Project name: 9788fc6caab2b95

Chain sequence(s)	H: EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYTMSWVRQAPGKGLEWVATISGGGFGTYYPDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARPGYNNYYFDIWGQGTTVTVSS; L: EIVLTQSPATLSLSPGERATLSCHASDSISNSLHWYQQKPGQAPRLLIYYARQSIQGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQSESWPLHFGGGTKVEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:01:32)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:34)

• Minimal score value: -2.6185
• Maximal score value: 1.6677
• Average score: -0.5763
• Total score value: -130.2447

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-1.9070
2	V	H	-0.7485
3	Q	H	-0.9462
4	L	H	0.0000
5	V	H	0.8738
6	E	H	0.0000
7	S	H	-0.3829
8	G	H	-0.7722
9	G	H	-0.2622
11	G	H	0.4099
12	L	H	1.1901
13	V	H	-0.0031
14	Q	H	-1.3061
15	P	H	-1.6381
16	G	H	-1.4943
17	G	H	-1.2344
18	S	H	-1.2019
19	L	H	-0.6434
20	R	H	-1.2598
21	L	H	0.0000
22	S	H	-0.2382
23	C	H	0.0000
24	A	H	-0.1788
25	A	H	0.0000
26	S	H	-0.7591
27	G	H	-1.0308
28	F	H	-0.4099
29	T	H	-0.2272
30	F	H	0.0000
35	S	H	-0.8332
36	S	H	-0.3212
37	Y	H	-0.0373
38	T	H	-0.1996
39	M	H	0.0000
40	S	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	R	H	0.0000
44	Q	H	-0.8142
45	A	H	-1.2158
46	P	H	-0.9847
47	G	H	-1.4597
48	K	H	-2.2813
49	G	H	-1.4094
50	L	H	0.0000
51	E	H	-1.0067
52	W	H	0.0000
53	V	H	0.0000
54	A	H	0.0000
55	T	H	0.0000
56	I	H	0.0000
57	S	H	0.0913
58	G	H	-0.3171
59	G	H	-0.1560
62	G	H	0.3697
63	F	H	1.6677
64	G	H	0.8326
65	T	H	0.6595
66	Y	H	0.2680
67	Y	H	-0.4944
68	P	H	-1.4021
69	D	H	-2.3865
70	S	H	-1.6678
71	V	H	0.0000
72	K	H	-2.3132
74	G	H	-1.7044
75	R	H	-1.5523
76	F	H	0.0000
77	T	H	-0.7142
78	I	H	0.0000
79	S	H	-0.1021
80	R	H	-0.7516
81	D	H	-1.4602
82	N	H	-1.6463
83	A	H	-1.3360
84	K	H	-2.2776
85	N	H	-1.7610
86	S	H	-1.0312
87	L	H	0.0000
88	Y	H	-0.3358
89	L	H	0.0000
90	Q	H	-0.9304
91	M	H	0.0000
92	N	H	-1.6908
93	S	H	-1.4390
94	L	H	0.0000
95	R	H	-2.2000
96	A	H	-1.6351
97	E	H	-2.1903
98	D	H	0.0000
99	T	H	-0.5942
100	A	H	0.0000
101	V	H	0.1636
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	A	H	0.0000
106	R	H	0.0000
107	P	H	0.0000
108	G	H	0.0000
109	Y	H	0.6258
110	N	H	-0.6802
112	N	H	-0.4856
113	Y	H	-0.1455
114	Y	H	0.0000
115	F	H	0.0000
116	D	H	-0.1887
117	I	H	-0.0454
118	W	H	-0.2940
119	G	H	0.0000
120	Q	H	-1.1915
121	G	H	-0.4886
122	T	H	-0.1913
123	T	H	0.1037
124	V	H	0.0000
125	T	H	-0.0005
126	V	H	0.0000
127	S	H	-0.6965
128	S	H	-0.5571
1	E	L	-1.4778
2	I	L	-0.5601
3	V	L	0.8496
4	L	L	0.0000
5	T	L	-0.2483
6	Q	L	-0.5331
7	S	L	-0.5267
8	P	L	-0.4098
9	A	L	-0.3708
10	T	L	-0.4393
11	L	L	-0.0991
12	S	L	-0.1884
13	L	L	-0.5475
14	S	L	-0.9026
15	P	L	-1.3328
16	G	L	-1.7169
17	E	L	-2.4631
18	R	L	-2.6185
19	A	L	0.0000
20	T	L	-0.6785
21	L	L	0.0000
22	S	L	-0.7040
23	C	L	0.0000
24	H	L	-1.4511
25	A	L	0.0000
26	S	L	-1.0540
27	D	L	-2.1565
28	S	L	-1.8502
29	I	L	0.0000
36	S	L	-1.3354
37	N	L	-1.5984
38	S	L	0.0000
39	L	L	0.0000
40	H	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	Q	L	0.0000
44	Q	L	0.0000
45	K	L	-1.2364
46	P	L	-0.8818
47	G	L	-1.3290
48	Q	L	-1.8858
49	A	L	-1.2567
50	P	L	0.0000
51	R	L	-1.3978
52	L	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	Y	L	-0.3771
56	Y	L	-0.8181
57	A	L	0.0000
65	R	L	-2.2986
66	Q	L	-1.6064
67	S	L	-0.9925
68	I	L	-0.6685
69	Q	L	-1.2880
70	G	L	-0.8847
71	I	L	-0.5364
72	P	L	-0.3200
74	A	L	-0.3050
75	R	L	-0.6661
76	F	L	0.0000
77	S	L	-0.8036
78	G	L	-1.0843
79	S	L	-1.4086
80	G	L	-1.4174
83	S	L	-1.3964
84	G	L	-1.4459
85	T	L	-1.9358
86	D	L	-2.5143
87	F	L	0.0000
88	T	L	-0.9185
89	L	L	0.0000
90	T	L	-0.6327
91	I	L	0.0000
92	S	L	-1.3192
93	S	L	-1.6190
94	L	L	0.0000
95	E	L	-1.9293
96	P	L	-1.1708
97	E	L	-1.9079
98	D	L	0.0000
99	F	L	-0.2432
100	A	L	0.0000
101	V	L	-0.1447
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	Q	L	0.0000
106	Q	L	0.0000
107	S	L	0.0000
108	E	L	-1.8357
109	S	L	-0.9862
114	W	L	-0.2033
115	P	L	-0.6605
116	L	L	0.0000
117	H	L	-0.1736
118	F	L	0.0000
119	G	L	0.0000
120	G	L	-0.8109
121	G	L	-0.7273
122	T	L	0.0000
123	K	L	-0.8107
124	V	L	0.0000
125	E	L	0.0140
126	I	L	0.9125
127	K	L	-0.9032