| Chain sequence(s) |
A: GPLPLNPAPPLRHTSEYVEETDLLYYAETDDITEVGNPTKDVVENGKVVEPRVSATDWRVFKLTLPDPNKLPLPSEDFINPETEILIWRLKAFYIGRGGPLGKGSYGHENFNALGDVTNPTTYQHGGPDMTKNLSWYPKRLQEYIIGDEPPLGKYTTKAPPEPGLPPGAKPPTEVKSATIEDGDRADIGFGAKDYKELDPEKDNVPDIILDTTTKVPDYDAMLAEPTGRRLFTHDRYESSYASKKLVLNGPDLFPLPDSPPPSPLYTKPPASSPYAVRPPTNYFTLPDYGEITEEDLLFNKPVILEKTPGKNDGVLWHNQLYVTVVDNTRAEIETIETQLATPAVNVYNPDYYKTSKRYTRTYKLSLIIQLCKIPLTPETLEELRRLDPSILVNANLPFIPPVERPDPYAGKKFIELDLTDKLSSDLSKSELGRFYLNR
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:04)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | G | A | -0.2077 | |
| 2 | P | A | 0.4207 | |
| 3 | L | A | 1.3981 | |
| 4 | P | A | 0.7104 | |
| 5 | L | A | 1.1425 | |
| 6 | N | A | -0.5213 | |
| 7 | P | A | -0.5676 | |
| 8 | A | A | -0.4070 | |
| 9 | P | A | -0.6369 | |
| 10 | P | A | -0.5235 | |
| 11 | L | A | -0.5561 | |
| 12 | R | A | -1.2601 | |
| 13 | H | A | -1.3456 | |
| 14 | T | A | 0.0000 | |
| 15 | S | A | -2.0408 | |
| 16 | E | A | -2.3982 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | E | A | -2.6839 | |
| 20 | E | A | -2.9235 | |
| 21 | T | A | -1.9537 | |
| 22 | D | A | -1.9481 | |
| 23 | L | A | -0.6572 | |
| 24 | L | A | -0.0756 | |
| 25 | Y | A | -0.0049 | |
| 26 | Y | A | -0.3230 | |
| 27 | A | A | 0.0000 | |
| 28 | E | A | -1.4899 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -2.9137 | |
| 31 | D | A | -2.8943 | |
| 32 | I | A | -1.3689 | |
| 33 | T | A | -0.8485 | |
| 34 | E | A | -0.4430 | |
| 35 | V | A | -0.0376 | |
| 36 | G | A | 0.0000 | |
| 37 | N | A | -1.8264 | |
| 38 | P | A | 0.0000 | |
| 39 | T | A | -1.7251 | |
| 40 | K | A | -2.2756 | |
| 41 | D | A | -1.4771 | |
| 42 | V | A | 0.1377 | |
| 43 | V | A | 0.6007 | |
| 44 | E | A | -1.5044 | |
| 45 | N | A | -2.0055 | |
| 46 | G | A | -1.3173 | |
| 47 | K | A | -1.1472 | |
| 48 | V | A | 1.0276 | |
| 49 | V | A | 1.3692 | |
| 50 | E | A | 0.1365 | |
| 51 | P | A | -0.4281 | |
| 52 | R | A | -1.3921 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | A | A | 0.0000 | |
| 56 | T | A | 0.0000 | |
| 57 | D | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | K | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | T | A | -1.1813 | |
| 65 | L | A | 0.0000 | |
| 66 | P | A | -1.2586 | |
| 67 | D | A | -1.2115 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.7593 | |
| 70 | K | A | -1.9732 | |
| 71 | L | A | -0.8483 | |
| 72 | P | A | -0.6565 | |
| 73 | L | A | -0.5549 | |
| 74 | P | A | -0.6512 | |
| 75 | S | A | -1.4928 | |
| 76 | E | A | -2.7229 | |
| 77 | D | A | -2.7012 | |
| 78 | F | A | -1.2969 | |
| 79 | I | A | -1.5077 | |
| 80 | N | A | -2.2225 | |
| 81 | P | A | -2.0160 | |
| 82 | E | A | -2.1383 | |
| 83 | T | A | -1.3907 | |
| 84 | E | A | -1.2596 | |
| 85 | I | A | 0.0000 | |
| 86 | L | A | 0.0000 | |
| 87 | I | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | K | A | -0.4819 | |
| 92 | A | A | 0.0000 | |
| 93 | F | A | 0.0000 | |
| 94 | Y | A | -0.4896 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | 0.0000 | |
| 97 | R | A | 0.0000 | |
| 98 | G | A | -0.7459 | |
| 99 | G | A | -0.7528 | |
| 100 | P | A | -0.5708 | |
| 101 | L | A | -0.3170 | |
| 102 | G | A | -0.8577 | |
| 103 | K | A | -1.0340 | |
| 104 | G | A | 0.0000 | |
| 105 | S | A | -0.2477 | |
| 106 | Y | A | 0.0000 | |
| 107 | G | A | -1.2095 | |
| 108 | H | A | -2.4895 | |
| 109 | E | A | -3.4870 | |
| 110 | N | A | -3.4538 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | 0.0000 | |
| 113 | A | A | 0.0000 | |
| 114 | L | A | 0.0000 | |
| 115 | G | A | -0.6947 | |
| 116 | D | A | -1.4639 | |
| 117 | V | A | -0.8173 | |
| 118 | T | A | -1.4465 | |
| 119 | N | A | -1.6459 | |
| 120 | P | A | -0.9160 | |
| 121 | T | A | -0.4854 | |
| 122 | T | A | -0.2090 | |
| 123 | Y | A | 0.5712 | |
| 124 | Q | A | -0.1527 | |
| 125 | H | A | -0.2367 | |
| 126 | G | A | -0.7605 | |
| 127 | G | A | -1.0321 | |
| 128 | P | A | -1.2087 | |
| 129 | D | A | -2.1703 | |
| 130 | M | A | -1.2133 | |
| 131 | T | A | -2.0862 | |
| 132 | K | A | -2.8216 | |
| 133 | N | A | -3.0015 | |
| 134 | L | A | -1.5449 | |
| 135 | S | A | -0.8387 | |
| 136 | W | A | 0.0000 | |
| 137 | Y | A | 0.3715 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | R | A | 0.0000 | |
| 141 | L | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | E | A | 0.0000 | |
| 144 | Y | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | I | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | D | A | 0.0000 | |
| 149 | E | A | -0.2843 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | L | A | -0.1987 | |
| 153 | G | A | 0.0000 | |
| 154 | K | A | -0.5065 | |
| 155 | Y | A | -0.3181 | |
| 156 | T | A | -0.4625 | |
| 157 | T | A | 0.0000 | |
| 158 | K | A | -1.7434 | |
| 159 | A | A | -1.1678 | |
| 160 | P | A | -1.1931 | |
| 161 | P | A | -1.6165 | |
| 162 | E | A | -2.0842 | |
| 163 | P | A | -1.2795 | |
| 164 | G | A | -0.8233 | |
| 165 | L | A | -0.5577 | |
| 166 | P | A | -0.6934 | |
| 167 | P | A | -0.6974 | |
| 168 | G | A | -0.7682 | |
| 169 | A | A | -0.6386 | |
| 170 | K | A | -1.4078 | |
| 171 | P | A | -1.6657 | |
| 172 | P | A | -1.3094 | |
| 173 | T | A | -0.8763 | |
| 174 | E | A | -0.4198 | |
| 175 | V | A | 0.5843 | |
| 176 | K | A | -0.7268 | |
| 177 | S | A | -0.4411 | |
| 178 | A | A | -0.4072 | |
| 179 | T | A | -0.5093 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | -1.1964 | |
| 182 | D | A | -1.2877 | |
| 183 | G | A | -0.7392 | |
| 184 | D | A | -0.7223 | |
| 185 | R | A | 0.0000 | |
| 186 | A | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | -0.0299 | |
| 190 | F | A | -0.0456 | |
| 191 | G | A | -0.2290 | |
| 192 | A | A | -0.2078 | |
| 193 | K | A | -1.2260 | |
| 194 | D | A | -1.6580 | |
| 195 | Y | A | 0.0000 | |
| 196 | K | A | -3.4221 | |
| 197 | E | A | -2.8700 | |
| 198 | L | A | -1.7687 | |
| 199 | D | A | 0.0000 | |
| 200 | P | A | -2.4188 | |
| 201 | E | A | -3.0313 | |
| 202 | K | A | -3.2166 | |
| 203 | D | A | -2.3889 | |
| 204 | N | A | -1.3163 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | D | A | -2.1527 | |
| 208 | I | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | L | A | -1.6960 | |
| 211 | D | A | -2.6021 | |
| 212 | T | A | -1.4595 | |
| 213 | T | A | -1.0859 | |
| 214 | T | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | V | A | 0.0955 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | -0.6532 | |
| 219 | Y | A | -0.5195 | |
| 220 | D | A | -1.3400 | |
| 221 | A | A | -0.6635 | |
| 222 | M | A | 0.0000 | |
| 223 | L | A | 0.4180 | |
| 224 | A | A | -0.0673 | |
| 225 | E | A | -0.3835 | |
| 226 | P | A | -0.3577 | |
| 227 | T | A | -0.4188 | |
| 228 | G | A | 0.0000 | |
| 229 | R | A | 0.0000 | |
| 230 | R | A | -0.1126 | |
| 231 | L | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | T | A | -0.6756 | |
| 234 | H | A | -1.2509 | |
| 235 | D | A | -1.9541 | |
| 236 | R | A | -2.4724 | |
| 237 | Y | A | -1.3920 | |
| 238 | E | A | -1.7157 | |
| 239 | S | A | -0.8023 | |
| 240 | S | A | -0.3253 | |
| 241 | Y | A | 0.5551 | |
| 242 | A | A | -0.3466 | |
| 243 | S | A | -0.7846 | |
| 244 | K | A | -2.0788 | |
| 245 | K | A | -1.9679 | |
| 246 | L | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | L | A | 0.0615 | |
| 249 | N | A | -0.6672 | |
| 250 | G | A | -0.6767 | |
| 251 | P | A | -0.1343 | |
| 252 | D | A | 0.7467 | |
| 253 | L | A | 1.5182 | |
| 254 | F | A | 2.2324 | |
| 255 | P | A | 0.9163 | |
| 256 | L | A | 1.1870 | |
| 257 | P | A | -0.1420 | |
| 258 | D | A | -1.8404 | |
| 259 | S | A | -1.1024 | |
| 260 | P | A | -1.2104 | |
| 261 | P | A | -0.9830 | |
| 262 | P | A | -0.5745 | |
| 263 | S | A | -0.5294 | |
| 264 | P | A | 0.4162 | |
| 265 | L | A | 1.2120 | |
| 266 | Y | A | 0.2827 | |
| 267 | T | A | -0.7234 | |
| 268 | K | A | -1.7237 | |
| 269 | P | A | -0.6107 | |
| 270 | P | A | -0.6039 | |
| 271 | A | A | -0.0431 | |
| 272 | S | A | 0.0013 | |
| 273 | S | A | 0.3138 | |
| 274 | P | A | 0.5291 | |
| 275 | Y | A | 1.1015 | |
| 276 | A | A | 0.6558 | |
| 277 | V | A | 1.4717 | |
| 278 | R | A | 0.2008 | |
| 279 | P | A | -0.1581 | |
| 280 | P | A | -0.2761 | |
| 281 | T | A | 0.2109 | |
| 282 | N | A | 0.2585 | |
| 283 | Y | A | 0.8465 | |
| 284 | F | A | 0.1828 | |
| 285 | T | A | -0.5748 | |
| 286 | L | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | D | A | 0.0000 | |
| 289 | Y | A | 0.0000 | |
| 290 | G | A | -0.7595 | |
| 291 | E | A | -1.8943 | |
| 292 | I | A | -1.3713 | |
| 293 | T | A | -1.8911 | |
| 294 | E | A | -2.6959 | |
| 295 | E | A | -2.8983 | |
| 296 | D | A | -2.1595 | |
| 297 | L | A | -1.4618 | |
| 298 | L | A | -1.2358 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.1653 | |
| 301 | K | A | -1.4453 | |
| 302 | P | A | -0.5193 | |
| 303 | V | A | 0.1515 | |
| 304 | I | A | -0.2121 | |
| 305 | L | A | 0.0000 | |
| 306 | E | A | -2.5008 | |
| 307 | K | A | -2.6985 | |
| 308 | T | A | -1.5228 | |
| 309 | P | A | -0.5233 | |
| 310 | G | A | -0.5684 | |
| 311 | K | A | -1.1594 | |
| 312 | N | A | 0.0000 | |
| 313 | D | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | L | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.4909 | |
| 319 | N | A | -0.5487 | |
| 320 | Q | A | -0.6265 | |
| 321 | L | A | 0.0000 | |
| 322 | Y | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | 0.0000 | |
| 331 | A | A | 0.0000 | |
| 332 | E | A | -2.1146 | |
| 333 | I | A | -1.7716 | |
| 334 | E | A | -2.3277 | |
| 335 | T | A | -1.5428 | |
| 336 | I | A | -1.0588 | |
| 337 | E | A | -2.0972 | |
| 338 | T | A | -1.0883 | |
| 339 | Q | A | -0.7357 | |
| 340 | L | A | 0.4316 | |
| 341 | A | A | 0.4727 | |
| 342 | T | A | 0.1270 | |
| 343 | P | A | -0.3195 | |
| 344 | A | A | 0.0856 | |
| 345 | V | A | 0.7738 | |
| 346 | N | A | 0.1009 | |
| 347 | V | A | 1.9355 | |
| 348 | Y | A | 1.6874 | |
| 349 | N | A | 0.2317 | |
| 350 | P | A | -0.8522 | |
| 351 | D | A | -1.6407 | |
| 352 | Y | A | -0.1840 | |
| 353 | Y | A | -0.8011 | |
| 354 | K | A | -2.0656 | |
| 355 | T | A | -1.6820 | |
| 356 | S | A | -1.7298 | |
| 357 | K | A | -2.1897 | |
| 358 | R | A | -1.9527 | |
| 359 | Y | A | 0.0000 | |
| 360 | T | A | -0.6478 | |
| 361 | R | A | 0.0000 | |
| 362 | T | A | -0.7077 | |
| 363 | Y | A | 0.0000 | |
| 364 | K | A | -1.7398 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | 0.0000 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | I | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -1.3474 | |
| 374 | I | A | 0.0000 | |
| 375 | P | A | -0.9364 | |
| 376 | L | A | -0.9213 | |
| 377 | T | A | -0.9195 | |
| 378 | P | A | -1.4612 | |
| 379 | E | A | -2.3815 | |
| 380 | T | A | 0.0000 | |
| 381 | L | A | -1.6200 | |
| 382 | E | A | -2.7033 | |
| 383 | E | A | 0.0000 | |
| 384 | L | A | 0.0000 | |
| 385 | R | A | -2.1765 | |
| 386 | R | A | -1.7036 | |
| 387 | L | A | -1.0283 | |
| 388 | D | A | -0.8656 | |
| 389 | P | A | -1.2676 | |
| 390 | S | A | -0.6085 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | 0.0000 | |
| 393 | V | A | -0.4039 | |
| 394 | N | A | -1.1885 | |
| 395 | A | A | -1.2704 | |
| 396 | N | A | -1.1169 | |
| 397 | L | A | 0.0000 | |
| 398 | P | A | 0.0932 | |
| 399 | F | A | 1.5252 | |
| 400 | I | A | 0.9573 | |
| 401 | P | A | 0.3239 | |
| 402 | P | A | -0.0658 | |
| 403 | V | A | 0.4163 | |
| 404 | E | A | -1.5444 | |
| 405 | R | A | -1.4990 | |
| 406 | P | A | -1.3375 | |
| 407 | D | A | -1.7972 | |
| 408 | P | A | -1.0232 | |
| 409 | Y | A | -1.0643 | |
| 410 | A | A | -1.1513 | |
| 411 | G | A | -1.4405 | |
| 412 | K | A | -2.1642 | |
| 413 | K | A | -2.5616 | |
| 414 | F | A | -1.4359 | |
| 415 | I | A | -1.0954 | |
| 416 | E | A | -2.2139 | |
| 417 | L | A | -1.6709 | |
| 418 | D | A | -2.5623 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.6193 | |
| 421 | D | A | -2.3598 | |
| 422 | K | A | -1.9464 | |
| 423 | L | A | -0.7137 | |
| 424 | S | A | -0.8381 | |
| 425 | S | A | -0.5515 | |
| 426 | D | A | -1.4828 | |
| 427 | L | A | 0.0000 | |
| 428 | S | A | -1.8298 | |
| 429 | K | A | -2.7796 | |
| 430 | S | A | 0.0000 | |
| 431 | E | A | -2.5790 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -2.3603 | |
| 435 | F | A | -0.5806 | |
| 436 | Y | A | -0.3103 | |
| 437 | L | A | 0.1086 | |
| 438 | N | A | -1.4755 | |
| 439 | R | A | -1.8375 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine