Chain sequence(s) |
A: MVSYWDTGVLLCALLSCLLLTGSSSGSDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG
input PDB |
Selected Chain(s) | A |
Distance of aggregation | 10 Å |
FoldX usage | Yes |
Dynamic mode | No |
Automated mutations | No |
Downloads | Download all the data |
Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:01) [WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow to prevent this behavior) (00:00:01) [INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:01) [INFO] runJob: Creating pdb object from: input.pdb (00:00:01) [INFO] FoldX: Starting FoldX energy minimalization (00:00:01) [INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:05:54) [INFO] Main: Simulation completed successfully. (00:05:57) |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
residue index | residue name | chain | Aggrescan3D score | mutation |
---|---|---|---|---|
residue index | residue name | chain | Aggrescan3D score | |
1 | M | A | 1.9952 | |
2 | V | A | 2.6426 | |
3 | S | A | 1.4064 | |
4 | Y | A | 1.8088 | |
5 | W | A | 0.9432 | |
6 | D | A | -1.0833 | |
7 | T | A | 0.0093 | |
8 | G | A | 0.5452 | |
9 | V | A | 2.5030 | |
10 | L | A | 3.2478 | |
11 | L | A | 3.2232 | |
12 | C | A | 2.4587 | |
13 | A | A | 2.0591 | |
14 | L | A | 2.6458 | |
15 | L | A | 2.5529 | |
16 | S | A | 1.7856 | |
17 | C | A | 2.2598 | |
18 | L | A | 3.1793 | |
19 | L | A | 3.1530 | |
20 | L | A | 2.6172 | |
21 | T | A | 0.9421 | |
22 | G | A | -0.0987 | |
23 | S | A | -0.4998 | |
24 | S | A | -0.7063 | |
25 | S | A | -0.9511 | |
26 | G | A | -1.3028 | |
27 | S | A | -1.5412 | |
28 | D | A | -2.4395 | |
29 | T | A | -1.5666 | |
30 | G | A | -1.6333 | |
31 | R | A | -1.5300 | |
32 | P | A | 0.0000 | |
33 | F | A | 0.0000 | |
34 | V | A | -0.8249 | |
35 | E | A | -1.5503 | |
36 | M | A | -0.7877 | |
37 | Y | A | -0.4580 | |
38 | S | A | -0.8888 | |
39 | E | A | -1.0784 | |
40 | I | A | 1.0811 | |
41 | P | A | 0.4970 | |
42 | E | A | -0.2349 | |
43 | I | A | 0.6348 | |
44 | I | A | -0.1664 | |
45 | H | A | -1.2545 | |
46 | M | A | 0.0000 | |
47 | T | A | -2.2412 | |
48 | E | A | -2.3805 | |
49 | G | A | -2.3060 | |
50 | R | A | -3.6342 | |
51 | E | A | -3.2688 | |
52 | L | A | 0.0000 | |
53 | V | A | -0.0086 | |
54 | I | A | 0.0000 | |
55 | P | A | -1.2220 | |
56 | C | A | 0.0000 | |
57 | R | A | -2.4275 | |
58 | V | A | 0.0000 | |
59 | T | A | -1.2389 | |
60 | S | A | -1.0373 | |
61 | P | A | -1.3897 | |
62 | N | A | -1.3458 | |
63 | I | A | -0.6175 | |
64 | T | A | -0.3077 | |
65 | V | A | 0.0000 | |
66 | T | A | 0.0280 | |
67 | L | A | 0.0000 | |
68 | K | A | -0.3108 | |
69 | K | A | -0.0376 | |
70 | F | A | 1.6796 | |
71 | P | A | 1.0686 | |
72 | L | A | 1.0024 | |
73 | D | A | -0.8907 | |
74 | T | A | -0.1207 | |
75 | L | A | 0.0000 | |
76 | I | A | 1.2068 | |
77 | P | A | -0.2270 | |
78 | D | A | -2.0049 | |
79 | G | A | -1.7286 | |
80 | K | A | -2.6970 | |
81 | R | A | -1.9989 | |
82 | I | A | 0.0000 | |
83 | I | A | -0.1631 | |
84 | W | A | -0.1151 | |
85 | D | A | -1.2230 | |
86 | S | A | -2.0091 | |
87 | R | A | -2.9464 | |
88 | K | A | -2.4059 | |
89 | G | A | 0.0000 | |
90 | F | A | 0.0000 | |
