Project name: 9dcf16bd1a64fc2

Chain sequence(s)	H: EVQLVESGGGLVQPGGSLRLSCAASGFNIKDTYIHWVRQAPGKGLEWVARIYPTNGYTRYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCSRWGGDGFYAMDYWGQGTLVTVSS; L: DIQMTQSPSSLSASVGDRVTITCRASQDVNTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQHYTTPPTFGQGTKVEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:01)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:01)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:01)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:01)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:01)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:01:06)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:07)

• Minimal score value: -2.7687
• Maximal score value: 2.2536
• Average score: -0.6355
• Total score value: -144.2594

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-2.0619
2	V	H	-1.2865
3	Q	H	-1.3045
4	L	H	0.0000
5	V	H	0.1426
6	E	H	0.0000
7	S	H	-0.4231
8	G	H	-0.7737
9	G	H	0.0863
11	G	H	0.8474
12	L	H	1.3405
13	V	H	0.0000
14	Q	H	-1.3990
15	P	H	-1.6928
16	G	H	-1.5578
17	G	H	-1.1414
18	S	H	-1.5090
19	L	H	-1.1669
20	R	H	-2.2425
21	L	H	0.0000
22	S	H	-0.5073
23	C	H	0.0000
24	A	H	-0.2850
25	A	H	-0.6129
26	S	H	-0.9105
27	G	H	-1.2560
28	F	H	-1.1806
29	N	H	-1.8514
30	I	H	0.0000
35	K	H	-2.3871
36	D	H	-2.7687
37	T	H	0.0000
38	Y	H	-0.4841
39	I	H	0.0000
40	H	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	R	H	0.0000
44	Q	H	-0.6314
45	A	H	-1.0311
46	P	H	-0.8262
47	G	H	-1.4625
48	K	H	-2.3858
49	G	H	-1.6710
50	L	H	0.0000
51	E	H	-1.0337
52	W	H	0.0000
53	V	H	0.0000
54	A	H	0.0000
55	R	H	-0.2612
56	I	H	0.0000
57	Y	H	-0.3486
58	P	H	-0.9724
59	T	H	-1.1168
62	N	H	-0.9016
63	G	H	-0.4522
64	Y	H	0.6756
65	T	H	-0.0170
66	R	H	-1.0512
67	Y	H	-1.3968
68	A	H	-1.6120
69	D	H	-2.6076
70	S	H	-1.7754
71	V	H	0.0000
72	K	H	-2.7559
74	G	H	-1.8147
75	R	H	-1.7046
76	F	H	0.0000
77	T	H	-1.2021
78	I	H	0.0000
79	S	H	-0.1663
80	A	H	-0.7789
81	D	H	-1.2548
82	T	H	-1.3966
83	S	H	-1.4333
84	K	H	-2.1222
85	N	H	-1.5635
86	T	H	-0.8138
87	A	H	0.0000
88	Y	H	-0.5368
89	L	H	0.0000
90	Q	H	-1.7149
91	M	H	0.0000
92	N	H	-2.0081
93	S	H	-1.4679
94	L	H	0.0000
95	R	H	-2.4334
96	A	H	-1.7379
97	E	H	-2.2574
98	D	H	0.0000
99	T	H	-0.3869
100	A	H	0.0000
101	V	H	0.7142
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	S	H	0.0000
106	R	H	-0.3329
107	W	H	0.0000
108	G	H	-0.5877
109	G	H	-1.3130
110	D	H	-2.1710
111	G	H	-1.1324
112	F	H	-0.3882
113	Y	H	-0.0137
114	A	H	0.0000
115	M	H	0.0000
116	D	H	-0.3058
117	Y	H	-0.4208
118	W	H	0.0000
119	G	H	0.0000
120	Q	H	-1.5489
121	G	H	-0.4460
122	T	H	0.4643
123	L	H	1.6945
124	V	H	0.0000
125	T	H	0.3178
126	V	H	0.0000
127	S	H	-0.5870
128	S	H	-0.5636
1	D	L	-2.2351
2	I	L	0.0000
3	Q	L	-2.3046
4	M	L	0.0000
5	T	L	-1.4314
6	Q	L	0.0000
7	S	L	-0.8683
8	P	L	-0.6184
9	S	L	-0.8554
10	S	L	-0.8481
11	L	L	-0.6149
12	S	L	-0.9808
13	A	L	0.0000
14	S	L	-0.9601
15	V	L	-0.0781
16	G	L	-0.9502
17	D	L	-2.2081
18	R	L	-2.5252
19	V	L	0.0000
20	T	L	-0.6723
21	I	L	0.0000
22	T	L	-0.7315
23	C	L	0.0000
24	R	L	-2.7018
25	A	L	0.0000
26	S	L	-2.0480
27	Q	L	-2.4594
28	D	L	-2.0884
29	V	L	0.0000
36	N	L	-1.4432
37	T	L	-0.7793
38	A	L	-0.0674
39	V	L	0.0000
40	A	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	Q	L	0.0000
44	Q	L	0.0000
45	K	L	-1.7331
46	P	L	-1.1880
47	G	L	-1.6679
48	K	L	-2.7006
49	A	L	-1.7890
50	P	L	0.0000
51	K	L	-1.9201
52	L	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	Y	L	1.1606
56	S	L	0.4805
57	A	L	0.0000
65	S	L	0.7576
66	F	L	2.2536
67	L	L	1.5575
68	Y	L	0.6997
69	S	L	0.0823
70	G	L	-0.3837
71	V	L	-0.2454
72	P	L	-0.2689
74	S	L	-0.3274
75	R	L	-0.6883
76	F	L	0.0000
77	S	L	0.1005
78	G	L	0.1046
79	S	L	-0.5243
80	R	L	-1.5341
83	S	L	-1.1733
84	G	L	-1.6020
85	T	L	-1.9321
86	D	L	-1.8525
87	F	L	0.0000
88	T	L	-0.7405
89	L	L	0.0000
90	T	L	-0.5981
91	I	L	0.0000
92	S	L	-1.3484
93	S	L	-1.3366
94	L	L	0.0000
95	Q	L	-0.8704
96	P	L	-0.8875
97	E	L	-1.6193
98	D	L	0.0000
99	F	L	-0.2671
100	A	L	0.0000
101	T	L	-0.7763
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	Q	L	0.0000
106	Q	L	0.0000
107	H	L	0.2916
108	Y	L	0.4619
109	T	L	0.0144
114	T	L	-0.3796
115	P	L	-0.7728
116	P	L	0.0000
117	T	L	-0.7770
118	F	L	0.0000
119	G	L	0.0000
120	Q	L	-1.8995
121	G	L	0.0000
122	T	L	0.0000
123	K	L	-1.3747
124	V	L	0.0000
125	E	L	-1.1291
126	I	L	-0.4814
127	K	L	-1.5302