Project name: 9f723b0304c1d12

Chain sequence(s)	P: GCGELVWVGEPLTLRTAETITGKYGVWMRDPKPTYPYTQETTWRIDTVGTDVRQVFEYDLISQFMQGYPSKVHILPRPLESTGAVVYSGSLYFQGAESRTVIRYELNTETVKAEKEIPGAGYHGQFPYSWGGYTDIDLAVDEAGLWVIYSTDEAKGAIVLSKLNPENLELEQTWETNIRKQSVANAFIICGTLYTVSSYTSADATVNFAYDTGTGISKTLTIPFKNRYKYSSMIDYNPLEKKLFAWDNLNMVTYDFKLS
Selected Chain(s)	P
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with P chain(s) selected             (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:01:55)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:57)

• Minimal score value: -3.5887
• Maximal score value: 1.9403
• Average score: -0.5482
• Total score value: -141.9774

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
244	G	P	-0.3820
245	C	P	-0.0388
246	G	P	-0.7491
247	E	P	-1.4656
248	L	P	0.0000
249	V	P	1.0891
250	W	P	0.4543
251	V	P	0.0000
252	G	P	-1.5532
253	E	P	-2.0417
254	P	P	-0.7264
255	L	P	0.9157
256	T	P	0.2340
257	L	P	-0.4118
258	R	P	-2.0167
259	T	P	-1.0586
260	A	P	-1.2468
261	E	P	-1.5710
262	T	P	-0.3233
263	I	P	1.2229
264	T	P	0.1399
265	G	P	-0.6322
266	K	P	-1.3091
267	Y	P	-0.2932
268	G	P	-0.1251
269	V	P	0.3287
270	W	P	0.0000
271	M	P	0.0000
272	R	P	-0.6177
273	D	P	-0.9864
274	P	P	0.0000
275	K	P	-1.5974
276	P	P	-0.6210
277	T	P	0.1531
278	Y	P	1.0953
279	P	P	0.4747
280	Y	P	0.0915
281	T	P	-0.5699
282	Q	P	-1.3747
283	E	P	-1.5586
284	T	P	-1.0193
285	T	P	0.0000
286	W	P	-0.3213
287	R	P	-0.2048
288	I	P	0.2313
289	D	P	-0.1684
290	T	P	0.1621
291	V	P	1.2483
292	G	P	0.1080
293	T	P	-0.4559
294	D	P	-1.1706
295	V	P	0.7411
296	R	P	0.0000
297	Q	P	0.5233
298	V	P	0.0000
299	F	P	0.1065
300	E	P	-0.5123
301	Y	P	0.0000
302	D	P	-0.6754
303	L	P	1.3568
304	I	P	1.4511
305	S	P	0.6796
306	Q	P	0.4340
307	F	P	0.0000
308	M	P	-0.1354
309	Q	P	-0.6431
310	G	P	-0.1963
311	Y	P	0.6325
312	P	P	-0.1600
313	S	P	-0.4534
314	K	P	-0.9567
315	V	P	0.4452
316	H	P	0.0000
317	I	P	1.9403
318	L	P	0.0000
319	P	P	0.1190
320	R	P	-0.7262
321	P	P	-0.9180
322	L	P	0.0000
323	E	P	-0.8336
324	S	P	-0.2629
325	T	P	-0.3639
326	G	P	-0.3952
327	A	P	0.0000
328	V	P	0.0000
329	V	P	0.0000
330	Y	P	0.1818
331	S	P	-0.2954
332	G	P	-0.6564
333	S	P	0.0000
334	L	P	0.0000
335	Y	P	0.0000
336	F	P	0.0000
337	Q	P	0.0000
338	G	P	0.0000
339	A	P	-1.3058
340	E	P	-2.1122
341	S	P	-1.4651
342	R	P	-1.4005
343	T	P	-1.4344
344	V	P	0.0000
345	I	P	0.0000
346	R	P	0.0000
347	Y	P	0.0000
348	E	P	-1.6449
349	L	P	0.0000
350	N	P	-1.8276
351	T	P	-1.5318
352	E	P	-1.5964
353	T	P	-1.1192
354	V	P	-1.2655
355	K	P	-2.5729
356	A	P	-2.4744
357	E	P	-2.7782
358	K	P	-2.4611
359	E	P	-1.7677
360	I	P	0.0000
361	P	P	-0.2034
362	G	P	-0.5187
363	A	P	-0.9180
364	G	P	0.0000
365	Y	P	-0.8164
366	H	P	-1.6877
367	G	P	-1.2910
368	Q	P	-0.4830
369	F	P	1.3273
370	P	P	1.0078
371	Y	P	1.6777
372	S	P	0.9775
373	W	P	1.1918
374	G	P	0.1646
375	G	P	-0.2453
376	Y	P	-0.2049
377	T	P	-0.9208
378	D	P	-2.1605
379	I	P	0.0000
380	D	P	-0.8693
381	L	P	0.0000
382	A	P	-0.2905
383	V	P	0.0000
384	D	P	0.0000
385	E	P	-0.6298
386	A	P	-0.4336
387	G	P	-0.5790
388	L	P	0.0000
389	W	P	0.0000
390	V	P	0.0000
391	I	P	0.0000
392	Y	P	0.0000
393	S	P	-2.1630
394	T	P	0.0000
395	D	P	-3.2978
396	E	P	-3.2179
397	A	P	0.0000
398	K	P	-3.3069
399	G	P	-2.9478
400	A	P	0.0000
401	I	P	-1.7013
402	V	P	0.0000
403	L	P	0.0000
404	S	P	0.0000
405	K	P	-1.8120
406	L	P	0.0000
407	N	P	-2.3018
408	P	P	-1.8988
409	E	P	-3.3346
410	N	P	-3.4143
411	L	P	0.0000
412	E	P	-3.5887
413	L	P	-2.2014
414	E	P	-2.4136
415	Q	P	-2.1609
416	T	P	-1.3329
417	W	P	-1.1018
418	E	P	-1.9453
419	T	P	-1.4962
420	N	P	-2.0736
421	I	P	-1.8535
422	R	P	-3.2358
423	K	P	-3.2277
424	Q	P	-2.4031
425	S	P	-1.6676
426	V	P	-0.8598
427	A	P	-0.3498
428	N	P	0.0000
429	A	P	0.0000
430	F	P	0.0000
431	I	P	0.0000
432	I	P	0.0000
433	C	P	0.0024
434	G	P	0.0000
435	T	P	0.0794
436	L	P	0.0000
437	Y	P	-0.1285
438	T	P	0.0000
439	V	P	0.0000
440	S	P	-0.2560
441	S	P	-0.4782
442	Y	P	0.7810
443	T	P	0.1588
444	S	P	-0.2660
445	A	P	-0.5541
446	D	P	-1.8048
447	A	P	-1.2147
448	T	P	-0.7035
449	V	P	0.0000
450	N	P	-0.6139
451	F	P	-0.4926
452	A	P	0.0000
453	Y	P	0.0000
454	D	P	-0.2313
455	T	P	-0.3645
456	G	P	-0.3849
457	T	P	-0.0105
458	G	P	-0.0462
459	I	P	1.1390
460	S	P	-0.2143
461	K	P	-1.2550
462	T	P	-0.8066
463	L	P	-0.0934
464	T	P	0.1249
465	I	P	0.4550
466	P	P	-0.7143
467	F	P	0.0000
468	K	P	-2.1475
469	N	P	-1.6881
470	R	P	-1.5428
471	Y	P	-1.0621
472	K	P	-1.4192
473	Y	P	0.3779
474	S	P	-0.1498
475	S	P	0.0000
476	M	P	0.0602
477	I	P	0.0000
478	D	P	-0.3241
479	Y	P	0.0000
480	N	P	0.0000
481	P	P	-0.6297
482	L	P	-0.4881
483	E	P	-1.2210
484	K	P	-1.8768
485	K	P	-1.5543
486	L	P	0.0000
487	F	P	-0.0225
488	A	P	0.0000
489	W	P	-0.1354
490	D	P	0.0000
491	N	P	-1.0291
492	L	P	0.4252
493	N	P	-0.6299
494	M	P	0.0000
495	V	P	0.0000
496	T	P	-0.1596
497	Y	P	0.0000
498	D	P	-2.0809
499	F	P	0.0000
500	K	P	-1.6240
501	L	P	-0.3742
502	S	P	-0.5833