Project name: PDGFB

Chain sequence(s)	A: EGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA
Selected Chain(s)	A
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with A chain(s) selected             (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:02:28)
[INFO]       Main:     Simulation completed successfully.                                          (00:02:30)

• Minimal score value: -3.8854
• Maximal score value: 2.2753
• Average score: -1.2265
• Total score value: -271.0649

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	A	-1.9177
2	G	A	-1.3783
3	D	A	-1.5535
4	P	A	-0.9035
5	I	A	-0.6471
6	P	A	-1.7154
7	E	A	-2.7183
8	E	A	-2.8589
9	L	A	-1.1699
10	Y	A	-1.0865
11	E	A	-2.8242
12	M	A	-1.5944
13	L	A	-0.7460
14	S	A	-1.5894
15	D	A	-2.3699
16	H	A	-1.8221
17	S	A	-1.2736
18	I	A	-1.4019
19	R	A	-2.1879
20	S	A	-1.5539
21	F	A	-1.4956
22	D	A	-2.6149
23	D	A	-2.2389
24	L	A	0.0000
25	Q	A	-2.1979
26	R	A	-3.4350
27	L	A	-1.6719
28	L	A	-1.5768
29	H	A	-2.5047
30	G	A	-2.2581
31	D	A	-3.3069
32	P	A	-2.6046
33	G	A	-3.1905
34	E	A	-3.8312
35	E	A	-3.8854
36	D	A	-3.7640
37	G	A	-2.5588
38	A	A	-1.6597
39	E	A	-1.7617
40	L	A	0.0215
41	D	A	-1.0778
42	L	A	0.5663
43	N	A	-0.6518
44	M	A	0.0460
45	T	A	-0.8307
46	R	A	-2.1667
47	S	A	-1.5855
48	H	A	-1.9064
49	S	A	-1.3079
50	G	A	-1.3590
51	G	A	-1.3786
52	E	A	-1.7673
53	L	A	-0.4732
54	E	A	-1.1854
55	S	A	-0.2696
56	L	A	0.4831
57	A	A	-0.7537
58	R	A	-2.4153
59	G	A	-2.5849
60	R	A	-3.2900
61	R	A	-2.8740
62	S	A	-1.1939
63	L	A	0.5690
64	G	A	0.3174
65	S	A	0.8317
66	L	A	2.0890
67	T	A	1.2898
68	I	A	1.9144
69	A	A	0.2969
70	E	A	-1.2227
71	P	A	-0.3867
72	A	A	0.4569
73	M	A	1.6489
74	I	A	2.2753
75	A	A	0.8840
76	E	A	-0.4595
77	C	A	-1.3429
78	K	A	-1.7759
79	T	A	-1.2833
80	R	A	-1.1883
81	T	A	-0.9923
82	E	A	-0.8632
83	V	A	0.4888
84	F	A	-0.3146
85	E	A	-1.3790
86	I	A	0.0000
87	S	A	-1.5212
88	R	A	-2.3036
89	R	A	-2.5790
90	L	A	-0.5756
91	I	A	-0.7617
92	D	A	-1.7910
93	R	A	-2.7188
94	T	A	-1.7491
95	N	A	-1.6630
96	A	A	-1.2972
97	N	A	-0.7471
98	F	A	0.0000
99	L	A	-0.0961
100	V	A	0.0000
101	W	A	-0.5414
102	P	A	-0.6384
103	P	A	-0.6432
104	C	A	-0.2159
105	V	A	-0.3752
106	E	A	-1.5272
107	V	A	0.0000
108	Q	A	-1.1343
109	R	A	-1.0870
110	C	A	0.0000
111	S	A	-1.3355
112	G	A	-0.3947
113	C	A	-0.0592
114	C	A	-1.3103
115	N	A	-1.8346
116	N	A	-2.4739
117	R	A	-2.7174
118	N	A	-1.9172
119	V	A	-1.8377
120	Q	A	-2.2165
121	C	A	0.0000
122	R	A	-2.6738
123	P	A	-1.4821
124	T	A	-1.0234
125	Q	A	-0.8230
126	V	A	-0.0018
127	Q	A	-0.4499
128	L	A	0.1015
129	R	A	-0.6565
130	P	A	-0.6578
131	V	A	-0.5182
132	Q	A	-1.7492
133	V	A	0.0000
134	R	A	-1.8592
135	K	A	-1.4123
136	I	A	0.0000
137	E	A	0.0000
138	I	A	0.0000
139	V	A	-1.6642
140	R	A	-2.9085
141	K	A	-3.1972
142	K	A	-2.8625
143	P	A	-1.2580
144	I	A	-0.2571
145	F	A	-0.6339
146	K	A	-1.8182
147	K	A	-2.7470
148	A	A	-1.4903
149	T	A	-0.9096
150	V	A	0.0000
151	T	A	-0.3453
152	L	A	0.0000
153	E	A	-0.6303
154	D	A	0.0000
155	H	A	0.0000
156	L	A	0.7024
157	A	A	-0.4577
158	C	A	-1.6231
159	K	A	-2.8142
160	C	A	-2.0267
161	E	A	-1.7308
162	T	A	-0.8567
163	V	A	0.3742
164	A	A	0.2108
165	A	A	-0.1935
166	A	A	-0.3726
167	R	A	-1.4114
168	P	A	-0.5443
169	V	A	0.5079
170	T	A	-0.5701
171	R	A	-1.6234
172	S	A	-1.1877
173	P	A	-1.1969
174	G	A	-1.3274
175	G	A	-1.3240
176	S	A	-1.7446
177	Q	A	-2.6370
178	E	A	-3.4735
179	Q	A	-3.3073
180	R	A	-3.2205
181	A	A	-1.9553
182	K	A	-2.3641
183	T	A	-1.5214
184	P	A	-1.5529
185	Q	A	-1.8855
186	T	A	-1.1685
187	R	A	-1.1518
188	V	A	0.9890
189	T	A	0.6968
190	I	A	1.5182
191	R	A	-0.4575
192	T	A	0.1595
193	V	A	0.8371
194	R	A	-1.1289
195	V	A	-0.0453
196	R	A	-2.2665
197	R	A	-2.9362
198	P	A	-1.9828
199	P	A	-2.2128
200	K	A	-2.9157
201	G	A	-2.7241
202	K	A	-3.5696
203	H	A	-3.2538
204	R	A	-3.3569
205	K	A	-2.7050
206	F	A	-0.6260
207	K	A	-2.0753
208	H	A	-2.0583
209	T	A	-1.9948
210	H	A	-2.8743
211	D	A	-3.0673
212	K	A	-2.7405
213	T	A	-1.7067
214	A	A	-1.0758
215	L	A	-0.1457
216	K	A	-1.7853
217	E	A	-1.9137
218	T	A	-0.4346
219	L	A	0.6235
220	G	A	-0.3916
221	A	A	-0.0355