| Chain sequence(s) |
A: FSRPGLPVEYLQVPSPSMGRDIKVQFQSGGNNSPAVYLLDGLRAQDDYNGWDINTPAFEWYYQSGLSIVMPVGGQSSFYSDWYSPACGKAGCQTYKWETFLTSELPQWLSANRAVKPTGSAAIGLSMAGSSAMILAAYHPQQFIYAGSLSALLDPSQGMGPSLIGLAMGDAGGYKAADMWGPSSDPAWERNDPTQQIPKLVANNTRLWVYCGNGTPNELGGANIPAEFLENFVRSSNLKFQDAYNAAGGHNAVFNFPPNGTHSWEYWGAQLNAMKGDLQSSLGAGKESGSVSSEQLAQFRSLDFAVTNDGVI
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:02:11)
[INFO] Main: Simulation completed successfully. (00:02:13)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | F | A | 1.4274 | |
| 2 | S | A | -0.1931 | |
| 3 | R | A | -1.6191 | |
| 4 | P | A | -1.0995 | |
| 5 | G | A | -1.0084 | |
| 6 | L | A | -0.6629 | |
| 7 | P | A | -0.2675 | |
| 8 | V | A | 0.0042 | |
| 9 | E | A | 0.0816 | |
| 10 | Y | A | 0.6277 | |
| 11 | L | A | 0.0000 | |
| 12 | Q | A | -2.1071 | |
| 13 | V | A | 0.0000 | |
| 14 | P | A | -1.7137 | |
| 15 | S | A | 0.0000 | |
| 16 | P | A | -0.9724 | |
| 17 | S | A | -0.7054 | |
| 18 | M | A | 0.0000 | |
| 19 | G | A | -1.3142 | |
| 20 | R | A | -2.0380 | |
| 21 | D | A | -2.8741 | |
| 22 | I | A | 0.0000 | |
| 23 | K | A | -2.3649 | |
| 24 | V | A | 0.0000 | |
| 25 | Q | A | 0.0000 | |
| 26 | F | A | 0.0000 | |
| 27 | Q | A | 0.0000 | |
| 28 | S | A | -0.8693 | |
| 29 | G | A | -1.1246 | |
| 30 | G | A | -1.6760 | |
| 31 | N | A | -2.4695 | |
| 32 | N | A | -2.5248 | |
| 33 | S | A | 0.0000 | |
| 34 | P | A | 0.0000 | |
| 35 | A | A | 0.0000 | |
| 36 | V | A | 0.0000 | |
| 37 | Y | A | 0.0000 | |
| 38 | L | A | 0.0000 | |
| 39 | L | A | 0.0000 | |
| 40 | D | A | 0.0000 | |
| 41 | G | A | 0.0000 | |
| 42 | L | A | -1.0590 | |
| 43 | R | A | -2.4920 | |
| 44 | A | A | 0.0000 | |
| 45 | Q | A | -2.4157 | |
| 46 | D | A | -3.0513 | |
| 47 | D | A | -2.0659 | |
| 48 | Y | A | -0.4007 | |
| 49 | N | A | 0.0000 | |
| 50 | G | A | 0.0000 | |
| 51 | W | A | 0.0000 | |
| 52 | D | A | 0.0000 | |
| 53 | I | A | 0.9104 | |
| 54 | N | A | -0.0830 | |
| 55 | T | A | 0.0000 | |
| 56 | P | A | -0.2329 | |
| 57 | A | A | 0.0000 | |
| 58 | F | A | 0.0000 | |
| 59 | E | A | -0.9157 | |
| 60 | W | A | -0.4276 | |
| 61 | Y | A | 0.0000 | |
| 62 | Y | A | -0.2562 | |
| 63 | Q | A | -1.1765 | |
| 64 | S | A | 0.0000 | |
| 65 | G | A | -1.5049 | |
| 66 | L | A | 0.0000 | |
| 67 | S | A | 0.0000 | |
| 68 | I | A | 0.0000 | |
| 69 | V | A | 0.0000 | |
| 70 | M | A | 0.0000 | |
| 71 | P | A | 0.0000 | |
| 72 | V | A | 0.0000 | |
| 73 | G | A | 0.0000 | |
| 74 | G | A | 0.0000 | |
| 75 | Q | A | -1.4137 | |
| 76 | S | A | 0.0000 | |
| 77 | S | A | 0.0000 | |
| 78 | F | A | 0.0000 | |
| 79 | Y | A | 0.0000 | |
| 80 | S | A | 0.0000 | |
| 81 | D | A | -0.6296 | |
| 82 | W | A | 0.0000 | |
| 83 | Y | A | 0.8972 | |
| 84 | S | A | 0.0769 | |
| 85 | P | A | -0.2467 | |
| 86 | A | A | 0.0000 | |
| 87 | C | A | -0.5299 | |
| 88 | G | A | -1.4229 | |
| 89 | K | A | -1.9321 | |
| 90 | A | A | -0.8152 | |
| 91 | G | A | -0.5117 | |
| 92 | C | A | 0.1607 | |
| 93 | Q | A | -0.3158 | |
| 94 | T | A | -0.3635 | |
| 95 | Y | A | 0.0000 | |
| 96 | K | A | -0.8575 | |
| 97 | W | A | 0.0000 | |
| 98 | E | A | -0.6007 | |
| 99 | T | A | -0.5262 | |
| 100 | F | A | 0.0000 | |
| 101 | L | A | 0.0000 | |
| 102 | T | A | -0.3551 | |
| 103 | S | A | -0.5290 | |
| 104 | E | A | -0.6925 | |
| 105 | L | A | 0.0000 | |
| 106 | P | A | 0.0000 | |
| 107 | Q | A | -1.4646 | |
| 108 | W | A | -0.8605 | |
| 109 | L | A | 0.0000 | |
| 110 | S | A | -1.3359 | |
| 111 | A | A | -0.8874 | |
| 112 | N | A | -1.3339 | |
| 113 | R | A | -1.6785 | |
| 114 | A | A | -1.6623 | |
| 115 | V | A | 0.0000 | |
| 116 | K | A | -1.3670 | |
| 117 | P | A | -0.9425 | |
| 118 | T | A | -0.6745 | |
| 119 | G | A | -0.3239 | |
| 120 | S | A | 0.0000 | |
| 121 | A | A | 0.0000 | |
| 122 | A | A | 0.0000 | |
| 123 | I | A | 0.0000 | |
| 124 | G | A | 0.0000 | |
| 125 | L | A | 0.0000 | |
| 126 | S | A | -0.0973 | |
| 127 | M | A | 0.0000 | |
| 128 | A | A | 0.0000 | |
| 129 | G | A | 0.0000 | |
| 130 | S | A | 0.0000 | |
| 131 | S | A | 0.0000 | |
| 132 | A | A | 0.0000 | |
| 133 | M | A | 0.0000 | |
| 134 | I | A | 0.0000 | |
| 135 | L | A | 0.0000 | |
| 136 | A | A | 0.0000 | |
| 137 | A | A | 0.0000 | |
| 138 | Y | A | -0.2340 | |
| 139 | H | A | -0.4485 | |
| 140 | P | A | -0.8494 | |
| 141 | Q | A | -1.2185 | |
| 142 | Q | A | 0.0000 | |
| 143 | F | A | 0.0000 | |
| 144 | I | A | -0.1416 | |
| 145 | Y | A | 0.0000 | |
| 146 | A | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | S | A | 0.0000 | |
| 149 | L | A | 0.0000 | |
| 150 | S | A | 0.0000 | |
| 151 | A | A | 0.0000 | |
| 152 | L | A | 0.3097 | |
| 153 | L | A | 0.0000 | |
| 154 | D | A | 0.0000 | |
| 155 | P | A | 0.0000 | |
| 156 | S | A | -1.1026 | |
| 157 | Q | A | -1.0597 | |
| 158 | G | A | -0.3512 | |
| 159 | M | A | 0.6153 | |
| 160 | G | A | 0.0000 | |
| 161 | P | A | 0.1132 | |
| 162 | S | A | 0.4942 | |
| 163 | L | A | 0.9677 | |
| 164 | I | A | 0.0000 | |
| 165 | G | A | -0.0306 | |
| 166 | L | A | 0.7667 | |
| 167 | A | A | -0.2704 | |
| 168 | M | A | 0.0000 | |
| 169 | G | A | -1.2683 | |
| 170 | D | A | -2.1105 | |
| 171 | A | A | 0.0000 | |
| 172 | G | A | -1.8010 | |
| 173 | G | A | -1.6347 | |
| 174 | Y | A | 0.0000 | |
| 175 | K | A | -1.9053 | |
| 176 | A | A | 0.0000 | |
| 177 | A | A | -0.7412 | |
| 178 | D | A | -0.6329 | |
| 179 | M | A | 0.0000 | |
| 180 | W | A | 0.0000 | |
| 181 | G | A | 0.0000 | |
| 182 | P | A | -0.6564 | |
| 183 | S | A | -0.8796 | |
| 184 | S | A | -0.8749 | |
| 185 | D | A | -1.1356 | |
| 186 | P | A | -1.1858 | |
| 187 | A | A | 0.0000 | |
| 188 | W | A | 0.0000 | |
| 189 | E | A | -2.1491 | |
| 190 | R | A | -1.4330 | |
| 191 | N | A | 0.0000 | |
| 192 | D | A | 0.0000 | |
| 193 | P | A | 0.0000 | |
| 194 | T | A | -0.9033 | |
| 195 | Q | A | -1.3608 | |
| 196 | Q | A | 0.0000 | |
| 197 | I | A | 0.0000 | |
| 198 | P | A | -0.9045 | |
| 199 | K | A | -1.1512 | |
| 200 | L | A | 0.0000 | |
| 201 | V | A | -1.1354 | |
| 202 | A | A | -0.8300 | |
| 203 | N | A | -1.3158 | |
| 204 | N | A | -1.5550 | |
| 205 | T | A | 0.0000 | |
| 206 | R | A | -0.7596 | |
| 207 | L | A | 0.0000 | |
| 208 | W | A | 0.0000 | |
| 209 | V | A | 0.0000 | |
| 210 | Y | A | 0.0000 | |
| 211 | C | A | 0.0000 | |
| 212 | G | A | 0.0000 | |
| 213 | N | A | -0.6527 | |
| 214 | G | A | -0.3328 | |
| 215 | T | A | -0.7702 | |
| 216 | P | A | -1.1981 | |
| 217 | N | A | -1.7495 | |
| 218 | E | A | -2.0426 | |
| 219 | L | A | -0.6260 | |
| 220 | G | A | -0.8935 | |
| 221 | G | A | -0.6134 | |
| 222 | A | A | -0.4354 | |
| 223 | N | A | 0.2165 | |
| 224 | I | A | 1.9698 | |
| 225 | P | A | 1.0915 | |
| 226 | A | A | 0.0000 | |
| 227 | E | A | 0.6196 | |
| 228 | F | A | 2.0311 | |
| 229 | L | A | 1.2992 | |
| 230 | E | A | 0.0000 | |
| 231 | N | A | -0.5557 | |
| 232 | F | A | 0.5404 | |
| 233 | V | A | 0.0000 | |
| 234 | R | A | -0.5343 | |
| 235 | S | A | -0.5120 | |
| 236 | S | A | 0.0000 | |
| 237 | N | A | 0.0000 | |
| 238 | L | A | -0.4758 | |
| 239 | K | A | -1.7687 | |
| 240 | F | A | 0.0000 | |
| 241 | Q | A | -1.4699 | |
| 242 | D | A | -2.5016 | |
| 243 | A | A | -1.6508 | |
| 244 | Y | A | 0.0000 | |
| 245 | N | A | -2.1695 | |
| 246 | A | A | -1.1106 | |
| 247 | A | A | -0.9187 | |
| 248 | G | A | -1.0637 | |
| 249 | G | A | -1.6451 | |
| 250 | H | A | -1.6155 | |
| 251 | N | A | -1.1843 | |
| 252 | A | A | -0.5104 | |
| 253 | V | A | 0.2965 | |
| 254 | F | A | 0.5994 | |
| 255 | N | A | 0.1342 | |
| 256 | F | A | 0.2244 | |
| 257 | P | A | -0.2128 | |
| 258 | P | A | -0.5834 | |
| 259 | N | A | -0.9130 | |
| 260 | G | A | 0.0000 | |
| 261 | T | A | 0.0000 | |
| 262 | H | A | -0.2091 | |
| 263 | S | A | -0.4021 | |
| 264 | W | A | -0.2912 | |
| 265 | E | A | -0.9461 | |
| 266 | Y | A | 0.0000 | |
| 267 | W | A | 0.0000 | |
| 268 | G | A | 0.0000 | |
| 269 | A | A | -0.3594 | |
| 270 | Q | A | -0.5371 | |
| 271 | L | A | 0.0000 | |
| 272 | N | A | -0.9124 | |
| 273 | A | A | -0.6142 | |
| 274 | M | A | 0.0000 | |
| 275 | K | A | -1.0607 | |
| 276 | G | A | -1.0782 | |
| 277 | D | A | -0.8198 | |
| 278 | L | A | 0.0000 | |
| 279 | Q | A | -1.1258 | |
| 280 | S | A | -0.9634 | |
| 281 | S | A | -0.4759 | |
| 282 | L | A | 0.0000 | |
| 283 | G | A | -1.2418 | |
| 284 | A | A | -1.7002 | |
| 285 | G | A | -2.2899 | |
| 286 | K | A | -3.0900 | |
| 287 | E | A | -3.3031 | |
| 288 | S | A | -2.0513 | |
| 289 | G | A | -1.4004 | |
| 290 | S | A | -0.5297 | |
| 291 | V | A | 0.5351 | |
| 292 | S | A | -0.2357 | |
| 293 | S | A | -0.6841 | |
| 294 | E | A | -1.6188 | |
| 295 | Q | A | -0.8110 | |
| 296 | L | A | 0.6215 | |
| 297 | A | A | -0.5507 | |
| 298 | Q | A | -0.6671 | |
| 299 | F | A | 0.7154 | |
| 300 | R | A | -0.7681 | |
| 301 | S | A | 0.0243 | |
| 302 | L | A | 0.8769 | |
| 303 | D | A | -0.0457 | |
| 304 | F | A | 1.6615 | |
| 305 | A | A | 1.4976 | |
| 306 | V | A | 1.4934 | |
| 307 | T | A | -0.0807 | |
| 308 | N | A | -1.7050 | |
| 309 | D | A | -1.8461 | |
| 310 | G | A | -0.5197 | |
| 311 | V | A | 1.9977 | |
| 312 | I | A | 2.5623 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine