| Chain sequence(s) |
A: YLPPTTPVAKVQSTDEYVYPTSLFCHAHTDRLLTVGHPFEDIVVNGKVLVPKVSGWQWRVFRLKFPDPNKFALPQKDFYDPEKERLVWRLRGLEIGRGGPLGKGSVGHPLFNKFGDTENPTEYQHCGADDRVPFSFDPKQTQLFIVGCEPPTGEHWDIAEPCPGLPPGACPPIQLVNSVIEDGDMCDIGFGNMNFKELQQDRSGVPLDIVSTRCKWPDFLKMTNEAYGDKMFFFGRREQVYARHFYVRCGPVGFPLPDAPPPSPLYVKPPASSPYAVLPPYDYFGTPSGSLVSSDGQLFNRPFWLQRAQGNNNGVCWHNELFVTVVDNTRNTNFTISQQLCTPEENVYDPSCFKNYLRHVEQFELSLIAQLCKVPLDPGVLAHINTMNPTILENWNLGFVPPKEREDPYKGLIFWEVDLTERFSQDLDQFALGRKFLYQ
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:06)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Y | A | 1.9445 | |
| 2 | L | A | 1.9649 | |
| 3 | P | A | 0.8391 | |
| 4 | P | A | 0.3808 | |
| 5 | T | A | 0.1285 | |
| 6 | T | A | 0.1354 | |
| 7 | P | A | 0.1878 | |
| 8 | V | A | 1.2044 | |
| 9 | A | A | 0.0883 | |
| 10 | K | A | -1.0240 | |
| 11 | V | A | -0.1789 | |
| 12 | Q | A | -1.4119 | |
| 13 | S | A | -1.5634 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.4410 | |
| 16 | E | A | -2.4502 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | Y | A | 0.4524 | |
| 20 | P | A | 0.1013 | |
| 21 | T | A | 0.1096 | |
| 22 | S | A | -0.1716 | |
| 23 | L | A | 0.0000 | |
| 24 | F | A | -0.1117 | |
| 25 | C | A | 0.0000 | |
| 26 | H | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | H | A | -1.2863 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -2.9025 | |
| 31 | R | A | -2.6937 | |
| 32 | L | A | -0.8108 | |
| 33 | L | A | 1.1524 | |
| 34 | T | A | 1.3635 | |
| 35 | V | A | 1.8053 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -0.2900 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | -0.7107 | |
| 40 | E | A | -1.8133 | |
| 41 | D | A | -0.7976 | |
| 42 | I | A | 1.2244 | |
| 43 | V | A | 2.1716 | |
| 44 | V | A | 1.6261 | |
| 45 | N | A | -0.5582 | |
| 46 | G | A | -0.3827 | |
| 47 | K | A | -0.1515 | |
| 48 | V | A | 1.9695 | |
| 49 | L | A | 2.5040 | |
| 50 | V | A | 1.3805 | |
| 51 | P | A | 0.2684 | |
| 52 | K | A | -0.7668 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | G | A | 0.0000 | |
| 56 | W | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | R | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.1376 | |
| 65 | F | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.3785 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.2674 | |
| 70 | K | A | -1.7893 | |
| 71 | F | A | -0.6403 | |
| 72 | A | A | -0.5828 | |
| 73 | L | A | -0.8874 | |
| 74 | P | A | -1.2937 | |
| 75 | Q | A | -2.5023 | |
| 76 | K | A | -3.1055 | |
| 77 | D | A | -2.9871 | |
| 78 | F | A | -1.6701 | |
| 79 | Y | A | -1.8809 | |
| 80 | D | A | -2.6762 | |
| 81 | P | A | -2.2973 | |
| 82 | E | A | -3.0401 | |
| 83 | K | A | -3.3855 | |
| 84 | E | A | -2.4485 | |
| 85 | R | A | -1.2827 | |
| 86 | L | A | 0.0000 | |
| 87 | V | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.6476 | |
| 92 | G | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | E | A | -0.9705 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | -1.3688 | |
| 97 | R | A | 0.0000 | |
| 98 | G | A | -0.7016 | |
| 99 | G | A | -0.5429 | |
| 100 | P | A | -0.4160 | |
| 101 | L | A | 0.0213 | |
| 102 | G | A | -0.2285 | |
| 103 | K | A | -0.6612 | |
| 104 | G | A | -0.5005 | |
| 105 | S | A | -0.5319 | |
| 106 | V | A | 0.0000 | |
| 107 | G | A | 0.0573 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | 0.2603 | |
| 110 | L | A | 0.2315 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -1.1382 | |
| 113 | K | A | -0.3571 | |
| 114 | F | A | -1.0269 | |
| 115 | G | A | -1.1700 | |
| 116 | D | A | -1.8888 | |
| 117 | T | A | -1.2744 | |
| 118 | E | A | -2.0062 | |
| 119 | N | A | -2.2838 | |
| 120 | P | A | -2.0956 | |
| 121 | T | A | -1.6690 | |
| 122 | E | A | -2.3051 | |
| 123 | Y | A | -0.6140 | |
| 124 | Q | A | -1.1927 | |
| 125 | H | A | -0.7755 | |
| 126 | C | A | -0.9824 | |
| 127 | G | A | -1.3687 | |
| 128 | A | A | -1.2601 | |
| 129 | D | A | -2.1594 | |
| 130 | D | A | -1.7105 | |
| 131 | R | A | -1.1643 | |
| 132 | V | A | 0.0062 | |
| 133 | P | A | 0.0904 | |
| 134 | F | A | 0.0848 | |
| 135 | S | A | -0.1872 | |
| 136 | F | A | 0.0000 | |
| 137 | D | A | -0.7068 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | Q | A | 0.0000 | |
| 141 | T | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | C | A | 0.0000 | |
| 149 | E | A | -0.5559 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | 0.0000 | |
| 153 | G | A | 0.0000 | |
| 154 | E | A | -0.2213 | |
| 155 | H | A | 0.0000 | |
| 156 | W | A | 1.1320 | |
| 157 | D | A | 0.3037 | |
| 158 | I | A | 0.8489 | |
| 159 | A | A | 0.1224 | |
| 160 | E | A | -1.4787 | |
| 161 | P | A | -0.2325 | |
| 162 | C | A | 0.1863 | |
| 163 | P | A | -0.1633 | |
| 164 | G | A | -0.0673 | |
| 165 | L | A | 0.6094 | |
| 166 | P | A | -0.1025 | |
| 167 | P | A | -0.3352 | |
| 168 | G | A | -0.4173 | |
| 169 | A | A | 0.3226 | |
| 170 | C | A | 1.1222 | |
| 171 | P | A | 0.5518 | |
| 172 | P | A | 0.7897 | |
| 173 | I | A | 2.0500 | |
| 174 | Q | A | 0.8537 | |
| 175 | L | A | 1.4418 | |
| 176 | V | A | 0.8361 | |
| 177 | N | A | -0.3356 | |
| 178 | S | A | -0.0008 | |
| 179 | V | A | 0.3881 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | 0.3705 | |
| 182 | D | A | 0.0764 | |
| 183 | G | A | -0.1596 | |
| 184 | D | A | -0.5362 | |
| 185 | M | A | 0.0000 | |
| 186 | C | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | 0.1310 | |
| 190 | F | A | 0.0723 | |
| 191 | G | A | -0.1025 | |
| 192 | N | A | -0.2601 | |
| 193 | M | A | -0.1225 | |
| 194 | N | A | 0.0000 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -3.3627 | |
| 197 | E | A | -2.5879 | |
| 198 | L | A | -1.2083 | |
| 199 | Q | A | -2.5421 | |
| 200 | Q | A | -3.2949 | |
| 201 | D | A | -3.5614 | |
| 202 | R | A | -3.3124 | |
| 203 | S | A | 0.0000 | |
| 204 | G | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | L | A | 0.1410 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | V | A | -1.3577 | |
| 211 | S | A | -1.8926 | |
| 212 | T | A | -1.4279 | |
| 213 | R | A | -2.0632 | |
| 214 | C | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | W | A | -0.1543 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | F | A | 0.3308 | |
| 220 | L | A | 0.5383 | |
| 221 | K | A | -1.2444 | |
| 222 | M | A | 0.0000 | |
| 223 | T | A | -0.8576 | |
| 224 | N | A | -1.5394 | |
| 225 | E | A | -1.2686 | |
| 226 | A | A | -0.6065 | |
| 227 | Y | A | -0.3628 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | K | A | -0.6970 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | F | A | 0.0707 | |
| 234 | F | A | 0.2556 | |
| 235 | G | A | -0.8213 | |
| 236 | R | A | -2.6001 | |
| 237 | R | A | -2.8564 | |
| 238 | E | A | -2.0990 | |
| 239 | Q | A | -0.1444 | |
| 240 | V | A | 1.4730 | |
| 241 | Y | A | 1.1038 | |
| 242 | A | A | 0.1675 | |
| 243 | R | A | -1.0899 | |
| 244 | H | A | -0.9490 | |
| 245 | F | A | -0.0482 | |
| 246 | Y | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | R | A | -0.4876 | |
| 249 | C | A | -0.7271 | |
| 250 | G | A | -0.7143 | |
| 251 | P | A | -0.1374 | |
| 252 | V | A | 0.4500 | |
| 253 | G | A | 0.4669 | |
| 254 | F | A | 1.7610 | |
| 255 | P | A | 0.6551 | |
| 256 | L | A | 0.6535 | |
| 257 | P | A | -0.4319 | |
| 258 | D | A | -1.9497 | |
| 259 | A | A | -0.9141 | |
| 260 | P | A | -0.9331 | |
| 261 | P | A | -0.5763 | |
| 262 | P | A | -0.1518 | |
| 263 | S | A | 0.0177 | |
| 264 | P | A | 0.7183 | |
| 265 | L | A | 1.5292 | |
| 266 | Y | A | 1.1688 | |
| 267 | V | A | 1.1558 | |
| 268 | K | A | -0.7657 | |
| 269 | P | A | 0.0524 | |
| 270 | P | A | -0.3714 | |
| 271 | A | A | -0.0420 | |
| 272 | S | A | 0.0059 | |
| 273 | S | A | 0.3142 | |
| 274 | P | A | 0.5598 | |
| 275 | Y | A | 1.3114 | |
| 276 | A | A | 1.0796 | |
| 277 | V | A | 2.2387 | |
| 278 | L | A | 1.5761 | |
| 279 | P | A | 0.5696 | |
| 280 | P | A | 0.0000 | |
| 281 | Y | A | 0.5166 | |
| 282 | D | A | -0.1726 | |
| 283 | Y | A | 0.9570 | |
| 284 | F | A | 0.7767 | |
| 285 | G | A | 0.2459 | |
| 286 | T | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | S | A | 0.0000 | |
| 289 | G | A | 0.0000 | |
| 290 | S | A | 0.9090 | |
| 291 | L | A | 1.6207 | |
| 292 | V | A | 0.6244 | |
| 293 | S | A | -0.1634 | |
| 294 | S | A | -0.9647 | |
| 295 | D | A | -1.8433 | |
| 296 | G | A | 0.0000 | |
| 297 | Q | A | 0.0000 | |
| 298 | L | A | -1.1004 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.6350 | |
| 301 | R | A | -1.8441 | |
| 302 | P | A | -0.9765 | |
| 303 | F | A | -0.1838 | |
| 304 | W | A | -0.5512 | |
| 305 | L | A | 0.0000 | |
| 306 | Q | A | -2.0808 | |
| 307 | R | A | -2.8356 | |
| 308 | A | A | 0.0000 | |
| 309 | Q | A | -1.2641 | |
| 310 | G | A | -1.2296 | |
| 311 | N | A | -1.2773 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | C | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.7626 | |
| 319 | N | A | -0.8374 | |
| 320 | E | A | -1.0234 | |
| 321 | L | A | 0.0000 | |
| 322 | F | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.3544 | |
| 331 | N | A | 0.0000 | |
| 332 | T | A | -0.1026 | |
| 333 | N | A | 0.5483 | |
| 334 | F | A | 1.7510 | |
| 335 | T | A | 0.8874 | |
| 336 | I | A | 0.4762 | |
| 337 | S | A | -0.9451 | |
| 338 | Q | A | -1.7140 | |
| 339 | Q | A | -1.3479 | |
| 340 | L | A | 0.6615 | |
| 341 | C | A | 0.3036 | |
| 342 | T | A | -0.5014 | |
| 343 | P | A | -0.9867 | |
| 344 | E | A | -2.3618 | |
| 345 | E | A | -2.6521 | |
| 346 | N | A | -1.6087 | |
| 347 | V | A | 0.3230 | |
| 348 | Y | A | 0.8360 | |
| 349 | D | A | -0.2268 | |
| 350 | P | A | -0.3770 | |
| 351 | S | A | -0.2818 | |
| 352 | C | A | 0.0000 | |
| 353 | F | A | -0.7531 | |
| 354 | K | A | -1.7253 | |
| 355 | N | A | -1.7190 | |
| 356 | Y | A | -0.0386 | |
| 357 | L | A | 0.6487 | |
| 358 | R | A | 0.9396 | |
| 359 | H | A | 0.0000 | |
| 360 | V | A | 1.3778 | |
| 361 | E | A | 0.0000 | |
| 362 | Q | A | -0.0904 | |
| 363 | F | A | 0.0000 | |
| 364 | E | A | -2.0764 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | -0.6924 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | A | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.2996 | |
| 374 | V | A | 0.0000 | |
| 375 | P | A | -1.3050 | |
| 376 | L | A | -1.6997 | |
| 377 | D | A | -1.9724 | |
| 378 | P | A | -1.0290 | |
| 379 | G | A | -1.0079 | |
| 380 | V | A | -0.9293 | |
| 381 | L | A | -0.5308 | |
| 382 | A | A | -0.6574 | |
| 383 | H | A | -0.8128 | |
| 384 | I | A | 0.0000 | |
| 385 | N | A | -1.4148 | |
| 386 | T | A | -0.5546 | |
| 387 | M | A | -0.3002 | |
| 388 | N | A | -0.8654 | |
| 389 | P | A | -1.2336 | |
| 390 | T | A | -1.3973 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | -1.3748 | |
| 393 | E | A | -2.7003 | |
| 394 | N | A | -2.3973 | |
| 395 | W | A | -1.2674 | |
| 396 | N | A | -1.0012 | |
| 397 | L | A | -0.1516 | |
| 398 | G | A | 0.5707 | |
| 399 | F | A | 2.4288 | |
| 400 | V | A | 1.8549 | |
| 401 | P | A | 0.0613 | |
| 402 | P | A | -1.7465 | |
| 403 | K | A | -3.2900 | |
| 404 | E | A | -3.7941 | |
| 405 | R | A | -3.7861 | |
| 406 | E | A | -3.7290 | |
| 407 | D | A | -2.8395 | |
| 408 | P | A | -1.7458 | |
| 409 | Y | A | -0.9897 | |
| 410 | K | A | -2.1059 | |
| 411 | G | A | -0.6358 | |
| 412 | L | A | 0.6701 | |
| 413 | I | A | 1.5864 | |
| 414 | F | A | 0.0000 | |
| 415 | W | A | -0.3835 | |
| 416 | E | A | -1.6705 | |
| 417 | V | A | 0.0000 | |
| 418 | D | A | -2.9410 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -2.0431 | |
| 421 | E | A | -2.7677 | |
| 422 | R | A | -2.5365 | |
| 423 | F | A | -1.2682 | |
| 424 | S | A | -1.4676 | |
| 425 | Q | A | -1.7998 | |
| 426 | D | A | -2.9834 | |
| 427 | L | A | -2.1813 | |
| 428 | D | A | -3.0473 | |
| 429 | Q | A | -2.7647 | |
| 430 | F | A | -1.6184 | |
| 431 | A | A | -1.1493 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -2.3215 | |
| 435 | K | A | -1.1088 | |
| 436 | F | A | -0.1132 | |
| 437 | L | A | 0.7715 | |
| 438 | Y | A | 0.6168 | |
| 439 | Q | A | -0.3911 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine