| Chain sequence(s) |
A: YLPPTTPVAKVQSTDEYVYPTSLFCHAHTDRLLTVGHPFKDIVVNGKVLVPKVSGWQWRVFRLKFPDPNKFALPQKDFYDPEKERLVWRLRGLEIGRGGPLGKGTVGHPLFNKLGDTENPTAPVHCGADDRVNFSFDPKQTQLFIVGCEPPTGEHWDLAEPCPGLPPGACPPIQLVNSVIEDGDMCDIGFGNMNFKELQQDRSGVPLDIVSTRCKWPDFLKMTNEAYGDKMFFFGRREQVYARHFYVRCGPDGHPLPADPPPPKLYTPPPPSSPLAVPPPTDYFGTPSGSLVSSDGQLFNRPFWLQRAQGNNNGVCWHNELFVTVVDNTRNTNFTISQQLCTPAPNVYDPSCFKNYLRHVEQFELSLIAQLCKVPLDPGVLAHINTMNPTILENWNLGFVPPKEREDPYKGLIFWEVDLTERFSQDLDQFALGRKFLYQ
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:05)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Y | A | 1.9436 | |
| 2 | L | A | 1.9638 | |
| 3 | P | A | 0.8346 | |
| 4 | P | A | 0.3755 | |
| 5 | T | A | 0.1233 | |
| 6 | T | A | 0.1324 | |
| 7 | P | A | 0.1855 | |
| 8 | V | A | 1.2140 | |
| 9 | A | A | 0.0903 | |
| 10 | K | A | -1.0233 | |
| 11 | V | A | -0.1613 | |
| 12 | Q | A | -1.4062 | |
| 13 | S | A | -1.5606 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.4334 | |
| 16 | E | A | -2.4450 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | Y | A | 0.4589 | |
| 20 | P | A | 0.1287 | |
| 21 | T | A | 0.1651 | |
| 22 | S | A | -0.0892 | |
| 23 | L | A | 0.1293 | |
| 24 | F | A | -0.0147 | |
| 25 | C | A | 0.0000 | |
| 26 | H | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | H | A | -1.2759 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -2.8935 | |
| 31 | R | A | -2.6821 | |
| 32 | L | A | -0.8008 | |
| 33 | L | A | 1.1602 | |
| 34 | T | A | 1.3686 | |
| 35 | V | A | 1.8273 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -0.2572 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | -0.6473 | |
| 40 | K | A | -1.7013 | |
| 41 | D | A | -0.7656 | |
| 42 | I | A | 1.2477 | |
| 43 | V | A | 2.2135 | |
| 44 | V | A | 1.6726 | |
| 45 | N | A | -0.5275 | |
| 46 | G | A | -0.3595 | |
| 47 | K | A | -0.1407 | |
| 48 | V | A | 2.0185 | |
| 49 | L | A | 2.5227 | |
| 50 | V | A | 1.4273 | |
| 51 | P | A | 0.3149 | |
| 52 | K | A | -0.6972 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | G | A | 0.0000 | |
| 56 | W | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | R | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.1339 | |
| 65 | F | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.3821 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.2397 | |
| 70 | K | A | -1.7849 | |
| 71 | F | A | -0.6271 | |
| 72 | A | A | -0.5846 | |
| 73 | L | A | -0.8779 | |
| 74 | P | A | -1.2159 | |
| 75 | Q | A | -2.5127 | |
| 76 | K | A | -3.1189 | |
| 77 | D | A | -3.0009 | |
| 78 | F | A | -1.6649 | |
| 79 | Y | A | -1.9051 | |
| 80 | D | A | -2.7114 | |
| 81 | P | A | -2.3136 | |
| 82 | E | A | -3.0569 | |
| 83 | K | A | -3.4050 | |
| 84 | E | A | -2.4734 | |
| 85 | R | A | -1.3002 | |
| 86 | L | A | 0.0000 | |
| 87 | V | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.6610 | |
| 92 | G | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | E | A | -0.9848 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | -1.3716 | |
| 97 | R | A | 0.0000 | |
| 98 | G | A | -0.6976 | |
| 99 | G | A | -0.5355 | |
| 100 | P | A | -0.4049 | |
| 101 | L | A | 0.0413 | |
| 102 | G | A | -0.2137 | |
| 103 | K | A | -0.6041 | |
| 104 | G | A | 0.0000 | |
| 105 | T | A | -0.3564 | |
| 106 | V | A | 0.0000 | |
| 107 | G | A | -0.0668 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | -0.1244 | |
| 110 | L | A | -0.0661 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -1.2597 | |
| 113 | K | A | -0.5829 | |
| 114 | L | A | -0.7109 | |
| 115 | G | A | 0.0000 | |
| 116 | D | A | -1.2288 | |
| 117 | T | A | -0.8775 | |
| 118 | E | A | -1.8234 | |
| 119 | N | A | -2.0132 | |
| 120 | P | A | -1.3800 | |
| 121 | T | A | -0.6903 | |
| 122 | A | A | -0.3679 | |
| 123 | P | A | -0.1255 | |
| 124 | V | A | 0.0517 | |
| 125 | H | A | -0.2580 | |
| 126 | C | A | -0.6175 | |
| 127 | G | A | -1.1766 | |
| 128 | A | A | -1.1786 | |
| 129 | D | A | -2.2089 | |
| 130 | D | A | -1.7678 | |
| 131 | R | A | -1.4403 | |
| 132 | V | A | -0.4693 | |
| 133 | N | A | -0.8801 | |
| 134 | F | A | -0.3800 | |
| 135 | S | A | -0.3228 | |
| 136 | F | A | 0.0000 | |
| 137 | D | A | 0.0000 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | Q | A | -0.2275 | |
| 141 | T | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | C | A | 0.0000 | |
| 149 | E | A | -0.5701 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | 0.0000 | |
| 153 | G | A | 0.0000 | |
| 154 | E | A | -0.1933 | |
| 155 | H | A | 0.0000 | |
| 156 | W | A | 1.1514 | |
| 157 | D | A | 0.3330 | |
| 158 | L | A | 0.7995 | |
| 159 | A | A | 0.1657 | |
| 160 | E | A | -1.4600 | |
| 161 | P | A | -0.2121 | |
| 162 | C | A | 0.1918 | |
| 163 | P | A | -0.1602 | |
| 164 | G | A | -0.0553 | |
| 165 | L | A | 0.6385 | |
| 166 | P | A | -0.0940 | |
| 167 | P | A | -0.3308 | |
| 168 | G | A | -0.4424 | |
| 169 | A | A | -0.0129 | |
| 170 | C | A | 0.6648 | |
| 171 | P | A | 0.5337 | |
| 172 | P | A | 0.7585 | |
| 173 | I | A | 2.0038 | |
| 174 | Q | A | 0.8464 | |
| 175 | L | A | 1.4785 | |
| 176 | V | A | 0.8467 | |
| 177 | N | A | -0.2944 | |
| 178 | S | A | 0.0381 | |
| 179 | V | A | 0.4407 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | 0.3825 | |
| 182 | D | A | 0.0838 | |
| 183 | G | A | -0.1603 | |
| 184 | D | A | -0.5170 | |
| 185 | M | A | 0.0000 | |
| 186 | C | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | 0.1174 | |
| 190 | F | A | 0.0686 | |
| 191 | G | A | -0.0973 | |
| 192 | N | A | -0.2378 | |
| 193 | M | A | -0.0792 | |
| 194 | N | A | 0.0000 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -3.3632 | |
| 197 | E | A | -2.5687 | |
| 198 | L | A | -1.2079 | |
| 199 | Q | A | -2.5534 | |
| 200 | Q | A | -3.3183 | |
| 201 | D | A | -3.5825 | |
| 202 | R | A | -3.3178 | |
| 203 | S | A | 0.0000 | |
| 204 | G | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | L | A | 0.2256 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | V | A | -1.3204 | |
| 211 | S | A | -1.8381 | |
| 212 | T | A | -1.3657 | |
| 213 | R | A | -1.9811 | |
| 214 | C | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | W | A | -0.1513 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | F | A | 0.3403 | |
| 220 | L | A | 0.5822 | |
| 221 | K | A | -1.1546 | |
| 222 | M | A | 0.0000 | |
| 223 | T | A | -0.9063 | |
| 224 | N | A | -1.6340 | |
| 225 | E | A | -1.2563 | |
| 226 | A | A | -0.6061 | |
| 227 | Y | A | -0.4067 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | K | A | -0.6890 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | F | A | -0.1534 | |
| 234 | F | A | 0.0088 | |
| 235 | G | A | -0.9108 | |
| 236 | R | A | -2.6381 | |
| 237 | R | A | -2.8662 | |
| 238 | E | A | -2.1773 | |
| 239 | Q | A | -0.2368 | |
| 240 | V | A | 1.4041 | |
| 241 | Y | A | 1.1586 | |
| 242 | A | A | 0.3067 | |
| 243 | R | A | -0.7316 | |
| 244 | H | A | -0.8763 | |
| 245 | F | A | 0.0483 | |
| 246 | Y | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | R | A | -0.6293 | |
| 249 | C | A | -0.8782 | |
| 250 | G | A | -0.9439 | |
| 251 | P | A | -0.9991 | |
| 252 | D | A | -1.4544 | |
| 253 | G | A | -1.3415 | |
| 254 | H | A | -1.4936 | |
| 255 | P | A | -1.0024 | |
| 256 | L | A | -0.0030 | |
| 257 | P | A | -0.4392 | |
| 258 | A | A | -0.8700 | |
| 259 | D | A | -1.9364 | |
| 260 | P | A | -1.4710 | |
| 261 | P | A | -0.8674 | |
| 262 | P | A | -0.7653 | |
| 263 | P | A | -0.7257 | |
| 264 | K | A | -1.0317 | |
| 265 | L | A | 0.8112 | |
| 266 | Y | A | 0.5274 | |
| 267 | T | A | -0.0663 | |
| 268 | P | A | 0.1297 | |
| 269 | P | A | -0.0104 | |
| 270 | P | A | -0.4601 | |
| 271 | P | A | -0.2132 | |
| 272 | S | A | -0.3891 | |
| 273 | S | A | 0.0627 | |
| 274 | P | A | 0.2211 | |
| 275 | L | A | 0.9405 | |
| 276 | A | A | 0.8580 | |
| 277 | V | A | 1.7239 | |
| 278 | P | A | 0.8184 | |
| 279 | P | A | 0.1136 | |
| 280 | P | A | -0.4061 | |
| 281 | T | A | -0.6643 | |
| 282 | D | A | -1.2155 | |
| 283 | Y | A | 0.6851 | |
| 284 | F | A | 0.6164 | |
| 285 | G | A | 0.2812 | |
| 286 | T | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | S | A | 0.0000 | |
| 289 | G | A | 0.0000 | |
| 290 | S | A | 0.9539 | |
| 291 | L | A | 1.6035 | |
| 292 | V | A | 0.6185 | |
| 293 | S | A | -0.1606 | |
| 294 | S | A | -0.9644 | |
| 295 | D | A | -1.8434 | |
| 296 | G | A | 0.0000 | |
| 297 | Q | A | 0.0000 | |
| 298 | L | A | -1.1119 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.6868 | |
| 301 | R | A | -1.9219 | |
| 302 | P | A | -1.0108 | |
| 303 | F | A | -0.2346 | |
| 304 | W | A | -0.5713 | |
| 305 | L | A | 0.0000 | |
| 306 | Q | A | -2.0881 | |
| 307 | R | A | -2.9310 | |
| 308 | A | A | 0.0000 | |
| 309 | Q | A | -1.7890 | |
| 310 | G | A | -1.4256 | |
| 311 | N | A | -1.3651 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | C | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.7846 | |
| 319 | N | A | -0.8393 | |
| 320 | E | A | -1.0301 | |
| 321 | L | A | 0.0000 | |
| 322 | F | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.3380 | |
| 331 | N | A | 0.0000 | |
| 332 | T | A | -0.0620 | |
| 333 | N | A | 0.5797 | |
| 334 | F | A | 1.7719 | |
| 335 | T | A | 0.7579 | |
| 336 | I | A | 0.4474 | |
| 337 | S | A | -0.8434 | |
| 338 | Q | A | -1.5331 | |
| 339 | Q | A | -0.9146 | |
| 340 | L | A | 0.7735 | |
| 341 | C | A | 0.4102 | |
| 342 | T | A | 0.1433 | |
| 343 | P | A | -0.2826 | |
| 344 | A | A | 0.1148 | |
| 345 | P | A | 0.1569 | |
| 346 | N | A | -0.2802 | |
| 347 | V | A | 1.5519 | |
| 348 | Y | A | 1.4635 | |
| 349 | D | A | 0.1023 | |
| 350 | P | A | -0.3136 | |
| 351 | S | A | -0.2539 | |
| 352 | C | A | 0.0000 | |
| 353 | F | A | -0.5642 | |
| 354 | K | A | -1.6538 | |
| 355 | N | A | -1.7000 | |
| 356 | Y | A | -0.0906 | |
| 357 | L | A | 0.6437 | |
| 358 | R | A | 0.9722 | |
| 359 | H | A | 0.0000 | |
| 360 | V | A | 1.3932 | |
| 361 | E | A | 0.0000 | |
| 362 | Q | A | -0.0775 | |
| 363 | F | A | 0.0000 | |
| 364 | E | A | -2.0429 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | -0.6883 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | A | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.2753 | |
| 374 | V | A | 0.0000 | |
| 375 | P | A | -1.3170 | |
| 376 | L | A | -1.7118 | |
| 377 | D | A | -1.9955 | |
| 378 | P | A | -1.0391 | |
| 379 | G | A | -1.0156 | |
| 380 | V | A | -0.9359 | |
| 381 | L | A | -0.5331 | |
| 382 | A | A | -0.6551 | |
| 383 | H | A | -0.8085 | |
| 384 | I | A | 0.0000 | |
| 385 | N | A | -1.4072 | |
| 386 | T | A | -0.5494 | |
| 387 | M | A | -0.2965 | |
| 388 | N | A | -0.8641 | |
| 389 | P | A | -1.2326 | |
| 390 | T | A | -1.4016 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | -1.3826 | |
| 393 | E | A | -2.6997 | |
| 394 | N | A | -2.4269 | |
| 395 | W | A | -1.2801 | |
| 396 | N | A | -0.9805 | |
| 397 | L | A | -0.1436 | |
| 398 | G | A | 0.5676 | |
| 399 | F | A | 2.4342 | |
| 400 | V | A | 1.8539 | |
| 401 | P | A | 0.0602 | |
| 402 | P | A | -1.7730 | |
| 403 | K | A | -3.3021 | |
| 404 | E | A | -3.8234 | |
| 405 | R | A | -3.8386 | |
| 406 | E | A | -3.7572 | |
| 407 | D | A | -2.8475 | |
| 408 | P | A | -1.7518 | |
| 409 | Y | A | -0.9820 | |
| 410 | K | A | -2.1090 | |
| 411 | G | A | -0.6342 | |
| 412 | L | A | 0.6815 | |
| 413 | I | A | 1.5943 | |
| 414 | F | A | 0.0000 | |
| 415 | W | A | -0.3815 | |
| 416 | E | A | -1.6645 | |
| 417 | V | A | 0.0000 | |
| 418 | D | A | -2.9359 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -2.0353 | |
| 421 | E | A | -2.7614 | |
| 422 | R | A | -2.5935 | |
| 423 | F | A | -1.2590 | |
| 424 | S | A | -1.4513 | |
| 425 | Q | A | -1.8355 | |
| 426 | D | A | -2.8907 | |
| 427 | L | A | -1.9824 | |
| 428 | D | A | -2.7755 | |
| 429 | Q | A | -2.6132 | |
| 430 | F | A | -1.4206 | |
| 431 | A | A | -0.8992 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -1.5847 | |
| 435 | K | A | -0.7227 | |
| 436 | F | A | 0.1362 | |
| 437 | L | A | 1.0237 | |
| 438 | Y | A | 0.8188 | |
| 439 | Q | A | -0.2766 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine