| Chain sequence(s) |
A: LCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELVKLVESGGGLVKPGGSLKLSCAASGFTFSSYAMSWVRQTPEKRLEWVATISSGGTYTYYPDSVKGRFTISRDNAENTLYLQMSSLRSEDTAMYYCVRDGNSMDYWGQGTSVDIQMTQTTSSLSASLGDRVTIICRASQDINNYLNWYQQKPDGTVKLLIYYTSRLSGVPSRFSGSGSGSDYSLTISNLEQEDIATYFCQQANELPPTFGAGTKLEL
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:01)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:03:35)
[INFO] Main: Simulation completed successfully. (00:03:37)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | L | A | 1.3720 | |
| 2 | C | A | 0.7298 | |
| 3 | P | A | -0.4411 | |
| 4 | F | A | 0.0000 | |
| 5 | G | A | -0.4816 | |
| 6 | E | A | -1.6175 | |
| 7 | V | A | 0.0000 | |
| 8 | F | A | -1.1990 | |
| 9 | N | A | -1.9905 | |
| 10 | A | A | -1.3304 | |
| 11 | T | A | -1.6661 | |
| 12 | R | A | -2.1965 | |
| 13 | F | A | 0.0000 | |
| 14 | A | A | -0.6022 | |
| 15 | S | A | 0.0000 | |
| 16 | V | A | 0.0000 | |
| 17 | Y | A | 0.0860 | |
| 18 | A | A | -0.1558 | |
| 19 | W | A | 0.0000 | |
| 20 | N | A | -0.9597 | |
| 21 | R | A | -1.2216 | |
| 22 | K | A | -1.5044 | |
| 23 | R | A | -2.1165 | |
| 24 | I | A | 0.0000 | |
| 25 | S | A | -1.1010 | |
| 26 | N | A | -1.0919 | |
| 27 | C | A | 0.0000 | |
| 28 | V | A | -0.0673 | |
| 29 | A | A | -0.6518 | |
| 30 | D | A | -1.4241 | |
| 31 | Y | A | 0.0000 | |
| 32 | S | A | -0.3150 | |
| 33 | V | A | 1.1467 | |
| 34 | L | A | 0.6036 | |
| 35 | Y | A | 0.8357 | |
| 36 | N | A | -0.1722 | |
| 37 | S | A | 0.2518 | |
| 38 | A | A | 0.1399 | |
| 39 | S | A | -0.0059 | |
| 40 | F | A | 0.2150 | |
| 41 | S | A | -0.2683 | |
| 42 | T | A | -0.1028 | |
| 43 | F | A | 0.0000 | |
| 44 | K | A | -0.9337 | |
| 45 | C | A | -0.3305 | |
| 46 | Y | A | -0.6916 | |
| 47 | G | A | -0.7994 | |
| 48 | V | A | -0.2610 | |
| 49 | S | A | -0.9022 | |
| 50 | P | A | -1.0154 | |
| 51 | T | A | -1.2574 | |
| 52 | K | A | -2.3660 | |
| 53 | L | A | 0.0000 | |
| 54 | N | A | -2.0339 | |
| 55 | D | A | -2.4191 | |
| 56 | L | A | -0.5617 | |
| 57 | C | A | -0.0112 | |
| 58 | F | A | -0.2231 | |
| 59 | T | A | -0.7764 | |
| 60 | N | A | -1.4035 | |
| 61 | V | A | 0.0000 | |
| 62 | Y | A | -0.7780 | |
| 63 | A | A | 0.0000 | |
| 64 | D | A | 0.0000 | |
| 65 | S | A | 0.0000 | |
| 66 | F | A | 0.0000 | |
| 67 | V | A | 0.0000 | |
| 68 | I | A | 0.0000 | |
| 69 | R | A | 0.2001 | |
| 70 | G | A | 0.1065 | |
| 71 | D | A | -0.1633 | |
| 72 | E | A | 0.0000 | |
| 73 | V | A | -0.5282 | |
| 74 | R | A | -1.7804 | |
| 75 | Q | A | -1.2640 | |
| 76 | I | A | 0.0000 | |
| 77 | A | A | -1.0093 | |
| 78 | P | A | -1.5890 | |
| 79 | G | A | -2.0352 | |
| 80 | Q | A | -1.4758 | |
| 81 | T | A | -1.0286 | |
| 82 | G | A | -0.9591 | |
| 83 | K | A | -0.8424 | |
| 84 | I | A | 0.0000 | |
| 85 | A | A | 0.0000 | |
| 86 | D | A | -1.4320 | |
| 87 | Y | A | -1.0401 | |
| 88 | N | A | 0.0000 | |
| 89 | Y | A | 0.0000 | |
| 90 | K | A | -1.2479 | |
| 91 | L | A | 0.0000 | |
| 92 | P | A | -2.0453 | |
| 93 | D | A | -3.0328 | |
| 94 | D | A | -2.8470 | |
| 95 | F | A | 0.0000 | |
| 96 | T | A | -0.7661 | |
| 97 | G | A | 0.0000 | |
| 98 | C | A | 0.0000 | |
| 99 | V | A | 0.0000 | |
| 100 | I | A | 0.0000 | |
| 101 | A | A | 0.0000 | |
| 102 | W | A | -0.1715 | |
| 103 | N | A | -0.5082 | |
| 104 | S | A | 0.0000 | |
| 105 | N | A | -0.5417 | |
| 106 | N | A | -1.0695 | |
| 107 | L | A | 0.1748 | |
| 108 | D | A | 0.0000 | |
| 109 | S | A | -0.3433 | |
| 110 | K | A | -0.3748 | |
| 111 | V | A | 0.7698 | |
| 112 | G | A | -0.3063 | |
| 113 | G | A | 0.0000 | |
| 114 | N | A | -0.2539 | |
| 115 | Y | A | 0.2415 | |
| 116 | N | A | 0.0038 | |
| 117 | Y | A | 0.0000 | |
| 118 | L | A | 0.3905 | |
| 119 | Y | A | 0.0000 | |
| 120 | R | A | 0.0000 | |
| 121 | L | A | 0.4048 | |
| 122 | F | A | -0.1067 | |
| 123 | R | A | -1.4270 | |
| 124 | K | A | -2.2314 | |
| 125 | S | A | -1.8597 | |
| 126 | N | A | -2.3584 | |
| 127 | L | A | 0.0000 | |
| 128 | K | A | -2.2755 | |
| 129 | P | A | -1.6241 | |
| 130 | F | A | -0.2815 | |
| 131 | E | A | -1.5149 | |
| 132 | R | A | -1.4913 | |
| 133 | D | A | -1.4507 | |
| 134 | I | A | -0.5985 | |
| 135 | S | A | -0.7894 | |
| 136 | T | A | -1.0995 | |
| 137 | E | A | -1.6965 | |
| 138 | I | A | -0.5292 | |
| 139 | Y | A | -0.6177 | |
| 140 | Q | A | -0.7913 | |
| 141 | A | A | -0.6021 | |
| 142 | G | A | -0.6739 | |
| 143 | S | A | -0.6220 | |
| 144 | T | A | -0.2543 | |
| 145 | P | A | -0.1578 | |
| 146 | C | A | -0.0459 | |
| 147 | N | A | -1.0861 | |
| 148 | G | A | -0.2125 | |
| 149 | V | A | 0.5134 | |
| 150 | E | A | 0.0738 | |
| 151 | G | A | 0.4447 | |
| 152 | F | A | 1.5739 | |
| 153 | N | A | 0.3089 | |
| 154 | C | A | 0.0000 | |
| 155 | Y | A | 0.8137 | |
| 156 | F | A | 0.3271 | |
| 157 | P | A | 0.0000 | |
| 158 | L | A | 0.4615 | |
| 159 | Q | A | 0.0708 | |
| 160 | S | A | 0.1704 | |
| 161 | Y | A | 0.0000 | |
| 162 | G | A | -0.0019 | |
| 163 | F | A | 0.0000 | |
| 164 | Q | A | -0.4401 | |
| 165 | P | A | -0.7188 | |
| 166 | T | A | -0.2373 | |
| 167 | N | A | -0.2043 | |
| 168 | G | A | 0.3596 | |
| 169 | V | A | 1.4630 | |
| 170 | G | A | 0.7788 | |
| 171 | Y | A | 1.1563 | |
| 172 | Q | A | 0.2299 | |
| 173 | P | A | 0.0000 | |
| 174 | Y | A | 0.1420 | |
| 175 | R | A | -0.6613 | |
| 176 | V | A | 0.0000 | |
| 177 | V | A | 0.0000 | |
| 178 | V | A | 0.0000 | |
| 179 | L | A | 0.0000 | |
| 180 | S | A | -0.2850 | |
| 181 | F | A | 0.0000 | |
| 182 | E | A | -0.9906 | |
| 183 | L | A | 0.6928 | |
| 184 | V | A | 0.8884 | |
| 185 | K | A | -0.6875 | |
| 186 | L | A | 0.0000 | |
| 187 | V | A | 0.4601 | |
| 188 | E | A | 0.0200 | |
| 189 | S | A | -0.5114 | |
| 190 | G | A | -1.1154 | |
| 191 | G | A | -0.3091 | |
| 192 | G | A | 0.5176 | |
| 193 | L | A | 1.5462 | |
| 194 | V | A | 0.6634 | |
| 195 | K | A | -1.4645 | |
| 196 | P | A | -1.4244 | |
| 197 | G | A | -1.4114 | |
| 198 | G | A | -0.8657 | |
| 199 | S | A | -0.7628 | |
| 200 | L | A | -0.7592 | |
| 201 | K | A | -2.1495 | |
| 202 | L | A | 0.0000 | |
| 203 | S | A | -0.5367 | |
| 204 | C | A | 0.0000 | |
| 205 | A | A | -0.3788 | |
| 206 | A | A | -0.4948 | |
| 207 | S | A | -0.2238 | |
| 208 | G | A | -0.1284 | |
| 209 | F | A | 0.2298 | |
| 210 | T | A | 0.0549 | |
| 211 | F | A | 0.0000 | |
| 212 | S | A | -0.5019 | |
| 213 | S | A | 0.0000 | |
| 214 | Y | A | -0.0301 | |
| 215 | A | A | 0.0000 | |
| 216 | M | A | 0.0000 | |
| 217 | S | A | 0.0000 | |
| 218 | W | A | 0.0000 | |
| 219 | V | A | 0.0000 | |
| 220 | R | A | -0.5806 | |
| 221 | Q | A | 0.0000 | |
| 222 | T | A | 0.0000 | |
| 223 | P | A | -1.7593 | |
| 224 | E | A | -2.6076 | |
| 225 | K | A | -2.3060 | |
| 226 | R | A | -1.9920 | |
| 227 | L | A | 0.0000 | |
| 228 | E | A | -0.8527 | |
| 229 | W | A | 0.0000 | |
| 230 | V | A | 0.0000 | |
| 231 | A | A | 0.0000 | |
| 232 | T | A | 0.0000 | |
| 233 | I | A | 0.0000 | |
| 234 | S | A | 0.0000 | |
| 235 | S | A | 0.0000 | |
| 236 | G | A | -0.7075 | |
| 237 | G | A | -0.3783 | |
| 238 | T | A | 0.0879 | |
| 239 | Y | A | 0.6443 | |
| 240 | T | A | 0.2726 | |
| 241 | Y | A | -0.0750 | |
| 242 | Y | A | -0.7017 | |
| 243 | P | A | -1.0672 | |
| 244 | D | A | -2.1405 | |
| 245 | S | A | -1.5862 | |
| 246 | V | A | -1.3584 | |
| 247 | K | A | -2.5022 | |
| 248 | G | A | -1.7659 | |
| 249 | R | A | -1.4849 | |
| 250 | F | A | 0.0000 | |
| 251 | T | A | -0.9915 | |
| 252 | I | A | 0.0000 | |
| 253 | S | A | -0.3853 | |
| 254 | R | A | -1.0019 | |
| 255 | D | A | -1.7090 | |
| 256 | N | A | -1.6779 | |
| 257 | A | A | -1.3975 | |
| 258 | E | A | -2.3413 | |
| 259 | N | A | -1.6576 | |
| 260 | T | A | -0.9553 | |
| 261 | L | A | 0.0000 | |
| 262 | Y | A | -0.5341 | |
| 263 | L | A | 0.0000 | |
| 264 | Q | A | -1.6438 | |
| 265 | M | A | 0.0000 | |
| 266 | S | A | -1.1894 | |
| 267 | S | A | -1.1243 | |
| 268 | L | A | 0.0000 | |
| 269 | R | A | -2.9111 | |
| 270 | S | A | -2.0848 | |
| 271 | E | A | -2.5499 | |
| 272 | D | A | 0.0000 | |
| 273 | T | A | -0.6971 | |
| 274 | A | A | 0.0000 | |
| 275 | M | A | -0.1482 | |
| 276 | Y | A | 0.0000 | |
| 277 | Y | A | 0.0000 | |
| 278 | C | A | 0.0000 | |
| 279 | V | A | 0.0000 | |
| 280 | R | A | 0.0000 | |
| 281 | D | A | -0.6765 | |
| 282 | G | A | -0.9830 | |
| 283 | N | A | -0.5565 | |
| 284 | S | A | -0.2653 | |
| 285 | M | A | 0.0000 | |
| 286 | D | A | -0.2374 | |
| 287 | Y | A | 0.1295 | |
| 288 | W | A | 0.0000 | |
| 289 | G | A | 0.0000 | |
| 290 | Q | A | -1.2272 | |
| 291 | G | A | -0.3342 | |
| 292 | T | A | -0.2902 | |
| 293 | S | A | -0.0116 | |
| 294 | V | A | 0.5766 | |
| 295 | D | A | -2.2539 | |
| 296 | I | A | 0.0000 | |
| 297 | Q | A | -2.0524 | |
| 298 | M | A | -1.2897 | |
| 299 | T | A | -0.9680 | |
| 300 | Q | A | -0.3537 | |
| 301 | T | A | -0.2437 | |
| 302 | T | A | -0.2608 | |
| 303 | S | A | -0.6285 | |
| 304 | S | A | -1.0928 | |
| 305 | L | A | -0.6420 | |
| 306 | S | A | -0.5352 | |
| 307 | A | A | -0.7716 | |
| 308 | S | A | -1.0109 | |
| 309 | L | A | -0.7689 | |
| 310 | G | A | -2.3053 | |
| 311 | D | A | -3.4625 | |
| 312 | R | A | -3.2517 | |
| 313 | V | A | 0.0000 | |
| 314 | T | A | -0.2348 | |
| 315 | I | A | 0.0000 | |
| 316 | I | A | 0.0077 | |
| 317 | C | A | 0.0000 | |
| 318 | R | A | -2.7742 | |
| 319 | A | A | -2.1026 | |
| 320 | S | A | -1.7677 | |
| 321 | Q | A | -2.4566 | |
| 322 | D | A | -2.2736 | |
| 323 | I | A | 0.0000 | |
| 324 | N | A | -1.0477 | |
| 325 | N | A | -0.9336 | |
| 326 | Y | A | 0.0000 | |
| 327 | L | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | W | A | 0.0000 | |
| 330 | Y | A | 0.0000 | |
| 331 | Q | A | -0.7407 | |
| 332 | Q | A | -1.0838 | |
| 333 | K | A | -1.8689 | |
| 334 | P | A | -1.3676 | |
| 335 | D | A | -1.6622 | |
| 336 | G | A | -1.3150 | |
| 337 | T | A | -1.2708 | |
| 338 | V | A | 0.0000 | |
| 339 | K | A | -1.0638 | |
| 340 | L | A | -0.2118 | |
| 341 | L | A | 0.0000 | |
| 342 | I | A | 0.0000 | |
| 343 | Y | A | -0.2801 | |
| 344 | Y | A | -0.2868 | |
| 345 | T | A | 0.0000 | |
| 346 | S | A | -0.8871 | |
| 347 | R | A | -1.4790 | |
| 348 | L | A | -0.2572 | |
| 350 | S | A | -0.4411 | |
| 351 | G | A | -0.3784 | |
| 352 | V | A | -0.0611 | |
| 353 | P | A | -0.2064 | |
| 354 | S | A | -0.3081 | |
| 355 | R | A | -1.0629 | |
| 356 | F | A | 0.0000 | |
| 357 | S | A | -0.5482 | |
| 358 | G | A | 0.0000 | |
| 359 | S | A | -0.8600 | |
| 360 | G | A | -1.1916 | |
| 361 | S | A | -1.4604 | |
| 362 | G | A | -1.7136 | |
| 363 | S | A | -2.3578 | |
| 364 | D | A | -2.7183 | |
| 365 | Y | A | 0.0000 | |
| 366 | S | A | -0.5078 | |
| 367 | L | A | 0.0000 | |
| 368 | T | A | -0.6124 | |
| 369 | I | A | 0.0000 | |
| 370 | S | A | -2.2948 | |
| 371 | N | A | -3.1692 | |
| 372 | L | A | 0.0000 | |
| 373 | E | A | -2.5897 | |
| 374 | Q | A | -2.1285 | |
| 375 | E | A | -2.7380 | |
| 376 | D | A | 0.0000 | |
| 377 | I | A | -1.0398 | |
| 378 | A | A | -1.1107 | |
| 379 | T | A | -0.9667 | |
| 380 | Y | A | 0.0000 | |
| 381 | F | A | 0.0000 | |
| 382 | C | A | 0.0000 | |
| 383 | Q | A | 0.0000 | |
| 384 | Q | A | 0.0000 | |
| 385 | A | A | -0.3815 | |
| 386 | N | A | -0.8383 | |
| 387 | E | A | -1.0888 | |
| 388 | L | A | -0.4988 | |
| 389 | P | A | -0.7720 | |
| 390 | P | A | -0.4829 | |
| 391 | T | A | -0.7408 | |
| 392 | F | A | -0.2769 | |
| 393 | G | A | 0.0000 | |
| 394 | A | A | -0.7391 | |
| 395 | G | A | -0.7665 | |
| 396 | T | A | 0.0000 | |
| 397 | K | A | -1.6295 | |
| 398 | L | A | 0.0000 | |
| 399 | E | A | -1.1956 | |
| 400 | L | A | 0.7678 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine