| Chain sequence(s) |
A: MTCGSYRAVPAFSCVSACGPRPGRCCITAAPYRGISCYRGLTGGFGSRSVCGGFRAGSCGRSFGYRSGGVGGLSPPCITTVSVNESLLTPLNLEIDPNAQCVKQEEKEQIKCLNNRFAAFIDKVRFLEQQNKLLETKLQFYQNRQCCESNLEPLFSGYIETLRREAECAEADSGRLSSELNSLQEVLEGYKKRYEEEIALRATAENEFVALKKDVDCAYLRKSDLEANVEALIQETDFLRRLYEEEIRVLQAHISDTSVIVKMDNSRDLNMDNIVAEIKAHYDDIASRSRAEAESWYRSKCEEIKATVIRHGETLRRTKEEINELNRVIQRLTAEVENAKCQNSKLEAAVTQAEQQGEAALADAKCKLAGLEEALQKAKQDMACLLKEYQEVMNSKLGLDIEIATYRRLLEGEEQRLCEGVGAVNVCVSSSRGGVVCGDLCASGAAPAVTTSVCSAPCSGNVVVGTSDVCSPCSRVGGSILGCKKC
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:01)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:14:11)
[INFO] Main: Simulation completed successfully. (00:14:17)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | M | A | 1.1823 | |
| 2 | T | A | 0.7771 | |
| 3 | C | A | 0.6568 | |
| 4 | G | A | 0.0644 | |
| 5 | S | A | -0.0633 | |
| 6 | Y | A | 0.2168 | |
| 7 | R | A | -0.8877 | |
| 8 | A | A | 0.1336 | |
| 9 | V | A | 1.4810 | |
| 10 | P | A | 0.9280 | |
| 11 | A | A | 1.2728 | |
| 12 | F | A | 2.3355 | |
| 13 | S | A | 1.4920 | |
| 14 | C | A | 1.8423 | |
| 15 | V | A | 2.2024 | |
| 16 | S | A | 1.0159 | |
| 17 | A | A | 0.6843 | |
| 18 | C | A | 0.2351 | |
| 19 | G | A | -0.7108 | |
| 20 | P | A | -1.2996 | |
| 21 | R | A | -2.4518 | |
| 22 | P | A | -1.9514 | |
| 23 | G | A | -1.6404 | |
| 24 | R | A | -1.5585 | |
| 25 | C | A | 0.5524 | |
| 26 | C | A | 1.5206 | |
| 27 | I | A | 2.3295 | |
| 28 | T | A | 1.1985 | |
| 29 | A | A | 0.7261 | |
| 30 | A | A | 0.2686 | |
| 31 | P | A | -0.1278 | |
| 32 | Y | A | 0.4357 | |
| 33 | R | A | -0.9842 | |
| 34 | G | A | -0.0671 | |
| 35 | I | A | 1.6692 | |
| 36 | S | A | 0.8776 | |
| 37 | C | A | 1.2369 | |
| 38 | Y | A | 1.0785 | |
| 39 | R | A | -0.7490 | |
| 40 | G | A | 0.0802 | |
| 41 | L | A | 0.9933 | |
| 42 | T | A | 0.1308 | |
| 43 | G | A | 0.0469 | |
| 44 | G | A | 0.2772 | |
| 45 | F | A | 1.3372 | |
| 46 | G | A | -0.2378 | |
| 47 | S | A | -0.8043 | |
| 48 | R | A | -1.6539 | |
| 49 | S | A | -0.1836 | |
| 50 | V | A | 1.3836 | |
| 51 | C | A | 1.0181 | |
| 52 | G | A | 0.2976 | |
| 53 | G | A | 0.1418 | |
| 54 | F | A | 0.6752 | |
| 55 | R | A | -1.1777 | |
| 56 | A | A | -0.6340 | |
| 57 | G | A | -0.6918 | |
| 58 | S | A | -0.6060 | |
| 59 | C | A | -0.2062 | |
| 60 | G | A | -0.9544 | |
| 61 | R | A | -1.5690 | |
| 62 | S | A | -0.1946 | |
| 63 | F | A | 1.1963 | |
| 64 | G | A | 0.3270 | |
| 65 | Y | A | 0.5501 | |
| 66 | R | A | -1.3884 | |
| 67 | S | A | -1.1772 | |
| 68 | G | A | -0.7849 | |
| 69 | G | A | -0.2339 | |
| 70 | V | A | 1.1138 | |
| 71 | G | A | 0.4067 | |
| 72 | G | A | 0.3588 | |
| 73 | L | A | 1.0655 | |
| 74 | S | A | 0.2536 | |
| 75 | P | A | 0.1905 | |
| 76 | P | A | 0.3585 | |
| 77 | C | A | 1.5020 | |
| 78 | I | A | 2.4653 | |
| 79 | T | A | 1.4666 | |
| 80 | T | A | 1.5236 | |
| 81 | V | A | 2.2131 | |
| 82 | S | A | 0.9262 | |
| 83 | V | A | 1.4001 | |
| 84 | N | A | -0.5620 | |
| 85 | E | A | -1.1376 | |
| 86 | S | A | -0.0557 | |
| 87 | L | A | 1.6750 | |
| 88 | L | A | 1.8096 | |
| 89 | T | A | 0.8969 | |
| 90 | P | A | 0.9658 | |
| 91 | L | A | 1.3881 | |
| 92 | N | A | -0.1265 | |
| 93 | L | A | 0.9140 | |
| 94 | E | A | -0.6716 | |
| 95 | I | A | 0.3226 | |
| 96 | D | A | -1.3358 | |
| 97 | P | A | -1.1970 | |
| 98 | N | A | -1.5189 | |
| 99 | A | A | -1.1913 | |
| 100 | Q | A | -1.9775 | |
| 101 | C | A | -1.4551 | |
| 102 | V | A | -1.3071 | |
| 103 | K | A | -3.7119 | |
| 104 | Q | A | -3.9726 | |
| 105 | E | A | -4.5119 | |
| 106 | E | A | -4.7337 | |
| 107 | K | A | -4.6701 | |
| 108 | E | A | -4.6803 | |
| 109 | Q | A | -3.6606 | |
| 110 | I | A | -2.3689 | |
| 111 | K | A | -3.1647 | |
| 112 | C | A | -1.6735 | |
| 113 | L | A | -0.9989 | |
| 114 | N | A | -1.6705 | |
| 115 | N | A | -1.6903 | |
| 116 | R | A | -1.2039 | |
| 117 | F | A | 0.7973 | |
| 118 | A | A | 0.2824 | |
| 119 | A | A | -0.1194 | |
| 120 | F | A | 1.5812 | |
| 121 | I | A | 1.5276 | |
| 122 | D | A | -0.7427 | |
| 123 | K | A | -0.0965 | |
| 124 | V | A | 0.8264 | |
| 125 | R | A | -1.3899 | |
| 126 | F | A | 0.1365 | |
| 127 | L | A | -0.6041 | |
| 128 | E | A | -2.7095 | |
| 129 | Q | A | -2.4831 | |
| 130 | Q | A | -1.6900 | |
| 131 | N | A | -2.9174 | |
| 132 | K | A | -2.9731 | |
| 133 | L | A | -1.1399 | |
| 134 | L | A | -0.7674 | |
| 135 | E | A | -1.9536 | |
| 136 | T | A | -0.9730 | |
| 137 | K | A | -0.6250 | |
| 138 | L | A | 0.1437 | |
| 139 | Q | A | -1.0771 | |
| 140 | F | A | 0.3305 | |
| 141 | Y | A | 0.1058 | |
| 142 | Q | A | -1.2446 | |
| 143 | N | A | -1.9778 | |
| 144 | R | A | -2.4476 | |
| 145 | Q | A | -2.5418 | |
| 146 | C | A | -1.2036 | |
| 147 | C | A | -1.5898 | |
| 148 | E | A | -2.8152 | |
| 149 | S | A | -1.8633 | |
| 150 | N | A | -1.5425 | |
| 151 | L | A | -0.0599 | |
| 152 | E | A | -1.1106 | |
| 153 | P | A | 0.2272 | |
| 154 | L | A | 1.8985 | |
| 155 | F | A | 2.1278 | |
| 156 | S | A | 1.1874 | |
| 157 | G | A | 0.9370 | |
| 158 | Y | A | 1.8508 | |
| 159 | I | A | 1.1703 | |
| 160 | E | A | -0.9295 | |
| 161 | T | A | -1.1578 | |
| 162 | L | A | -1.1940 | |
| 163 | R | A | -3.2230 | |
| 164 | R | A | -3.9878 | |
| 165 | E | A | -3.6148 | |
| 166 | A | A | -3.3055 | |
| 167 | E | A | -3.9587 | |
| 168 | C | A | -2.5326 | |
| 169 | A | A | -2.8829 | |
| 170 | E | A | -3.4579 | |
| 171 | A | A | -2.5776 | |
| 172 | D | A | -2.8981 | |
| 173 | S | A | -2.2463 | |
| 174 | G | A | -1.9940 | |
| 175 | R | A | -2.5494 | |
| 176 | L | A | -0.7039 | |
| 177 | S | A | -0.7568 | |
| 178 | S | A | -1.4844 | |
| 179 | E | A | -1.5888 | |
| 180 | L | A | 0.0007 | |
| 181 | N | A | -1.3070 | |
| 182 | S | A | -0.9840 | |
| 183 | L | A | -0.0748 | |
| 184 | Q | A | -1.5289 | |
| 185 | E | A | -2.2087 | |
| 186 | V | A | 0.0919 | |
| 187 | L | A | -0.6379 | |
| 188 | E | A | -2.5928 | |
| 189 | G | A | -1.5923 | |
| 190 | Y | A | -0.9963 | |
| 191 | K | A | -3.1405 | |
| 192 | K | A | -3.7117 | |
| 193 | R | A | -3.3220 | |
| 194 | Y | A | -1.7501 | |
| 195 | E | A | -2.9575 | |
| 196 | E | A | -2.5158 | |
| 197 | E | A | -2.4496 | |
| 198 | I | A | -0.6935 | |
| 199 | A | A | -0.6489 | |
| 200 | L | A | -0.2184 | |
| 201 | R | A | -2.1998 | |
| 202 | A | A | -1.2926 | |
| 203 | T | A | -1.0534 | |
| 204 | A | A | -1.1092 | |
| 205 | E | A | -1.6961 | |
| 206 | N | A | -1.7399 | |
| 207 | E | A | -1.6861 | |
| 208 | F | A | 0.5046 | |
| 209 | V | A | 0.5080 | |
| 210 | A | A | -0.6975 | |
| 211 | L | A | -0.3246 | |
| 212 | K | A | -1.7978 | |
| 213 | K | A | -2.5281 | |
| 214 | D | A | -1.8989 | |
| 215 | V | A | -0.8145 | |
| 216 | D | A | -2.1908 | |
| 217 | C | A | -1.3431 | |
| 218 | A | A | -1.1315 | |
| 219 | Y | A | 0.0858 | |
| 220 | L | A | -0.1305 | |
| 221 | R | A | -2.0314 | |
| 222 | K | A | -2.3166 | |
| 223 | S | A | -1.6485 | |
| 224 | D | A | -2.5535 | |
| 225 | L | A | -1.2519 | |
| 226 | E | A | -2.3692 | |
| 227 | A | A | -1.8421 | |
| 228 | N | A | -1.4142 | |
| 229 | V | A | -0.2752 | |
| 230 | E | A | -1.6281 | |
| 231 | A | A | -0.7850 | |
| 232 | L | A | 0.6001 | |
| 233 | I | A | 0.6308 | |
| 234 | Q | A | -1.2211 | |
| 235 | E | A | -1.4352 | |
| 236 | T | A | -0.8901 | |
| 237 | D | A | -1.1334 | |
| 238 | F | A | 0.0350 | |
| 239 | L | A | -0.8217 | |
| 240 | R | A | -2.9965 | |
| 241 | R | A | -2.9164 | |
| 242 | L | A | -1.4151 | |
| 243 | Y | A | -1.2356 | |
| 244 | E | A | -2.9342 | |
| 245 | E | A | -3.3770 | |
| 246 | E | A | -2.1929 | |
| 247 | I | A | -0.3788 | |
| 248 | R | A | -1.8142 | |
| 249 | V | A | -0.2147 | |
| 250 | L | A | 0.3541 | |
| 251 | Q | A | -0.8207 | |
| 252 | A | A | -0.6786 | |
| 253 | H | A | -0.6470 | |
| 254 | I | A | 0.3993 | |
| 255 | S | A | -0.5340 | |
| 256 | D | A | -1.6563 | |
| 257 | T | A | -0.2541 | |
| 258 | S | A | 1.1314 | |
| 259 | V | A | 2.8891 | |
| 260 | I | A | 3.3544 | |
| 261 | V | A | 2.4823 | |
| 262 | K | A | -0.2161 | |
| 263 | M | A | -0.2546 | |
| 264 | D | A | -2.4410 | |
| 265 | N | A | -2.9465 | |
| 266 | S | A | -2.3904 | |
| 267 | R | A | -3.1550 | |
| 268 | D | A | -2.4200 | |
| 269 | L | A | -0.5973 | |
| 270 | N | A | -1.5983 | |
| 271 | M | A | -0.6075 | |
| 272 | D | A | -1.8158 | |
| 273 | N | A | -1.9114 | |
| 274 | I | A | -0.3218 | |
| 275 | V | A | -0.4542 | |
| 276 | A | A | -1.2397 | |
| 277 | E | A | -2.0693 | |
| 278 | I | A | -0.9803 | |
| 279 | K | A | -1.8794 | |
| 280 | A | A | -1.7383 | |
| 281 | H | A | -1.5811 | |
| 282 | Y | A | -0.6635 | |
| 283 | D | A | -2.5041 | |
| 284 | D | A | -2.5048 | |
| 285 | I | A | -0.3494 | |
| 286 | A | A | -1.3853 | |
| 287 | S | A | -2.4157 | |
| 288 | R | A | -3.1334 | |
| 289 | S | A | -2.7149 | |
| 290 | R | A | -3.3002 | |
| 291 | A | A | -2.4868 | |
| 292 | E | A | -3.1347 | |
| 293 | A | A | -2.0347 | |
| 294 | E | A | -2.5305 | |
| 295 | S | A | -1.5714 | |
| 296 | W | A | -0.3944 | |
| 297 | Y | A | -0.5091 | |
| 298 | R | A | -2.3379 | |
| 299 | S | A | -1.9107 | |
| 300 | K | A | -1.8654 | |
| 301 | C | A | -1.8075 | |
| 302 | E | A | -3.1002 | |
| 303 | E | A | -2.5629 | |
| 304 | I | A | -0.8432 | |
| 305 | K | A | -1.6101 | |
| 306 | A | A | -1.0040 | |
| 307 | T | A | -0.3723 | |
| 308 | V | A | 0.9107 | |
| 309 | I | A | 1.0936 | |
| 310 | R | A | -1.1533 | |
| 311 | H | A | -1.1470 | |
| 312 | G | A | -0.5737 | |
| 313 | E | A | -1.5839 | |
| 314 | T | A | -1.5906 | |
| 315 | L | A | -1.2845 | |
| 316 | R | A | -3.4027 | |
| 317 | R | A | -3.9412 | |
| 318 | T | A | -2.9246 | |
| 319 | K | A | -3.7360 | |
| 320 | E | A | -4.6544 | |
| 321 | E | A | -4.0370 | |
| 322 | I | A | -2.0570 | |
| 323 | N | A | -3.1539 | |
| 324 | E | A | -3.2330 | |
| 325 | L | A | -1.1783 | |
| 326 | N | A | -1.9361 | |
| 327 | R | A | -2.2876 | |
| 328 | V | A | -0.2103 | |
| 329 | I | A | 0.4037 | |
| 330 | Q | A | -1.5000 | |
| 331 | R | A | -1.8545 | |
| 332 | L | A | -0.1890 | |
| 333 | T | A | -0.6328 | |
| 334 | A | A | -1.7124 | |
| 335 | E | A | -2.2686 | |
| 336 | V | A | -1.0580 | |
| 337 | E | A | -2.9689 | |
| 338 | N | A | -2.9397 | |
| 339 | A | A | -2.5856 | |
| 340 | K | A | -3.2066 | |
| 341 | C | A | -2.5547 | |
| 342 | Q | A | -2.7355 | |
| 343 | N | A | -3.1302 | |
| 344 | S | A | -2.3117 | |
| 345 | K | A | -2.2546 | |
| 346 | L | A | -0.8171 | |
| 347 | E | A | -1.7126 | |
| 348 | A | A | -1.2373 | |
| 349 | A | A | -0.5810 | |
| 350 | V | A | 0.1094 | |
| 351 | T | A | -1.3500 | |
| 352 | Q | A | -2.2469 | |
| 353 | A | A | -2.1006 | |
| 354 | E | A | -3.2718 | |
| 355 | Q | A | -3.4089 | |
| 356 | Q | A | -3.0064 | |
| 357 | G | A | -2.8085 | |
| 358 | E | A | -3.1526 | |
| 359 | A | A | -2.1550 | |
| 360 | A | A | -1.4769 | |
| 361 | L | A | -0.8149 | |
| 362 | A | A | -1.3293 | |
| 363 | D | A | -2.1338 | |
| 364 | A | A | -1.3405 | |
| 365 | K | A | -1.4176 | |
| 366 | C | A | -0.8930 | |
| 367 | K | A | -1.6084 | |
| 368 | L | A | -0.1869 | |
| 369 | A | A | -0.7803 | |
| 370 | G | A | -0.8603 | |
| 371 | L | A | -0.0447 | |
| 372 | E | A | -1.8737 | |
| 373 | E | A | -2.8506 | |
| 374 | A | A | -1.4486 | |
| 375 | L | A | -1.3519 | |
| 376 | Q | A | -3.3325 | |
| 377 | K | A | -3.7234 | |
| 378 | A | A | -2.7043 | |
| 379 | K | A | -3.2376 | |
| 380 | Q | A | -2.9999 | |
| 381 | D | A | -2.6673 | |
| 382 | M | A | -1.1888 | |
| 383 | A | A | -0.8884 | |
| 384 | C | A | -0.7229 | |
| 385 | L | A | -0.1403 | |
| 386 | L | A | 0.4936 | |
| 387 | K | A | -1.7140 | |
| 388 | E | A | -1.6932 | |
| 389 | Y | A | 0.1293 | |
| 390 | Q | A | -1.7789 | |
| 391 | E | A | -2.2940 | |
| 392 | V | A | -0.0435 | |
| 393 | M | A | -0.4056 | |
| 394 | N | A | -1.4881 | |
| 395 | S | A | -0.6384 | |
| 396 | K | A | -1.2091 | |
| 397 | L | A | 0.2029 | |
| 398 | G | A | 0.3905 | |
| 399 | L | A | 0.7698 | |
| 400 | D | A | -0.2779 | |
| 401 | I | A | 1.3989 | |
| 402 | E | A | 0.1516 | |
| 403 | I | A | 1.1490 | |
| 404 | A | A | 0.2904 | |
| 405 | T | A | 0.0989 | |
| 406 | Y | A | 0.6577 | |
| 407 | R | A | -1.6077 | |
| 408 | R | A | -2.3527 | |
| 409 | L | A | -0.3395 | |
| 410 | L | A | -1.5622 | |
| 411 | E | A | -3.5031 | |
| 412 | G | A | -2.7628 | |
| 413 | E | A | -3.6344 | |
| 414 | E | A | -3.7642 | |
| 415 | Q | A | -3.5483 | |
| 416 | R | A | -3.3527 | |
| 417 | L | A | -1.0558 | |
| 418 | C | A | -0.8596 | |
| 419 | E | A | -2.2061 | |
| 420 | G | A | -0.5359 | |
| 421 | V | A | 1.4643 | |
| 422 | G | A | 0.3394 | |
| 423 | A | A | 0.7499 | |
| 424 | V | A | 1.9775 | |
| 425 | N | A | 0.8399 | |
| 426 | V | A | 2.5015 | |
| 427 | C | A | 2.2699 | |
| 428 | V | A | 2.2989 | |
| 429 | S | A | 0.7195 | |
| 430 | S | A | -0.3435 | |
| 431 | S | A | -1.4625 | |
| 432 | R | A | -2.3533 | |
| 433 | G | A | -1.2600 | |
| 434 | G | A | 0.2304 | |
| 435 | V | A | 2.4768 | |
| 436 | V | A | 2.7800 | |
| 437 | C | A | 1.3625 | |
| 438 | G | A | -0.3851 | |
| 439 | D | A | -0.9662 | |
| 440 | L | A | 0.9372 | |
| 441 | C | A | 1.1377 | |
| 442 | A | A | 0.5685 | |
| 443 | S | A | -0.2596 | |
| 444 | G | A | -0.5241 | |
| 445 | A | A | -0.2511 | |
| 446 | A | A | -0.1383 | |
| 447 | P | A | 0.1808 | |
| 448 | A | A | 0.8541 | |
| 449 | V | A | 1.7035 | |
| 450 | T | A | 0.7081 | |
| 451 | T | A | 0.5029 | |
| 452 | S | A | 0.7597 | |
| 453 | V | A | 1.9922 | |
| 454 | C | A | 1.5272 | |
| 455 | S | A | 0.5587 | |
| 456 | A | A | 0.0990 | |
| 457 | P | A | -0.0154 | |
| 458 | C | A | 0.3993 | |
| 459 | S | A | -0.4294 | |
| 460 | G | A | -0.7103 | |
| 461 | N | A | -0.2393 | |
| 462 | V | A | 2.2770 | |
| 463 | V | A | 3.0721 | |
| 464 | V | A | 2.8029 | |
| 465 | G | A | 0.7392 | |
| 466 | T | A | -0.3804 | |
| 467 | S | A | -0.8589 | |
| 468 | D | A | -0.9345 | |
| 469 | V | A | 1.1583 | |
| 470 | C | A | 1.1145 | |
| 471 | S | A | 0.5659 | |
| 472 | P | A | -0.0775 | |
| 473 | C | A | 0.2615 | |
| 474 | S | A | -0.4501 | |
| 475 | R | A | -1.0812 | |
| 476 | V | A | 0.5530 | |
| 477 | G | A | -0.4000 | |
| 478 | G | A | -0.0856 | |
| 479 | S | A | 0.7449 | |
| 480 | I | A | 2.4259 | |
| 481 | L | A | 2.3525 | |
| 482 | G | A | 0.8588 | |
| 483 | C | A | -0.4026 | |
| 484 | K | A | -2.0981 | |
| 485 | K | A | -1.9807 | |
| 486 | C | A | -0.5245 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine