Project name: 2_i20e6_i14e7_x4e7_x11e6

Chain sequence(s)	A: AAYVYDFAFRDLAAYRFHNIAGHYAAYCYSLYGTTLAAYKTVLELTEVAAYRAHYNIVTFAAYTLQDIVLHLAAYLLMGTLGIVAAYLPARRAEPQAAYLLCHEQLSDSEEENDGPGPGQSTHVDIRTLEDLLMGPGPGTPTLHEYMLDLQPETGPGPGLQDIVLHLEPQNEIPGPGPGAEKLRHLNEKRRFHNGPGPGLDKKQRFHNIRGRWTGPGPGNPAEKLRHLNEKRRFGPGPGSKISEYRHYCYSLYGGPGPG
Selected Chain(s)	A
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with A chain(s) selected             (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:01)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:05:24)
[INFO]       Main:     Simulation completed successfully.                                          (00:05:26)

• Minimal score value: -4.6845
• Maximal score value: 3.7702
• Average score: -0.2299
• Total score value: -59.5542

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	A	A	1.1464
2	A	A	1.5893
3	Y	A	2.6510
4	V	A	3.5361
5	Y	A	2.8469
6	D	A	1.2388
7	F	A	2.2128
8	A	A	1.6719
9	F	A	1.7794
10	R	A	-0.9141
11	D	A	-0.8385
12	L	A	0.7704
13	A	A	0.0219
14	A	A	-0.1772
15	Y	A	0.3978
16	R	A	-0.8341
17	F	A	0.9905
18	H	A	-0.4661
19	N	A	-0.9631
20	I	A	0.7330
21	A	A	0.3597
22	G	A	-0.4056
23	H	A	0.0113
24	Y	A	1.5332
25	A	A	1.2326
26	A	A	1.4261
27	Y	A	2.3588
28	C	A	2.3139
29	Y	A	2.4922
30	S	A	1.8390
31	L	A	2.4687
32	Y	A	2.6527
33	G	A	1.5341
34	T	A	1.2871
35	T	A	1.4289
36	L	A	2.0265
37	A	A	1.0623
38	A	A	1.4332
39	Y	A	1.8766
40	K	A	0.4486
41	T	A	0.9659
42	V	A	2.0692
43	L	A	1.1815
44	E	A	-0.5171
45	L	A	1.3259
46	T	A	0.4121
47	E	A	-0.8552
48	V	A	0.1800
49	A	A	-0.0063
50	A	A	-0.0806
51	Y	A	0.3963
52	R	A	-0.7175
53	A	A	0.0500
54	H	A	0.6133
55	Y	A	1.7984
56	N	A	1.5391
57	I	A	3.0850
58	V	A	3.3692
59	T	A	2.9467
60	F	A	3.7702
61	A	A	2.8702
62	A	A	2.0137
63	Y	A	2.3353
64	T	A	1.8658
65	L	A	2.4485
66	Q	A	1.1121
67	D	A	0.5048
68	I	A	2.8101
69	V	A	3.2094
70	L	A	2.5405
71	H	A	1.7552
72	L	A	3.0882
73	A	A	2.7307
74	A	A	2.6358
75	Y	A	3.3342
76	L	A	3.3409
77	L	A	3.1591
78	M	A	3.2300
79	G	A	2.4006
80	T	A	2.6552
81	L	A	3.3249
82	G	A	2.3629
83	I	A	3.4597
84	V	A	3.3212
85	A	A	2.0873
86	A	A	1.8019
87	Y	A	1.8807
88	L	A	0.6452
89	P	A	-0.8160
90	A	A	-1.3329
91	R	A	-2.9257
92	R	A	-3.2562
93	A	A	-2.4282
94	E	A	-3.0604
95	P	A	-1.7715
96	Q	A	-1.0718
97	A	A	0.0727
98	A	A	0.7687
99	Y	A	1.4918
100	L	A	1.6178
101	L	A	1.6960
102	C	A	0.9076
103	H	A	-0.3651
104	E	A	-1.6324
105	Q	A	-1.5002
106	L	A	-0.5866
107	S	A	-2.2326
108	D	A	-3.5181
109	S	A	-2.8445
110	E	A	-3.7927
111	E	A	-4.6845
112	E	A	-4.5417
113	N	A	-3.9299
114	D	A	-3.4254
115	G	A	-2.0566
116	P	A	-1.1739
117	G	A	-1.1193
118	P	A	-1.0489
119	G	A	-1.3700
120	Q	A	-1.7293
121	S	A	-1.0259
122	T	A	-0.7419
123	H	A	-0.5818
124	V	A	0.7013
125	D	A	-0.5412
126	I	A	0.7517
127	R	A	-1.5826
128	T	A	-0.3683
129	L	A	0.7377
130	E	A	-0.9322
131	D	A	-1.1044
132	L	A	1.5303
133	L	A	1.8608
134	M	A	1.1469
135	G	A	0.2537
136	P	A	-0.4060
137	G	A	-0.7914
138	P	A	-0.8772
139	G	A	-0.8724
140	T	A	-0.3712
141	P	A	-0.2300
142	T	A	0.0109
143	L	A	0.7288
144	H	A	-0.7351
145	E	A	-0.8778
146	Y	A	1.0259
147	M	A	1.6567
148	L	A	1.5233
149	D	A	-0.1734
150	L	A	0.2507
151	Q	A	-1.3022
152	P	A	-1.6473
153	E	A	-2.2432
154	T	A	-1.5264
155	G	A	-1.2406
156	P	A	-1.0312
157	G	A	-0.7658
158	P	A	-0.6432
159	G	A	-0.4702
160	L	A	0.4170
161	Q	A	-0.8642
162	D	A	-0.4780
163	I	A	2.2993
164	V	A	2.9697
165	L	A	2.5147
166	H	A	0.5541
167	L	A	0.6288
168	E	A	-1.8355
169	P	A	-1.8913
170	Q	A	-2.5577
171	N	A	-2.5368
172	E	A	-1.8652
173	I	A	0.4138
174	P	A	-0.2076
175	G	A	-0.4712
176	P	A	-0.9246
177	G	A	-1.3650
178	P	A	-1.4570
179	G	A	-1.7434
180	A	A	-1.8895
181	E	A	-3.2684
182	K	A	-2.9104
183	L	A	-1.4380
184	R	A	-3.5047
185	H	A	-3.5206
186	L	A	-2.3236
187	N	A	-3.2578
188	E	A	-3.8138
189	K	A	-3.2352
190	R	A	-4.0822
191	R	A	-3.5880
192	F	A	-1.2962
193	H	A	-2.5639
194	N	A	-2.7804
195	G	A	-1.3175
196	P	A	-0.5810
197	G	A	-0.6977
198	P	A	-0.9910
199	G	A	-1.0383
200	L	A	-0.7607
201	D	A	-2.6235
202	K	A	-3.2330
203	K	A	-2.8890
204	Q	A	-3.2698
205	R	A	-3.3915
206	F	A	-1.8306
207	H	A	-3.0711
208	N	A	-2.7531
209	I	A	-1.3954
210	R	A	-2.3305
211	G	A	-2.1632
212	R	A	-2.1929
213	W	A	-0.7159
214	T	A	-0.7578
215	G	A	-1.2067
216	P	A	-1.0063
217	G	A	-1.2792
218	P	A	-1.0285
219	G	A	-1.7206
220	N	A	-2.1812
221	P	A	-1.7291
222	A	A	-1.3887
223	E	A	-2.4426
224	K	A	-2.3296
225	L	A	-0.8468
226	R	A	-3.0209
227	H	A	-2.8923
228	L	A	-1.4816
229	N	A	-2.7205
230	E	A	-3.6798
231	K	A	-3.2987
232	R	A	-3.7254
233	R	A	-3.0712
234	F	A	-0.7587
235	G	A	-1.3571
236	P	A	-1.1037
237	G	A	-1.2302
238	P	A	-0.8323
239	G	A	-0.9199
240	S	A	-1.2043
241	K	A	-1.6526
242	I	A	0.4742
243	S	A	-0.7671
244	E	A	-1.4779
245	Y	A	0.4834
246	R	A	-0.4064
247	H	A	-0.3564
248	Y	A	1.5972
249	C	A	1.4457
250	Y	A	1.7939
251	S	A	1.3838
252	L	A	2.4215
253	Y	A	2.1898
254	G	A	0.5298
255	G	A	-0.1602
256	P	A	-0.7890
257	G	A	-1.0179
258	P	A	-0.8283
259	G	A	-0.7447