| Chain sequence(s) |
A: YLPPTTPVAKVQSTDEYVYPTSLFCHAHTDRLLTVGHPFKDIVKNGKVVVPKVSGYQWRVFRLKFPDPNKFALPQKDFYDPEKERLVWRLRGLEIGRGGPLGKGTVGHPLFNKLGDTENPTEPVHEGPDVRVNFSFDPKQTQLFIVGCEPPTGEHWDLAEPCPGLPPGACPPIQLVNSVIEDGDMCDIGFGNMNFKELQQDRSGVPLDIVSTRCKWPDFLKMTNEAYGDKMFFFGRREQVYARHFFRRAGPVGHPLPAAPPPSPLYVPPPPTSPYWVLPSYDYFGTPSGSLVSSDGQLFNRPFWLQRAQGNNNGVCWHNELFVTVVDNTRNTNFTISQQLCTPEINVYDPSCFKNYLRHVEQFELSLIAQLCKVPLDPGVLAHINTMNPTILENWNLGFVPPKEREDPYKGLIFWEVDLTERFSQDLDQFALGRKFLYQ
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:04)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Y | A | 1.9484 | |
| 2 | L | A | 1.9708 | |
| 3 | P | A | 0.6485 | |
| 4 | P | A | 0.3705 | |
| 5 | T | A | 0.1206 | |
| 6 | T | A | 0.1265 | |
| 7 | P | A | 0.1769 | |
| 8 | V | A | 1.2167 | |
| 9 | A | A | 0.0258 | |
| 10 | K | A | -1.1664 | |
| 11 | V | A | -0.4281 | |
| 12 | Q | A | -1.5546 | |
| 13 | S | A | -1.6280 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.4710 | |
| 16 | E | A | -2.4662 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | Y | A | 0.4490 | |
| 20 | P | A | 0.0987 | |
| 21 | T | A | 0.1140 | |
| 22 | S | A | -0.1724 | |
| 23 | L | A | 0.0000 | |
| 24 | F | A | -0.1149 | |
| 25 | C | A | 0.0000 | |
| 26 | H | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | H | A | -1.2682 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -2.8728 | |
| 31 | R | A | -2.6459 | |
| 32 | L | A | -0.7711 | |
| 33 | L | A | 1.1542 | |
| 34 | T | A | 1.3394 | |
| 35 | V | A | 1.7699 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -0.2416 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | -0.6106 | |
| 40 | K | A | -1.6232 | |
| 41 | D | A | -0.8958 | |
| 42 | I | A | 0.8359 | |
| 43 | V | A | 1.0322 | |
| 44 | K | A | -1.1823 | |
| 45 | N | A | -1.9258 | |
| 46 | G | A | -1.2308 | |
| 47 | K | A | -0.9444 | |
| 48 | V | A | 1.5131 | |
| 49 | V | A | 2.0621 | |
| 50 | V | A | 1.2699 | |
| 51 | P | A | 0.4633 | |
| 52 | K | A | -0.6384 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | G | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | R | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.1174 | |
| 65 | F | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.4841 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.2659 | |
| 70 | K | A | -1.8098 | |
| 71 | F | A | -0.6642 | |
| 72 | A | A | -0.5750 | |
| 73 | L | A | -0.8695 | |
| 74 | P | A | -1.2650 | |
| 75 | Q | A | -2.4795 | |
| 76 | K | A | -3.0953 | |
| 77 | D | A | -2.9919 | |
| 78 | F | A | -1.6478 | |
| 79 | Y | A | -1.9301 | |
| 80 | D | A | -2.7675 | |
| 81 | P | A | -2.3516 | |
| 82 | E | A | -3.0761 | |
| 83 | K | A | -3.4456 | |
| 84 | E | A | -2.5070 | |
| 85 | R | A | -1.3185 | |
| 86 | L | A | 0.0000 | |
| 87 | V | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.6648 | |
| 92 | G | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | E | A | -0.9456 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | -1.3149 | |
| 97 | R | A | 0.0000 | |
