Project name: 9fee3435d4825da

Chain sequence(s)	H: EVQLVESGGGLVQPGGSLRLSCAASGYSITNDYAWNWVRQAPGKGLEWVGYISYSGYTTYNPSLKSRFTISRDTSKNTLYLQMNSLRAEDTAVYYCARWTSGLDYWGQGTLVTVSS; L: DIQMTQSPSSLSASVGDRVTITCKASDLIHNWLAWYQQKPGKAPKLLIYGATSLETGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQYWTTPFTFGQGTKVEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:01:40)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:41)

• Minimal score value: -2.558
• Maximal score value: 1.4646
• Average score: -0.5104
• Total score value: -113.8189

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-2.1421
2	V	H	-1.2546
3	Q	H	-1.4294
4	L	H	0.0000
5	V	H	0.3752
6	E	H	0.0000
7	S	H	-0.3133
8	G	H	-0.4664
9	G	H	0.1427
11	G	H	0.7810
12	L	H	1.2753
13	V	H	0.0000
14	Q	H	-1.4124
15	P	H	-1.4622
16	G	H	-1.4193
17	G	H	-1.1520
18	S	H	-1.1470
19	L	H	-0.7847
20	R	H	-1.5973
21	L	H	0.0000
22	S	H	-0.3883
23	C	H	0.0000
24	A	H	-0.3233
25	A	H	-0.4597
26	S	H	-0.8722
27	G	H	-1.1876
28	Y	H	-0.6619
29	S	H	-0.4447
30	I	H	0.0000
31	T	H	-0.6448
35	N	H	-1.3793
36	D	H	-1.0529
37	Y	H	-0.2226
38	A	H	0.2006
39	W	H	0.0000
40	N	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	R	H	-0.3916
44	Q	H	-0.7174
45	A	H	-1.0767
46	P	H	-0.8679
47	G	H	-1.4807
48	K	H	-2.3890
49	G	H	-1.6660
50	L	H	0.0000
51	E	H	-0.9425
52	W	H	0.0000
53	V	H	0.0000
54	G	H	0.0000
55	Y	H	0.4415
56	I	H	0.0000
57	S	H	0.5100
58	Y	H	0.5291
59	S	H	0.2800
63	G	H	0.5244
64	Y	H	1.3141
65	T	H	0.6947
66	T	H	0.0949
67	Y	H	-0.4946
68	N	H	-0.9689
69	P	H	-1.2418
70	S	H	-0.9427
71	L	H	0.0000
72	K	H	-2.0036
74	S	H	-1.2741
75	R	H	-1.0901
76	F	H	0.0000
77	T	H	-0.6983
78	I	H	0.0000
79	S	H	-0.2594
80	R	H	-0.8407
81	D	H	-1.2587
82	T	H	-1.1436
83	S	H	-1.3058
84	K	H	-2.1282
85	N	H	-1.3453
86	T	H	-0.8898
87	L	H	0.0000
88	Y	H	-0.5192
89	L	H	0.0000
90	Q	H	-0.9890
91	M	H	0.0000
92	N	H	-1.2022
93	S	H	-1.1496
94	L	H	0.0000
95	R	H	-2.2839
96	A	H	-1.6977
97	E	H	-2.1917
98	D	H	0.0000
99	T	H	-0.4209
100	A	H	0.0000
101	V	H	0.4989
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	A	H	0.0000
106	R	H	0.0000
107	W	H	0.0000
108	T	H	-0.0966
109	S	H	-0.0039
114	G	H	0.0000
115	L	H	0.0000
116	D	H	-0.1786
117	Y	H	-0.0320
118	W	H	-0.3610
119	G	H	0.0000
120	Q	H	-1.3339
121	G	H	-0.4485
122	T	H	0.4317
123	L	H	1.4646
124	V	H	0.0000
125	T	H	0.2667
126	V	H	0.0000
127	S	H	-0.5286
128	S	H	-0.4890
1	D	L	-2.2845
2	I	L	0.0000
3	Q	L	-2.2043
4	M	L	0.0000
5	T	L	-1.3835
6	Q	L	0.0000
7	S	L	-0.8470
8	P	L	-0.7062
9	S	L	-1.0252
10	S	L	-1.2318
11	L	L	-0.9515
12	S	L	-1.2171
13	A	L	-0.9666
14	S	L	-0.7570
15	V	L	0.3213
16	G	L	-0.6640
17	D	L	-1.7435
18	R	L	-2.3393
19	V	L	0.0000
20	T	L	-0.6270
21	I	L	0.0000
22	T	L	-0.8071
23	C	L	0.0000
24	K	L	-2.3143
25	A	L	0.0000
26	S	L	-1.6744
27	D	L	-1.4766
28	L	L	0.2673
29	I	L	0.0000
36	H	L	-0.8899
37	N	L	-0.6459
38	W	L	0.5378
39	L	L	0.0000
40	A	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	Q	L	-0.7115
44	Q	L	0.0000
45	K	L	-1.4966
46	P	L	-1.1189
47	G	L	-1.6631
48	K	L	-2.5580
49	A	L	-1.5270
50	P	L	0.0000
51	K	L	-1.1867
52	L	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	Y	L	0.4294
56	G	L	-0.0306
57	A	L	0.0000
65	T	L	-0.0714
66	S	L	0.2319
67	L	L	0.4708
68	E	L	-0.1396
69	T	L	-0.2826
70	G	L	-0.5015
71	V	L	0.0000
72	P	L	-0.3581
74	S	L	-0.4120
75	R	L	-0.7469
76	F	L	0.0000
77	S	L	-0.2626
78	G	L	-0.1347
79	S	L	-0.7358
80	G	L	-1.3175
83	S	L	-1.1590
84	G	L	-0.9146
85	T	L	-1.4506
86	D	L	-2.4659
87	F	L	0.0000
88	T	L	-0.7714
89	L	L	0.0000
90	T	L	0.0000
91	I	L	0.0000
92	S	L	-1.4310
93	S	L	-1.2498
94	L	L	0.0000
95	Q	L	-0.8952
96	P	L	-0.8693
97	E	L	-1.4004
98	D	L	0.0000
99	F	L	-0.0617
100	A	L	0.0000
101	T	L	-1.0350
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	Q	L	0.0000
106	Q	L	0.0000
107	Y	L	0.6801
108	W	L	1.0833
109	T	L	0.2635
114	T	L	-0.0862
115	P	L	0.0000
116	F	L	-0.0359
117	T	L	-0.6086
118	F	L	0.0000
119	G	L	0.0000
120	Q	L	-1.9628
121	G	L	0.0000
122	T	L	0.0000
123	K	L	-2.1068
124	V	L	0.0000
125	E	L	-1.5925
126	I	L	-0.6875
127	K	L	-1.5720