Project name: 5SX4

Chain sequence(s)	H: QVQLQESGPGLVKPSETLSLTCTVSGGSVSSGDYYWTWIRQSPGKGLEWIGHIYYSGNTNYNPSLKSRLTISIDTSKTQFSLKLSSVTAADTAIYYCVRDRVTGAFDIWGQGTMVTVSS; L: DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTDFTFTISSLQPEDIATYFCQHFDHLPLAFGGGTKVEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:01:16)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:17)

• Minimal score value: -2.5941
• Maximal score value: 0.8966
• Average score: -0.5743
• Total score value: -129.7847

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	Q	H	-1.7571
2	V	H	0.0000
3	Q	H	-2.0990
4	L	H	0.0000
5	Q	H	-1.8951
6	E	H	0.0000
7	S	H	-0.8798
8	G	H	-0.5374
9	P	H	-0.1810
11	G	H	0.1831
12	L	H	0.5522
13	V	H	0.0000
14	K	H	-1.4874
15	P	H	-1.1384
16	S	H	-1.1647
17	E	H	-1.5519
18	T	H	-1.2331
19	L	H	0.0000
20	S	H	-0.9671
21	L	H	0.0000
22	T	H	-0.6821
23	C	H	0.0000
24	T	H	-1.1614
25	V	H	0.0000
26	S	H	-1.5319
27	G	H	-1.4810
28	G	H	-1.1982
29	S	H	-0.8924
30	V	H	0.0000
31	S	H	-0.3894
34	S	H	-0.6146
35	G	H	-0.7286
36	D	H	-1.3746
37	Y	H	-0.2263
38	Y	H	0.1922
39	W	H	0.0000
40	T	H	0.0000
41	W	H	0.0000
42	I	H	0.0000
43	R	H	0.0000
44	Q	H	-0.3320
45	S	H	-0.5876
46	P	H	-0.9067
47	G	H	-1.1675
48	K	H	-1.5837
49	G	H	-1.1736
50	L	H	0.0000
51	E	H	-0.6103
52	W	H	0.0000
53	I	H	0.0000
54	G	H	0.0000
55	H	H	0.0000
56	I	H	0.0000
57	Y	H	-0.0413
58	Y	H	0.0832
59	S	H	-0.3725
63	G	H	-0.8422
64	N	H	-1.3095
65	T	H	-0.5947
66	N	H	-0.3225
67	Y	H	-0.2815
68	N	H	-0.6275
69	P	H	-0.8899
70	S	H	-0.8290
71	L	H	0.0000
72	K	H	-1.9803
74	S	H	-1.2761
75	R	H	-1.3189
76	L	H	0.0000
77	T	H	-0.9897
78	I	H	0.0000
79	S	H	-0.5550
80	I	H	-0.4971
81	D	H	-1.2003
82	T	H	-0.9558
83	S	H	-1.3065
84	K	H	-2.1072
85	T	H	-1.3230
86	Q	H	-1.2635
87	F	H	0.0000
88	S	H	-0.6173
89	L	H	0.0000
90	K	H	-1.5597
91	L	H	0.0000
92	S	H	-1.0294
93	S	H	-0.9177
94	V	H	0.0000
95	T	H	-0.4960
96	A	H	-0.1926
97	A	H	-0.1594
98	D	H	0.0000
99	T	H	0.2339
100	A	H	0.0000
101	I	H	0.7154
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	V	H	0.0000
106	R	H	0.0000
107	D	H	0.0000
108	R	H	-0.1514
109	V	H	0.5324
110	T	H	0.2233
113	G	H	0.0000
114	A	H	0.0000
115	F	H	0.0000
116	D	H	-0.3490
117	I	H	0.0000
118	W	H	-0.7686
119	G	H	0.0000
120	Q	H	-2.0118
121	G	H	-0.8275
122	T	H	-0.1322
123	M	H	0.8966
124	V	H	0.0000
125	T	H	0.2706
126	V	H	0.0000
127	S	H	-0.4550
128	S	H	-0.5992
1	D	L	-2.1861
2	I	L	0.0000
3	Q	L	-2.0166
4	M	L	0.0000
5	T	L	-1.1024
6	Q	L	-0.8251
7	S	L	-0.6780
8	P	L	-0.5692
9	S	L	-0.7469
10	S	L	-0.9687
11	L	L	-0.7940
12	S	L	-0.9599
13	A	L	-1.0996
14	S	L	-0.8031
15	V	L	0.0586
16	G	L	-0.5685
17	D	L	-1.6869
18	R	L	-2.3218
19	V	L	0.0000
20	T	L	-0.6302
21	I	L	0.0000
22	T	L	-0.6346
23	C	L	0.0000
24	Q	L	-2.0295
25	A	L	0.0000
26	S	L	-1.8671
27	Q	L	-2.3113
28	D	L	-2.5316
29	I	L	0.0000
36	S	L	-1.0939
37	N	L	-0.9217
38	Y	L	-0.0138
39	L	L	0.0000
40	N	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	Q	L	-0.8372
44	Q	L	-1.2831
45	K	L	-1.6733
46	P	L	-1.1821
47	G	L	-1.6934
48	K	L	-2.5941
49	A	L	-1.5746
50	P	L	0.0000
51	K	L	-1.2509
52	L	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	Y	L	-0.1441
56	D	L	-0.5884
57	A	L	0.0000
65	S	L	-0.7160
66	N	L	-0.7327
67	L	L	0.1129
68	E	L	0.0000
69	T	L	-0.2090
70	G	L	-0.3676
71	V	L	-0.1685
72	P	L	-0.2747
74	S	L	-0.3765
75	R	L	-0.8367
76	F	L	0.0000
77	S	L	-0.4110
78	G	L	-0.4171
79	S	L	-0.8243
80	G	L	-1.0674
83	S	L	-1.2678
84	G	L	-1.5578
85	T	L	-1.9502
86	D	L	-2.0131
87	F	L	0.0000
88	T	L	-0.6058
89	F	L	0.0000
90	T	L	0.0000
91	I	L	0.0000
92	S	L	-1.4059
93	S	L	-1.1707
94	L	L	0.0000
95	Q	L	-0.7731
96	P	L	-0.8965
97	E	L	-1.5092
98	D	L	0.0000
99	I	L	-0.4930
100	A	L	0.0000
101	T	L	-0.8434
102	Y	L	0.0000
103	F	L	0.0000
104	C	L	0.0000
105	Q	L	0.0000
106	H	L	0.0000
107	F	L	0.3011
108	D	L	-0.7502
109	H	L	-0.7099
114	L	L	0.3798
115	P	L	-0.0691
116	L	L	0.0000
117	A	L	-0.5929
118	F	L	0.0000
119	G	L	0.0000
120	G	L	-1.0240
121	G	L	0.0000
122	T	L	0.0000
123	K	L	-1.4703
124	V	L	0.0000
125	E	L	-1.6431
126	I	L	-0.8824
127	K	L	-1.6237