Project name: 948e1bef9ed374f

Chain sequence(s)	P: GCGELVWVGEPLTLRTAETITGKYGVWMRDPKPTYPYTQETTWRIDTVGTDVRQVFEYDLISQFMQGYPSKVHILPRPLESTGAVVYSGSLYFQGAESRTVIRYELNTETVKAEKEIPGAGYHGQFPYSWGGYTDIDLAVDEAGLWVIYSTDEAKGAIVLSKLNPENLELEQTWETNIRKQSVANAFIICGTLYTVSSYTSADATVNFAYDTGTGISKTLTIPFKNRYKYSSMIDYNPLEKKLFAWDNLNMVTYDFKLS
Selected Chain(s)	P
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with P chain(s) selected             (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:01:39)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:40)

• Minimal score value: -3.3991
• Maximal score value: 1.8571
• Average score: -0.5612
• Total score value: -145.358

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
244	G	P	-0.2537
245	C	P	0.4532
246	G	P	0.0000
247	E	P	0.3725
248	L	P	0.0000
249	V	P	1.6552
250	W	P	0.4622
251	V	P	0.0000
252	G	P	0.0000
253	E	P	-2.2880
254	P	P	-0.8420
255	L	P	1.0145
256	T	P	0.5913
257	L	P	0.1213
258	R	P	-2.0604
259	T	P	-1.4893
260	A	P	-1.5690
261	E	P	-1.9288
262	T	P	-0.6976
263	I	P	0.1740
264	T	P	0.0132
265	G	P	0.0638
266	K	P	-0.1198
267	Y	P	0.0422
268	G	P	0.0428
269	V	P	0.2571
270	W	P	0.3383
271	M	P	-0.0476
272	R	P	-0.6585
273	D	P	-0.6888
274	P	P	-0.6956
275	K	P	-0.4746
276	P	P	-0.2907
277	T	P	0.4309
278	Y	P	1.4815
279	P	P	0.7996
280	Y	P	1.1993
281	T	P	0.0529
282	Q	P	-0.6089
283	E	P	-1.1273
284	T	P	0.0000
285	T	P	0.0000
286	W	P	0.0000
287	R	P	-1.5951
288	I	P	-1.2985
289	D	P	-1.8835
290	T	P	-0.5589
291	V	P	0.9346
292	G	P	-0.2592
293	T	P	-0.6763
294	D	P	-1.8330
295	V	P	-0.5070
296	R	P	-0.9815
297	Q	P	-0.6889
298	V	P	0.0000
299	F	P	-0.3343
300	E	P	0.0000
301	Y	P	-0.2244
302	D	P	-0.2297
303	L	P	0.5867
304	I	P	1.7583
305	S	P	0.7209
306	Q	P	0.1891
307	F	P	1.8571
308	M	P	1.1094
309	Q	P	0.2769
310	G	P	0.0965
311	Y	P	0.7502
312	P	P	0.0034
313	S	P	-0.4749
314	K	P	-0.6078
315	V	P	0.3989
316	H	P	0.0000
317	I	P	0.5537
318	L	P	0.0000
319	P	P	-0.6445
320	R	P	-1.4232
321	P	P	-1.5783
322	L	P	-0.8991
323	E	P	-0.7744
324	S	P	-0.5198
325	T	P	-0.1425
326	G	P	-0.0569
327	A	P	0.0000
328	V	P	0.0000
329	V	P	0.0000
330	Y	P	0.1718
331	S	P	-0.4844
332	G	P	0.0000
333	S	P	0.0000
334	L	P	0.0000
335	Y	P	0.0000
336	F	P	0.0000
337	Q	P	0.0000
338	G	P	0.0000
339	A	P	-1.4500
340	E	P	-2.0835
341	S	P	-1.5628
342	R	P	-1.6538
343	T	P	-1.9097
344	V	P	0.0000
345	I	P	0.0000
346	R	P	-1.6250
347	Y	P	0.0000
348	E	P	-1.5744
349	L	P	0.0000
350	N	P	-1.9548
351	T	P	-1.7159
352	E	P	-2.1341
353	T	P	-1.2746
354	V	P	-1.2390
355	K	P	-2.7146
356	A	P	-2.7212
357	E	P	-3.1915
358	K	P	-2.9355
359	E	P	-2.9254
360	I	P	0.0000
361	P	P	-0.9791
362	G	P	-0.9476
363	A	P	-0.9250
364	G	P	0.0000
365	Y	P	0.0000
366	H	P	0.0000
367	G	P	-1.2402
368	Q	P	-0.5102
369	F	P	0.5606
370	P	P	0.2821
371	Y	P	0.7348
372	S	P	0.4658
373	W	P	1.2315
374	G	P	0.5627
375	G	P	0.3162
376	Y	P	1.2971
377	T	P	0.2846
378	D	P	-0.3220
379	I	P	0.0000
380	D	P	0.0000
381	L	P	0.0000
382	A	P	0.0000
383	V	P	-0.5466
384	D	P	-1.6755
385	E	P	-2.2252
386	A	P	-1.3442
387	G	P	-1.4489
388	L	P	0.0000
389	W	P	0.0000
390	V	P	0.0000
391	I	P	0.0000
392	Y	P	-0.4399
393	S	P	0.0000
394	T	P	-1.7367
395	D	P	-2.6470
396	E	P	-2.5860
397	A	P	-2.2592
398	K	P	-2.9616
399	G	P	-2.6261
400	A	P	-2.5117
401	I	P	0.0000
402	V	P	0.0000
403	L	P	0.0000
404	S	P	0.0000
405	K	P	0.0000
406	L	P	0.0000
407	N	P	-2.1534
408	P	P	-1.7259
409	E	P	-2.9948
410	N	P	-3.3637
411	L	P	0.0000
412	E	P	-3.3991
413	L	P	-1.9528
414	E	P	-2.7150
415	Q	P	-2.0740
416	T	P	-1.1271
417	W	P	-0.9739
418	E	P	-1.8657
419	T	P	0.0000
420	N	P	-2.0610
421	I	P	0.0000
422	R	P	-2.8829
423	K	P	0.0000
424	Q	P	-2.5673
425	S	P	-1.1706
426	V	P	0.0000
427	A	P	0.0000
428	N	P	0.0000
429	A	P	0.0000
430	F	P	0.0000
431	I	P	0.0000
432	I	P	0.0000
433	C	P	0.3839
434	G	P	0.0548
435	T	P	0.0000
436	L	P	0.0000
437	Y	P	0.0000
438	T	P	0.0000
439	V	P	0.0000
440	S	P	-0.1442
441	S	P	-0.1243
442	Y	P	0.5787
443	T	P	0.1248
444	S	P	-0.1475
445	A	P	-0.2901
446	D	P	0.0000
447	A	P	0.0000
448	T	P	-0.3163
449	V	P	0.0000
450	N	P	-0.4843
451	F	P	0.6145
452	A	P	0.0000
453	Y	P	0.0000
454	D	P	0.0000
455	T	P	0.1785
456	G	P	-0.1961
457	T	P	0.0989
458	G	P	0.1321
459	I	P	0.8238
460	S	P	0.4281
461	K	P	-0.2762
462	T	P	-0.1764
463	L	P	-0.0449
464	T	P	-0.1657
465	I	P	0.0000
466	P	P	-0.3387
467	F	P	-1.5850
468	K	P	-2.9668
469	N	P	-3.2924
470	R	P	-3.0184
471	Y	P	-1.8139
472	K	P	-1.8417
473	Y	P	-0.4032
474	S	P	-0.8019
475	S	P	-1.0156
476	M	P	0.0000
477	I	P	0.0000
478	D	P	0.0000
479	Y	P	0.0000
480	N	P	-1.0168
481	P	P	-0.8015
482	L	P	-0.6702
483	E	P	-1.9328
484	K	P	-2.1624
485	K	P	-1.9964
486	L	P	0.0000
487	F	P	0.0000
488	A	P	0.0000
489	W	P	-0.8281
490	D	P	-2.4690
491	N	P	-2.4098
492	L	P	-1.5399
493	N	P	-1.8498
494	M	P	0.0000
495	V	P	0.2436
496	T	P	0.0261
497	Y	P	-0.9541
498	D	P	-2.4132
499	F	P	-1.2399
500	K	P	-0.8740
501	L	P	0.5373
502	S	P	0.4521