| Chain sequence(s) |
A: GPLPLNPGPELVSDSEYVTPTDLLYIAETDLITREGNPFKDIVENGKVVLPRVSAYDFRVFLLTLPDPNKLPLPSEDFLNPDTEIRIWQLRAFKIGVYGPLGYGEYGHPNFNALGDVDNPTEPLHGTEDDRVALSFRPVYRQEFIIGDRPPIGKYTAPAPPTPGLPPGAKPPLVEKTDIIQDGDRADIGFGAKDFKALYPRKDEVPDIILDTTTKEIDYEGMKAEPWGDRMFTYGRKEKSKDVKHLVLDGPDLYPLPSSPPPSKLYTKPPPSSPYAVPPPYRYFTIPDAGEITEEDLMFNKPYFLTKAEGKNNGILWGNRLYVTVLDNSRAEIEKIEKQLSTPEENVYNPEDYETSYLYKEEYQLSLILQLCKIPLTPETLALLERRDPRILVDANLPDIPPVERPDPLAGKKFHNIDLTDKLSSDLEKSELGREYLNR
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:04)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | G | A | -0.2136 | |
| 2 | P | A | 0.4178 | |
| 3 | L | A | 1.3954 | |
| 4 | P | A | 0.7030 | |
| 5 | L | A | 1.0562 | |
| 6 | N | A | -0.6479 | |
| 7 | P | A | -1.0547 | |
| 8 | G | A | -1.3752 | |
| 9 | P | A | -1.8525 | |
| 10 | E | A | -1.8120 | |
| 11 | L | A | -0.8238 | |
| 12 | V | A | -0.6233 | |
| 13 | S | A | -0.9292 | |
| 14 | D | A | 0.0000 | |
| 15 | S | A | -1.4133 | |
| 16 | E | A | -1.9308 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | T | A | -0.6322 | |
| 20 | P | A | -0.7175 | |
| 21 | T | A | -0.8898 | |
| 22 | D | A | -1.5951 | |
| 23 | L | A | -0.4711 | |
| 24 | L | A | -0.1661 | |
| 25 | Y | A | -0.0836 | |
| 26 | I | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | E | A | -1.1159 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -1.3759 | |
| 31 | L | A | 0.3068 | |
| 32 | I | A | 0.1335 | |
| 33 | T | A | -0.6394 | |
| 34 | R | A | -1.4160 | |
| 35 | E | A | -2.0768 | |
| 36 | G | A | 0.0000 | |
| 37 | N | A | 0.0000 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | -0.5117 | |
| 40 | K | A | -1.5460 | |
| 41 | D | A | -1.0271 | |
| 42 | I | A | 0.5785 | |
| 43 | V | A | 0.7094 | |
| 44 | E | A | -1.4679 | |
| 45 | N | A | -2.0577 | |
| 46 | G | A | -1.3689 | |
| 47 | K | A | -1.1159 | |
| 48 | V | A | 1.1919 | |
| 49 | V | A | 1.6209 | |
| 50 | L | A | 0.6980 | |
| 51 | P | A | -0.2264 | |
| 52 | R | A | -1.1754 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | A | A | 0.0000 | |
| 56 | Y | A | 0.0000 | |
| 57 | D | A | 0.0000 | |
| 58 | F | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | L | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | T | A | -1.5172 | |
| 65 | L | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.3917 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.4758 | |
| 70 | K | A | -1.8088 | |
| 71 | L | A | -0.6580 | |
| 72 | P | A | -0.3879 | |
| 73 | L | A | -0.1916 | |
| 74 | P | A | -0.4247 | |
| 75 | S | A | -1.3607 | |
| 76 | E | A | -2.6747 | |
| 77 | D | A | -2.6887 | |
| 78 | F | A | -1.3415 | |
| 79 | L | A | 0.0000 | |
| 80 | N | A | -2.4132 | |
| 81 | P | A | -1.7870 | |
| 82 | D | A | -2.3741 | |
| 83 | T | A | -1.4894 | |
| 84 | E | A | -1.4200 | |
| 85 | I | A | 0.0000 | |
| 86 | R | A | 0.0000 | |
| 87 | I | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | Q | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.4532 | |
| 92 | A | A | 0.0000 | |
| 93 | F | A | 0.0000 | |
| 94 | K | A | -0.9687 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | 0.0000 | |
| 97 | V | A | 0.0000 | |
| 98 | Y | A | 0.3535 | |