| 98 | G | A | -0.6818 | |
| 99 | G | A | -0.5367 | |
| 100 | P | A | -0.4408 | |
| 101 | L | A | -0.0360 | |
| 102 | G | A | -0.4368 | |
| 103 | K | A | -1.0906 | |
| 104 | G | A | 0.0000 | |
| 105 | T | A | -0.5437 | |
| 106 | V | A | 0.0000 | |
| 107 | G | A | -0.1070 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | -0.1982 | |
| 110 | L | A | -0.0639 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -1.2140 | |
| 113 | K | A | -0.5872 | |
| 114 | L | A | 0.0000 | |
| 115 | G | A | 0.0000 | |
| 116 | D | A | -1.6521 | |
| 117 | T | A | -1.3906 | |
| 118 | E | A | -2.5442 | |
| 119 | N | A | -2.6676 | |
| 120 | P | A | -2.0996 | |
| 121 | T | A | -1.7404 | |
| 122 | E | A | -2.2787 | |
| 123 | P | A | -1.4092 | |
| 124 | V | A | -1.0543 | |
| 125 | H | A | -1.9471 | |
| 126 | E | A | -2.6838 | |
| 127 | G | A | -2.1610 | |
| 128 | P | A | -1.8411 | |
| 129 | D | A | -2.3297 | |
| 130 | V | A | -1.5201 | |
| 131 | R | A | -1.1444 | |
| 132 | V | A | -0.3380 | |
| 133 | N | A | -0.9126 | |
| 134 | F | A | -0.3748 | |
| 135 | S | A | -0.3638 | |
| 136 | F | A | 0.0000 | |
| 137 | D | A | -0.7888 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | Q | A | -0.2361 | |
| 141 | T | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | C | A | 0.0000 | |
| 149 | E | A | -0.5630 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | 0.0000 | |
| 153 | G | A | 0.0000 | |
| 154 | E | A | -0.2237 | |
| 155 | H | A | 0.0000 | |
| 156 | W | A | 1.0947 | |
| 157 | D | A | 0.2584 | |
| 158 | L | A | 0.7355 | |
| 159 | A | A | 0.1247 | |
| 160 | E | A | -1.4639 | |
| 161 | P | A | -0.2164 | |
| 162 | C | A | 0.1937 | |
| 163 | P | A | -0.1662 | |
| 164 | G | A | -0.0755 | |
| 165 | L | A | 0.5949 | |
| 166 | P | A | -0.1169 | |
| 167 | P | A | -0.3418 | |
| 168 | G | A | -0.4454 | |
| 169 | A | A | -0.0234 | |
| 170 | C | A | 0.6557 | |
| 171 | P | A | 0.5003 | |
| 172 | P | A | 0.6368 | |
| 173 | I | A | 1.8823 | |
| 174 | Q | A | 0.7865 | |
| 175 | L | A | 1.4603 | |
| 176 | V | A | 0.8312 | |
| 177 | N | A | -0.3121 | |
| 178 | S | A | 0.0383 | |
| 179 | V | A | 0.4469 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | 0.3811 | |
| 182 | D | A | 0.0850 | |
| 183 | G | A | -0.1625 | |
| 184 | D | A | -0.5671 | |
| 185 | M | A | 0.0000 | |
| 186 | C | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | 0.1286 | |
| 190 | F | A | 0.0495 | |
| 191 | G | A | -0.1141 | |
| 192 | N | A | -0.2851 | |
| 193 | M | A | -0.1737 | |
| 194 | N | A | 0.0000 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -3.4424 | |
| 197 | E | A | -2.6596 | |
| 198 | L | A | -1.2645 | |
| 199 | Q | A | -2.5594 | |
| 200 | Q | A | -3.3529 | |
| 201 | D | A | -3.6082 | |
| 202 | R | A | -3.3502 | |
| 203 | S | A | 0.0000 | |
| 204 | G | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | L | A | 0.1766 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | V | A | -1.3973 | |
| 211 | S | A | -1.9270 | |
| 212 | T | A | -1.4919 | |
| 213 | R | A | -2.1847 | |
| 214 | C | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | W | A | -0.1749 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | F | A | 0.3255 | |
| 220 | L | A | 0.5538 | |
| 221 | K | A | -1.2110 | |
| 222 | M | A | 0.0000 | |
| 223 | T | A | -0.9349 | |
| 224 | N | A | -1.5471 | |
| 225 | E | A | -1.3056 | |
| 226 | A | A | -0.6760 | |
| 227 | Y | A | -0.4547 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | K | A | -0.6934 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | F | A | -0.1358 | |
| 234 | F | A | 0.0366 | |
| 235 | G | A | -0.9028 | |
| 236 | R | A | -2.6244 | |
| 237 | R | A | -2.8464 | |
| 238 | E | A | -2.0596 | |
| 239 | Q | A | -0.1211 | |
| 240 | V | A | 1.5272 | |
| 241 | Y | A | 1.2298 | |
| 242 | A | A | 0.1306 | |
| 243 | R | A | -1.2216 | |
| 244 | H | A | -1.2285 | |
| 245 | F | A | -0.2713 | |
| 246 | F | A | 0.0000 | |
| 247 | R | A | -0.2222 | |
| 248 | R | A | -0.4872 | |
| 249 | A | A | -1.1336 | |
| 250 | G | A | -1.0607 | |
| 251 | P | A | -0.6637 | |
| 252 | V | A | -0.5048 | |
| 253 | G | A | -0.9173 | |
| 254 | H | A | -1.1405 | |
| 255 | P | A | -0.4765 | |
| 256 | L | A | 0.4552 | |
| 257 | P | A | 0.0259 | |
| 258 | A | A | 0.0337 | |
| 259 | A | A | 0.3086 | |
| 260 | P | A | -0.2334 | |
| 261 | P | A | -0.1477 | |
| 262 | P | A | 0.0547 | |
| 263 | S | A | 0.6264 | |
| 264 | P | A | 0.6988 | |
| 265 | L | A | 1.9183 | |
| 266 | Y | A | 1.7819 | |
| 267 | V | A | 1.9686 | |
| 268 | P | A | 1.4898 | |
| 269 | P | A | 1.0905 | |
| 270 | P | A | 0.1615 | |
| 271 | P | A | 0.2518 | |
| 272 | T | A | 0.0530 | |
| 273 | S | A | 0.6909 | |
| 274 | P | A | 1.0456 | |
| 275 | Y | A | 2.3379 | |
| 276 | W | A | 2.4151 | |
| 277 | V | A | 2.8988 | |
| 278 | L | A | 2.1842 | |
| 279 | P | A | 0.6067 | |
| 280 | S | A | 0.0000 | |
| 281 | Y | A | 0.2360 | |
| 282 | D | A | -0.3541 | |
| 283 | Y | A | 1.0135 | |
| 284 | F | A | 0.7470 | |
| 285 | G | A | 0.0770 | |
| 286 | T | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | S | A | 0.0000 | |
| 289 | G | A | 0.0000 | |
| 290 | S | A | 0.8556 | |
| 291 | L | A | 1.5435 | |
| 292 | V | A | 0.5212 | |
| 293 | S | A | -0.1689 | |
| 294 | S | A | -0.9678 | |
| 295 | D | A | -1.8461 | |
| 296 | G | A | 0.0000 | |
| 297 | Q | A | 0.0000 | |
| 298 | L | A | -1.1209 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.6277 | |
| 301 | R | A | -1.8362 | |
| 302 | P | A | -0.9390 | |
| 303 | F | A | -0.1659 | |
| 304 | W | A | -0.5091 | |
| 305 | L | A | 0.0000 | |
| 306 | Q | A | -2.0839 | |
| 307 | R | A | -2.9315 | |
| 308 | A | A | 0.0000 | |
| 309 | Q | A | -1.6535 | |
| 310 | G | A | -1.4204 | |
| 311 | N | A | -1.4062 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | C | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.9767 | |
| 319 | N | A | -0.9004 | |
| 320 | E | A | -1.0579 | |
| 321 | L | A | 0.0000 | |
| 322 | F | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.4471 | |
| 331 | N | A | 0.0000 | |
| 332 | T | A | -0.2277 | |
| 333 | N | A | 0.4789 | |
| 334 | F | A | 1.7581 | |
| 335 | T | A | 0.8851 | |
| 336 | I | A | 0.4692 | |
| 337 | S | A | -0.8688 | |
| 338 | Q | A | -1.5377 | |
| 339 | Q | A | -1.1847 | |
| 340 | L | A | 0.6482 | |
| 341 | C | A | 0.2093 | |
| 342 | T | A | -0.2221 | |
| 343 | P | A | -0.9892 | |
| 344 | E | A | -1.6777 | |
| 345 | I | A | -0.1762 | |
| 346 | N | A | -0.4429 | |
| 347 | V | A | 1.5246 | |
| 348 | Y | A | 1.5906 | |
| 349 | D | A | 0.0548 | |
| 350 | P | A | -0.3903 | |
| 351 | S | A | -0.2933 | |
| 352 | C | A | 0.0000 | |
| 353 | F | A | -0.6228 | |
| 354 | K | A | -1.6771 | |
| 355 | N | A | -1.6982 | |
| 356 | Y | A | -0.0598 | |
| 357 | L | A | 0.6530 | |
| 358 | R | A | 0.9462 | |
| 359 | H | A | 0.0000 | |
| 360 | V | A | 1.3381 | |
| 361 | E | A | 0.0000 | |
| 362 | Q | A | -0.0376 | |
| 363 | F | A | 0.0000 | |
| 364 | E | A | -1.9322 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | -0.6631 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | A | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.2831 | |
| 374 | V | A | 0.0000 | |
| 375 | P | A | -1.3251 | |
| 376 | L | A | -1.7557 | |
| 377 | D | A | -2.0388 | |
| 378 | P | A | -1.0645 | |
| 379 | G | A | -1.0242 | |
| 380 | V | A | -0.9346 | |
| 381 | L | A | -0.5448 | |
| 382 | A | A | -0.6655 | |
| 383 | H | A | -0.8564 | |
| 384 | I | A | 0.0000 | |
| 385 | N | A | -1.4196 | |
| 386 | T | A | -0.5868 | |
| 387 | M | A | -0.3411 | |
| 388 | N | A | -0.8809 | |
| 389 | P | A | -1.3020 | |
| 390 | T | A | -1.6378 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | -1.5938 | |
| 393 | E | A | -3.0464 | |
| 394 | N | A | -2.8780 | |
| 395 | W | A | -1.6116 | |
| 396 | N | A | -1.4164 | |
| 397 | L | A | -0.2488 | |
| 398 | G | A | 0.5100 | |
| 399 | F | A | 2.4240 | |
| 400 | V | A | 1.8454 | |
| 401 | P | A | 0.0506 | |
| 402 | P | A | -2.0313 | |
| 403 | K | A | -3.6820 | |
| 404 | E | A | -4.1279 | |
| 405 | R | A | -4.7044 | |
| 406 | E | A | -4.1309 | |
| 407 | D | A | -3.0263 | |
| 408 | P | A | -1.8509 | |
| 409 | Y | A | -0.9778 | |
| 410 | K | A | -2.0967 | |
| 411 | G | A | -0.6407 | |
| 412 | L | A | 0.6656 | |
| 413 | I | A | 1.5830 | |
| 414 | F | A | 0.0000 | |
| 415 | W | A | -0.3910 | |
| 416 | E | A | -1.6544 | |
| 417 | V | A | 0.0000 | |
| 418 | D | A | -2.9219 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -2.0526 | |
| 421 | E | A | -2.7766 | |
| 422 | R | A | -2.5626 | |
| 423 | F | A | -1.2939 | |
| 424 | S | A | -1.4612 | |
| 425 | Q | A | -1.7842 | |
| 426 | D | A | -2.8957 | |
| 427 | L | A | -2.0020 | |
| 428 | D | A | -2.7802 | |
| 429 | Q | A | -2.6169 | |
| 430 | F | A | -1.4440 | |
| 431 | A | A | -0.9221 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -1.6629 | |
| 435 | K | A | -0.7761 | |
| 436 | F | A | 0.1220 | |
| 437 | L | A | 1.0023 | |
| 438 | Y | A | 0.7991 | |
| 439 | Q | A | -0.2806 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine