Project name: 973f65587e8053c

Chain sequence(s)	H: QVQLQESGGGLVQPGGSLRLSCAASGFTFSSYSMSWVRQAPGKGLEWVAVISYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDRYFDLWGRGTLVTVSS; L: QSALTQPASVSGSPGQSITISCTGTSSDIGAYNYVSWYQQYPGKAPKLLIYDVSNRPSGISNRFSGSKSGDTASLTISGLQAEDEADYYCSSFANSGPLFGGGTKVTVL
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:00:38)
[INFO]       Main:     Simulation completed successfully.                                          (00:00:39)

• Minimal score value: -2.639
• Maximal score value: 1.6252
• Average score: -0.572
• Total score value: -128.1281

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	Q	H	-1.0001
2	V	H	0.0177
3	Q	H	-0.6274
4	L	H	0.0000
5	Q	H	-1.3657
6	E	H	-0.9490
7	S	H	-0.8883
8	G	H	-0.7333
9	G	H	0.1312
11	G	H	0.8037
12	L	H	1.4139
13	V	H	-0.0082
14	Q	H	-1.3140
15	P	H	-1.5803
16	G	H	-1.3994
17	G	H	-0.9718
18	S	H	-1.2246
19	L	H	-0.7464
20	R	H	-1.7625
21	L	H	0.0000
22	S	H	-0.7246
23	C	H	0.0000
24	A	H	-0.8494
25	A	H	0.0000
26	S	H	-0.7867
27	G	H	-0.5335
28	F	H	-0.1154
29	T	H	-0.1605
30	F	H	0.0000
35	S	H	-0.4860
36	S	H	0.0728
37	Y	H	0.2700
38	S	H	-0.0745
39	M	H	0.0000
40	S	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	R	H	0.0000
44	Q	H	-0.6563
45	A	H	-1.0429
46	P	H	-0.8284
47	G	H	-1.4535
48	K	H	-2.3004
49	G	H	-1.5411
50	L	H	0.0000
51	E	H	-1.1971
52	W	H	0.0000
53	V	H	0.0000
54	A	H	0.0000
55	V	H	0.2590
56	I	H	0.0000
57	S	H	-0.2539
58	Y	H	0.5163
59	D	H	-0.8528
62	G	H	-0.8995
63	S	H	-0.9658
64	N	H	-1.0567
65	K	H	-0.4988
66	Y	H	0.4887
67	Y	H	-0.3498
68	A	H	0.0000
69	D	H	-2.5507
70	S	H	-1.9844
71	V	H	0.0000
72	K	H	-2.3926
74	G	H	-1.7704
75	R	H	-1.6163
76	F	H	0.0000
77	T	H	-0.7361
78	I	H	0.0000
79	S	H	-0.5040
80	R	H	-0.8750
81	D	H	-1.5766
82	N	H	-1.6274
83	S	H	-1.5771
84	K	H	-2.4257
85	N	H	-1.8866
86	T	H	-1.2897
87	L	H	0.0000
88	Y	H	-0.4609
89	L	H	0.0000
90	Q	H	-1.1115
91	M	H	0.0000
92	N	H	-1.5534
93	S	H	-1.3035
94	L	H	0.0000
95	R	H	-2.3023
96	A	H	-1.7000
97	E	H	-2.2400
98	D	H	0.0000
99	T	H	-0.3439
100	A	H	0.0000
101	V	H	0.5963
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	A	H	0.0000
106	R	H	-0.4559
107	D	H	-0.6994
108	R	H	-1.1129
114	Y	H	-0.3895
115	F	H	0.0000
116	D	H	-0.8298
117	L	H	-0.1395
118	W	H	0.0000
119	G	H	0.0000
120	R	H	-2.6390
121	G	H	-1.1128
122	T	H	0.0354
123	L	H	1.6252
124	V	H	0.0000
125	T	H	0.3820
126	V	H	0.0000
127	S	H	-0.6774
128	S	H	-0.6800
1	Q	L	-1.6463
2	S	L	-0.8098
3	A	L	-0.6048
4	L	L	0.0000
5	T	L	-0.3514
6	Q	L	-0.4752
7	P	L	-0.3801
8	A	L	-0.4469
9	S	L	-0.5505
11	V	L	-0.1300
12	S	L	-0.0203
13	G	L	0.0000
14	S	L	-0.1962
15	P	L	-0.8577
16	G	L	-1.4957
17	Q	L	-1.7780
18	S	L	-1.1066
19	I	L	-0.2803
20	T	L	-0.0491
21	I	L	0.0000
22	S	L	-0.2868
23	C	L	0.0000
24	T	L	-0.6159
25	G	L	-0.6310
26	T	L	-0.7040
27	S	L	-0.7819
28	S	L	-0.5821
29	D	L	0.0000
30	I	L	0.0000
31	G	L	-1.1561
35	A	L	-0.4272
36	Y	L	-0.2632
37	N	L	-0.7600
38	Y	L	0.4599
39	V	L	0.0000
40	S	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	Q	L	0.0000
44	Q	L	0.0000
45	Y	L	-0.9961
46	P	L	-1.0170
47	G	L	-1.5849
48	K	L	-2.4348
49	A	L	-1.6079
50	P	L	0.0000
51	K	L	-0.6661
52	L	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	Y	L	-0.5800
56	D	L	-0.7958
57	V	L	-0.7898
65	S	L	-1.2194
66	N	L	-1.8856
67	R	L	-1.8327
68	P	L	-1.0858
69	S	L	-0.8557
70	G	L	-0.7419
71	I	L	-0.6605
72	S	L	-0.9453
74	N	L	-1.6545
75	R	L	-1.1335
76	F	L	0.0000
77	S	L	-0.9379
78	G	L	0.0000
79	S	L	-0.8497
80	K	L	-1.1727
83	S	L	-0.9515
84	G	L	-1.2528
85	D	L	-1.5482
86	T	L	-0.9993
87	A	L	0.0000
88	S	L	-0.3382
89	L	L	0.0000
90	T	L	-0.2102
91	I	L	0.0000
92	S	L	-1.1105
93	G	L	-1.2465
94	L	L	0.0000
95	Q	L	-1.6162
96	A	L	-0.9321
97	E	L	-1.4584
98	D	L	0.0000
99	E	L	-1.2092
100	A	L	0.0000
101	D	L	-1.0740
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	S	L	0.0000
106	S	L	0.0000
107	F	L	0.5661
108	A	L	-0.2233
109	N	L	-1.1545
114	S	L	-0.8650
115	G	L	0.0000
116	P	L	0.0449
117	L	L	-0.2148
118	F	L	0.0000
119	G	L	0.0000
120	G	L	-1.0400
121	G	L	-1.0651
122	T	L	0.0000
123	K	L	-1.2154
124	V	L	0.0000
125	T	L	-0.0208
126	V	L	0.1429
127	L	L	1.3895