| 99 | G | A | -0.3981 | |
| 100 | P | A | -0.1753 | |
| 101 | L | A | 0.0828 | |
| 102 | G | A | -0.2818 | |
| 103 | Y | A | -0.5459 | |
| 104 | G | A | 0.0000 | |
| 105 | E | A | -1.9982 | |
| 106 | Y | A | 0.0000 | |
| 107 | G | A | -1.0645 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | -0.8014 | |
| 110 | N | A | -1.6760 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | 0.0000 | |
| 113 | A | A | 0.0000 | |
| 114 | L | A | -0.7456 | |
| 115 | G | A | -1.3797 | |
| 116 | D | A | -2.6621 | |
| 117 | V | A | -1.9736 | |
| 118 | D | A | -3.0937 | |
| 119 | N | A | -2.8112 | |
| 120 | P | A | -2.1360 | |
| 121 | T | A | -1.7264 | |
| 122 | E | A | -2.2381 | |
| 123 | P | A | -0.8482 | |
| 124 | L | A | -0.7389 | |
| 125 | H | A | -1.0032 | |
| 126 | G | A | -1.8177 | |
| 127 | T | A | -2.1558 | |
| 128 | E | A | -3.0393 | |
| 129 | D | A | -3.2401 | |
| 130 | D | A | -2.2746 | |
| 131 | R | A | -1.9374 | |
| 132 | V | A | -0.1870 | |
| 133 | A | A | -0.0689 | |
| 134 | L | A | -0.1456 | |
| 135 | S | A | -0.6580 | |
| 136 | F | A | 0.0000 | |
| 137 | R | A | -1.1731 | |
| 138 | P | A | 0.0000 | |
| 139 | V | A | 0.0000 | |
| 140 | Y | A | 0.0000 | |
| 141 | R | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | E | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | I | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | D | A | 0.0000 | |
| 149 | R | A | -0.7307 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | I | A | -0.3443 | |
| 153 | G | A | 0.0000 | |
| 154 | K | A | -1.2913 | |
| 155 | Y | A | -1.2451 | |
| 156 | T | A | -0.6571 | |
| 157 | A | A | 0.0000 | |
| 158 | P | A | -0.0762 | |
| 159 | A | A | -0.1442 | |
| 160 | P | A | -0.2095 | |
| 161 | P | A | -0.4371 | |
| 162 | T | A | -0.3072 | |
| 163 | P | A | -0.3694 | |
| 164 | G | A | -0.2463 | |
| 165 | L | A | 0.1409 | |
| 166 | P | A | -0.3625 | |
| 167 | P | A | -0.6279 | |
| 168 | G | A | -0.9453 | |
| 169 | A | A | -1.0306 | |
| 170 | K | A | -1.6088 | |
| 171 | P | A | -0.5812 | |
| 172 | P | A | 0.1159 | |
| 173 | L | A | 0.9558 | |
| 174 | V | A | 0.1859 | |
| 175 | E | A | -1.6334 | |
| 176 | K | A | -1.5933 | |
| 177 | T | A | -1.1628 | |
| 178 | D | A | -0.7730 | |
| 179 | I | A | -0.4218 | |
| 180 | I | A | 0.0000 | |
| 181 | Q | A | -1.0613 | |
| 182 | D | A | -1.1227 | |
| 183 | G | A | -0.7050 | |
| 184 | D | A | -0.6559 | |
| 185 | R | A | 0.0000 | |
| 186 | A | A | 0.0000 | |
| 187 | D | A | -0.5788 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | -0.4305 | |
| 190 | F | A | 0.0000 | |
| 191 | G | A | -0.4815 | |
| 192 | A | A | -0.8220 | |
| 193 | K | A | -1.0068 | |
| 194 | D | A | -1.2878 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -2.8081 | |
| 197 | A | A | -1.0864 | |
| 198 | L | A | -0.6968 | |
| 199 | Y | A | -1.5700 | |
| 200 | P | A | -1.8653 | |
| 201 | R | A | -2.4371 | |
| 202 | K | A | -3.2303 | |
| 203 | D | A | 0.0000 | |
| 204 | E | A | -1.3692 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | D | A | -1.9005 | |
| 208 | I | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | L | A | -2.3263 | |
| 211 | D | A | -2.8655 | |
| 212 | T | A | -1.6587 | |
| 213 | T | A | -1.0818 | |
| 214 | T | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | E | A | -0.7557 | |
| 217 | I | A | 0.0000 | |
| 218 | D | A | -1.1511 | |
| 219 | Y | A | 0.0000 | |
| 220 | E | A | -2.3807 | |
| 221 | G | A | -1.5822 | |
| 222 | M | A | 0.0000 | |
| 223 | K | A | -2.4423 | |
| 224 | A | A | -1.3282 | |
| 225 | E | A | -1.2827 | |
| 226 | P | A | -0.6607 | |
| 227 | W | A | 0.0000 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | R | A | -0.6487 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | T | A | -0.5808 | |
| 234 | Y | A | -0.0764 | |
| 235 | G | A | -0.5133 | |
| 236 | R | A | -1.6579 | |
| 237 | K | A | -2.1796 | |
| 238 | E | A | -2.4378 | |
| 239 | K | A | -2.4953 | |
| 240 | S | A | -2.1923 | |
| 241 | K | A | -2.7446 | |
| 242 | D | A | -2.6094 | |
| 243 | V | A | -1.4152 | |
| 244 | K | A | -2.2156 | |
| 245 | H | A | -1.6825 | |
| 246 | L | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | L | A | 0.0000 | |
| 249 | D | A | -1.2026 | |
| 250 | G | A | -0.7348 | |
| 251 | P | A | -0.0855 | |
| 252 | D | A | 0.5208 | |
| 253 | L | A | 1.8393 | |
| 254 | Y | A | 1.7882 | |
| 255 | P | A | 0.6047 | |
| 256 | L | A | 0.6652 | |
| 257 | P | A | -0.3002 | |
| 258 | S | A | -0.5341 | |
| 259 | S | A | -0.6730 | |
| 260 | P | A | -0.6629 | |
| 261 | P | A | -1.1084 | |
| 262 | P | A | -0.9919 | |
| 263 | S | A | -0.9903 | |
| 264 | K | A | -0.9532 | |
| 265 | L | A | 0.8111 | |
| 266 | Y | A | 0.4613 | |
| 267 | T | A | -0.7020 | |
| 268 | K | A | -1.3355 | |
| 269 | P | A | -0.6319 | |
| 270 | P | A | -0.6020 | |
| 271 | P | A | -0.3752 | |
| 272 | S | A | -0.3740 | |
| 273 | S | A | -0.0602 | |
| 274 | P | A | -0.0079 | |
| 275 | Y | A | 0.6613 | |
| 276 | A | A | 0.6331 | |
| 277 | V | A | 1.5598 | |
| 278 | P | A | 0.7388 | |
| 279 | P | A | 0.2065 | |
| 280 | P | A | 0.3385 | |
| 281 | Y | A | 0.9128 | |
| 282 | R | A | 0.9253 | |
| 283 | Y | A | 1.2957 | |
| 284 | F | A | 0.6146 | |
| 285 | T | A | -0.3115 | |
| 286 | I | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | D | A | -1.9582 | |
| 289 | A | A | 0.0000 | |
| 290 | G | A | 0.0000 | |
| 291 | E | A | -2.2465 | |
| 292 | I | A | -1.4012 | |
| 293 | T | A | -1.8729 | |
| 294 | E | A | -2.6772 | |
| 295 | E | A | -2.8398 | |
| 296 | D | A | -2.4057 | |
| 297 | L | A | -1.4964 | |
| 298 | M | A | 0.0000 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.2638 | |
| 301 | K | A | -1.8475 | |
| 302 | P | A | -1.0420 | |
| 303 | Y | A | -0.0452 | |
| 304 | F | A | -0.2269 | |
| 305 | L | A | 0.0000 | |
| 306 | T | A | -0.8781 | |
| 307 | K | A | -2.3125 | |
| 308 | A | A | 0.0000 | |
| 309 | E | A | -2.6172 | |
| 310 | G | A | -2.0402 | |
| 311 | K | A | -1.5005 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | -1.2952 | |
| 314 | G | A | 0.0000 | |
| 315 | I | A | 0.0000 | |
| 316 | L | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | G | A | -1.1887 | |
| 319 | N | A | -1.0821 | |
| 320 | R | A | -1.3560 | |
| 321 | L | A | 0.0000 | |
| 322 | Y | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | L | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | S | A | 0.0000 | |
| 330 | R | A | -0.3531 | |
| 331 | A | A | 0.0000 | |
| 332 | E | A | -2.0416 | |
| 333 | I | A | -1.6377 | |
| 334 | E | A | -2.6397 | |
| 335 | K | A | -2.3046 | |
| 336 | I | A | -1.4286 | |
| 337 | E | A | -3.0686 | |
| 338 | K | A | -2.8488 | |
| 339 | Q | A | -2.0606 | |
| 340 | L | A | -0.2472 | |
| 341 | S | A | -0.5241 | |
| 342 | T | A | -0.7150 | |
| 343 | P | A | -1.3628 | |
| 344 | E | A | -2.4315 | |
| 345 | E | A | -2.6323 | |
| 346 | N | A | -1.5335 | |
| 347 | V | A | 0.4449 | |
| 348 | Y | A | 0.6748 | |
| 349 | N | A | -0.6317 | |
| 350 | P | A | -1.3855 | |
| 351 | E | A | -2.0885 | |
| 352 | D | A | -1.7179 | |
| 353 | Y | A | -1.8030 | |
| 354 | E | A | -2.5446 | |
| 355 | T | A | -2.0627 | |
| 356 | S | A | -1.1548 | |
| 357 | Y | A | -0.4966 | |
| 358 | L | A | -0.9670 | |
| 359 | Y | A | 0.0000 | |
| 360 | K | A | -2.1886 | |
| 361 | E | A | 0.0000 | |
| 362 | E | A | -0.3625 | |
| 363 | Y | A | 0.0000 | |
| 364 | Q | A | -0.4543 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | 0.0000 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | L | A | 0.0000 | |
| 370 | Q | A | -0.3825 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.5565 | |
| 374 | I | A | 0.0000 | |
| 375 | P | A | -0.7810 | |
| 376 | L | A | -0.6863 | |
| 377 | T | A | -0.6250 | |
| 378 | P | A | -0.9512 | |
| 379 | E | A | -1.9298 | |
| 380 | T | A | 0.0000 | |
| 381 | L | A | -0.7293 | |
| 382 | A | A | -1.3485 | |
| 383 | L | A | 0.0000 | |
| 384 | L | A | 0.0000 | |
| 385 | E | A | -2.2128 | |
| 386 | R | A | -2.2569 | |
| 387 | R | A | 0.0000 | |
| 388 | D | A | -1.2489 | |
| 389 | P | A | -1.2457 | |
| 390 | R | A | -1.5505 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | 0.0000 | |
| 393 | V | A | -1.5012 | |
| 394 | D | A | -2.2780 | |
| 395 | A | A | -1.5397 | |
| 396 | N | A | -2.0309 | |
| 397 | L | A | -1.5873 | |
| 398 | P | A | -1.4988 | |
| 399 | D | A | -1.8329 | |
| 400 | I | A | -0.6344 | |
| 401 | P | A | -0.4317 | |
| 402 | P | A | -0.6905 | |
| 403 | V | A | 0.3228 | |
| 404 | E | A | -1.9074 | |
| 405 | R | A | -2.1171 | |
| 406 | P | A | -1.6823 | |
| 407 | D | A | -2.0746 | |
| 408 | P | A | -1.1155 | |
| 409 | L | A | -0.8938 | |
| 410 | A | A | -1.0364 | |
| 411 | G | A | -1.2636 | |
| 412 | K | A | -1.7030 | |
| 413 | K | A | -2.3181 | |
| 414 | F | A | -1.3704 | |
| 415 | H | A | -1.2720 | |
| 416 | N | A | -1.8841 | |
| 417 | I | A | -1.5892 | |
| 418 | D | A | -2.5315 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.6208 | |
| 421 | D | A | -2.3524 | |
| 422 | K | A | -2.0008 | |
| 423 | L | A | -0.7493 | |
| 424 | S | A | -1.0557 | |
| 425 | S | A | -0.7718 | |
| 426 | D | A | -1.9415 | |
| 427 | L | A | 0.0000 | |
| 428 | E | A | -3.5022 | |
| 429 | K | A | -3.4220 | |
| 430 | S | A | 0.0000 | |
| 431 | E | A | -2.8015 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -3.1461 | |
| 435 | E | A | -2.2798 | |
| 436 | Y | A | -1.2227 | |
| 437 | L | A | -0.7492 | |
| 438 | N | A | -2.0085 | |
| 439 | R | A | -2.2396 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine