| Chain sequence(s) |
A: GEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLMDEEDMDDVVDADEYLIP
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:08)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:08)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:08)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:08)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:08)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:08:53)
[INFO] Main: Simulation completed successfully. (00:08:56)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 672 | G | A | -1.5841 | |
| 673 | E | A | -2.3740 | |
| 674 | A | A | -1.3584 | |
| 675 | P | A | -1.3546 | |
| 676 | N | A | -1.2208 | |
| 677 | Q | A | -1.0493 | |
| 678 | A | A | 0.0512 | |
| 679 | L | A | 1.7635 | |
| 680 | L | A | 1.8126 | |
| 681 | R | A | 0.8327 | |
| 682 | I | A | 1.6639 | |
| 683 | L | A | 0.0000 | |
| 684 | K | A | -2.1647 | |
| 685 | E | A | -2.6083 | |
| 686 | T | A | -1.9788 | |
| 687 | E | A | 0.0000 | |
| 688 | F | A | 0.0000 | |
| 689 | K | A | -1.9670 | |
| 690 | K | A | -1.5015 | |
| 691 | I | A | 0.4121 | |
| 692 | K | A | -0.6642 | |
| 693 | V | A | 0.5580 | |
| 694 | L | A | 0.9429 | |
| 695 | G | A | 0.3557 | |
| 696 | S | A | 0.0191 | |
| 697 | G | A | -0.0045 | |
| 698 | A | A | 0.5012 | |
| 699 | F | A | 1.4203 | |
| 700 | G | A | -0.2111 | |
| 701 | T | A | 0.1911 | |
| 702 | V | A | 0.4167 | |
| 703 | Y | A | 0.1717 | |
| 704 | K | A | -0.5528 | |
| 705 | G | A | 0.0000 | |
| 706 | L | A | -0.3474 | |
| 707 | W | A | 0.0000 | |
| 708 | I | A | -1.2262 | |
| 709 | P | A | 0.0000 | |
| 710 | E | A | -2.7869 | |
| 711 | G | A | -2.4155 | |
| 712 | E | A | -3.2550 | |
| 713 | K | A | -2.7746 | |
| 714 | V | A | -1.2716 | |
| 715 | K | A | -1.3548 | |
| 716 | I | A | -0.1627 | |
| 717 | P | A | -0.4239 | |
| 718 | V | A | 0.0000 | |
| 719 | A | A | 0.0000 | |
| 720 | I | A | 0.0000 | |
| 721 | K | A | 0.0490 | |
| 722 | E | A | -0.6588 | |
| 723 | L | A | -0.9857 | |
| 724 | R | A | -2.4450 | |
| 725 | E | A | -2.7437 | |
| 726 | A | A | -1.4696 | |
| 727 | T | A | -1.2064 | |
| 728 | S | A | -1.4466 | |
| 729 | P | A | -1.7318 | |
| 730 | K | A | -2.8875 | |
| 731 | A | A | -1.9969 | |
| 732 | N | A | -2.4084 | |
| 733 | K | A | -3.5288 | |
| 734 | E | A | -3.3850 | |
| 735 | I | A | 0.0000 | |
| 736 | L | A | -1.3033 | |
| 737 | D | A | -2.5038 | |
| 738 | E | A | -1.7613 | |
| 739 | A | A | 0.0000 | |
| 740 | Y | A | 0.5692 | |
| 741 | V | A | 0.0000 | |
| 742 | M | A | 0.0000 | |
| 743 | A | A | 0.0000 | |
| 744 | S | A | -0.3111 | |
| 745 | V | A | 0.0000 | |
| 746 | D | A | -2.2065 | |
| 747 | N | A | -1.4818 | |
| 748 | P | A | -1.0121 | |
| 749 | H | A | 0.0000 | |
| 750 | V | A | 0.0000 | |
| 751 | C | A | 0.0000 | |
| 752 | R | A | -1.4551 | |
| 753 | L | A | 0.0000 | |
| 754 | L | A | 0.2837 | |
| 755 | G | A | 0.0000 | |
| 756 | I | A | 0.0000 | |
| 757 | C | A | 0.0000 | |
| 758 | L | A | 1.1202 | |
| 759 | T | A | -0.0262 | |
| 760 | S | A | -0.2494 | |
| 761 | T | A | 0.0000 | |
| 762 | V | A | 0.0000 | |
| 763 | Q | A | 0.0000 | |
| 764 | L | A | 0.0000 | |
| 765 | I | A | 0.0000 | |
| 766 | T | A | 0.0000 | |
| 767 | Q | A | -0.7480 | |
| 768 | L | A | -0.1409 | |
| 769 | M | A | 0.0000 | |
| 770 | P | A | 0.2022 | |
| 771 | F | A | 1.0441 | |
| 772 | G | A | 0.2098 | |
| 773 | C | A | -0.4699 | |
| 774 | L | A | 0.0000 | |
| 775 | L | A | 0.0000 | |
| 776 | D | A | -2.4967 | |
| 777 | Y | A | -1.6412 | |
| 778 | V | A | 0.0000 | |
| 779 | R | A | -2.8481 | |
| 780 | E | A | -3.4658 | |
| 781 | H | A | -3.1656 | |
| 782 | K | A | -3.4416 | |
| 783 | D | A | -3.9665 | |
| 784 | N | A | -3.3925 | |
| 785 | I | A | 0.0000 | |
| 786 | G | A | -1.9821 | |
| 787 | S | A | 0.0000 | |
| 788 | Q | A | -1.7034 | |
| 789 | Y | A | -0.3342 | |
| 790 | L | A | 0.0000 | |
| 791 | L | A | 0.0000 | |
| 792 | N | A | -0.8502 | |
| 793 | W | A | 0.0000 | |
| 794 | C | A | 0.0000 | |
| 795 | V | A | -0.3702 | |
| 796 | Q | A | 0.0000 | |
| 797 | I | A | 0.0000 | |
| 798 | A | A | 0.0000 | |
| 799 | K | A | -1.1817 | |
| 800 | G | A | 0.0000 | |
| 801 | M | A | 0.0000 | |
| 802 | N | A | -2.1736 | |
| 803 | Y | A | -1.8034 | |
| 804 | L | A | 0.0000 | |
| 805 | E | A | -2.4668 | |
| 806 | D | A | -2.6606 | |
| 807 | R | A | -2.2060 | |
| 808 | R | A | -2.5624 | |
| 809 | L | A | 0.0000 | |
| 810 | V | A | 0.0000 | |
| 811 | H | A | 0.0000 | |
| 812 | R | A | -0.5770 | |
| 813 | D | A | -0.7388 | |
| 814 | L | A | 0.0000 | |
| 815 | A | A | 0.0000 | |
| 816 | A | A | 0.0000 | |
| 817 | R | A | -2.0709 | |
| 818 | N | A | 0.0000 | |
| 819 | V | A | 0.0000 | |
| 820 | L | A | -0.3099 | |
| 821 | V | A | 0.0000 | |
| 822 | K | A | -0.5113 | |
| 823 | T | A | -0.4621 | |
| 824 | P | A | -0.4557 | |
| 825 | Q | A | -1.4482 | |
| 826 | H | A | -0.9960 | |
| 827 | V | A | 0.0000 | |
| 828 | K | A | -0.5026 | |
| 829 | I | A | 0.0000 | |
| 830 | T | A | 0.0000 | |
| 831 | D | A | -1.9620 | |
| 832 | F | A | 0.0000 | |
| 833 | G | A | -1.6656 | |
| 834 | L | A | -1.1670 | |
| 835 | A | A | -0.9938 | |
| 836 | K | A | -1.2589 | |
| 837 | L | A | -0.9011 | |
| 838 | L | A | 0.0000 | |
| 839 | G | A | -2.4267 | |
| 840 | A | A | -2.4113 | |
| 841 | E | A | -3.5084 | |
| 842 | E | A | -3.8812 | |
| 843 | K | A | -3.6184 | |
| 844 | E | A | -2.8696 | |
| 845 | Y | A | -1.8635 | |
| 846 | H | A | -1.8239 | |
| 847 | A | A | -1.9297 | |
| 848 | E | A | -2.6160 | |
| 849 | G | A | -1.9649 | |
| 850 | G | A | -1.8278 | |
| 851 | K | A | -2.0416 | |
| 852 | V | A | -0.7654 | |
| 853 | P | A | -0.2868 | |
| 854 | I | A | -0.0939 | |
| 855 | K | A | -0.2971 | |
| 856 | W | A | 0.0000 | |
| 857 | M | A | 0.0000 | |
| 858 | A | A | 0.0000 | |
| 859 | L | A | 0.0000 | |
| 860 | E | A | -0.2466 | |
| 861 | S | A | 0.0000 | |
| 862 | I | A | 0.1261 | |
| 863 | L | A | 0.2607 | |
| 864 | H | A | -1.0173 | |
| 865 | R | A | -1.6434 | |
| 866 | I | A | -1.2307 | |
| 867 | Y | A | 0.0000 | |
| 868 | T | A | -1.3604 | |
| 869 | H | A | -1.5354 | |
| 870 | Q | A | -1.3326 | |
| 871 | S | A | 0.0000 | |
| 872 | D | A | 0.0000 | |
| 873 | V | A | 0.0000 | |
| 874 | W | A | 0.0000 | |
