Project name: 1-10C1

Chain sequence(s)	H: QVQLQQPGTELVKPGDSVKMSCKASGYTLTSYNLHWVKQTPGQGLEWIGAFYPGNGATSNNQKFKGKATLTADKSSSIAYMQLSSLTSEDSAVYYCARDGYYPWFAHWGQGTLVTVSA; L: DIVMTQSHKFMSTSLGDRVTITCKASQDVGDAIAWYQQKPGQSPKLLIYWASTRHTGVPDRFTGSGSGTDFTLTISNVQSEDLADYFCQQYTRYPYTFGGGTKLEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:01)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:02:08)
[INFO]       Main:     Simulation completed successfully.                                          (00:02:10)

• Minimal score value: -2.9156
• Maximal score value: 1.8375
• Average score: -0.5599
• Total score value: -125.9677

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	Q	H	-1.4789
2	V	H	-0.9738
3	Q	H	-1.8261
4	L	H	0.0000
5	Q	H	-1.9749
6	Q	H	0.0000
7	P	H	-0.8133
8	G	H	-0.7242
9	T	H	0.1211
11	E	H	0.0438
12	L	H	1.1790
13	V	H	-0.1310
14	K	H	-1.2820
15	P	H	-1.3642
16	G	H	-1.4261
17	D	H	-1.6117
18	S	H	-1.3679
19	V	H	0.0000
20	K	H	-1.6120
21	M	H	0.0000
22	S	H	-0.6321
23	C	H	0.0000
24	K	H	-1.3555
25	A	H	0.0000
26	S	H	-1.0913
27	G	H	-0.9678
28	Y	H	-0.3733
29	T	H	-0.2759
30	L	H	0.0000
35	T	H	-0.6607
36	S	H	0.0129
37	Y	H	0.6243
38	N	H	0.3183
39	L	H	0.0000
40	H	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	K	H	0.0000
44	Q	H	-0.4355
45	T	H	-0.7940
46	P	H	-0.7873
47	G	H	-1.2385
48	Q	H	-1.6931
49	G	H	-1.0839
50	L	H	0.0000
51	E	H	-0.9149
52	W	H	0.0000
53	I	H	0.0000
54	G	H	0.0000
55	A	H	0.0000
56	F	H	0.0000
57	Y	H	0.0725
58	P	H	0.0000
59	G	H	-0.8992
62	N	H	-1.4388
63	G	H	-0.8868
64	A	H	-0.3262
65	T	H	-0.2409
66	S	H	-0.3228
67	N	H	-1.2221
68	N	H	0.0000
69	Q	H	-2.2901
70	K	H	-2.3373
71	F	H	0.0000
72	K	H	-2.7958
74	G	H	-1.8602
75	K	H	-1.5864
76	A	H	0.0000
77	T	H	-0.8831
78	L	H	0.0000
79	T	H	-0.1667
80	A	H	-0.5612
81	D	H	-1.2974
82	K	H	-1.7644
83	S	H	-0.9921
84	S	H	-0.7925
85	S	H	-0.8693
86	I	H	-0.7264
87	A	H	0.0000
88	Y	H	-0.2633
89	M	H	0.0000
90	Q	H	-1.1509
91	L	H	0.0000
92	S	H	-1.0199
93	S	H	-1.0539
94	L	H	0.0000
95	T	H	-1.0456
96	S	H	-0.9890
97	E	H	-1.1446
98	D	H	0.0000
99	S	H	-0.1323
100	A	H	0.0000
101	V	H	0.4497
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	A	H	0.0000
106	R	H	-0.0153
107	D	H	0.0000
108	G	H	0.0000
109	Y	H	1.8375
110	Y	H	1.7079
113	P	H	0.8113
114	W	H	0.6170
115	F	H	0.0000
116	A	H	-0.3193
117	H	H	-0.8940
118	W	H	-0.8189
119	G	H	0.0000
120	Q	H	-1.6363
121	G	H	0.0000
122	T	H	0.0000
123	L	H	0.8237
124	V	H	0.0000
125	T	H	0.2969
126	V	H	0.0000
127	S	H	-0.2723
128	A	H	-0.2020
1	D	L	-1.3585
2	I	L	0.0000
3	V	L	0.8976
4	M	L	0.0000
5	T	L	-0.6022
6	Q	L	-0.8327
7	S	L	-1.0278
8	H	L	-1.1608
9	K	L	-1.3686
10	F	L	0.3935
11	M	L	0.0718
12	S	L	-0.3786
13	T	L	0.0000
14	S	L	-1.1232
15	L	L	-0.4337
16	G	L	-1.3413
17	D	L	-1.9668
18	R	L	-2.4824
19	V	L	0.0000
20	T	L	-0.5144
21	I	L	0.0000
22	T	L	-0.9284
23	C	L	0.0000
24	K	L	-2.1296
25	A	L	0.0000
26	S	L	-0.9431
27	Q	L	-1.6637
28	D	L	-2.2911
29	V	L	0.0000
36	G	L	-1.4739
37	D	L	-1.5609
38	A	L	0.0000
39	I	L	0.0000
40	A	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	Q	L	0.0000
44	Q	L	-0.9605
45	K	L	-1.2282
46	P	L	-0.8869
47	G	L	-1.3806
48	Q	L	-2.0017
49	S	L	-1.3532
50	P	L	0.0000
51	K	L	-1.3099
52	L	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	Y	L	0.0362
56	W	L	-0.1009
57	A	L	0.0000
65	S	L	-0.5001
66	T	L	-0.4204
67	R	L	-1.1322
68	H	L	-0.6985
69	T	L	-0.5527
70	G	L	-0.8930
71	V	L	0.0000
72	P	L	-1.3525
74	D	L	-2.3259
75	R	L	-1.8967
76	F	L	0.0000
77	T	L	-0.7835
78	G	L	0.0000
79	S	L	-0.7483
80	G	L	-1.3877
83	S	L	-1.5321
84	G	L	-1.9027
85	T	L	-2.2868
86	D	L	-2.9156
87	F	L	0.0000
88	T	L	-0.7813
89	L	L	0.0000
90	T	L	-0.6761
91	I	L	0.0000
92	S	L	-2.0937
93	N	L	-2.4072
94	V	L	0.0000
95	Q	L	-1.2861
96	S	L	-1.1308
97	E	L	-1.7089
98	D	L	0.0000
99	L	L	-0.0749
100	A	L	0.0000
101	D	L	0.0000
102	Y	L	0.0000
103	F	L	0.0000
104	C	L	0.0000
105	Q	L	0.0000
106	Q	L	0.0000
107	Y	L	0.0000
108	T	L	-0.4360
109	R	L	-0.5992
114	Y	L	0.3103
115	P	L	-0.3892
116	Y	L	0.0000
117	T	L	0.0079
118	F	L	0.0000
119	G	L	0.0000
120	G	L	-0.9669
121	G	L	0.0000
122	T	L	0.0000
123	K	L	-0.6958
124	L	L	0.0000
125	E	L	-0.6788
126	I	L	-0.8457
127	K	L	-1.5908