Project name: a3f394a4f803b29

Chain sequence(s)	H: EVQLVESGGGLVQPGRSLRLSCTASGFTFGDYAMSWVRQAPGKGLEWVGFIRSKAYGGTTEYAASVKGRFTISRDDSKSIAYLQMNSLKTEDTAVYYCTRVSLVTYYYYYYGMDVWGQGTTVTVSS; L: NIQMTQSPSSLSASVGDRVTITCRASQSISSYLNWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSYSTSSFTFGPGTKVDIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:01)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:01)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:01)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:01)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:01)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:01:33)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:35)

• Minimal score value: -2.8863
• Maximal score value: 3.0254
• Average score: -0.4639
• Total score value: -108.5543

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-2.0685
2	V	H	-1.1655
3	Q	H	-1.2996
4	L	H	0.0000
5	V	H	0.7976
6	E	H	0.0000
7	S	H	-0.4330
8	G	H	-0.6694
9	G	H	-0.3545
11	G	H	0.3233
12	L	H	1.1830
13	V	H	0.0000
14	Q	H	-1.2343
15	P	H	-1.6601
16	G	H	-2.0483
17	R	H	-2.3415
18	S	H	-1.6088
19	L	H	-1.0307
20	R	H	-1.6896
21	L	H	0.0000
22	S	H	-0.2728
23	C	H	0.0000
24	T	H	0.0173
25	A	H	0.0000
26	S	H	-0.8270
27	G	H	-1.1969
28	F	H	-0.6234
29	T	H	-0.5876
30	F	H	0.0000
35	G	H	-1.6233
36	D	H	-2.0048
37	Y	H	-0.6491
38	A	H	-0.4884
39	M	H	0.0000
40	S	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	R	H	0.0000
44	Q	H	-0.8048
45	A	H	-1.2030
46	P	H	-0.9603
47	G	H	-1.4578
48	K	H	-2.2262
49	G	H	-1.3695
50	L	H	0.0000
51	E	H	-0.9061
52	W	H	0.0000
53	V	H	0.0000
54	G	H	0.0000
55	F	H	0.0000
56	I	H	0.0000
57	R	H	-1.2048
58	S	H	0.0000
59	K	H	-2.1476
60	A	H	-0.8504
61	Y	H	-0.0562
62	G	H	-0.7302
63	G	H	-1.1143
64	T	H	-0.6571
65	T	H	-0.4942
66	E	H	-0.7608
67	Y	H	-0.7719
68	A	H	-0.6798
69	A	H	-0.7235
70	S	H	-0.7242
71	V	H	0.0000
72	K	H	-2.0794
74	G	H	-1.5597
75	R	H	-1.4389
76	F	H	0.0000
77	T	H	-0.9416
78	I	H	0.0000
79	S	H	-0.4711
80	R	H	-1.0968
81	D	H	-1.3174
82	D	H	-1.9950
83	S	H	-1.4813
84	K	H	-2.1100
85	S	H	-1.2510
86	I	H	-0.5018
87	A	H	0.0000
88	Y	H	-0.4531
89	L	H	0.0000
90	Q	H	-1.1548
91	M	H	0.0000
92	N	H	-1.7791
93	S	H	-1.7665
94	L	H	0.0000
95	K	H	-2.8863
96	T	H	-1.9760
97	E	H	-2.4208
98	D	H	0.0000
99	T	H	-0.7901
100	A	H	0.0000
101	V	H	0.1346
102	Y	H	0.0000
103	Y	H	0.0000
104	C	H	0.0000
105	T	H	0.0000
106	R	H	-0.1572
107	V	H	0.0000
108	S	H	0.7436
109	L	H	2.3535
110	V	H	2.1299
111	T	H	1.6322
111A	Y	H	2.5117
111B	Y	H	3.0254
112B	Y	H	2.8863
112A	Y	H	2.5080
112	Y	H	0.0000
113	Y	H	1.0704
114	G	H	0.0000
115	M	H	0.0000
116	D	H	-0.2732
117	V	H	-0.1593
118	W	H	-0.4176
119	G	H	0.0000
120	Q	H	-1.3608
121	G	H	-0.6097
122	T	H	-0.2003
123	T	H	0.0783
124	V	H	0.0000
125	T	H	-0.0775
126	V	H	0.0000
127	S	H	-0.6332
128	S	H	-0.3627
1	N	L	-1.7332
2	I	L	0.0000
3	Q	L	-2.0266
4	M	L	0.0000
5	T	L	-1.2584
6	Q	L	0.0000
7	S	L	-0.7897
8	P	L	-0.5354
9	S	L	-0.7276
10	S	L	-0.8844
11	L	L	-0.4461
12	S	L	-0.5080
13	A	L	0.0000
14	S	L	0.0530
15	V	L	0.7474
16	G	L	-0.4692
17	D	L	-1.2785
18	R	L	-2.1402
19	V	L	0.0000
20	T	L	-0.5818
21	I	L	0.0000
22	T	L	-0.7683
23	C	L	0.0000
24	R	L	-2.5992
25	A	L	0.0000
26	S	L	-1.7134
27	Q	L	-1.6140
28	S	L	-0.8809
29	I	L	0.0000
36	S	L	-0.2804
37	S	L	-0.0887
38	Y	L	0.4884
39	L	L	0.0000
40	N	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	Q	L	-0.8597
44	Q	L	0.0000
45	K	L	-1.7867
46	P	L	-1.2694
47	G	L	-1.6974
48	K	L	-2.5580
49	A	L	-1.5057
50	P	L	0.0000
51	K	L	-1.1703
52	L	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	Y	L	0.0000
56	A	L	0.1779
57	A	L	0.0000
65	S	L	-0.2894
66	S	L	0.0250
67	L	L	0.2930
68	Q	L	-0.2021
69	S	L	-0.3616
70	G	L	-0.4909
71	V	L	-0.2764
72	P	L	-0.3280
74	S	L	-0.4036
75	R	L	-0.8070
76	F	L	0.0000
77	S	L	-0.3501
78	G	L	-0.2810
79	S	L	-0.5697
80	G	L	-0.9033
83	S	L	-0.8750
84	G	L	-0.9759
85	T	L	-1.4566
86	D	L	-1.7662
87	F	L	0.0000
88	T	L	-0.6561
89	L	L	0.0000
90	T	L	-0.6123
91	I	L	0.0000
92	S	L	-1.3359
93	S	L	-1.0590
94	L	L	0.0000
95	Q	L	-0.6451
96	P	L	-0.4750
97	E	L	-1.4827
98	D	L	0.0000
99	F	L	-0.2920
100	A	L	0.0000
101	T	L	-0.8743
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	Q	L	0.0000
106	Q	L	0.0000
107	S	L	0.0000
108	Y	L	0.9027
109	S	L	0.0701
113	T	L	-0.0129
114	S	L	-0.3766
115	S	L	-0.3491
116	F	L	0.0000
117	T	L	-0.5222
118	F	L	0.0000
119	G	L	0.0000
120	P	L	-0.9458
121	G	L	0.0000
122	T	L	0.0000
123	K	L	-1.4930
124	V	L	0.0000
125	D	L	-0.1280
126	I	L	1.1742
127	K	L	-0.6711