| 875 | S | A | 0.0000 | |
| 876 | Y | A | 0.0000 | |
| 877 | G | A | 0.0000 | |
| 878 | V | A | 0.0000 | |
| 879 | T | A | 0.0000 | |
| 880 | V | A | 0.0000 | |
| 881 | W | A | 0.0000 | |
| 882 | E | A | 0.0000 | |
| 883 | L | A | 0.0000 | |
| 884 | M | A | 0.0000 | |
| 885 | T | A | -0.5767 | |
| 886 | F | A | -1.2696 | |
| 887 | G | A | -1.4950 | |
| 888 | S | A | -1.1774 | |
| 889 | K | A | -2.2209 | |
| 890 | P | A | 0.0000 | |
| 891 | Y | A | -1.2503 | |
| 892 | D | A | -2.3974 | |
| 893 | G | A | -1.2798 | |
| 894 | I | A | -0.5690 | |
| 895 | P | A | -0.7403 | |
| 896 | A | A | -0.4209 | |
| 897 | S | A | -0.7706 | |
| 898 | E | A | -1.2637 | |
| 899 | I | A | 0.0000 | |
| 900 | S | A | -1.0170 | |
| 901 | S | A | -2.0008 | |
| 902 | I | A | 0.0000 | |
| 903 | L | A | 0.0000 | |
| 904 | E | A | -3.0113 | |
| 905 | K | A | -3.4507 | |
| 906 | G | A | -2.6132 | |
| 907 | E | A | -3.1730 | |
| 908 | R | A | -1.8806 | |
| 909 | L | A | 0.0000 | |
| 910 | P | A | -0.9980 | |
| 911 | Q | A | -0.6882 | |
| 912 | P | A | 0.0000 | |
| 913 | P | A | -0.2137 | |
| 914 | I | A | 0.0000 | |
| 915 | C | A | 0.0000 | |
| 916 | T | A | 0.4488 | |
| 917 | I | A | 1.5155 | |
| 918 | D | A | -0.1755 | |
| 919 | V | A | 0.0000 | |
| 920 | Y | A | 0.5304 | |
| 921 | M | A | 0.6841 | |
| 922 | I | A | 0.1743 | |
| 923 | M | A | 0.0000 | |
| 924 | V | A | 0.1536 | |
| 925 | K | A | -0.4068 | |
| 926 | C | A | 0.0000 | |
| 927 | W | A | 0.0000 | |
| 928 | M | A | 0.0719 | |
| 929 | I | A | 0.5651 | |
| 930 | D | A | -1.3527 | |
| 931 | A | A | -1.5213 | |
| 932 | D | A | -2.3592 | |
| 933 | S | A | -1.5760 | |
| 934 | R | A | 0.0000 | |
| 935 | P | A | -1.8309 | |
| 936 | K | A | -2.7848 | |
| 937 | F | A | 0.0000 | |
| 938 | R | A | -2.6692 | |
| 939 | E | A | -1.8988 | |
| 940 | L | A | 0.0000 | |
| 941 | I | A | -0.9210 | |
| 942 | I | A | -0.3191 | |
| 943 | E | A | -1.2177 | |
| 944 | F | A | 0.0000 | |
| 945 | S | A | -1.3546 | |
| 946 | K | A | -2.5021 | |
| 947 | M | A | 0.0000 | |
| 948 | A | A | 0.0000 | |
| 949 | R | A | -3.5625 | |
| 950 | D | A | -3.5316 | |
| 951 | P | A | -2.5539 | |
| 952 | Q | A | -2.3979 | |
| 953 | R | A | -2.7512 | |
| 954 | Y | A | -1.0093 | |
| 955 | L | A | 0.0000 | |
| 956 | V | A | 0.7555 | |
| 957 | I | A | -0.4481 | |
| 958 | Q | A | -1.4878 | |
| 959 | G | A | -2.1467 | |
| 960 | D | A | -2.6964 | |
| 961 | E | A | -3.5796 | |
| 962 | R | A | -3.4449 | |
| 963 | M | A | -1.4845 | |
| 964 | H | A | -0.8601 | |
| 977 | L | A | 1.1038 | |
| 978 | M | A | -0.0036 | |
| 979 | D | A | -2.5334 | |
| 980 | E | A | -3.3094 | |
| 981 | E | A | -3.8729 | |
| 982 | D | A | -3.4140 | |
| 983 | M | A | -1.9865 | |
| 984 | D | A | -2.2921 | |
| 985 | D | A | -1.3586 | |
| 986 | V | A | 0.3225 | |
| 987 | V | A | 0.6712 | |
| 988 | D | A | -1.3308 | |
| 989 | A | A | -0.9574 | |
| 990 | D | A | -2.2248 | |
| 991 | E | A | -1.5785 | |
| 992 | Y | A | 0.9822 | |
| 993 | L | A | 2.2488 | |
| 994 | I | A | 2.7268 | |
| 995 | P | A | 1.3200 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine