 358 | R | A | -1.2877 | |
| 359 | Y | A | 0.0000 | |
| 360 | T | A | -0.8977 | |
| 361 | E | A | 0.0000 | |
| 362 | E | A | -0.1266 | |
| 363 | Y | A | 0.0000 | |
| 364 | Q | A | -0.2389 | |
| 365 | L | A | 0.0000 | |
| 366 | A | A | 0.0000 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | V | A | 0.0000 | |
| 370 | Q | A | -0.4006 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.4203 | |
| 374 | I | A | 0.0000 | |
| 375 | P | A | -0.6336 | |
| 376 | L | A | -0.4307 | |
| 377 | T | A | -0.7827 | |
| 378 | P | A | -1.2431 | |
| 379 | E | A | -2.3018 | |
| 380 | T | A | 0.0000 | |
| 381 | L | A | -1.3607 | |
| 382 | E | A | -2.4434 | |
| 383 | Y | A | -1.8721 | |
| 384 | I | A | 0.0000 | |
| 385 | R | A | -2.9006 | |
| 386 | R | A | -2.4030 | |
| 387 | L | A | 0.0000 | |
| 388 | D | A | 0.0000 | |
| 389 | P | A | -1.4905 | |
| 390 | R | A | -1.3612 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | 0.0000 | |
| 393 | V | A | -1.0035 | |
| 394 | N | A | -1.2824 | |
| 395 | A | A | 0.0000 | |
| 396 | N | A | -1.7609 | |
| 397 | L | A | -1.1977 | |
| 398 | P | A | -1.2525 | |
| 399 | D | A | -1.8465 | |
| 400 | I | A | -0.5459 | |
| 401 | P | A | -0.3888 | |
| 402 | P | A | -0.4645 | |
| 403 | V | A | 0.4717 | |
| 404 | E | A | -1.8039 | |
| 405 | E | A | -1.9659 | |
| 406 | P | A | -1.6240 | |
| 407 | D | A | -1.8610 | |
| 408 | P | A | -1.0244 | |
| 409 | Y | A | -0.8855 | |
| 410 | A | A | -0.9860 | |
| 411 | G | A | -1.2563 | |
| 412 | K | A | -1.6959 | |
| 413 | K | A | -2.2882 | |
| 414 | F | A | -1.2534 | |
| 415 | I | A | -0.9426 | |
| 416 | E | A | -2.1255 | |
| 417 | I | A | -1.6094 | |
| 418 | D | A | -2.4937 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.5636 | |
| 421 | D | A | -2.2765 | |
| 422 | K | A | -1.7713 | |
| 423 | L | A | -0.5878 | |
| 424 | S | A | -0.6600 | |
| 425 | T | A | -0.4156 | |
| 426 | D | A | -1.2305 | |
| 427 | L | A | 0.0000 | |
| 428 | S | A | -1.4404 | |
| 429 | K | A | -2.1512 | |
| 430 | Y | A | -1.1933 | |
| 431 | P | A | -0.8677 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -1.7154 | |
| 435 | A | A | -0.9322 | |
| 436 | Y | A | -0.4013 | |
| 437 | L | A | 0.0158 | |
| 438 | N | A | -1.6912 | |
| 439 | R | A | -2.0318 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine