Project name: 2510-18.pdb

Chain sequence(s)	H: EVQLVQSGAEVKKPGASVKVSCKASGYTFTSYTIHWVRQAPGQGLEWMGYINPSSGYTNYNQKFKDKATMTRDTSTSTVYMELSSLRSEDTAVYYCARGGLGWAYWGQGTLVTVSS; L: DIQMTQSPSSLSASVGDRVTITCRASQEISGYLSWLQQKPGGAIKRLIYAASTLDSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCLQYASYPLTFGQGTKLEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:01)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:01)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:01)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:01)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:01)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:01:40)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:42)

• Minimal score value: -3.505
• Maximal score value: 1.1037
• Average score: -0.5346
• Total score value: -119.2157

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-1.9944
2	V	H	-0.9726
3	Q	H	-0.9008
4	L	H	0.0000
5	V	H	0.8557
6	Q	H	0.0000
7	S	H	-0.3620
8	G	H	-0.3879
9	A	H	0.3096
11	E	H	0.1791
12	V	H	1.0858
13	K	H	-0.9185
14	K	H	-2.2332
15	P	H	-2.2016
16	G	H	-1.6565
17	A	H	-1.2923
18	S	H	-1.3430
19	V	H	0.0000
20	K	H	-1.7631
21	V	H	0.0000
22	S	H	-0.4768
23	C	H	0.0000
24	K	H	-0.6813
25	A	H	0.0000
26	S	H	-0.7423
27	G	H	-1.1023
28	Y	H	-0.3819
29	T	H	-0.0265
30	F	H	0.0000
35	T	H	-0.2499
36	S	H	-0.0653
37	Y	H	0.2603
38	T	H	0.0772
39	I	H	0.0000
40	H	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	R	H	0.0000
44	Q	H	-0.4422
45	A	H	-0.8454
46	P	H	-1.0026
47	G	H	-1.2098
48	Q	H	-1.8489
49	G	H	-1.3371
50	L	H	0.0000
51	E	H	-0.5833
52	W	H	0.0000
53	M	H	0.0000
54	G	H	0.0000
55	Y	H	0.0000
56	I	H	0.0000
57	N	H	-0.0585
58	P	H	0.0000
59	S	H	-0.2742
62	S	H	-0.0732
63	G	H	0.0383
64	Y	H	0.9399
65	T	H	0.3814
66	N	H	-0.1229
67	Y	H	-1.1324
68	N	H	-1.8334
69	Q	H	-2.8230
70	K	H	-3.0997
71	F	H	0.0000
72	K	H	-3.5050
74	D	H	-3.2226
75	K	H	-2.2080
76	A	H	0.0000
77	T	H	-1.0964
78	M	H	0.0000
79	T	H	-0.4277
80	R	H	-0.7975
81	D	H	-0.9625
82	T	H	-0.5947
83	S	H	-0.4882
84	T	H	-0.5900
85	S	H	-0.6913
86	T	H	0.0000
87	V	H	0.0000
88	Y	H	-0.6368
89	M	H	0.0000
90	E	H	-1.2270
91	L	H	0.0000
92	S	H	-1.3302
93	S	H	-1.4424
94	L	H	0.0000
95	R	H	-3.1579
96	S	H	-2.3736
97	E	H	-2.4581
98	D	H	0.0000
99	T	H	-0.6553
100	A	H	0.0000
101	V	H	0.6618
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	A	H	0.0000
106	R	H	0.1390
107	G	H	0.0000
108	G	H	0.2175
109	L	H	1.1037
114	G	H	0.0000
115	W	H	0.0000
116	A	H	0.2563
117	Y	H	0.3051
118	W	H	0.1052
119	G	H	-0.2007
120	Q	H	-0.8311
121	G	H	-0.0909
122	T	H	0.0000
123	L	H	1.0183
124	V	H	0.0000
125	T	H	-0.0843
126	V	H	0.0000
127	S	H	-0.9964
128	S	H	-1.2251
1	D	L	-2.0227
2	I	L	-1.7470
3	Q	L	-2.2546
4	M	L	0.0000
5	T	L	-1.3964
6	Q	L	0.0000
7	S	L	-0.7400
8	P	L	-0.5962
9	S	L	-0.8952
10	S	L	-1.0166
11	L	L	-0.5348
12	S	L	-0.8173
13	A	L	0.0000
14	S	L	-0.1707
15	V	L	0.7424
16	G	L	-0.4345
17	D	L	-1.4053
18	R	L	-2.1192
19	V	L	0.0000
20	T	L	-0.5469
21	I	L	0.0000
22	T	L	-0.7847
23	C	L	0.0000
24	R	L	-2.8244
25	A	L	0.0000
26	S	L	-2.2124
27	Q	L	-2.8690
28	E	L	-2.6941
29	I	L	0.0000
36	S	L	-0.7813
37	G	L	-0.1731
38	Y	L	0.9300
39	L	L	0.0000
40	S	L	0.0000
41	W	L	0.0000
42	L	L	0.0000
43	Q	L	-0.6660
44	Q	L	-0.8526
45	K	L	-1.2095
46	P	L	-0.7760
47	G	L	-0.9412
48	G	L	-0.7433
49	A	L	-0.8027
50	I	L	-0.5926
51	K	L	-0.7614
52	R	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	Y	L	0.7180
56	A	L	0.4996
57	A	L	0.0000
65	S	L	-0.2441
66	T	L	0.1132
67	L	L	0.3400
68	D	L	0.0000
69	S	L	-0.3233
70	G	L	-0.5471
71	V	L	0.0000
72	P	L	-0.4144
74	S	L	-0.4354
75	R	L	-0.8395
76	F	L	0.0000
77	S	L	-0.3498
78	G	L	-0.4099
79	S	L	-0.9188
80	R	L	-1.6723
83	S	L	-1.2820
84	G	L	-1.6502
85	T	L	-2.0871
86	D	L	-1.8972
87	F	L	0.0000
88	T	L	-0.8122
89	L	L	0.0000
90	T	L	-0.6375
91	I	L	0.0000
92	S	L	-1.3789
93	S	L	-1.0252
94	L	L	0.0000
95	Q	L	-0.5564
96	P	L	-0.8029
97	E	L	-1.9172
98	D	L	0.0000
99	F	L	-0.7459
100	A	L	0.0000
101	T	L	-1.0380
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	L	L	0.0000
106	Q	L	0.0000
107	Y	L	0.8358
108	A	L	0.3011
109	S	L	0.1248
114	Y	L	0.5174
115	P	L	-0.3078
116	L	L	0.0000
117	T	L	-0.5829
118	F	L	0.0000
119	G	L	0.0000
120	Q	L	-1.7785
121	G	L	0.0000
122	T	L	0.0000
123	K	L	-1.8822
124	L	L	0.0000
125	E	L	-1.3467
126	I	L	0.6388
127	K	L	-0.9134