| Chain sequence(s) |
A: LVQPGGSLRLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRSKYNNYATYYAASVKGRFTISRDDSKNSLYLQMNSLKTEDTAVYYCARHGNFGNSYVSWFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEP
B: QTVVTQEPSLTVSPGGTVTLTCRSSTGAVTTSNYANWVQQKPGQAPRGLIGGTNKRAPGTPARFSGSLLGGKAALTLSGVQPEDEAEYYCALWYSNLWVFGGGTKLTVL input PDB |
| Selected Chain(s) | A,B |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:07)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:07)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with all chain(s) selected (00:00:07)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:07)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:08)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:03:45)
[INFO] Main: Simulation completed successfully. (00:03:48)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 153 | L | A | 0.2352 | |
| 154 | V | A | -0.4402 | |
| 155 | Q | A | -1.4427 | |
| 156 | P | A | -1.6563 | |
| 157 | G | A | -1.4440 | |
| 158 | G | A | -1.0645 | |
| 159 | S | A | -1.2256 | |
| 160 | L | A | -0.8720 | |
| 161 | R | A | -2.0566 | |
| 162 | L | A | 0.0000 | |
| 163 | S | A | -0.6204 | |
| 164 | C | A | -0.1033 | |
| 165 | A | A | -0.5393 | |
| 166 | A | A | -0.6533 | |
| 167 | S | A | -0.6276 | |
| 168 | G | A | -0.3844 | |
| 169 | F | A | -0.1480 | |
| 170 | T | A | -0.5114 | |
| 171 | F | A | 0.0000 | |
| 172 | N | A | -1.9348 | |
| 173 | T | A | -0.9960 | |
| 174 | Y | A | -0.7131 | |
| 175 | A | A | 0.0000 | |
| 176 | M | A | 0.0000 | |
| 177 | N | A | 0.0000 | |
| 178 | W | A | 0.0000 | |
| 179 | V | A | 0.0000 | |
| 180 | R | A | 0.0000 | |
| 181 | Q | A | -0.7294 | |
| 182 | A | A | -1.0658 | |
| 183 | P | A | -1.0922 | |
| 184 | G | A | -1.4626 | |
| 185 | K | A | -2.3312 | |
| 186 | G | A | 0.0000 | |
| 187 | L | A | 0.0000 | |
| 188 | E | A | -0.5342 | |
| 189 | W | A | 0.0000 | |
| 190 | V | A | 0.0000 | |
| 191 | A | A | 0.0000 | |
| 192 | R | A | -0.2448 | |
| 193 | I | A | 0.0000 | |
| 194 | R | A | -1.4614 | |
| 195 | S | A | -1.7276 | |
| 196 | K | A | -2.2374 | |
| 197 | Y | A | -0.8398 | |
| 198 | N | A | -1.5038 | |
| 199 | N | A | -1.6286 | |
| 200 | Y | A | -0.5741 | |
| 201 | A | A | -0.3785 | |
| 202 | T | A | -0.1540 | |
| 203 | Y | A | -0.3339 | |
| 204 | Y | A | -0.2641 | |
| 205 | A | A | -0.4321 | |
| 206 | A | A | -0.4287 | |
| 207 | S | A | -0.8859 | |
| 208 | V | A | 0.0000 | |
| 209 | K | A | -1.8549 | |
| 210 | G | A | -1.4334 | |
| 211 | R | A | -1.3238 | |
| 212 | F | A | 0.0000 | |
| 213 | T | A | -0.9582 | |
| 214 | I | A | 0.0000 | |
| 215 | S | A | -0.4029 | |
| 216 | R | A | 0.0000 | |
| 217 | D | A | -1.8289 | |
| 218 | D | A | -2.2409 | |
| 219 | S | A | -1.9108 | |
| 220 | K | A | -2.5183 | |
| 221 | N | A | -2.1379 | |
| 222 | S | A | 0.0000 | |
| 223 | L | A | 0.0000 | |
| 224 | Y | A | -0.6465 | |
| 225 | L | A | 0.0000 | |
| 226 | Q | A | -1.6149 | |
| 227 | M | A | 0.0000 | |
| 228 | N | A | -1.4343 | |
| 229 | S | A | -1.2225 | |
| 230 | L | A | 0.0000 | |
| 231 | K | A | -2.2478 | |
| 232 | T | A | -1.6044 | |
| 233 | E | A | -1.8316 | |
| 234 | D | A | 0.0000 | |
| 235 | T | A | -0.5738 | |
| 236 | A | A | 0.0000 | |
| 237 | V | A | 0.1769 | |
| 238 | Y | A | 0.0000 | |
| 239 | Y | A | 0.0000 | |
| 240 | C | A | 0.0000 | |
| 241 | A | A | 0.0000 | |
| 242 | R | A | -0.0095 | |
| 243 | H | A | 0.0000 | |
| 244 | G | A | 0.0000 | |
| 245 | N | A | -0.5342 | |
| 246 | F | A | 0.9409 | |
| 247 | G | A | -0.3500 | |
| 248 | N | A | -1.0476 | |
| 249 | S | A | -0.6149 | |
| 250 | Y | A | -0.6622 | |
| 251 | V | A | 0.0538 | |
| 252 | S | A | 0.0000 | |
| 253 | W | A | 0.0000 | |
| 254 | F | A | 0.0000 | |
| 255 | A | A | 0.1117 | |
| 256 | Y | A | 0.7903 | |
| 257 | W | A | 0.0000 | |
| 258 | G | A | -0.8727 | |
| 259 | Q | A | -1.7410 | |
| 260 | G | A | -0.9471 | |
| 261 | T | A | -0.1351 | |
| 262 | L | A | 0.3027 | |
| 263 | V | A | 0.0000 | |
| 264 | T | A | 0.0000 | |
| 265 | V | A | 0.0000 | |
| 266 | S | A | -0.8812 | |
| 267 | S | A | -0.6751 | |
| 268 | A | A | -0.4243 | |
| 269 | S | A | -0.5220 | |
| 270 | T | A | -0.5053 | |
| 271 | K | A | -1.1170 | |
| 272 | G | A | -1.4349 | |
| 273 | P | A | -0.5798 | |
| 274 | S | A | -0.0347 | |
| 275 | V | A | 0.0000 | |
| 276 | F | A | 1.0373 | |
| 277 | P | A | 0.1508 | |
| 278 | L | A | 0.5924 | |
| 279 | A | A | -0.3956 | |
| 280 | P | A | 0.0000 | |
| 281 | S | A | -1.1335 | |
| 282 | S | A | -1.2867 | |
| 283 | K | A | -2.0030 | |
| 284 | S | A | -1.0946 | |
| 285 | T | A | -1.0937 | |
| 286 | S | A | -0.9268 | |
| 287 | G | A | -1.0937 | |
| 288 | G | A | -0.8994 | |
| 289 | T | A | -0.6229 | |
| 290 | A | A | 0.0000 | |
| 291 | A | A | -0.0764 | |
| 292 | L | A | 0.0000 | |
| 293 | G | A | 0.0000 | |
| 294 | C | A | 0.0000 | |
| 295 | L | A | 0.8512 | |
| 296 | V | A | 0.0000 | |
| 297 | K | A | -0.0025 | |
| 298 | D | A | -0.3045 | |
| 299 | Y | A | 0.0000 | |
| 300 | F | A | 0.0000 | |
| 301 | P | A | 0.0000 | |
| 302 | E | A | -0.4382 | |
| 303 | P | A | -0.6188 | |
| 304 | V | A | -0.7611 | |
| 305 | T | A | -0.7247 | |
| 306 | V | A | -0.1962 | |
| 307 | S | A | -0.4297 | |
| 308 | W | A | 0.0000 | |
| 309 | N | A | -0.5178 | |
| 310 | S | A | -0.5157 | |
| 311 | G | A | -0.5130 | |
| 312 | A | A | -0.1741 | |
| 313 | L | A | 0.0965 | |
| 314 | T | A | -0.2106 | |
| 315 | S | A | -0.2704 | |
| 316 | G | A | -0.1250 | |
| 317 | V | A | 0.1444 | |
| 318 | H | A | -0.3623 | |
| 319 | T | A | 0.2278 | |
| 320 | F | A | 0.9740 | |
| 321 | P | A | 0.7293 | |
| 322 | A | A | 1.4054 | |
| 323 | V | A | 2.5254 | |
| 324 | L | A | 2.2207 | |
| 325 | Q | A | 0.7639 | |
| 326 | S | A | 0.0539 | |
| 327 | S | A | -0.2460 | |
| 328 | G | A | 0.1165 | |
| 329 | L | A | 0.3030 | |
| 330 | Y | A | 0.9216 | |
| 331 | S | A | 0.0000 | |
| 332 | L | A | 1.0299 | |
| 333 | S | A | 0.8019 | |
| 334 | S | A | 0.0000 | |
| 335 | V | A | 0.6465 | |
| 336 | V | A | 0.0000 | |
| 337 | T | A | -0.0815 | |
| 338 | V | A | 0.0000 | |
| 339 | P | A | -0.6191 | |
| 340 | S | A | -0.6040 | |
| 341 | S | A | -0.6392 | |
| 342 | S | A | -0.6566 | |
| 343 | L | A | -0.8134 | |
| 344 | G | A | -0.9796 | |
| 345 | T | A | -0.7968 | |
| 346 | Q | A | -1.3951 | |
| 347 | T | A | -1.1352 | |
| 348 | Y | A | 0.0000 | |
| 349 | I | A | -0.9435 | |
| 350 | C | A | 0.0000 | |
| 351 | N | A | -1.2339 | |
| 352 | V | A | 0.0000 | |
| 353 | N | A | -2.3363 | |
| 354 | H | A | 0.0000 | |
| 355 | K | A | -2.8584 | |
| 356 | P | A | -1.4901 | |
| 357 | S | A | -1.8217 | |
| 358 | N | A | -2.6307 | |
| 359 | T | A | -2.2289 | |
| 360 | K | A | -2.7552 | |
| 361 | V | A | -1.3312 | |
| 362 | D | A | -1.6801 | |
| 363 | K | A | -1.4426 | |
| 364 | K | A | -1.8138 | |
| 365 | V | A | 0.0000 | |
| 366 | E | A | -2.3537 | |
| 367 | P | A | -1.1679 | |
| 1 | Q | B | -1.2147 | |
| 2 | T | B | -0.4413 | |
| 3 | V | B | 0.6209 | |
| 4 | V | B | 0.0000 | |
| 5 | T | B | -0.9592 | |
| 6 | Q | B | 0.0000 | |
| 7 | E | B | -1.2662 | |
| 8 | P | B | -1.1334 | |
| 9 | S | B | -1.0813 | |
| 10 | L | B | -0.5110 | |
| 11 | T | B | 0.1490 | |
| 12 | V | B | 0.4327 | |
| 13 | S | B | 0.2093 | |
| 14 | P | B | -0.4570 | |
| 15 | G | B | -0.9131 | |
| 16 | G | B | -0.6032 | |
| 17 | T | B | -0.4159 | |
| 18 | V | B | 0.0000 | |
| 19 | T | B | -0.0329 | |
| 20 | L | B | 0.0000 | |
| 21 | T | B | -0.7666 | |
| 22 | C | B | 0.0000 | |
| 23 | R | B | -2.0724 | |
| 24 | S | B | 0.0000 | |
| 25 | S | B | -0.7040 | |
| 26 | T | B | -0.2523 | |
| 27 | G | B | -0.0423 | |
| 28 | A | B | 0.0000 | |
| 29 | V | B | 0.0000 | |
| 30 | T | B | -0.5507 | |
| 31 | T | B | -0.2913 | |
| 32 | S | B | -0.4058 | |
| 33 | N | B | -1.1306 | |
| 34 | Y | B | -0.1953 | |
| 35 | A | B | 0.0000 | |
| 36 | N | B | 0.0000 | |
| 37 | W | B | 0.0000 | |
| 38 | V | B | 0.0000 | |
| 39 | Q | B | 0.0000 | |
| 40 | Q | B | 0.0000 | |
| 41 | K | B | -1.8848 | |
| 42 | P | B | -1.1798 | |
| 43 | G | B | -1.4858 | |
| 44 | Q | B | -2.1717 | |
| 45 | A | B | -1.5918 | |
| 46 | P | B | 0.0000 | |
| 47 | R | B | -1.7697 | |
| 48 | G | B | -0.7749 | |
| 49 | L | B | 0.0000 | |
| 50 | I | B | 0.0000 | |
| 51 | G | B | 0.0000 | |
| 52 | G | B | -1.2559 | |
| 53 | T | B | 0.0000 | |
| 54 | N | B | -2.3648 | |
| 55 | K | B | -2.6431 | |
| 56 | R | B | -1.8996 | |
| 57 | A | B | -0.9064 | |
| 58 | P | B | -0.8263 | |
| 59 | G | B | -0.7165 | |
| 60 | T | B | 0.0000 | |
| 61 | P | B | -0.5556 | |
| 62 | A | B | -0.5215 | |
| 63 | R | B | -0.6595 | |
| 64 | F | B | 0.0000 | |
| 65 | S | B | -1.1074 | |
| 66 | G | B | 0.0000 | |
| 67 | S | B | -0.5469 | |
| 68 | L | B | 0.0545 | |
| 69 | L | B | 0.9574 | |
| 70 | G | B | -0.2013 | |
| 71 | G | B | -0.8953 | |
| 72 | K | B | -1.2751 | |
| 73 | A | B | 0.0000 | |
| 74 | A | B | -0.3486 | |
| 75 | L | B | 0.0000 | |
| 76 | T | B | -0.2669 | |
| 77 | L | B | 0.0000 | |
| 78 | S | B | -0.6829 | |
| 79 | G | B | -0.8658 | |
| 80 | V | B | 0.0000 | |
| 81 | Q | B | -1.6041 | |
| 82 | P | B | -1.5612 | |
| 83 | E | B | -2.4926 | |
| 84 | D | B | 0.0000 | |
| 85 | E | B | -1.9684 | |
| 86 | A | B | 0.0000 | |
| 87 | E | B | -1.7256 | |
| 88 | Y | B | 0.0000 | |
| 89 | Y | B | 0.0000 | |
| 90 | C | B | 0.0000 | |
| 91 | A | B | 0.0000 | |
| 92 | L | B | 0.0000 | |
| 93 | W | B | 0.4080 | |
| 94 | Y | B | 0.7452 | |
| 95 | S | B | -0.0902 | |
| 96 | N | B | -0.4616 | |
| 97 | L | B | 0.1958 | |
| 98 | W | B | 0.0000 | |
| 99 | V | B | 0.0000 | |
| 100 | F | B | 0.0000 | |
| 101 | G | B | 0.0000 | |
| 102 | G | B | -1.2007 | |
| 103 | G | B | -1.3010 | |
| 104 | T | B | 0.0000 | |
| 105 | K | B | -2.2098 | |
| 106 | L | B | 0.0000 | |
| 107 | T | B | -0.5035 | |
| 108 | V | B | -0.0245 | |
| 109 | L | B | 1.3850 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine