| Chain sequence(s) |
A: GLPPADPAPALRDTSEYVTPTDLLYVAETDLITETGNPTSDIVVDGKVITPRVSALQWDVFKLTLPDPNTMPLPSADFLNPATEIRIWQLRALYIGVYGPLGTGSYGHPNFNRLGDVTNPTSYQHETADDTVNYSFTPKYLQLYIVGDQPPTGVYTAPAAPAPGLPPGARPPTRVVTTTIEHGDMADIGFGARDFKALLPRKNDVPDIILDTSTKVPDIAGMKAEPTGRRMFDYDEKTTSSNSETYVRCGPDLDPLPDAPPPSPLYTPPPPTSPYAIRPSTDYFTIPNRGEITEDQLLFNRPIFFTKTAGKNNGVLWHNQLYITVLDNSRDTIATNTTQISTPAVNVYDPSNYVTSKTYTREYKISLIVQLCTIPLTPETLAELARLDPSILVDAKLPDIPPVERPDPYAGKKFKEIDLTDKLSRDLSKFELGRLYLNR
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:05)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | G | A | 0.1501 | |
| 2 | L | A | 1.1532 | |
| 3 | P | A | -0.0370 | |
| 4 | P | A | -0.5143 | |
| 5 | A | A | -0.7907 | |
| 6 | D | A | -2.0175 | |
| 7 | P | A | -1.1882 | |
| 8 | A | A | -0.5914 | |
| 9 | P | A | -0.5759 | |
| 10 | A | A | -0.2109 | |
| 11 | L | A | -0.4522 | |
| 12 | R | A | -1.2907 | |
| 13 | D | A | -1.5590 | |
| 14 | T | A | 0.0000 | |
| 15 | S | A | -1.7053 | |
| 16 | E | A | -2.2642 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | T | A | -0.5782 | |
| 20 | P | A | -0.7380 | |
| 21 | T | A | -0.9247 | |
| 22 | D | A | -1.7461 | |
| 23 | L | A | 0.0000 | |
| 24 | L | A | -0.8327 | |
| 25 | Y | A | 0.0000 | |
| 26 | V | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | E | A | -0.9248 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -1.2814 | |
| 31 | L | A | 0.3700 | |
| 32 | I | A | 0.0000 | |
| 33 | T | A | -0.2306 | |
| 34 | E | A | -0.3986 | |
| 35 | T | A | -0.4192 | |
| 36 | G | A | 0.0000 | |
| 37 | N | A | -0.6887 | |
| 38 | P | A | 0.0000 | |
| 39 | T | A | -0.7373 | |
| 40 | S | A | -0.7225 | |
| 41 | D | A | -0.0930 | |
| 42 | I | A | 1.7586 | |
| 43 | V | A | 2.2980 | |
| 44 | V | A | 1.3807 | |
| 45 | D | A | -1.0765 | |
| 46 | G | A | -0.6027 | |
| 47 | K | A | -0.2650 | |
| 48 | V | A | 2.0511 | |
| 49 | I | A | 2.6732 | |
| 50 | T | A | 1.3956 | |
| 51 | P | A | 0.1993 | |
| 52 | R | A | -0.5103 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | A | A | 0.0000 | |
| 56 | L | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | D | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | K | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | T | A | -1.1357 | |
| 65 | L | A | 0.0000 | |
| 66 | P | A | -0.9330 | |
| 67 | D | A | -0.6160 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -0.8303 | |
| 70 | T | A | -0.4451 | |
| 71 | M | A | -0.0703 | |
| 72 | P | A | -0.0926 | |
| 73 | L | A | 0.0290 | |
| 74 | P | A | -0.2775 | |
| 75 | S | A | -0.4860 | |
| 76 | A | A | -0.7639 | |
| 77 | D | A | -1.5993 | |
| 78 | F | A | -0.6551 | |
| 79 | L | A | -0.7389 | |
| 80 | N | A | -1.4545 | |
| 81 | P | A | -1.0208 | |
| 82 | A | A | -0.5404 | |
| 83 | T | A | -0.5573 | |
| 84 | E | A | -0.6335 | |
| 85 | I | A | 0.0000 | |
| 86 | R | A | -0.4921 | |
| 87 | I | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | Q | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.3413 | |
| 92 | A | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | Y | A | -0.6828 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | 0.0000 | |
| 97 | V | A | 0.0000 | |
| 98 | Y | A | 0.2805 | |
| 99 | G | A | -0.2133 | |
| 100 | P | A | -0.0889 | |
| 101 | L | A | 0.1122 | |
| 102 | G | A | 0.0952 | |
| 103 | T | A | -0.2217 | |
| 104 | G | A | 0.0000 | |
| 105 | S | A | -0.1838 | |
| 106 | Y | A | 0.0000 | |
| 107 | G | A | -0.9854 | |
| 108 | H | A | -1.5305 | |
| 109 | P | A | -1.5625 | |
| 110 | N | A | -2.3889 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | 0.0000 | |
| 113 | R | A | -0.7227 | |
| 114 | L | A | -0.6482 | |
| 115 | G | A | 0.0000 | |
| 116 | D | A | -0.6570 | |
| 117 | V | A | -0.0500 | |
| 118 | T | A | -0.8015 | |
| 119 | N | A | -1.4961 | |
| 120 | P | A | -0.8571 | |
| 121 | T | A | -0.5355 | |
| 122 | S | A | -0.3344 | |
| 123 | Y | A | 0.5295 | |
| 124 | Q | A | -0.2108 | |
| 125 | H | A | -0.5997 | |
| 126 | E | A | -1.5341 | |
| 127 | T | A | -1.2991 | |
| 128 | A | A | -1.1268 | |
| 129 | D | A | -2.2344 | |
| 130 | D | A | -1.5967 | |
| 131 | T | A | -1.3599 | |
| 132 | V | A | -1.0498 | |
| 133 | N | A | -1.6277 | |
| 134 | Y | A | -0.8710 | |
| 135 | S | A | -0.5932 | |
| 136 | F | A | 0.0000 | |
| 137 | T | A | -0.4155 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | -0.7446 | |
| 140 | Y | A | 0.0000 | |
| 141 | L | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | Y | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | D | A | 0.0000 | |
| 149 | Q | A | -0.3278 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | -0.0906 | |
| 153 | G | A | 0.0000 | |
| 154 | V | A | 0.7905 | |
| 155 | Y | A | 0.3347 | |
| 156 | T | A | -0.0743 | |
| 157 | A | A | 0.0000 | |
| 158 | P | A | -0.5613 | |
| 159 | A | A | -0.5028 | |
| 160 | A | A | -0.3975 | |
| 161 | P | A | -0.4931 | |
| 162 | A | A | -0.1748 | |
| 163 | P | A | -0.3649 | |
| 164 | G | A | -0.4025 | |
| 165 | L | A | -0.2607 | |
| 166 | P | A | -0.5669 | |
| 167 | P | A | -0.7653 | |
| 168 | G | A | -0.7888 | |
| 169 | A | A | -0.8924 | |
| 170 | R | A | -1.9968 | |
| 171 | P | A | -1.2423 | |
| 172 | P | A | -1.0717 | |
| 173 | T | A | -1.0171 | |
| 174 | R | A | -1.0365 | |
| 175 | V | A | 0.9451 | |
| 176 | V | A | 0.5506 | |
| 177 | T | A | 0.3453 | |
| 178 | T | A | 0.1862 | |
| 179 | T | A | -0.4786 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | -1.2306 | |
| 182 | H | A | -1.2904 | |
| 183 | G | A | -0.7726 | |
| 184 | D | A | -0.7338 | |
| 185 | M | A | 0.0000 | |
| 186 | A | A | 0.0000 | |
| 187 | D | A | -0.2228 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | -0.5169 | |
| 190 | F | A | -0.0596 | |
| 191 | G | A | -0.2693 | |
| 192 | A | A | -0.0071 | |
| 193 | R | A | -0.7149 | |
| 194 | D | A | -1.3102 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -2.8646 | |
| 197 | A | A | -1.3408 | |
| 198 | L | A | 0.0000 | |
| 199 | L | A | -1.4768 | |
| 200 | P | A | -1.4721 | |
| 201 | R | A | -2.0556 | |
| 202 | K | A | -3.1062 | |
| 203 | N | A | -1.9601 | |
| 204 | D | A | -1.2610 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | D | A | -1.8064 | |
| 208 | I | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | L | A | -2.1429 | |
| 211 | D | A | -2.7838 | |
| 212 | T | A | -1.6253 | |
| 213 | S | A | -1.0819 | |
| 214 | T | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | V | A | 0.4880 | |
| 217 | P | A | 0.2349 | |
| 218 | D | A | -0.2320 | |
| 219 | I | A | -0.2718 | |
| 220 | A | A | -0.6154 | |
| 221 | G | A | -0.8166 | |
| 222 | M | A | 0.0000 | |
| 223 | K | A | -1.8961 | |
| 224 | A | A | -1.0479 | |
| 225 | E | A | -1.1576 | |
| 226 | P | A | -0.8649 | |
| 227 | T | A | -0.7425 | |
| 228 | G | A | 0.0000 | |
| 229 | R | A | 0.0000 | |
| 230 | R | A | -0.7690 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | D | A | -0.7028 | |
| 234 | Y | A | -0.5582 | |
| 235 | D | A | -1.4225 | |
| 236 | E | A | -1.6990 | |
| 237 | K | A | -1.3692 | |
| 238 | T | A | -0.7176 | |
| 239 | T | A | -0.7191 | |
| 240 | S | A | -0.9424 | |
| 241 | S | A | -1.3093 | |
| 242 | N | A | -1.8491 | |
| 243 | S | A | -1.3152 | |
| 244 | E | A | -1.3176 | |
| 245 | T | A | -0.4650 | |
| 246 | Y | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | R | A | 0.0000 | |
| 249 | C | A | -0.8939 | |
| 250 | G | A | -0.6306 | |
| 251 | P | A | -0.7280 | |
| 252 | D | A | -0.7157 | |
| 253 | L | A | -0.1739 | |
| 254 | D | A | -1.5626 | |
| 255 | P | A | -1.1309 | |
| 256 | L | A | -0.0198 | |
| 257 | P | A | -0.8414 | |
| 258 | D | A | -1.6809 | |
| 259 | A | A | -0.8237 | |
| 260 | P | A | -0.9059 | |
| 261 | P | A | -0.6243 | |
| 262 | P | A | -0.3093 | |
| 263 | S | A | -0.1594 | |
| 264 | P | A | 0.4154 | |
| 265 | L | A | 1.3795 | |
| 266 | Y | A | 0.6696 | |
| 267 | T | A | 0.0812 | |
| 268 | P | A | -0.2959 | |
| 269 | P | A | 0.1252 | |
| 270 | P | A | -0.3152 | |
| 271 | P | A | -0.0280 | |
| 272 | T | A | 0.0423 | |
| 273 | S | A | 0.3642 | |
| 274 | P | A | 0.6356 | |
| 275 | Y | A | 1.4829 | |
| 276 | A | A | 1.1344 | |
| 277 | I | A | 1.8665 | |
| 278 | R | A | 0.4527 | |
| 279 | P | A | -0.1097 | |
| 280 | S | A | 0.0000 | |
| 281 | T | A | -0.6480 | |
| 282 | D | A | -1.0370 | |
| 283 | Y | A | 0.6804 | |
| 284 | F | A | 0.2638 | |
| 285 | T | A | -0.2233 | |
| 286 | I | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | N | A | -1.4639 | |
| 289 | R | A | 0.0000 | |
| 290 | G | A | -1.5539 | |
| 291 | E | A | -1.9737 | |
| 292 | I | A | -1.4495 | |
| 293 | T | A | -1.9137 | |
| 294 | E | A | -2.7050 | |
| 295 | D | A | -2.8939 | |
| 296 | Q | A | -2.2378 | |
| 297 | L | A | -1.5061 | |
| 298 | L | A | -1.3311 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.2217 | |
| 301 | R | A | -1.8396 | |
| 302 | P | A | -0.8476 | |
| 303 | I | A | -0.0940 | |
| 304 | F | A | -0.0947 | |
| 305 | F | A | 0.0000 | |
| 306 | T | A | -0.8503 | |
| 307 | K | A | -1.9204 | |
| 308 | T | A | 0.0000 | |
| 309 | A | A | -0.9446 | |
| 310 | G | A | -1.3026 | |
| 311 | K | A | -1.4653 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | -1.2338 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | L | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.4334 | |
| 319 | N | A | -0.4730 | |
| 320 | Q | A | -0.5288 | |
| 321 | L | A | 0.0000 | |
| 322 | Y | A | 0.0000 | |
| 323 | I | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | L | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | S | A | 0.0000 | |
| 330 | R | A | -0.0296 | |
| 331 | D | A | 0.0000 | |
| 332 | T | A | 0.0230 | |
| 333 | I | A | -0.2094 | |
| 334 | A | A | -0.5058 | |
| 335 | T | A | -0.9442 | |
| 336 | N | A | -0.9196 | |
| 337 | T | A | 0.0314 | |
| 338 | T | A | 0.6444 | |
| 339 | Q | A | 0.9917 | |
| 340 | I | A | 2.1340 | |
| 341 | S | A | 0.7493 | |
| 342 | T | A | 0.1723 | |
| 343 | P | A | -0.1490 | |
| 344 | A | A | 0.1746 | |
| 345 | V | A | 0.4586 | |
| 346 | N | A | 0.0083 | |
| 347 | V | A | 1.7038 | |
| 348 | Y | A | 1.5047 | |
| 349 | D | A | -0.0204 | |
| 350 | P | A | 0.0087 | |
| 351 | S | A | 0.1627 | |
| 352 | N | A | 0.9046 | |
| 353 | Y | A | 1.3160 | |
| 354 | V | A | 1.8599 | |
| 355 | T | A | 0.0840 | |
| 356 | S | A | -0.7874 | |
| 357 | K | A | -1.6410 | |
| 358 | T | A | -0.8848 | |
| 359 | Y | A | 0.0000 | |
| 360 | T | A | -0.2676 | |
| 361 | R | A | 0.0000 | |
| 362 | E | A | -0.2295 | |
| 363 | Y | A | 0.0000 | |
| 364 | K | A | -0.5018 | |
| 365 | I | A | 0.0000 | |
| 366 | S | A | 0.0000 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | V | A | 0.0000 | |
| 370 | Q | A | -0.5019 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | T | A | -0.1854 | |
| 374 | I | A | 0.0000 | |
| 375 | P | A | -0.4740 | |
| 376 | L | A | -0.1678 | |
| 377 | T | A | -0.6010 | |
| 378 | P | A | -0.9446 | |
| 379 | E | A | -1.7604 | |
| 380 | T | A | 0.0000 | |
| 381 | L | A | -0.2512 | |
| 382 | A | A | -0.6366 | |
| 383 | E | A | 0.0000 | |
| 384 | L | A | 0.0000 | |
| 385 | A | A | -0.5962 | |
| 386 | R | A | -0.9783 | |
| 387 | L | A | -0.5021 | |
| 388 | D | A | -0.5893 | |
| 389 | P | A | -0.5553 | |
| 390 | S | A | -0.4761 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | -0.1546 | |
| 393 | V | A | -0.5512 | |
| 394 | D | A | -1.0539 | |
| 395 | A | A | -1.0564 | |
| 396 | K | A | -1.8471 | |
| 397 | L | A | -1.2213 | |
| 398 | P | A | -1.3750 | |
| 399 | D | A | -1.9002 | |
| 400 | I | A | -0.5610 | |
| 401 | P | A | -0.4625 | |
| 402 | P | A | -0.4400 | |
| 403 | V | A | 0.4007 | |
| 404 | E | A | -1.5890 | |
| 405 | R | A | -1.6298 | |
| 406 | P | A | -1.4180 | |
| 407 | D | A | -1.8093 | |
| 408 | P | A | -1.0284 | |
| 409 | Y | A | -1.0402 | |
| 410 | A | A | -1.1193 | |
| 411 | G | A | -1.4107 | |
| 412 | K | A | -2.0906 | |
| 413 | K | A | -2.6172 | |
| 414 | F | A | -1.6467 | |
| 415 | K | A | -1.6458 | |
| 416 | E | A | -2.4625 | |
| 417 | I | A | -1.8232 | |
| 418 | D | A | -2.5771 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.5968 | |
| 421 | D | A | -2.3105 | |
| 422 | K | A | -1.8617 | |
| 423 | L | A | -1.0748 | |
| 424 | S | A | -1.5659 | |
| 425 | R | A | -2.2232 | |
| 426 | D | A | -2.1619 | |
| 427 | L | A | 0.0000 | |
| 428 | S | A | -2.0331 | |
| 429 | K | A | -2.7596 | |
| 430 | F | A | -1.9421 | |
| 431 | E | A | -2.4668 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -2.3282 | |
| 435 | L | A | -1.0947 | |
| 436 | Y | A | -0.4685 | |
| 437 | L | A | 0.0369 | |
| 438 | N | A | -1.6030 | |
| 439 | R | A | -1.9215 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine