Project name: 9c06b9244b5eca8

Chain sequence(s)	H: EVQLVESGGDLVKPGGSLKLSCAASGFTFSSYGMSWVRQTPDKRLEWVATISSGGSYIYYPDSVKGRFTISRDNAKNTLYLQMSSLKSEDTAMYYCARHVLLYYNMDYWGQGTSVTVSS; L: DIQMNQSPSSLSASLGDTITITCHASQNINVWLSWYQQKPGNIPKLLIYKASNLHTGVPSRFSGSGSGTGFTLTISSLQPEDIATYYCQQGQSFPWTFGGGTKLEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:01:09)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:10)

• Minimal score value: -3.6168
• Maximal score value: 2.6963
• Average score: -0.515
• Total score value: -116.3937

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-1.9977
2	V	H	-0.9243
3	Q	H	-0.8032
4	L	H	0.0000
5	V	H	1.0241
6	E	H	0.0000
7	S	H	-0.6230
8	G	H	-1.3173
9	G	H	-1.2313
11	D	H	-1.6585
12	L	H	0.0259
13	V	H	-0.8901
14	K	H	-2.1054
15	P	H	-1.8477
16	G	H	-1.4930
17	G	H	-1.0781
18	S	H	-1.0764
19	L	H	-1.0682
20	K	H	-2.0220
21	L	H	0.0000
22	S	H	-0.3795
23	C	H	0.0000
24	A	H	-0.0785
25	A	H	0.0000
26	S	H	-0.7044
27	G	H	-1.1295
28	F	H	-0.4697
29	T	H	-0.2174
30	F	H	0.0000
35	S	H	-0.7695
36	S	H	-0.0011
37	Y	H	0.6137
38	G	H	0.8135
39	M	H	0.0000
40	S	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	R	H	0.0000
44	Q	H	0.0000
45	T	H	-2.2181
46	P	H	-2.1441
47	D	H	-3.3040
48	K	H	-3.6168
49	R	H	-3.4578
50	L	H	0.0000
51	E	H	-1.0736
52	W	H	0.0000
53	V	H	0.0000
54	A	H	0.0000
55	T	H	0.9800
56	I	H	0.0000
57	S	H	0.4718
58	S	H	-0.0126
59	G	H	-0.5469
62	G	H	-0.0525
63	S	H	0.4151
64	Y	H	1.7505
65	I	H	2.0099
66	Y	H	1.6100
67	Y	H	-0.0443
68	P	H	0.0000
69	D	H	-2.4012
70	S	H	-1.7742
71	V	H	0.0000
72	K	H	-2.4601
74	G	H	-1.7191
75	R	H	-1.5599
76	F	H	0.0000
77	T	H	-0.6452
78	I	H	0.0000
79	S	H	-0.3288
80	R	H	-0.9482
81	D	H	-1.4223
82	N	H	-1.5475
83	A	H	-1.3054
84	K	H	-2.2488
85	N	H	-1.7294
86	T	H	-0.9562
87	L	H	0.0000
88	Y	H	-0.5594
89	L	H	0.0000
90	Q	H	-1.4218
91	M	H	0.0000
92	S	H	-1.0403
93	S	H	-1.1381
94	L	H	0.0000
95	K	H	-2.3164
96	S	H	-1.9849
97	E	H	-2.3694
98	D	H	0.0000
99	T	H	-0.7405
100	A	H	0.0000
101	M	H	-0.2062
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	A	H	0.0000
106	R	H	0.0000
107	H	H	0.0000
108	V	H	1.7866
109	L	H	2.6548
110	L	H	2.6963
112	Y	H	1.9395
113	Y	H	1.5358
114	N	H	0.0000
115	M	H	0.0000
116	D	H	0.1939
117	Y	H	0.2698
118	W	H	0.0000
119	G	H	0.0000
120	Q	H	-1.0562
121	G	H	-0.4676
122	T	H	-0.5438
123	S	H	-0.5902
124	V	H	0.0000
125	T	H	-0.6958
126	V	H	0.0000
127	S	H	-1.0080
128	S	H	-0.7820
1	D	L	-2.1470
2	I	L	0.0000
3	Q	L	-2.3857
4	M	L	0.0000
5	N	L	-2.2173
6	Q	L	-1.3095
7	S	L	-0.9828
8	P	L	-0.7016
9	S	L	-0.8879
10	S	L	-0.7479
11	L	L	-0.4160
12	S	L	-0.5144
13	A	L	0.0000
14	S	L	-0.4486
15	L	L	0.2799
16	G	L	-0.3934
17	D	L	-0.6643
18	T	L	-0.5116
19	I	L	0.0000
20	T	L	-0.1875
21	I	L	0.0000
22	T	L	-0.6853
23	C	L	0.0000
24	H	L	-2.0704
25	A	L	0.0000
26	S	L	-1.9664
27	Q	L	-2.2014
28	N	L	-1.9290
29	I	L	0.0000
36	N	L	-1.1752
37	V	L	-0.2325
38	W	L	0.0770
39	L	L	0.0000
40	S	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	Q	L	-0.9491
44	Q	L	-1.2445
45	K	L	-1.6141
46	P	L	-0.9998
47	G	L	-1.2495
48	N	L	-1.9480
49	I	L	-1.2455
50	P	L	0.0000
51	K	L	-1.5650
52	L	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	Y	L	0.0748
56	K	L	-0.3690
57	A	L	0.0000
65	S	L	-0.5914
66	N	L	-0.7670
67	L	L	-0.0809
68	H	L	-0.3345
69	T	L	-0.3038
70	G	L	-0.4120
71	V	L	-0.2590
72	P	L	-0.3208
74	S	L	-0.4009
75	R	L	-0.6138
76	F	L	0.0000
77	S	L	-0.4463
78	G	L	-0.4717
79	S	L	-0.6259
80	G	L	-0.7543
83	S	L	-0.8391
84	G	L	-1.1449
85	T	L	-1.2851
86	G	L	-1.1491
87	F	L	0.0000
88	T	L	-0.4651
89	L	L	0.0000
90	T	L	-0.2660
91	I	L	0.0000
92	S	L	-0.6951
93	S	L	-0.5919
94	L	L	0.0000
95	Q	L	-0.6707
96	P	L	-0.7455
97	E	L	-1.3380
98	D	L	0.0000
99	I	L	-0.1308
100	A	L	0.0000
101	T	L	-0.9860
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	Q	L	0.0000
106	Q	L	0.0000
107	G	L	0.1981
108	Q	L	-0.3061
109	S	L	-0.2258
114	F	L	0.3187
115	P	L	-0.3860
116	W	L	0.0000
117	T	L	-0.7360
118	F	L	0.0000
119	G	L	0.0000
120	G	L	-2.1068
121	G	L	0.0000
122	T	L	0.0000
123	K	L	-1.3424
124	L	L	0.0000
125	E	L	-0.4634
126	I	L	-0.2723
127	K	L	-1.3214