91 | I | A | -0.4466 | |
92 | I | A | 0.0000 | |
93 | S | A | -2.1688 | |
94 | N | A | -3.1427 | |
95 | A | A | 0.0000 | |
96 | T | A | -1.1248 | |
97 | Y | A | 0.3182 | |
98 | K | A | -1.2954 | |
99 | E | A | 0.0000 | |
100 | I | A | 0.1329 | |
101 | G | A | 0.5002 | |
102 | L | A | 0.7611 | |
103 | L | A | 0.0000 | |
104 | T | A | 0.0000 | |
105 | C | A | 0.0000 | |
106 | E | A | -0.5088 | |
107 | A | A | 0.0000 | |
108 | T | A | -0.3919 | |
109 | V | A | -0.6918 | |
110 | N | A | -1.5777 | |
111 | G | A | -1.2363 | |
112 | H | A | -1.0855 | |
113 | L | A | -0.0296 | |
114 | Y | A | -0.3551 | |
115 | K | A | -0.9728 | |
116 | T | A | 0.0000 | |
117 | N | A | -0.4858 | |
118 | Y | A | 0.0000 | |
119 | L | A | 0.5119 | |
120 | T | A | 0.0000 | |
121 | H | A | -1.2649 | |
122 | R | A | -1.7220 | |
123 | Q | A | -2.2481 | |
124 | T | A | -1.3413 | |
125 | N | A | -0.3953 | |
126 | T | A | -0.3769 | |
127 | I | A | 0.0000 | |
128 | I | A | -0.0618 | |
129 | D | A | -0.5982 | |
130 | V | A | 0.0000 | |
131 | V | A | 0.3020 | |
132 | L | A | 0.0000 | |
133 | S | A | -0.1460 | |
134 | P | A | -0.3938 | |
135 | S | A | -0.5556 | |
136 | H | A | -1.2146 | |
137 | G | A | -1.2746 | |
138 | I | A | 0.0000 | |
139 | E | A | -2.2726 | |
140 | L | A | -2.3091 | |
141 | S | A | -2.5917 | |
142 | V | A | -2.1886 | |
143 | G | A | -2.2846 | |
144 | E | A | -2.7321 | |
145 | K | A | -2.8802 | |
146 | L | A | 0.0000 | |
147 | V | A | -0.3215 | |
148 | L | A | 0.0000 | |
149 | N | A | 0.0816 | |
150 | C | A | 0.0000 | |
151 | T | A | -0.5544 | |
152 | A | A | 0.0000 | |
153 | R | A | -0.8883 | |
154 | T | A | 0.0000 | |
155 | E | A | -1.5025 | |
156 | L | A | -1.4588 | |
157 | N | A | -1.7762 | |
158 | V | A | 0.0000 | |
159 | G | A | -1.4013 | |
160 | I | A | -1.6553 | |
161 | D | A | -2.2567 | |
162 | F | A | -1.4596 | |
163 | N | A | -2.1197 | |
164 | W | A | -1.3978 | |
165 | E | A | -1.7963 | |
166 | Y | A | -0.4710 | |
167 | P | A | -0.6752 | |
168 | S | A | 0.0000 | |
169 | S | A | -1.6473 | |
170 | K | A | -2.4022 | |
171 | H | A | -2.5236 | |
172 | Q | A | -2.8597 | |
173 | H | A | -3.1505 | |
174 | K | A | -2.9137 | |
175 | K | A | -1.9277 | |
176 | L | A | 0.3575 | |
177 | V | A | 0.2472 | |
178 | N | A | -1.8237 | |
179 | R | A | -3.2229 | |
180 | D | A | -3.7109 | |
181 | L | A | -2.5336 | |
182 | K | A | -2.7449 | |
183 | T | A | -2.1994 | |
184 | Q | A | -2.1938 | |
185 | S | A | -1.4990 | |
186 | G | A | -1.3456 | |
187 | S | A | -1.7001 | |
188 | E | A | -2.1651 | |
189 | M | A | -1.6021 | |
190 | K | A | -2.2172 | |
191 | K | A | -2.1527 | |
192 | F | A | 0.0000 | |
193 | L | A | -1.1193 | |
194 | S | A | 0.0000 | |
195 | T | A | -0.1489 | |
196 | L | A | 0.0000 | |
197 | T | A | -1.2897 | |
198 | I | A | 0.0000 | |
199 | D | A | -3.7683 | |
200 | G | A | -2.4405 | |
201 | V | A | 0.0000 | |
202 | T | A | -1.8121 | |
203 | R | A | -2.1204 | |
204 | S | A | -1.1387 | |
205 | D | A | 0.0000 | |
206 | Q | A | -1.0644 | |
207 | G | A | 0.4817 | |
208 | L | A | 1.6211 | |
209 | Y | A | 0.0000 | |
210 | T | A | -0.7546 | |
211 | C | A | 0.0000 | |
212 | A | A | 0.0000 | |
213 | A | A | 0.0000 | |
214 | S | A | -1.0658 | |
215 | S | A | -0.3274 | |
216 | G | A | -0.0114 | |
217 | L | A | 1.4168 | |
218 | M | A | 0.6814 | |
219 | T | A | -0.7450 | |
220 | K | A | -1.6683 | |
221 | K | A | -2.4331 | |
222 | N | A | -1.3232 | |
223 | S | A | -0.2091 | |
224 | T | A | 0.0000 | |
225 | F | A | 1.3201 | |
226 | V | A | 0.0000 | |
227 | R | A | -1.8192 | |
228 | V | A | 0.0000 | |
229 | H | A | -2.9477 | |
230 | E | A | -3.7923 | |
231 | K | A | -4.0947 | |
232 | D | A | -4.2715 | |
233 | K | A | -3.5147 | |
234 | T | A | -2.0449 | |
235 | H | A | -1.8874 | |
236 | T | A | -0.7666 | |
237 | C | A | 0.3323 | |
238 | P | A | -0.0024 | |
239 | P | A | 0.1073 | |
240 | C | A | 0.5305 | |
241 | P | A | -0.2661 | |
242 | A | A | -0.2778 | |
243 | P | A | -0.6242 | |
244 | E | A | -0.9322 | |
245 | L | A | 1.0943 | |
246 | L | A | 1.1124 | |
247 | G | A | 0.1484 | |
248 | G | A | -0.2708 | |
249 | P | A | 0.0000 | |
250 | S | A | 0.0152 | |
251 | V | A | 0.0000 | |
252 | F | A | 1.0909 | |
253 | L | A | 0.7901 | |
254 | F | A | 0.9833 | |
255 | P | A | -0.2959 | |
256 | P | A | 0.0000 | |
257 | K | A | -2.1644 | |
258 | P | A | -1.5043 | |
259 | K | A | -1.2029 | |
260 | D | A | -1.1790 | |
261 | T | A | 0.0000 | |
262 | L | A | 0.0000 | |
263 | M | A | 0.3926 | |
264 | I | A | 1.4249 | |
265 | S | A | 0.2662 | |
266 | R | A | -0.7475 | |
267 | T | A | -0.5368 | |
268 | P | A | 0.0000 | |
269 | E | A | -1.1485 | |
270 | V | A | 0.0000 | |
271 | T | A | 0.1139 | |
272 | C | A | 0.0000 | |
273 | V | A | 0.0000 | |
274 | V | A | 0.0000 | |
275 | V | A | -0.8309 | |
276 | D | A | -1.4913 | |
277 | V | A | 0.0000 | |
278 | S | A | -2.0468 | |
279 | H | A | -2.6105 | |
280 | E | A | -2.9677 | |
281 | D | A | -2.5995 | |
282 | P | A | -2.5154 | |
283 | E | A | -3.1010 | |
284 | V | A | -2.0043 | |
285 | K | A | -2.2348 | |
286 | F | A | -1.1736 | |
287 | N | A | -1.1472 | |
288 | W | A | 0.0000 | |
289 | Y | A | -0.6812 | |
290 | V | A | -0.9129 | |
291 | D | A | -2.1652 | |
292 | G | A | -0.9258 | |
293 | V | A | 0.6622 | |
294 | E | A | -0.7314 | |
295 | V | A | -0.5670 | |
296 | H | A | -1.8939 | |
297 | N | A | -2.1736 | |
298 | A | A | -1.8558 | |
299 | K | A | -2.3425 | |
300 | T | A | -1.7378 | |
301 | K | A | -1.8808 | |
302 | P | A | -2.0248 | |
303 | R | A | -3.0958 | |
304 | E | A | -3.3475 | |
305 | E | A | -3.1543 | |
306 | Q | A | -1.5093 | |
307 | Y | A | 0.2412 | |
308 | N | A | -0.7218 | |
309 | S | A | -0.9703 | |
310 | T | A | -1.8200 | |
311 | Y | A | 0.0000 | |
312 | R | A | -2.2249 | |
313 | V | A | 0.0000 | |
314 | V | A | 0.0000 | |
315 | S | A | 0.0000 | |
316 | V | A | 0.0000 | |
317 | L | A | 0.0000 | |
318 | T | A | -0.6566 | |
319 | V | A | 0.0000 | |
320 | L | A | 0.8412 | |
321 | H | A | -0.0569 | |
322 | Q | A | -1.1031 | |
323 | D | A | -1.1519 | |
324 | W | A | 0.0000 | |
325 | L | A | -0.9723 | |
326 | N | A | -2.0807 | |
327 | G | A | -2.1421 | |
328 | K | A | -2.1822 | |
329 | E | A | -2.4148 | |
330 | Y | A | 0.0000 | |
331 | K | A | -1.6475 | |
332 | C | A | 0.0000 | |
333 | K | A | -1.4791 | |
334 | V | A | 0.0000 | |
335 | S | A | -1.4481 | |
336 | N | A | 0.0000 | |
337 | K | A | -2.5648 | |
338 | A | A | -1.4695 | |
339 | L | A | -0.6016 | |
340 | P | A | -0.4566 | |
341 | A | A | -0.6284 | |
342 | P | A | -0.8841 | |
343 | I | A | -0.7980 | |
344 | E | A | -1.8590 | |
345 | K | A | -1.2157 | |
346 | T | A | -1.0413 | |
347 | I | A | -0.2828 | |
348 | S | A | -1.2074 | |
349 | K | A | -1.3407 | |
350 | A | A | -1.2076 | |
351 | K | A | -2.3576 | |
352 | G | A | -1.9804 | |
353 | Q | A | -2.1331 | |
354 | P | A | -1.7633 | |
355 | R | A | -2.2146 | |
356 | E | A | -2.7888 | |
357 | P | A | 0.0000 | |
358 | Q | A | -1.3459 | |
359 | V | A | -0.3004 | |
360 | Y | A | 0.6921 | |
361 | T | A | 0.3938 | |
362 | L | A | 0.5104 | |
363 | P | A | -0.1868 | |
364 | P | A | -0.9418 | |
365 | S | A | -1.7287 | |
366 | R | A | -2.8818 | |
367 | D | A | -3.1017 | |
368 | E | A | -2.6010 | |
369 | L | A | -2.2697 | |
370 | T | A | -2.0738 | |
371 | K | A | -2.9609 | |
372 | N | A | -2.8172 | |
373 | Q | A | -2.4897 | |
374 | V | A | 0.0000 | |
375 | S | A | -0.7426 | |
376 | L | A | 0.0000 | |
377 | T | A | -0.2102 | |
378 | C | A | 0.0000 | |
379 | L | A | 0.4880 | |
380 | V | A | 0.0000 | |
381 | K | A | -0.7203 | |
382 | G | A | -1.3995 | |
383 | F | A | 0.0000 | |
384 | Y | A | -1.0785 | |
385 | P | A | 0.0000 | |
386 | S | A | -0.0866 | |
387 | D | A | -1.3318 | |
388 | I | A | 0.0000 | |
389 | A | A | -0.6972 | |
390 | V | A | 0.0000 | |
391 | E | A | -1.2659 | |
392 | W | A | 0.0000 | |
393 | E | A | -1.7550 | |
394 | S | A | 0.0000 | |
395 | N | A | -1.8912 | |
396 | G | A | -1.7728 | |
397 | Q | A | -2.2515 | |
398 | P | A | -1.9413 | |
399 | E | A | 0.0000 | |
400 | N | A | -2.4350 | |
401 | N | A | -2.3620 | |
402 | Y | A | -2.1810 | |
403 | K | A | -2.5042 | |
404 | T | A | -1.1093 | |
405 | T | A | -0.3315 | |
406 | P | A | 0.0462 | |
407 | P | A | 0.6364 | |
408 | V | A | 1.6033 | |
409 | L | A | 1.2941 | |
410 | D | A | -0.6015 | |
411 | S | A | -1.1090 | |
412 | D | A | -2.0405 | |
413 | G | A | -0.8728 | |
414 | S | A | 0.0000 | |
415 | F | A | 0.3325 | |
416 | F | A | 0.7166 | |
417 | L | A | 0.0000 | |
418 | Y | A | 0.3817 | |
419 | S | A | 0.0000 | |
420 | K | A | -1.8263 | |
421 | L | A | 0.0000 | |
422 | T | A | -1.5063 | |
423 | V | A | 0.0000 | |
424 | D | A | -2.4637 | |
425 | K | A | -2.6716 | |
426 | S | A | -2.1620 | |
427 | R | A | -2.0111 | |
428 | W | A | 0.0000 | |
429 | Q | A | -2.2940 | |
430 | Q | A | -2.1303 | |
431 | G | A | -1.2327 | |
432 | N | A | -0.9243 | |
433 | V | A | -0.0652 | |
434 | F | A | 0.0000 | |
435 | S | A | 0.0000 | |
436 | C | A | 0.0000 | |
437 | S | A | 0.0000 | |
438 | V | A | 0.0000 | |
439 | M | A | 0.0000 | |
440 | H | A | 0.0000 | |
441 | E | A | -1.1033 | |
442 | A | A | -1.4868 | |
443 | L | A | -1.4249 | |
444 | H | A | -1.7212 | |
445 | N | A | -1.4285 | |
446 | H | A | -0.9280 | |
447 | Y | A | -0.2722 | |
448 | T | A | -0.5753 | |
449 | Q | A | -0.7635 | |
450 | K | A | -0.8443 | |
451 | S | A | -0.4044 | |
452 | L | A | 0.0000 | |
453 | S | A | -0.1612 | |
454 | L | A | -0.3176 | |
455 | S | A | -0.3221 | |
456 | P | A | -0.4969 | |
457 | G | A | -0.5700 |