Project name: a3d2e2da24c1cd4

Chain sequence(s)	A: MIVWTVANQKGGVGKTTTVVSLAGILAQRGQRVLLIDTDPHASLTSYLDFDSDRLDGTLYELFQAVKPTAELVNKLTLRTKFDNIHLLPASITLATLDRVMGNREGMGLVLKRALLRIQDQYDYVLIDCPPVLGVMMVNALAACDRILVPVQTEFLALKGLERMMKTFEIMQRSKREKFRYTVIPTMFDKRTRASLMTLQSIKEQHGNAVWNAVIPIDTKFRDASLLHIPPSIYSPSSRGTYAYETLLNYLDAQERQRAHEVTS
Selected Chain(s)	A
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with A chain(s) selected             (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:00)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:03:19)
[INFO]       Main:     Simulation completed successfully.                                          (00:03:20)

• Minimal score value: -3.9857
• Maximal score value: 2.0019
• Average score: -0.7719
• Total score value: -203.7878

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	M	A	-0.3902
2	I	A	0.2061
3	V	A	0.0000
4	W	A	0.0000
5	T	A	0.0000
6	V	A	0.0000
7	A	A	0.0000
8	N	A	0.0000
9	Q	A	-0.6621
10	K	A	-0.7878
11	G	A	-0.7602
12	G	A	-0.8650
13	V	A	0.0000
14	G	A	-0.3012
15	K	A	0.0000
16	T	A	-0.1430
17	T	A	-0.3044
18	T	A	0.0000
19	V	A	0.0000
20	V	A	0.0000
21	S	A	0.0000
22	L	A	0.0000
23	A	A	0.0000
24	G	A	0.0000
25	I	A	0.0000
26	L	A	0.0000
27	A	A	-1.9127
28	Q	A	-2.0470
29	R	A	-1.8147
30	G	A	-1.9868
31	Q	A	-1.9177
32	R	A	-2.3099
33	V	A	0.0000
34	L	A	0.0000
35	L	A	0.0000
36	I	A	0.0000
37	D	A	0.0000
38	T	A	0.0000
39	D	A	0.0035
40	P	A	0.2646
41	H	A	-0.5557
42	A	A	0.0000
43	S	A	-0.4641
44	L	A	0.0000
45	T	A	0.0000
46	S	A	-1.2290
47	Y	A	0.0000
48	L	A	0.0000
49	D	A	-1.9378
50	F	A	-1.8456
51	D	A	-3.1184
52	S	A	-2.4220
53	D	A	-3.0981
54	R	A	-3.4802
55	L	A	-2.3258
56	D	A	-2.6369
57	G	A	-1.6369
58	T	A	0.0000
59	L	A	0.0000
60	Y	A	-0.1574
61	E	A	-1.1495
62	L	A	0.0000
63	F	A	0.0000
64	Q	A	-0.9788
65	A	A	-0.3531
66	V	A	0.6930
67	K	A	-1.0941
68	P	A	0.0000
69	T	A	-1.3057
70	A	A	-1.6984
71	E	A	-2.5803
72	L	A	-1.8505
73	V	A	0.0000
74	N	A	-2.2754
75	K	A	-2.6463
76	L	A	0.0000
77	T	A	-1.3113
78	L	A	-1.2280
79	R	A	-2.4881
80	T	A	-2.2793
81	K	A	-2.7034
82	F	A	-1.8783
83	D	A	-3.0311
84	N	A	-2.6631
85	I	A	0.0000
86	H	A	-1.5504
87	L	A	0.0000
88	L	A	0.0000
89	P	A	0.0000
90	A	A	0.0000
91	S	A	0.0000
92	I	A	1.4494
93	T	A	0.6053
94	L	A	0.0000
95	A	A	-0.0327
96	T	A	-0.3084
97	L	A	0.0000
98	D	A	-2.0836
99	R	A	-2.1999
100	V	A	-0.7505
101	M	A	0.0000
102	G	A	-2.4453
103	N	A	-3.0358
104	R	A	-3.3047
105	E	A	-3.0595
106	G	A	-1.4161
107	M	A	-0.8551
108	G	A	-0.4632
109	L	A	-0.0997
110	V	A	0.0000
111	L	A	0.0000
112	K	A	-0.7907
113	R	A	-1.1406
114	A	A	0.0000
115	L	A	0.0000
116	L	A	-0.4194
117	R	A	-1.8151
118	I	A	0.0000
119	Q	A	-1.8977
120	D	A	-2.6500
121	Q	A	-2.1453
122	Y	A	0.0000
123	D	A	-1.3398
124	Y	A	0.0000
125	V	A	0.0000
126	L	A	0.0000
127	I	A	0.0000
128	D	A	0.0000
129	C	A	0.0000
130	P	A	0.0000
131	P	A	0.4802
132	V	A	1.9149
133	L	A	1.4138
134	G	A	0.3656
135	V	A	0.0101
136	M	A	0.0000
137	M	A	0.0000
138	V	A	0.7132
139	N	A	0.0000
140	A	A	0.0000
141	L	A	0.0000
142	A	A	0.0000
143	A	A	-0.1954
144	C	A	-0.2293
145	D	A	-0.3194
146	R	A	0.0000
147	I	A	0.0000
148	L	A	0.0000
149	V	A	0.0000
150	P	A	0.0000
151	V	A	0.0000
152	Q	A	-0.0197
153	T	A	0.0000
154	E	A	0.1498
155	F	A	2.0019
156	L	A	1.6630
157	A	A	0.0000
158	L	A	-0.4946
159	K	A	-1.7572
160	G	A	0.0000
161	L	A	0.0000
162	E	A	-3.0999
163	R	A	-3.0664
164	M	A	0.0000
165	M	A	-1.8764
166	K	A	-2.4321
167	T	A	0.0000
168	F	A	0.0000
169	E	A	-2.5216
170	I	A	-0.6099
171	M	A	0.0000
172	Q	A	-2.8592
173	R	A	-2.9741
174	S	A	-2.0357
175	K	A	-3.0580
176	R	A	-3.7471
177	E	A	-3.9857
178	K	A	-3.5913
179	F	A	-1.8817
180	R	A	-1.0820
181	Y	A	-0.3735
182	T	A	0.0000
183	V	A	0.0000
184	I	A	0.0000
185	P	A	0.0000
186	T	A	0.0000
187	M	A	0.5788
188	F	A	-0.0125
189	D	A	-1.3457
190	K	A	-2.6471
191	R	A	-3.0746
192	T	A	-2.3435
193	R	A	-2.4307
194	A	A	-0.9981
195	S	A	0.0000
196	L	A	-1.0432
197	M	A	-0.1075
198	T	A	0.0000
199	L	A	-0.8456
200	Q	A	-1.8696
201	S	A	-1.7274
202	I	A	0.0000
203	K	A	-3.3238
204	E	A	-3.5716
205	Q	A	-2.9383
206	H	A	-2.1221
207	G	A	-2.5288
208	N	A	-2.2125
209	A	A	-1.2792
210	V	A	0.0000
211	W	A	0.0000
212	N	A	-1.5542
213	A	A	-0.3754
214	V	A	0.3408
215	I	A	0.0000
216	P	A	0.4231
217	I	A	1.1846
218	D	A	-0.4612
219	T	A	-1.1359
220	K	A	-1.7100
221	F	A	-0.9933
222	R	A	-2.0167
223	D	A	-1.1782
224	A	A	0.0000
225	S	A	-0.1523
226	L	A	0.8891
227	L	A	1.4547
228	H	A	0.0558
229	I	A	0.7876
230	P	A	0.0000
231	P	A	0.0000
232	S	A	0.0000
233	I	A	1.0071
234	Y	A	0.7778
235	S	A	-0.0764
236	P	A	-0.1788
237	S	A	-0.3325
238	S	A	-0.9341
239	R	A	-1.5188
240	G	A	0.0000
241	T	A	0.0000
242	Y	A	0.2917
243	A	A	0.0000
244	Y	A	0.0000
245	E	A	-0.7230
246	T	A	-0.2803
247	L	A	0.0000
248	L	A	0.0000
249	N	A	-1.0958
250	Y	A	-0.6369
251	L	A	0.0000
252	D	A	-1.2836
253	A	A	-1.4854
254	Q	A	-1.7612
255	E	A	0.0000
256	R	A	-3.3378
257	Q	A	-3.1819
258	R	A	-2.5932
259	A	A	-1.9362
260	H	A	-2.4544
261	E	A	-2.3485
262	V	A	0.1399
263	T	A	-0.3070
264	S	A	-0.5494