| Chain sequence(s) |
A: SCSALPSSLTLTSNEKLVDLFTHFNGTKVTTKAQFACRQAELSELIQRYELGTLPGRPSTLTASFSGNTLTINCGENGKSISFTVTITYPSSGTAPYPAIIGFGGGSIPQPSGVALINFNNDEIAKQTSKSSRGQGKFYDLYGSSHSAGAMTAWAWGVSRVIDALELTPAANIDTTKIGVTGCSRNGKGALVAGAFEKRIVLTIPQESGMGGSACWRISDDLKSQGYNIQTASEIVGEYPWFSTTFNSYVNNVSNLPFDHHHLAALIAPRGLLVIDNVIDWLGPQSCYGCMTAARRAWQALGVPDNMGYSQIGSHAHCAFPSSQQADLTAFVNKFLLGQSVNTAIFSSDFSANESQYIDWTTPTLS
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:02:08)
[INFO] Main: Simulation completed successfully. (00:02:10)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | S | A | -0.0492 | |
| 2 | C | A | 0.2651 | |
| 3 | S | A | -0.1845 | |
| 4 | A | A | -0.0576 | |
| 5 | L | A | -0.2159 | |
| 6 | P | A | -0.3698 | |
| 7 | S | A | -0.3747 | |
| 8 | S | A | -0.2415 | |
| 9 | L | A | 0.0212 | |
| 10 | T | A | 0.0572 | |
| 11 | L | A | 0.1279 | |
| 12 | T | A | -0.2659 | |
| 13 | S | A | -1.2992 | |
| 14 | N | A | -1.7675 | |
| 15 | E | A | -2.7299 | |
| 16 | K | A | -2.1892 | |
| 17 | L | A | 0.0000 | |
| 18 | V | A | -0.6772 | |
| 19 | D | A | -0.7617 | |
| 20 | L | A | 0.0000 | |
| 21 | F | A | 0.0000 | |
| 22 | T | A | -1.0691 | |
| 23 | H | A | -0.9778 | |
| 24 | F | A | -0.3815 | |
| 25 | N | A | -1.4684 | |
| 26 | G | A | -1.3933 | |
| 27 | T | A | -1.4417 | |
| 28 | K | A | -2.0758 | |
| 29 | V | A | 0.0000 | |
| 30 | T | A | -0.9329 | |
| 31 | T | A | -1.0319 | |
| 32 | K | A | -1.3483 | |
| 33 | A | A | -0.6864 | |
| 34 | Q | A | -0.9813 | |
| 35 | F | A | 0.0000 | |
| 36 | A | A | -0.3139 | |
| 37 | C | A | -0.1691 | |
| 38 | R | A | 0.0000 | |
| 39 | Q | A | -0.3361 | |
| 40 | A | A | -0.2530 | |
| 41 | E | A | -0.3538 | |
| 42 | L | A | 0.0000 | |
| 43 | S | A | -0.5869 | |
| 44 | E | A | -1.0662 | |
| 45 | L | A | 0.0000 | |
| 46 | I | A | 0.0000 | |
| 47 | Q | A | -0.6698 | |
| 48 | R | A | -0.7541 | |
| 49 | Y | A | -0.4250 | |
| 50 | E | A | 0.0000 | |
| 51 | L | A | 0.0000 | |
| 52 | G | A | 0.0000 | |
| 53 | T | A | -0.3204 | |
| 54 | L | A | -0.1841 | |
| 55 | P | A | -0.5293 | |
| 56 | G | A | -1.3373 | |
| 57 | R | A | -2.1140 | |
| 58 | P | A | 0.0000 | |
| 59 | S | A | -1.0554 | |
| 60 | T | A | -0.9143 | |
| 61 | L | A | -0.2380 | |
| 62 | T | A | 0.1142 | |
| 63 | A | A | 0.0165 | |
| 64 | S | A | 0.0534 | |
| 65 | F | A | -0.1610 | |
| 66 | S | A | -0.5689 | |
| 67 | G | A | -0.9349 | |
| 68 | N | A | -1.0928 | |
| 69 | T | A | -0.6864 | |
| 70 | L | A | 0.0000 | |
| 71 | T | A | -0.1866 | |
| 72 | I | A | 0.0000 | |
| 73 | N | A | -0.5301 | |
| 74 | C | A | 0.0000 | |
| 75 | G | A | -1.4650 | |
| 76 | E | A | -1.8601 | |
| 77 | N | A | -2.1656 | |
| 78 | G | A | -2.0107 | |
| 79 | K | A | -2.7181 | |
| 80 | S | A | -1.7878 | |
| 81 | I | A | 0.0000 | |
| 82 | S | A | -0.3972 | |
| 83 | F | A | 0.0000 | |
| 84 | T | A | -0.5825 | |
| 85 | V | A | 0.0000 | |
| 86 | T | A | -0.6681 | |
| 87 | I | A | 0.0000 | |
| 88 | T | A | -0.1853 | |
| 89 | Y | A | -0.0236 | |
| 90 | P | A | -0.1962 | |
| 91 | S | A | -0.3472 | |
| 92 | S | A | -0.4491 | |
| 93 | G | A | -0.4801 | |
| 94 | T | A | -0.4530 | |
| 95 | A | A | -0.4789 | |
| 96 | P | A | -0.7922 | |
| 97 | Y | A | -0.2875 | |
| 98 | P | A | -0.2454 | |
| 99 | A | A | 0.0000 | |
| 100 | I | A | 0.0000 | |
| 101 | I | A | 0.0000 | |
| 102 | G | A | 0.0000 | |
| 103 | F | A | 0.0000 | |
| 104 | G | A | -1.3240 | |
| 105 | G | A | -0.8332 | |
| 106 | G | A | -0.4559 | |
| 107 | S | A | -0.1887 | |
| 108 | I | A | -0.0145 | |
| 109 | P | A | -0.3618 | |
| 110 | Q | A | -0.5792 | |
| 111 | P | A | -0.4678 | |
| 112 | S | A | -0.4141 | |
| 113 | G | A | 0.0000 | |
| 114 | V | A | 0.0000 | |
| 115 | A | A | 0.0000 | |
| 116 | L | A | -0.0227 | |
| 117 | I | A | 0.0000 | |
| 118 | N | A | -1.0338 | |
| 119 | F | A | 0.0000 | |
| 120 | N | A | -2.4026 | |
| 121 | N | A | 0.0000 | |
| 122 | D | A | -2.6238 | |
| 123 | E | A | -2.6907 | |
| 124 | I | A | 0.0000 | |
| 125 | A | A | 0.0000 | |
| 126 | K | A | -2.3585 | |
| 127 | Q | A | 0.0000 | |
| 128 | T | A | -0.9419 | |
| 129 | S | A | -1.3061 | |
| 130 | K | A | -2.1820 | |
| 131 | S | A | -1.5155 | |
| 132 | S | A | 0.0000 | |
| 133 | R | A | -1.6727 | |
| 134 | G | A | 0.0000 | |
| 135 | Q | A | -2.0735 | |
| 136 | G | A | -2.0672 | |
| 137 | K | A | -1.8242 | |
| 138 | F | A | 0.0000 | |
| 139 | Y | A | 0.0000 | |
| 140 | D | A | -2.4186 | |
| 141 | L | A | 0.0000 | |
| 142 | Y | A | -1.0494 | |
| 143 | G | A | -1.1631 | |
| 144 | S | A | -1.1803 | |
| 145 | S | A | -0.6584 | |
| 146 | H | A | -0.5050 | |
| 147 | S | A | -0.3760 | |
| 148 | A | A | 0.0000 | |
| 149 | G | A | 0.0000 | |
| 150 | A | A | 0.0000 | |
| 151 | M | A | 0.0000 | |
| 152 | T | A | 0.0000 | |
| 153 | A | A | 0.0000 | |
| 154 | W | A | 0.0000 | |
| 155 | A | A | 0.0000 | |
| 156 | W | A | 0.0000 | |
| 157 | G | A | 0.0000 | |
| 158 | V | A | 0.0000 | |
| 159 | S | A | -0.6729 | |
| 160 | R | A | 0.0000 | |
| 161 | V | A | 0.0000 | |
| 162 | I | A | 0.0000 | |
| 163 | D | A | 0.0000 | |
| 164 | A | A | 0.0000 | |
| 165 | L | A | 0.0000 | |
| 166 | E | A | -1.1928 | |
| 167 | L | A | 0.5999 | |
| 168 | T | A | 0.0000 | |
| 169 | P | A | -0.5953 | |
| 170 | A | A | -0.3264 | |
| 171 | A | A | 0.0000 | |
| 172 | N | A | -0.9529 | |
| 173 | I | A | 0.0000 | |
| 174 | D | A | -1.0661 | |
| 175 | T | A | -1.0501 | |
| 176 | T | A | -0.6813 | |
| 177 | K | A | -0.5064 | |
| 178 | I | A | 0.0000 | |
| 179 | G | A | 0.0000 | |
| 180 | V | A | 0.0000 | |
| 181 | T | A | 0.0000 | |
| 182 | G | A | 0.0000 | |
| 183 | C | A | 0.0000 | |
| 184 | S | A | -0.7611 | |
| 185 | R | A | -1.2535 | |
| 186 | N | A | -1.0153 | |
| 187 | G | A | 0.0000 | |
| 188 | K | A | 0.0000 | |
| 189 | G | A | 0.0000 | |
| 190 | A | A | 0.0000 | |
| 191 | L | A | 0.0000 | |
| 192 | V | A | 0.0000 | |
| 193 | A | A | 0.0000 | |
| 194 | G | A | 0.0000 | |
| 195 | A | A | 0.0000 | |
| 196 | F | A | -0.2885 | |
| 197 | E | A | 0.0000 | |
| 198 | K | A | -1.9276 | |
| 199 | R | A | -1.4442 | |
| 200 | I | A | 0.0000 | |
| 201 | V | A | -0.3857 | |
| 202 | L | A | 0.0000 | |
| 203 | T | A | 0.0000 | |
| 204 | I | A | 0.0000 | |
| 205 | P | A | 0.0000 | |
| 206 | Q | A | 0.0000 | |
| 207 | E | A | 0.0000 | |
| 208 | S | A | 0.0000 | |
| 209 | G | A | 0.0000 | |
| 210 | M | A | 0.0000 | |
| 211 | G | A | 0.0000 | |
| 212 | G | A | 0.0000 | |
| 213 | S | A | 0.0000 | |
| 214 | A | A | 0.0000 | |
| 215 | C | A | 0.0000 | |
| 216 | W | A | 0.0000 | |
| 217 | R | A | 0.0000 | |
| 218 | I | A | 0.0000 | |
| 219 | S | A | 0.0000 | |
| 220 | D | A | -2.7575 | |
| 221 | D | A | -2.0955 | |
| 222 | L | A | 0.0000 | |
| 223 | K | A | -2.2213 | |
| 224 | S | A | -1.9245 | |
| 225 | Q | A | -2.1383 | |
| 226 | G | A | -1.7228 | |
| 227 | Y | A | -1.5856 | |
| 228 | N | A | -1.6959 | |
| 229 | I | A | 0.0000 | |
| 230 | Q | A | 0.0000 | |
| 231 | T | A | 0.0000 | |
| 232 | A | A | 0.0000 | |
| 233 | S | A | -1.4588 | |
| 234 | E | A | -1.0285 | |
| 235 | I | A | 0.0000 | |
| 236 | V | A | -0.7289 | |
| 237 | G | A | -1.1558 | |
| 238 | E | A | -1.1853 | |
| 239 | Y | A | -1.0476 | |
| 240 | P | A | 0.0000 | |
| 241 | W | A | 0.0000 | |
| 242 | F | A | 0.0000 | |
| 243 | S | A | 0.0000 | |
| 244 | T | A | -0.6023 | |
| 245 | T | A | -0.5781 | |
| 246 | F | A | 0.0000 | |
| 247 | N | A | -1.6509 | |
| 248 | S | A | -1.1757 | |
| 249 | Y | A | -1.1901 | |
| 250 | V | A | 0.0000 | |
| 251 | N | A | -2.4298 | |
| 252 | N | A | -2.5105 | |
| 253 | V | A | 0.0000 | |
| 254 | S | A | -1.9110 | |
| 255 | N | A | -1.2858 | |
| 256 | L | A | 0.0000 | |
| 257 | P | A | -0.0156 | |
| 258 | F | A | 0.0000 | |
| 259 | D | A | 0.0000 | |
| 260 | H | A | 0.0000 | |
| 261 | H | A | 0.0000 | |
| 262 | H | A | 0.0000 | |
| 263 | L | A | 0.0000 | |
| 264 | A | A | 0.0000 | |
| 265 | A | A | 0.0000 | |
| 266 | L | A | 0.0000 | |
| 267 | I | A | 0.0000 | |
| 268 | A | A | 0.0000 | |
| 269 | P | A | -0.4532 | |
| 270 | R | A | -0.5436 | |
| 271 | G | A | 0.0000 | |
| 272 | L | A | 0.0000 | |
| 273 | L | A | 0.0000 | |
| 274 | V | A | 0.0000 | |
| 275 | I | A | 0.0000 | |
| 276 | D | A | 0.0000 | |
| 277 | N | A | 0.0000 | |
| 278 | V | A | 0.0938 | |
| 279 | I | A | -0.1154 | |
| 280 | D | A | -0.9660 | |
| 281 | W | A | -0.1703 | |
| 282 | L | A | 0.0000 | |
| 283 | G | A | 0.0000 | |
| 284 | P | A | 0.0000 | |
| 285 | Q | A | -0.5493 | |
| 286 | S | A | 0.0000 | |
| 287 | C | A | 0.0000 | |
| 288 | Y | A | -0.1995 | |
| 289 | G | A | 0.0000 | |
| 290 | C | A | 0.0000 | |
| 291 | M | A | 0.0000 | |
| 292 | T | A | -0.3757 | |
| 293 | A | A | 0.0000 | |
| 294 | A | A | 0.0000 | |
| 295 | R | A | -0.7450 | |
| 296 | R | A | -0.8950 | |
| 297 | A | A | 0.0000 | |
| 298 | W | A | 0.0000 | |
| 299 | Q | A | -1.5004 | |
| 300 | A | A | 0.0000 | |
| 301 | L | A | 0.0000 | |
| 302 | G | A | -0.8332 | |
| 303 | V | A | -0.4625 | |
| 304 | P | A | -0.8209 | |
| 305 | D | A | -0.9078 | |
| 306 | N | A | -0.7589 | |
| 307 | M | A | 0.0000 | |
| 308 | G | A | 0.0000 | |
| 309 | Y | A | 0.0000 | |
| 310 | S | A | 0.0000 | |
| 311 | Q | A | 0.0000 | |
| 312 | I | A | 0.5783 | |
| 313 | G | A | -0.0291 | |
| 314 | S | A | -0.1318 | |
| 315 | H | A | -0.0888 | |
| 316 | A | A | -0.1856 | |
| 317 | H | A | -0.4477 | |
| 318 | C | A | -0.0805 | |
| 319 | A | A | 0.0087 | |
| 320 | F | A | 0.0953 | |
| 321 | P | A | -0.1043 | |
| 322 | S | A | -0.4490 | |
| 323 | S | A | -0.2455 | |
| 324 | Q | A | 0.0000 | |
| 325 | Q | A | -0.6182 | |
| 326 | A | A | -0.3435 | |
| 327 | D | A | -0.4841 | |
| 328 | L | A | 0.0000 | |
| 329 | T | A | -0.3305 | |
| 330 | A | A | -0.5129 | |
| 331 | F | A | 0.0000 | |
| 332 | V | A | 0.0000 | |
| 333 | N | A | -0.6134 | |
| 334 | K | A | -0.8749 | |
| 335 | F | A | 0.0000 | |
| 336 | L | A | 0.0000 | |
| 337 | L | A | 0.1545 | |
| 338 | G | A | -0.7080 | |
| 339 | Q | A | -1.2853 | |
| 340 | S | A | -0.8914 | |
| 341 | V | A | -0.7785 | |
| 342 | N | A | -1.3810 | |
| 343 | T | A | 0.0000 | |
| 344 | A | A | -0.3023 | |
| 345 | I | A | 0.0368 | |
| 346 | F | A | 0.2701 | |
| 347 | S | A | -0.0471 | |
| 348 | S | A | -0.4960 | |
| 349 | D | A | -1.4257 | |
| 350 | F | A | -0.5658 | |
| 351 | S | A | -0.8659 | |
| 352 | A | A | -1.0378 | |
| 353 | N | A | -1.6518 | |
| 354 | E | A | -1.9193 | |
| 355 | S | A | -1.6522 | |
| 356 | Q | A | -1.8418 | |
| 357 | Y | A | 0.0000 | |
| 358 | I | A | 0.0000 | |
| 359 | D | A | -2.2222 | |
| 360 | W | A | 0.0000 | |
| 361 | T | A | -0.5633 | |
| 362 | T | A | -0.4492 | |
| 363 | P | A | -0.5429 | |
| 364 | T | A | -0.6137 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | -0.6711 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine