| Chain sequence(s) |
A: GGSEGERQRGRHKGAKDEADKAGHGQDGGGRGGKSHPETKEKGDRGKHGKTEAEGKASEDGKKHGGTGGTAGGAKGKKKGHHEAEGKPGAQSHATKHKGPKKNKEGGSEAGGHGGHSRHPGDGGADAQGAGNKGGEGGRKDGAAKKKEKGGQGGGSEGERQGGRHKGAKDEADKAGHGQDGGGRGKKSHPETKEKGDRGKHGKTEAEGKASEDGKKHGGTGGTAGGAKGKKKGHHEAEGKPGAQSHATKHKGPKKNKEGGSEAGGHGGHSRHPGDGGADAQGAGNKAGEGGRKDGAAKKKEGGGQG
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:03:17)
[INFO] Main: Simulation completed successfully. (00:03:19)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | G | A | -0.9345 | |
| 2 | G | A | -1.2728 | |
| 3 | S | A | -1.6951 | |
| 4 | E | A | -2.9737 | |
| 5 | G | A | -2.9069 | |
| 6 | E | A | -3.9804 | |
| 7 | R | A | -4.1497 | |
| 8 | Q | A | -3.9905 | |
| 9 | R | A | -3.9604 | |
| 10 | G | A | -3.5087 | |
| 11 | R | A | -3.8261 | |
| 12 | H | A | -3.5334 | |
| 13 | K | A | -3.7752 | |
| 14 | G | A | -3.1178 | |
| 15 | A | A | -2.6856 | |
| 16 | K | A | -3.9128 | |
| 17 | D | A | -4.1817 | |
| 18 | E | A | -3.8587 | |
| 19 | A | A | -3.1576 | |
| 20 | D | A | -3.5589 | |
| 21 | K | A | -3.1131 | |
| 22 | A | A | -1.7850 | |
| 23 | G | A | -2.0147 | |
| 24 | H | A | -2.5076 | |
| 25 | G | A | -2.3113 | |
| 26 | Q | A | -2.9577 | |
| 27 | D | A | -3.0678 | |
| 28 | G | A | -2.2739 | |
| 29 | G | A | -2.1229 | |
| 30 | G | A | -2.0474 | |
| 31 | R | A | -2.7609 | |
| 32 | G | A | -2.4014 | |
| 33 | G | A | -2.1043 | |
| 34 | K | A | -2.4039 | |
| 35 | S | A | -1.9185 | |
| 36 | H | A | -2.1323 | |
| 37 | P | A | -2.0199 | |
| 38 | E | A | -2.5985 | |
| 39 | T | A | -2.3246 | |
| 40 | K | A | -3.3642 | |
| 41 | E | A | -3.5246 | |
| 42 | K | A | -3.4435 | |
| 43 | G | A | -3.0178 | |
| 44 | D | A | -3.3654 | |
| 45 | R | A | -3.3648 | |
| 46 | G | A | -2.6949 | |
| 47 | K | A | -2.8435 | |
| 48 | H | A | -2.5267 | |
| 49 | G | A | -2.3707 | |
| 50 | K | A | -2.6828 | |
| 51 | T | A | -2.1827 | |
| 52 | E | A | -3.1327 | |
| 53 | A | A | -2.5123 | |
| 54 | E | A | -2.9735 | |
| 55 | G | A | -2.4657 | |
| 56 | K | A | -2.7096 | |
| 57 | A | A | -1.8444 | |
| 58 | S | A | -2.0999 | |
| 59 | E | A | -3.2680 | |
| 60 | D | A | -3.5594 | |
| 61 | G | A | -3.0997 | |
| 62 | K | A | -3.6430 | |
| 63 | K | A | -3.4268 | |
| 64 | H | A | -2.5803 | |
| 65 | G | A | -1.5720 | |
| 66 | G | A | -1.0226 | |
| 67 | T | A | -0.7096 | |
| 68 | G | A | -0.8721 | |
| 69 | G | A | -1.2090 | |
| 70 | T | A | -0.8829 | |
| 71 | A | A | -0.4038 | |
| 72 | G | A | -0.8530 | |
| 73 | G | A | -1.2175 | |
| 74 | A | A | -1.3952 | |
| 75 | K | A | -2.7261 | |
| 76 | G | A | -2.9331 | |
| 77 | K | A | -3.6181 | |
| 78 | K | A | -3.8200 | |
| 79 | K | A | -3.5244 | |
| 80 | G | A | -2.7596 | |
| 81 | H | A | -2.6924 | |
| 82 | H | A | -2.8405 | |
| 83 | E | A | -3.1055 | |
| 84 | A | A | -2.4305 | |
| 85 | E | A | -3.0863 | |
| 86 | G | A | -2.5596 | |
| 87 | K | A | -2.6375 | |
| 88 | P | A | -1.8016 | |
| 89 | G | A | -1.4442 | |
| 90 | A | A | -1.4252 | |
| 91 | Q | A | -1.8037 | |
| 92 | S | A | -1.7881 | |
| 93 | H | A | -1.9148 | |
| 94 | A | A | -1.8370 | |
| 95 | T | A | -1.9486 | |
| 96 | K | A | -2.9885 | |
| 97 | H | A | -2.8573 | |
| 98 | K | A | -3.3078 | |
| 99 | G | A | -3.0039 | |
| 100 | P | A | -2.9121 | |
| 101 | K | A | -3.6781 | |
| 102 | K | A | -4.3898 | |
| 103 | N | A | -4.1190 | |
| 104 | K | A | -4.1198 | |
| 105 | E | A | -3.8954 | |
| 106 | G | A | -3.0086 | |
| 107 | G | A | -2.8465 | |
| 108 | S | A | -2.2839 | |
| 109 | E | A | -3.0234 | |
| 110 | A | A | -2.2136 | |
| 111 | G | A | -2.0884 | |
| 112 | G | A | -1.5992 | |
| 113 | H | A | -1.9079 | |
| 114 | G | A | -1.5879 | |
| 115 | G | A | -1.7459 | |
| 116 | H | A | -2.1489 | |
| 117 | S | A | -2.0007 | |
| 118 | R | A | -2.8503 | |
| 119 | H | A | -2.4927 | |
| 120 | P | A | -1.8971 | |
| 121 | G | A | -2.0340 | |
| 122 | D | A | -2.5050 | |
| 123 | G | A | -1.8438 | |
| 124 | G | A | -1.4582 | |
| 125 | A | A | -1.4394 | |
| 126 | D | A | -2.2602 | |
| 127 | A | A | -1.5419 | |
| 128 | Q | A | -1.9122 | |
| 129 | G | A | -1.5350 | |
| 130 | A | A | -1.1660 | |
| 131 | G | A | -1.7656 | |
| 132 | N | A | -2.4888 | |
| 133 | K | A | -3.6554 | |
| 134 | G | A | -2.5127 | |
| 135 | G | A | -2.7067 | |
| 136 | E | A | -2.9743 | |
| 137 | G | A | -2.7228 | |
| 138 | G | A | -2.8707 | |
| 139 | R | A | -3.6298 | |
| 140 | K | A | -3.5587 | |
| 141 | D | A | -3.2496 | |
| 142 | G | A | -2.1555 | |
| 143 | A | A | -1.2322 | |
| 144 | A | A | -1.7914 | |
| 145 | K | A | -3.2938 | |
| 146 | K | A | -3.8593 | |
| 147 | K | A | -4.2357 | |
| 148 | E | A | -4.0277 | |
| 149 | K | A | -3.4317 | |
| 150 | G | A | -2.2704 | |
| 151 | G | A | -1.8372 | |
| 152 | Q | A | -2.1192 | |
| 153 | G | A | -1.6150 | |
| 154 | G | A | -1.5631 | |
| 155 | G | A | -1.5885 | |
| 156 | S | A | -1.8550 | |
| 157 | E | A | -3.1446 | |
| 158 | G | A | -3.2967 | |
| 159 | E | A | -4.0005 | |
| 160 | R | A | -4.3856 | |
| 161 | Q | A | -3.1600 | |
| 162 | G | A | -2.6097 | |
| 163 | G | A | -2.6078 | |
| 164 | R | A | -3.1063 | |
| 165 | H | A | -2.9482 | |
| 166 | K | A | -3.0800 | |
| 167 | G | A | -2.6995 | |
| 168 | A | A | -2.2006 | |
| 169 | K | A | -3.3181 | |
| 170 | D | A | -3.7772 | |
| 171 | E | A | -3.6535 | |
| 172 | A | A | -2.5553 | |
| 173 | D | A | -3.3885 | |
| 174 | K | A | -3.1123 | |
| 175 | A | A | -2.1127 | |
| 176 | G | A | -1.5013 | |
| 177 | H | A | -1.9878 | |
| 178 | G | A | -1.9228 | |
| 179 | Q | A | -2.5793 | |
| 180 | D | A | -2.7245 | |
| 181 | G | A | -1.9905 | |
| 182 | G | A | -1.6083 | |
| 183 | G | A | -1.7026 | |
| 184 | R | A | -2.8074 | |
| 185 | G | A | -2.6548 | |
| 186 | K | A | -3.1848 | |
| 187 | K | A | -3.0564 | |
| 188 | S | A | -2.2676 | |
| 189 | H | A | -2.2584 | |
| 190 | P | A | -2.4090 | |
| 191 | E | A | -3.2204 | |
| 192 | T | A | -2.6992 | |
| 193 | K | A | -3.5231 | |
| 194 | E | A | -4.0833 | |
| 195 | K | A | -3.8852 | |
| 196 | G | A | -3.4678 | |
| 197 | D | A | -3.9423 | |
| 198 | R | A | -3.9727 | |
| 199 | G | A | -3.1040 | |
| 200 | K | A | -3.5556 | |
| 201 | H | A | -2.9831 | |
| 202 | G | A | -2.9417 | |
| 203 | K | A | -3.0402 | |
| 204 | T | A | -2.4037 | |
| 205 | E | A | -3.0923 | |
| 206 | A | A | -2.4997 | |
| 207 | E | A | -3.1878 | |
| 208 | G | A | -2.7918 | |
| 209 | K | A | -2.8489 | |
| 210 | A | A | -2.7599 | |
| 211 | S | A | -2.8099 | |
| 212 | E | A | -3.2927 | |
| 213 | D | A | -3.4844 | |
| 214 | G | A | -2.8713 | |
| 215 | K | A | -3.6086 | |
| 216 | K | A | -3.5148 | |
| 217 | H | A | -2.5214 | |
| 218 | G | A | -1.5626 | |
| 219 | G | A | -1.2962 | |
| 220 | T | A | -0.8458 | |
| 221 | G | A | -0.9047 | |
| 222 | G | A | -0.8415 | |
| 223 | T | A | -0.4772 | |
| 224 | A | A | -0.4684 | |
| 225 | G | A | -0.7205 | |
| 226 | G | A | -1.0233 | |
| 227 | A | A | -1.1442 | |
| 228 | K | A | -2.5441 | |
| 229 | G | A | -2.8087 | |
| 230 | K | A | -3.5807 | |
| 231 | K | A | -3.9445 | |
| 232 | K | A | -3.5772 | |
| 233 | G | A | -2.8510 | |
| 234 | H | A | -2.9617 | |
| 235 | H | A | -2.8632 | |
| 236 | E | A | -3.2247 | |
| 237 | A | A | -2.4472 | |
| 238 | E | A | -3.1945 | |
| 239 | G | A | -2.9310 | |
| 240 | K | A | -2.7035 | |
| 241 | P | A | -1.8435 | |
| 242 | G | A | -1.5035 | |
| 243 | A | A | -1.3257 | |
| 244 | Q | A | -1.7209 | |
| 245 | S | A | -1.3288 | |
| 246 | H | A | -1.6595 | |
| 247 | A | A | -1.2956 | |
| 248 | T | A | -1.6741 | |
| 249 | K | A | -2.8720 | |
| 250 | H | A | -2.8033 | |
| 251 | K | A | -3.1674 | |
| 252 | G | A | -2.5941 | |
| 253 | P | A | -2.3808 | |
| 254 | K | A | -3.4405 | |
| 255 | K | A | -3.8506 | |
| 256 | N | A | -3.6720 | |
| 257 | K | A | -3.7461 | |
| 258 | E | A | -3.8035 | |
| 259 | G | A | -2.7764 | |
| 260 | G | A | -2.5346 | |
| 261 | S | A | -2.1528 | |
| 262 | E | A | -2.4926 | |
| 263 | A | A | -1.2436 | |
| 264 | G | A | -1.2870 | |
| 265 | G | A | -1.3325 | |
| 266 | H | A | -1.6509 | |
| 267 | G | A | -1.5243 | |
| 268 | G | A | -1.7064 | |
| 269 | H | A | -2.0233 | |
| 270 | S | A | -2.0367 | |
| 271 | R | A | -2.8380 | |
| 272 | H | A | -2.4752 | |
| 273 | P | A | -1.8957 | |
| 274 | G | A | -2.0344 | |
| 275 | D | A | -2.4920 | |
| 276 | G | A | -1.9241 | |
| 277 | G | A | -1.8295 | |
| 278 | A | A | -1.6539 | |
| 279 | D | A | -2.3429 | |
| 280 | A | A | -1.6516 | |
| 281 | Q | A | -1.8985 | |
| 282 | G | A | -1.5021 | |
| 283 | A | A | -1.1727 | |
| 284 | G | A | -2.1559 | |
| 285 | N | A | -2.4423 | |
| 286 | K | A | -2.9481 | |
| 287 | A | A | -2.1609 | |
| 288 | G | A | -2.3368 | |
| 289 | E | A | -3.2274 | |
| 290 | G | A | -2.6721 | |
| 291 | G | A | -2.8423 | |
| 292 | R | A | -4.0604 | |
| 293 | K | A | -4.1202 | |
| 294 | D | A | -3.8183 | |
| 295 | G | A | -2.9517 | |
| 296 | A | A | -1.9123 | |
| 297 | A | A | -1.9440 | |
| 298 | K | A | -3.1613 | |
| 299 | K | A | -3.8603 | |
| 300 | K | A | -3.9764 | |
| 301 | E | A | -3.4311 | |
| 302 | G | A | -2.4728 | |
| 303 | G | A | -2.0268 | |
| 304 | G | A | -1.7989 | |
| 305 | Q | A | -1.8476 | |
| 306 | G | A | -1.2503 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine