| Chain sequence(s) |
A: YLPPTTPVAKVQSTDEYVYPTSLFCHAHTDRLLTVGHPFEDIIVNGKVLVPKVSGWQWRVFRLKFPDPNKFALPQKDFYDPEKERLVWRLRGLEIGRGGPLGKGTIGHPLFNKLGDTENPTAPQHEGADVREAFSFDPKQTQLFIVGCEPPTGEHWDIAEPCPGLPPGACPPIQLVNSVIEDGDMCDIGFGNMNFKELQQDRSGVPLDIVSTRCKWPDFLKMTNEAYGDKMFFFGRREQVYARHFFRRAGPEGHPLPSGPPPSKLYVKPPASSPYAVLPSTDYFGTPSGSLVSSDGQLFNRPFWLQRAQGNNNGVCWHNELFVTVVDNTRNTNFTISQQLCTPAPNVYDPSCFKNYLRHVEQFELSLIAQLCKVPLDPGVLAHINTMNPTILENWNLGFVPPKEREDPYKGLIFWEVDLTERFSQDLDQFALGRKFLYQ
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:06)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Y | A | 1.9489 | |
| 2 | L | A | 1.9729 | |
| 3 | P | A | 0.6552 | |
| 4 | P | A | 0.3605 | |
| 5 | T | A | 0.1169 | |
| 6 | T | A | 0.1255 | |
| 7 | P | A | 0.1601 | |
| 8 | V | A | 1.2159 | |
| 9 | A | A | 0.0325 | |
| 10 | K | A | -1.1516 | |
| 11 | V | A | -0.3988 | |
| 12 | Q | A | -1.5253 | |
| 13 | S | A | -1.6032 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.4259 | |
| 16 | E | A | -2.4399 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | Y | A | 0.4636 | |
| 20 | P | A | 0.1324 | |
| 21 | T | A | 0.1643 | |
| 22 | S | A | -0.0954 | |
| 23 | L | A | 0.1009 | |
| 24 | F | A | -0.0197 | |
| 25 | C | A | 0.0000 | |
| 26 | H | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | H | A | -1.1556 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -2.7620 | |
| 31 | R | A | -2.6108 | |
| 32 | L | A | -0.7434 | |
| 33 | L | A | 1.1903 | |
| 34 | T | A | 1.3736 | |
| 35 | V | A | 1.8203 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -0.2197 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | -0.6550 | |
| 40 | E | A | -1.8350 | |
| 41 | D | A | -0.4733 | |
| 42 | I | A | 1.5455 | |
| 43 | I | A | 2.6334 | |
| 44 | V | A | 1.8333 | |
| 45 | N | A | -0.4521 | |
| 46 | G | A | -0.2683 | |
| 47 | K | A | 0.0046 | |
| 48 | V | A | 2.3970 | |
| 49 | L | A | 2.7009 | |
| 50 | V | A | 1.5900 | |
| 51 | P | A | 0.4618 | |
| 52 | K | A | -0.6641 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | G | A | 0.0000 | |
| 56 | W | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | R | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.1305 | |
| 65 | F | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.4476 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.2840 | |
| 70 | K | A | -1.7983 | |
| 71 | F | A | -0.6508 | |
| 72 | A | A | -0.5766 | |
| 73 | L | A | -0.8584 | |
| 74 | P | A | -1.2527 | |
| 75 | Q | A | -2.4798 | |
| 76 | K | A | -3.0976 | |
| 77 | D | A | -2.9914 | |
| 78 | F | A | -1.6488 | |
| 79 | Y | A | -1.9188 | |
| 80 | D | A | -2.7613 | |
| 81 | P | A | -2.3589 | |
| 82 | E | A | -3.0799 | |
| 83 | K | A | -3.4433 | |
| 84 | E | A | -2.5063 | |
| 85 | R | A | -1.3171 | |
| 86 | L | A | 0.0000 | |
| 87 | V | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.6423 | |
| 92 | G | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | E | A | -0.9685 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | -1.3088 | |
| 97 | R | A | 0.0000 | |
| 98 | G | A | -0.6795 | |
| 99 | G | A | -0.5507 | |
| 100 | P | A | -0.4363 | |
| 101 | L | A | -0.0278 | |
| 102 | G | A | -0.2577 | |
| 103 | K | A | -0.6747 | |
| 104 | G | A | -0.4649 | |
| 105 | T | A | -0.4631 | |
| 106 | I | A | 0.0000 | |
| 107 | G | A | 0.1358 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | -0.1611 | |
| 110 | L | A | -0.3902 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -1.4260 | |
| 113 | K | A | -0.9304 | |
| 114 | L | A | 0.0000 | |
| 115 | G | A | 0.0000 | |
| 116 | D | A | -1.4846 | |
| 117 | T | A | -1.3399 | |
| 118 | E | A | -2.6792 | |
| 119 | N | A | -2.3824 | |
| 120 | P | A | -1.7220 | |
| 121 | T | A | -0.9372 | |
| 122 | A | A | -0.7442 | |
| 123 | P | A | -0.8794 | |
| 124 | Q | A | -1.9658 | |
| 125 | H | A | -2.2308 | |
| 126 | E | A | -3.0194 | |
| 127 | G | A | -2.2397 | |
| 128 | A | A | -1.4431 | |
| 129 | D | A | -2.4570 | |
| 130 | V | A | -2.0507 | |
| 131 | R | A | -1.8050 | |
| 132 | E | A | -1.7518 | |
| 133 | A | A | -0.6098 | |
| 134 | F | A | -0.3054 | |
| 135 | S | A | -0.3548 | |
| 136 | F | A | 0.0000 | |
| 137 | D | A | -0.5264 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | Q | A | 0.0000 | |
| 141 | T | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | C | A | 0.0000 | |
| 149 | E | A | -0.5525 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | 0.0000 | |
| 153 | G | A | 0.0000 | |
| 154 | E | A | -0.2318 | |
| 155 | H | A | 0.0000 | |
| 156 | W | A | 1.0973 | |
| 157 | D | A | 0.3389 | |
| 158 | I | A | 0.8529 | |
| 159 | A | A | 0.1120 | |
| 160 | E | A | -1.4825 | |
| 161 | P | A | -0.2842 | |
| 162 | C | A | 0.1390 | |
| 163 | P | A | -0.2109 | |
| 164 | G | A | -0.1343 | |
| 165 | L | A | 0.4677 | |
| 166 | P | A | -0.1672 | |
| 167 | P | A | -0.3674 | |
| 168 | G | A | -0.4319 | |
| 169 | A | A | -0.0395 | |
| 170 | C | A | 0.7421 | |
| 171 | P | A | 0.5277 | |
| 172 | P | A | 0.7657 | |
| 173 | I | A | 2.0342 | |
| 174 | Q | A | 0.8311 | |
| 175 | L | A | 1.4251 | |
| 176 | V | A | 0.8153 | |
| 177 | N | A | -0.2882 | |
| 178 | S | A | 0.0396 | |
| 179 | V | A | 0.4542 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | 0.3812 | |
| 182 | D | A | 0.0807 | |
| 183 | G | A | -0.1628 | |
| 184 | D | A | -0.5943 | |
| 185 | M | A | 0.0000 | |
| 186 | C | A | 0.0000 | |
| 187 | D | A | -0.4929 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | 0.0937 | |
| 190 | F | A | 0.0086 | |
| 191 | G | A | -0.1663 | |
| 192 | N | A | -0.3590 | |
| 193 | M | A | -0.1988 | |
| 194 | N | A | 0.0000 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -3.4178 | |
| 197 | E | A | -2.6192 | |
| 198 | L | A | -1.2077 | |
| 199 | Q | A | -2.5224 | |
| 200 | Q | A | -3.3364 | |
| 201 | D | A | -3.5948 | |
| 202 | R | A | -3.3412 | |
| 203 | S | A | 0.0000 | |
| 204 | G | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | L | A | 0.1648 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | V | A | -1.4111 | |
| 211 | S | A | -1.9463 | |
| 212 | T | A | -1.5101 | |
| 213 | R | A | -2.2443 | |
| 214 | C | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | W | A | -0.2258 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | F | A | 0.3225 | |
| 220 | L | A | 0.5494 | |
| 221 | K | A | -1.2090 | |
| 222 | M | A | 0.0000 | |
| 223 | T | A | -0.9375 | |
| 224 | N | A | -1.5491 | |
| 225 | E | A | -1.3105 | |
| 226 | A | A | -0.6784 | |
| 227 | Y | A | -0.4540 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | K | A | -0.6962 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | F | A | -0.1421 | |
| 234 | F | A | -0.0101 | |
| 235 | G | A | -0.8983 | |
| 236 | R | A | -2.6015 | |
| 237 | R | A | -2.7849 | |
| 238 | E | A | -1.9937 | |
| 239 | Q | A | -0.0473 | |
| 240 | V | A | 1.5477 | |
| 241 | Y | A | 1.2697 | |
| 242 | A | A | 0.1866 | |
| 243 | R | A | -1.2885 | |
| 244 | H | A | -1.1761 | |
| 245 | F | A | -0.2185 | |
| 246 | F | A | 0.0000 | |
| 247 | R | A | 0.0000 | |
| 248 | R | A | -0.5521 | |
| 249 | A | A | -1.4419 | |
| 250 | G | A | -1.1518 | |
| 251 | P | A | -1.1599 | |
| 252 | E | A | -1.3735 | |
| 253 | G | A | -1.2800 | |
| 254 | H | A | -1.4693 | |
| 255 | P | A | -0.9628 | |
| 256 | L | A | -0.0278 | |
| 257 | P | A | -0.4485 | |
| 258 | S | A | -0.7348 | |
| 259 | G | A | -0.8873 | |
| 260 | P | A | -1.0313 | |
| 261 | P | A | -0.8617 | |
| 262 | P | A | -0.6148 | |
| 263 | S | A | -0.5263 | |
| 264 | K | A | -0.8012 | |
| 265 | L | A | 0.9918 | |
| 266 | Y | A | 0.9436 | |
| 267 | V | A | 0.9530 | |
| 268 | K | A | -0.5381 | |
| 269 | P | A | 0.0767 | |
| 270 | P | A | -0.3433 | |
| 271 | A | A | 0.0004 | |
| 272 | S | A | -0.1342 | |
| 273 | S | A | 0.2329 | |
| 274 | P | A | 0.6091 | |
| 275 | Y | A | 1.6561 | |
| 276 | A | A | 1.2227 | |
| 277 | V | A | 2.3619 | |
| 278 | L | A | 1.6404 | |
| 279 | P | A | 0.1036 | |
| 280 | S | A | 0.0000 | |
| 281 | T | A | -0.2836 | |
| 282 | D | A | -0.8607 | |
| 283 | Y | A | 0.9067 | |
| 284 | F | A | 0.7256 | |
| 285 | G | A | 0.0628 | |
| 286 | T | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | S | A | 0.0000 | |
| 289 | G | A | 0.0000 | |
| 290 | S | A | 0.9650 | |
| 291 | L | A | 1.6501 | |
| 292 | V | A | 0.6447 | |
| 293 | S | A | -0.1680 | |
| 294 | S | A | -1.0024 | |
| 295 | D | A | -1.8738 | |
| 296 | G | A | 0.0000 | |
| 297 | Q | A | -1.0454 | |
| 298 | L | A | -1.1735 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.6654 | |
| 301 | R | A | -1.9205 | |
| 302 | P | A | -0.9791 | |
| 303 | F | A | -0.2388 | |
| 304 | W | A | -0.5254 | |
| 305 | L | A | 0.0000 | |
| 306 | Q | A | -2.0834 | |
| 307 | R | A | -2.9306 | |
| 308 | A | A | 0.0000 | |
| 309 | Q | A | -1.6622 | |
| 310 | G | A | -1.4308 | |
| 311 | N | A | -1.4024 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | C | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.9134 | |
| 319 | N | A | -0.8864 | |
| 320 | E | A | -1.0510 | |
| 321 | L | A | 0.0000 | |
| 322 | F | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.3680 | |
| 331 | N | A | 0.0000 | |
| 332 | T | A | -0.0859 | |
| 333 | N | A | 0.5819 | |
| 334 | F | A | 1.7913 | |
| 335 | T | A | 0.9013 | |
| 336 | I | A | 0.4843 | |
| 337 | S | A | -0.8212 | |
| 338 | Q | A | -1.4847 | |
| 339 | Q | A | -0.8789 | |
| 340 | L | A | 0.7965 | |
| 341 | C | A | 0.4420 | |
| 342 | T | A | 0.1563 | |
| 343 | P | A | -0.2753 | |
| 344 | A | A | 0.1210 | |
| 345 | P | A | 0.2062 | |
| 346 | N | A | -0.2856 | |
| 347 | V | A | 1.5489 | |
| 348 | Y | A | 1.4495 | |
| 349 | D | A | 0.0457 | |
| 350 | P | A | -0.3495 | |
| 351 | S | A | -0.2783 | |
| 352 | C | A | 0.0000 | |
| 353 | F | A | -0.5601 | |
| 354 | K | A | -1.6675 | |
| 355 | N | A | -1.6965 | |
| 356 | Y | A | -0.0440 | |
| 357 | L | A | 0.6758 | |
| 358 | R | A | 0.9779 | |
| 359 | H | A | 0.0000 | |
| 360 | V | A | 1.3697 | |
| 361 | E | A | 0.0000 | |
| 362 | Q | A | -0.0048 | |
| 363 | F | A | 0.0000 | |
| 364 | E | A | -1.9000 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | -0.6671 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | A | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.3014 | |
| 374 | V | A | 0.0000 | |
| 375 | P | A | -1.3249 | |
| 376 | L | A | -1.7554 | |
| 377 | D | A | -2.0314 | |
| 378 | P | A | -1.0626 | |
| 379 | G | A | -1.0187 | |
| 380 | V | A | -0.9311 | |
| 381 | L | A | -0.5420 | |
| 382 | A | A | -0.6599 | |
| 383 | H | A | -0.8443 | |
| 384 | I | A | 0.0000 | |
| 385 | N | A | -1.3940 | |
| 386 | T | A | -0.5720 | |
| 387 | M | A | -0.3288 | |
| 388 | N | A | -0.8705 | |
| 389 | P | A | -1.2677 | |
| 390 | T | A | -1.5455 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | -1.5442 | |
| 393 | E | A | -2.9503 | |
| 394 | N | A | -2.6720 | |
| 395 | W | A | -1.5413 | |
| 396 | N | A | -1.4421 | |
| 397 | L | A | -0.2653 | |
| 398 | G | A | 0.4943 | |
| 399 | F | A | 2.4077 | |
| 400 | V | A | 1.8408 | |
| 401 | P | A | 0.0491 | |
| 402 | P | A | -1.9371 | |
| 403 | K | A | -3.5456 | |
| 404 | E | A | -3.9065 | |
| 405 | R | A | -4.2351 | |
| 406 | E | A | -3.9064 | |
| 407 | D | A | -2.9682 | |
| 408 | P | A | -1.7874 | |
| 409 | Y | A | -0.9784 | |
| 410 | K | A | -2.0952 | |
| 411 | G | A | -0.6276 | |
| 412 | L | A | 0.7599 | |
| 413 | I | A | 1.5858 | |
| 414 | F | A | 0.0000 | |
| 415 | W | A | -0.4034 | |
| 416 | E | A | -1.6844 | |
| 417 | V | A | 0.0000 | |
| 418 | D | A | -2.8497 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.8810 | |
| 421 | E | A | -2.4932 | |
| 422 | R | A | -2.0551 | |
| 423 | F | A | -1.0071 | |
| 424 | S | A | -1.3049 | |
| 425 | Q | A | -1.7993 | |
| 426 | D | A | -2.8745 | |
| 427 | L | A | -1.9770 | |
| 428 | D | A | -2.7678 | |
| 429 | Q | A | -2.5973 | |
| 430 | F | A | -1.4270 | |
| 431 | A | A | -0.8860 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -1.5513 | |
| 435 | K | A | -0.7089 | |
| 436 | F | A | 0.1617 | |
| 437 | L | A | 1.0416 | |
| 438 | Y | A | 0.8361 | |
| 439 | Q | A | -0.2627 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine