| Chain sequence(s) |
A: YLPPTTPVAKVQSTDEYVYPTSLFCHAHTDRLLTVGHPFKDIVKNGKVVVPKVSGYQWRVFRLKFPDPNKFALPQKDFYDPEKERLVWRLRGLEIGRGGPLGKGTVGHPLFNKLGDTENPTAPLHPSADVRVAYSFDPKQTQLFIVGCEPPTGEHWDLAPPCPGLPPGACPPIQLVNSVIEDGDMCDIGFGNMNFKELQQDRSGVPLDIVSTRCKWPDFLKMTNEAYGDKMFFFGRREQVYARHFFVRNGPEGHPLPDAPPPSPLYVRPPPTSPYWVRPPTDYFGTPSGSLVSSDGQLFNRPFWLQRAQGNNNGVCWHNELFVTVVDNTRNTNFTISQQISTPPINVYNPENFKNYLRHVEQFELSLIAQLCKVPLDPGVLAHINTMNPTILENWNLGFVPPKEREDPYKGLIFWEVDLTERFSQDLDQFALGRKFLYQ
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:05)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Y | A | 1.9419 | |
| 2 | L | A | 1.9637 | |
| 3 | P | A | 0.8346 | |
| 4 | P | A | 0.3856 | |
| 5 | T | A | 0.1289 | |
| 6 | T | A | 0.1309 | |
| 7 | P | A | 0.1688 | |
| 8 | V | A | 1.2107 | |
| 9 | A | A | 0.0868 | |
| 10 | K | A | -1.0194 | |
| 11 | V | A | -0.1504 | |
| 12 | Q | A | -1.3978 | |
| 13 | S | A | -1.5334 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.3813 | |
| 16 | E | A | -2.4204 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | Y | A | 0.4672 | |
| 20 | P | A | 0.1329 | |
| 21 | T | A | 0.1795 | |
| 22 | S | A | -0.0969 | |
| 23 | L | A | 0.0932 | |
| 24 | F | A | -0.0307 | |
| 25 | C | A | 0.0000 | |
| 26 | H | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | H | A | -1.2836 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -2.8933 | |
| 31 | R | A | -2.6765 | |
| 32 | L | A | -0.7970 | |
| 33 | L | A | 1.1609 | |
| 34 | T | A | 1.3695 | |
| 35 | V | A | 1.8323 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -0.1965 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | -0.6065 | |
| 40 | K | A | -1.6258 | |
| 41 | D | A | -0.9213 | |
| 42 | I | A | 0.8390 | |
| 43 | V | A | 1.0181 | |
| 44 | K | A | -1.1876 | |
| 45 | N | A | -1.9323 | |
| 46 | G | A | -1.2313 | |
| 47 | K | A | -0.9779 | |
| 48 | V | A | 1.4546 | |
| 49 | V | A | 2.0361 | |
| 50 | V | A | 1.2478 | |
| 51 | P | A | 0.4423 | |
| 52 | K | A | -0.6376 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | G | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | R | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.1511 | |
| 65 | F | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.4044 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.2730 | |
| 70 | K | A | -1.7911 | |
| 71 | F | A | -0.6404 | |
| 72 | A | A | -0.5773 | |
| 73 | L | A | -0.8652 | |
| 74 | P | A | -1.2093 | |
| 75 | Q | A | -2.5081 | |
| 76 | K | A | -3.1106 | |
| 77 | D | A | -2.9935 | |
| 78 | F | A | -1.6723 | |
| 79 | Y | A | -1.8901 | |
| 80 | D | A | -2.6934 | |
| 81 | P | A | -2.3128 | |
| 82 | E | A | -3.0547 | |
| 83 | K | A | -3.3997 | |
| 84 | E | A | -2.4685 | |
| 85 | R | A | -1.3002 | |
| 86 | L | A | 0.0000 | |
| 87 | V | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.6657 | |
| 92 | G | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | E | A | -0.9599 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | -1.3467 | |
| 97 | R | A | 0.0000 | |
| 98 | G | A | -0.6914 | |
| 99 | G | A | -0.5375 | |
| 100 | P | A | -0.4092 | |
| 101 | L | A | 0.0327 | |
| 102 | G | A | -0.2290 | |
| 103 | K | A | -0.6521 | |
| 104 | G | A | -0.4746 | |
| 105 | T | A | -0.4598 | |
| 106 | V | A | 0.0000 | |
| 107 | G | A | 0.1438 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | 0.4484 | |
| 110 | L | A | 0.4650 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -0.9945 | |
| 113 | K | A | -0.3512 | |
| 114 | L | A | -0.7788 | |
| 115 | G | A | -0.7248 | |
| 116 | D | A | -1.0735 | |
| 117 | T | A | -0.7818 | |
| 118 | E | A | -1.7477 | |
| 119 | N | A | -1.9266 | |
| 120 | P | A | -1.3130 | |
| 121 | T | A | -0.6657 | |
| 122 | A | A | -0.4248 | |
| 123 | P | A | 0.1033 | |
| 124 | L | A | -0.1865 | |
| 125 | H | A | -0.5984 | |
| 126 | P | A | -0.8455 | |
| 127 | S | A | -1.0571 | |
| 128 | A | A | -1.0043 | |
| 129 | D | A | -1.8075 | |
| 130 | V | A | -0.9666 | |
| 131 | R | A | -0.6954 | |
| 132 | V | A | 0.4626 | |
| 133 | A | A | 0.4546 | |
| 134 | Y | A | 0.2618 | |
| 135 | S | A | -0.0888 | |
| 136 | F | A | 0.0000 | |
| 137 | D | A | -0.5522 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | Q | A | 0.0000 | |
| 141 | T | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | C | A | 0.0000 | |
| 149 | E | A | -0.5608 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | 0.0000 | |
| 153 | G | A | 0.0000 | |
| 154 | E | A | -0.1977 | |
| 155 | H | A | 0.0000 | |
| 156 | W | A | 1.2111 | |
| 157 | D | A | 0.5505 | |
| 158 | L | A | 1.1907 | |
| 159 | A | A | 0.9681 | |
| 160 | P | A | 0.0962 | |
| 161 | P | A | 0.4559 | |
| 162 | C | A | 0.5092 | |
| 163 | P | A | 0.0036 | |
| 164 | G | A | -0.0987 | |
| 165 | L | A | 0.5560 | |
| 166 | P | A | -0.1234 | |
| 167 | P | A | -0.3437 | |
| 168 | G | A | -0.4571 | |
| 169 | A | A | -0.0397 | |
| 170 | C | A | 0.6444 | |
| 171 | P | A | 0.7599 | |
| 172 | P | A | 1.2102 | |
| 173 | I | A | 2.3517 | |
| 174 | Q | A | 1.2739 | |
| 175 | L | A | 1.5864 | |
| 176 | V | A | 0.8954 | |
| 177 | N | A | -0.2849 | |
| 178 | S | A | 0.0229 | |
| 179 | V | A | 0.4275 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | 0.3814 | |
| 182 | D | A | 0.0807 | |
| 183 | G | A | -0.1585 | |
| 184 | D | A | -0.5403 | |
| 185 | M | A | 0.0000 | |
| 186 | C | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | 0.1384 | |
| 190 | F | A | 0.0611 | |
| 191 | G | A | -0.1034 | |
| 192 | N | A | -0.2626 | |
| 193 | M | A | -0.1041 | |
| 194 | N | A | 0.0000 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -3.4058 | |
| 197 | E | A | -2.6064 | |
| 198 | L | A | -1.2242 | |
| 199 | Q | A | -2.5604 | |
| 200 | Q | A | -3.3318 | |
| 201 | D | A | -3.5869 | |
| 202 | R | A | -3.3299 | |
| 203 | S | A | 0.0000 | |
| 204 | G | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | L | A | 0.2205 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | V | A | -1.3508 | |
| 211 | S | A | -1.8838 | |
| 212 | T | A | -1.4341 | |
| 213 | R | A | -2.0914 | |
| 214 | C | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | W | A | -0.1581 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | F | A | 0.3825 | |
| 220 | L | A | 0.6190 | |
| 221 | K | A | -1.0881 | |
| 222 | M | A | 0.0000 | |
| 223 | T | A | -0.8056 | |
| 224 | N | A | -1.4808 | |
| 225 | E | A | -1.2169 | |
| 226 | A | A | -0.5909 | |
| 227 | Y | A | -0.3514 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | K | A | -0.6679 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | F | A | 0.0794 | |
| 234 | F | A | 0.2662 | |
| 235 | G | A | -0.8120 | |
| 236 | R | A | -2.5970 | |
| 237 | R | A | -2.8580 | |
| 238 | E | A | -2.1231 | |
| 239 | Q | A | -0.1326 | |
| 240 | V | A | 1.4921 | |
| 241 | Y | A | 1.2598 | |
| 242 | A | A | 0.2035 | |
| 243 | R | A | -1.1367 | |
| 244 | H | A | -0.9722 | |
| 245 | F | A | 0.0558 | |
| 246 | F | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | R | A | -0.7739 | |
| 249 | N | A | -1.1628 | |
| 250 | G | A | -1.0131 | |
| 251 | P | A | -1.0939 | |
| 252 | E | A | -1.4332 | |
| 253 | G | A | -1.2981 | |
| 254 | H | A | -1.4876 | |
| 255 | P | A | -1.3220 | |
| 256 | L | A | -0.3941 | |
| 257 | P | A | -0.9201 | |
| 258 | D | A | -1.8987 | |
| 259 | A | A | -0.8362 | |
| 260 | P | A | -0.8823 | |
| 261 | P | A | -0.4464 | |
| 262 | P | A | -0.0916 | |
| 263 | S | A | 0.0788 | |
| 264 | P | A | 0.6760 | |
| 265 | L | A | 1.5394 | |
| 266 | Y | A | 1.2167 | |
| 267 | V | A | 1.3663 | |
| 268 | R | A | -0.3100 | |
| 269 | P | A | 0.2822 | |
| 270 | P | A | -0.1969 | |
| 271 | P | A | 0.0065 | |
| 272 | T | A | 0.1610 | |
| 273 | S | A | 0.4546 | |
| 274 | P | A | 0.6853 | |
| 275 | Y | A | 1.5478 | |
| 276 | W | A | 1.4994 | |
| 277 | V | A | 1.9702 | |
| 278 | R | A | 0.6060 | |
| 279 | P | A | -0.1655 | |
| 280 | P | A | 0.0000 | |
| 281 | T | A | -0.5848 | |
| 282 | D | A | -1.0848 | |
| 283 | Y | A | 0.7674 | |
| 284 | F | A | 0.6768 | |
| 285 | G | A | 0.2335 | |
| 286 | T | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | S | A | 0.0000 | |
| 289 | G | A | 0.0000 | |
| 290 | S | A | 0.9392 | |
| 291 | L | A | 1.6218 | |
| 292 | V | A | 0.6312 | |
| 293 | S | A | -0.1631 | |
| 294 | S | A | -0.9630 | |
| 295 | D | A | -1.8431 | |
| 296 | G | A | 0.0000 | |
| 297 | Q | A | 0.0000 | |
| 298 | L | A | -1.0977 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.6387 | |
| 301 | R | A | -1.8493 | |
| 302 | P | A | -0.9693 | |
| 303 | F | A | -0.1900 | |
| 304 | W | A | -0.5618 | |
| 305 | L | A | 0.0000 | |
| 306 | Q | A | -2.0864 | |
| 307 | R | A | -2.8327 | |
| 308 | A | A | 0.0000 | |
| 309 | Q | A | -1.2600 | |
| 310 | G | A | -1.2185 | |
| 311 | N | A | -1.2579 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | C | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.8347 | |
| 319 | N | A | -0.9444 | |
| 320 | E | A | -1.0423 | |
| 321 | L | A | 0.0000 | |
| 322 | F | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.3520 | |
| 331 | N | A | 0.0000 | |
| 332 | T | A | -0.1073 | |
| 333 | N | A | 0.5402 | |
| 334 | F | A | 1.7206 | |
| 335 | T | A | 0.7844 | |
| 336 | I | A | 0.4258 | |
| 337 | S | A | -0.8665 | |
| 338 | Q | A | -1.5068 | |
| 339 | Q | A | -0.9366 | |
| 340 | I | A | 0.7291 | |
| 341 | S | A | 0.4678 | |
| 342 | T | A | 0.0157 | |
| 343 | P | A | -0.3321 | |
| 344 | P | A | -0.1536 | |
| 345 | I | A | 0.5597 | |
| 346 | N | A | -0.0424 | |
| 347 | V | A | 1.7210 | |
| 348 | Y | A | 1.3927 | |
| 349 | N | A | -0.3336 | |
| 350 | P | A | -1.3561 | |
| 351 | E | A | -2.0175 | |
| 352 | N | A | -0.8494 | |
| 353 | F | A | -1.2106 | |
| 354 | K | A | -2.2581 | |
| 355 | N | A | -1.7754 | |
| 356 | Y | A | 0.0171 | |
| 357 | L | A | 0.7354 | |
| 358 | R | A | 0.9968 | |
| 359 | H | A | 0.0000 | |
| 360 | V | A | 1.3724 | |
| 361 | E | A | 0.0000 | |
| 362 | Q | A | -0.0741 | |
| 363 | F | A | 0.0000 | |
| 364 | E | A | -2.0203 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | -0.6828 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | A | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.3068 | |
| 374 | V | A | 0.0000 | |
| 375 | P | A | -1.3152 | |
| 376 | L | A | -1.7140 | |
| 377 | D | A | -1.9817 | |
| 378 | P | A | -1.0317 | |
| 379 | G | A | -1.0113 | |
| 380 | V | A | -0.9310 | |
| 381 | L | A | -0.5283 | |
| 382 | A | A | -0.6547 | |
| 383 | H | A | -0.8089 | |
| 384 | I | A | 0.0000 | |
| 385 | N | A | -1.4194 | |
| 386 | T | A | -0.5531 | |
| 387 | M | A | -0.2982 | |
| 388 | N | A | -0.8684 | |
| 389 | P | A | -1.2513 | |
| 390 | T | A | -1.4507 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | -1.4461 | |
| 393 | E | A | -2.7840 | |
| 394 | N | A | -2.3966 | |
| 395 | W | A | -1.3803 | |
| 396 | N | A | -1.1176 | |
| 397 | L | A | -0.1980 | |
| 398 | G | A | 0.5197 | |
| 399 | F | A | 2.4149 | |
| 400 | V | A | 1.8314 | |
| 401 | P | A | 0.0443 | |
| 402 | P | A | -1.8603 | |
| 403 | K | A | -3.3268 | |
| 404 | E | A | -3.7929 | |
| 405 | R | A | -3.9557 | |
| 406 | E | A | -3.8110 | |
| 407 | D | A | -2.8872 | |
| 408 | P | A | -1.7724 | |
| 409 | Y | A | -0.9871 | |
| 410 | K | A | -2.1192 | |
| 411 | G | A | -0.6376 | |
| 412 | L | A | 0.6776 | |
| 413 | I | A | 1.5897 | |
| 414 | F | A | 0.0000 | |
| 415 | W | A | -0.3880 | |
| 416 | E | A | -1.6777 | |
| 417 | V | A | 0.0000 | |
| 418 | D | A | -2.9472 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -2.0560 | |
| 421 | E | A | -2.7842 | |
| 422 | R | A | -2.6358 | |
| 423 | F | A | -1.2825 | |
| 424 | S | A | -1.4670 | |
| 425 | Q | A | -1.8436 | |
| 426 | D | A | -2.8921 | |
| 427 | L | A | -1.9800 | |
| 428 | D | A | -2.7661 | |
| 429 | Q | A | -2.6139 | |
| 430 | F | A | -1.4233 | |
| 431 | A | A | -0.9005 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -1.6007 | |
| 435 | K | A | -0.7083 | |
| 436 | F | A | 0.1373 | |
| 437 | L | A | 1.0224 | |
| 438 | Y | A | 0.8233 | |
| 439 | Q | A | -0.2756 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine