| Chain sequence(s) |
A: GPLPLNPEPPLRSTDEFVEPTDLLLVAETDLITRTGHPTKDIIENGKVVVPKVSATQFKVFKLTLPDPNTLPLPSADFLDPATEIRIWRLRALRIKIGGALGKGTYGHKNFNRLGDVTNPTEYQHEGADDTIDYSFTPKRLQLYVVGDRPPIGKYTAPAAPAPGLPPGARLPTTTVSTIIEDGDNADIGFGAKDYKALEPSKDNVPDDILDTKTIILDLDGMRAEPYGRRMFDYGVKESSKDSKKYVRSGPDLIPLPSANPPSPLYVPPPPSSPYWKLPSYNYFTVPDQGEITEDDLLFNQPRFFEKTAGLNNGILWGNQLYVTILDNTRAEIQTIETQISTPEVNVYDPSNYVTSKLYTEEYQLELILQLCRIPLTPETLEELRRLDDSFLVDANLPDIPPVERPDPLAGKKFIEIDLTDKLSTNLEETELGREYLNR
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:04)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | G | A | -0.2123 | |
| 2 | P | A | 0.4199 | |
| 3 | L | A | 1.3927 | |
| 4 | P | A | 0.7122 | |
| 5 | L | A | 0.8622 | |
| 6 | N | A | -1.0020 | |
| 7 | P | A | -1.4739 | |
| 8 | E | A | -2.1758 | |
| 9 | P | A | -1.4956 | |
| 10 | P | A | -0.8711 | |
| 11 | L | A | -0.4038 | |
| 12 | R | A | -1.2079 | |
| 13 | S | A | -1.2168 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.9240 | |
| 16 | E | A | -2.9224 | |
| 17 | F | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | E | A | -2.5225 | |
| 20 | P | A | -1.7655 | |
| 21 | T | A | 0.0000 | |
| 22 | D | A | -1.8135 | |
| 23 | L | A | -0.7721 | |
| 24 | L | A | -0.3568 | |
| 25 | L | A | 0.0000 | |
| 26 | V | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | E | A | -0.9124 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -1.1949 | |
| 31 | L | A | 0.4214 | |
| 32 | I | A | 0.1916 | |
| 33 | T | A | -0.2139 | |
| 34 | R | A | -0.5138 | |
| 35 | T | A | -0.2136 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -1.1888 | |
| 38 | P | A | 0.0000 | |
| 39 | T | A | -1.4498 | |
| 40 | K | A | -1.7977 | |
| 41 | D | A | -0.7810 | |
| 42 | I | A | 0.8507 | |
| 43 | I | A | 1.0346 | |
| 44 | E | A | -1.3338 | |
| 45 | N | A | -2.0317 | |
| 46 | G | A | -1.3274 | |
| 47 | K | A | -1.0781 | |
| 48 | V | A | 1.2367 | |
| 49 | V | A | 1.5857 | |
| 50 | V | A | 1.2080 | |
| 51 | P | A | 0.1960 | |
| 52 | K | A | -0.8329 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | A | A | 0.0000 | |
| 56 | T | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | F | A | 0.0000 | |
| 59 | K | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | K | A | -1.2772 | |
| 63 | L | A | 0.0000 | |
| 64 | T | A | -1.2857 | |
| 65 | L | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.0041 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -0.7879 | |
| 70 | T | A | -0.3326 | |
| 71 | L | A | -0.1007 | |
| 72 | P | A | -0.1452 | |
| 73 | L | A | -0.1106 | |
| 74 | P | A | -0.3089 | |
| 75 | S | A | -0.3113 | |
| 76 | A | A | 0.2731 | |
| 77 | D | A | -0.1722 | |
| 78 | F | A | 1.2895 | |
| 79 | L | A | 0.1486 | |
| 80 | D | A | -0.7414 | |
| 81 | P | A | -0.7252 | |
| 82 | A | A | -0.4907 | |
| 83 | T | A | -0.5180 | |
| 84 | E | A | -0.4882 | |
| 85 | I | A | 0.0000 | |
| 86 | R | A | -0.8781 | |
| 87 | I | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.7796 | |
| 92 | A | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | R | A | 0.0000 | |
| 95 | I | A | 0.0000 | |
| 96 | K | A | -0.9440 | |
| 97 | I | A | 0.0000 | |
| 98 | G | A | -0.5676 | |
| 99 | G | A | -0.8146 | |
| 100 | A | A | -0.4507 | |
| 101 | L | A | -0.5124 | |
| 102 | G | A | -1.2552 | |
| 103 | K | A | -1.8950 | |
| 104 | G | A | 0.0000 | |
| 105 | T | A | -0.6605 | |
| 106 | Y | A | 0.0000 | |
| 107 | G | A | -1.3412 | |
| 108 | H | A | -2.1972 | |
| 109 | K | A | -3.0556 | |
| 110 | N | A | -2.9958 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | 0.0000 | |
| 113 | R | A | -0.5617 | |
| 114 | L | A | -0.5851 | |
| 115 | G | A | 0.0000 | |
| 116 | D | A | -1.2591 | |
| 117 | V | A | -0.6955 | |
| 118 | T | A | -1.3251 | |
| 119 | N | A | -1.9123 | |
| 120 | P | A | -1.4013 | |
| 121 | T | A | -1.3547 | |
| 122 | E | A | -2.1030 | |
| 123 | Y | A | -0.6941 | |
| 124 | Q | A | -1.2314 | |
| 125 | H | A | -1.7923 | |
| 126 | E | A | -1.9154 | |
| 127 | G | A | -1.6792 | |
| 128 | A | A | -1.2596 | |
| 129 | D | A | -2.1862 | |
| 130 | D | A | -1.5728 | |
| 131 | T | A | -1.4635 | |
| 132 | I | A | -1.0013 | |
| 133 | D | A | -2.4677 | |
| 134 | Y | A | -1.2901 | |
| 135 | S | A | -0.8041 | |
| 136 | F | A | 0.0000 | |
| 137 | T | A | -0.6806 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | R | A | 0.0000 | |
| 141 | L | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | Y | A | 0.0000 | |
| 145 | V | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | D | A | 0.0000 | |
| 149 | R | A | -0.6554 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | I | A | 0.1226 | |
| 153 | G | A | 0.0000 | |
| 154 | K | A | -0.0463 | |
| 155 | Y | A | -0.1885 | |
| 156 | T | A | -0.2482 | |
| 157 | A | A | -0.3300 | |
| 158 | P | A | 0.0332 | |
| 159 | A | A | 0.0540 | |
| 160 | A | A | -0.0421 | |
| 161 | P | A | -0.1329 | |
| 162 | A | A | -0.0733 | |
| 163 | P | A | -0.3839 | |
| 164 | G | A | -0.4102 | |
| 165 | L | A | -0.1056 | |
| 166 | P | A | -0.4915 | |
| 167 | P | A | -0.6550 | |
| 168 | G | A | -0.6180 | |
| 169 | A | A | -0.6091 | |
| 170 | R | A | -1.0372 | |
| 171 | L | A | -0.1486 | |
| 172 | P | A | -0.1638 | |
| 173 | T | A | -0.1632 | |
| 174 | T | A | -0.0560 | |
| 175 | T | A | -0.0483 | |
| 176 | V | A | 0.1323 | |
| 177 | S | A | 0.0251 | |
| 178 | T | A | 0.2016 | |
| 179 | I | A | -0.0675 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | -1.0832 | |
| 182 | D | A | -1.2011 | |
| 183 | G | A | -0.7138 | |
| 184 | D | A | -0.7656 | |
| 185 | N | A | 0.0000 | |
| 186 | A | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | -0.6189 | |
| 190 | F | A | 0.0021 | |
| 191 | G | A | -0.2241 | |
| 192 | A | A | -0.2699 | |
| 193 | K | A | -0.8269 | |
| 194 | D | A | -1.4022 | |
| 195 | Y | A | 0.0000 | |
| 196 | K | A | -2.7194 | |
| 197 | A | A | -1.2502 | |
| 198 | L | A | -0.8172 | |
| 199 | E | A | -1.4883 | |
| 200 | P | A | -1.4983 | |
| 201 | S | A | -1.4357 | |
| 202 | K | A | -2.6717 | |
| 203 | D | A | -1.8452 | |
| 204 | N | A | -1.1298 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | D | A | -1.8682 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | L | A | -1.6949 | |
| 211 | D | A | -2.3295 | |
| 212 | T | A | -1.5243 | |
| 213 | K | A | -1.4856 | |
| 214 | T | A | 0.0000 | |
| 215 | I | A | 0.0000 | |
| 216 | I | A | 0.6816 | |
| 217 | L | A | 0.3417 | |
| 218 | D | A | -0.7291 | |
| 219 | L | A | -1.0515 | |
| 220 | D | A | -2.4526 | |
| 221 | G | A | -1.7674 | |
| 222 | M | A | 0.0000 | |
| 223 | R | A | -2.6662 | |
| 224 | A | A | -1.6262 | |
| 225 | E | A | -1.3207 | |
| 226 | P | A | -0.6483 | |
| 227 | Y | A | 0.0000 | |
| 228 | G | A | 0.0000 | |
| 229 | R | A | 0.0000 | |
| 230 | R | A | -0.7284 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | D | A | -0.5699 | |
| 234 | Y | A | 0.2634 | |
| 235 | G | A | 0.1052 | |
| 236 | V | A | 0.1203 | |
| 237 | K | A | -1.2127 | |
| 238 | E | A | -2.0466 | |
| 239 | S | A | -1.6619 | |
| 240 | S | A | -2.1209 | |
| 241 | K | A | -3.2698 | |
| 242 | D | A | -3.3933 | |
| 243 | S | A | -2.3667 | |
| 244 | K | A | -2.6382 | |
| 245 | K | A | -2.0040 | |
| 246 | Y | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | R | A | 0.0000 | |
| 249 | S | A | -1.0185 | |
| 250 | G | A | -0.7065 | |
| 251 | P | A | -0.1008 | |
| 252 | D | A | 0.7539 | |
| 253 | L | A | 1.7071 | |
| 254 | I | A | 2.4049 | |
| 255 | P | A | 1.2876 | |
| 256 | L | A | 1.2660 | |
| 257 | P | A | 0.1753 | |
| 258 | S | A | -0.6404 | |
| 259 | A | A | -0.4410 | |
| 260 | N | A | -1.5988 | |
| 261 | P | A | -1.2153 | |
| 262 | P | A | -0.2413 | |
| 263 | S | A | 0.0000 | |
| 264 | P | A | 0.8153 | |
| 265 | L | A | 1.9226 | |
| 266 | Y | A | 1.7798 | |
| 267 | V | A | 2.0260 | |
| 268 | P | A | 0.8316 | |
| 269 | P | A | 0.4800 | |
| 270 | P | A | 0.0439 | |
| 271 | P | A | -0.3851 | |
| 272 | S | A | -0.1673 | |
| 273 | S | A | -0.0375 | |
| 274 | P | A | 0.0120 | |
| 275 | Y | A | 0.6775 | |
| 276 | W | A | 0.2902 | |
| 277 | K | A | -1.1150 | |
| 278 | L | A | -0.0621 | |
| 279 | P | A | -0.4340 | |
| 280 | S | A | 0.0000 | |
| 281 | Y | A | 0.2772 | |
| 282 | N | A | -0.3109 | |
| 283 | Y | A | 0.6780 | |
| 284 | F | A | -0.0534 | |
| 285 | T | A | -1.1068 | |
| 286 | V | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | D | A | -2.1353 | |
| 289 | Q | A | 0.0000 | |
| 290 | G | A | -1.9500 | |
| 291 | E | A | -2.1710 | |
| 292 | I | A | -1.4982 | |
| 293 | T | A | -1.8945 | |
| 294 | E | A | -2.7160 | |
| 295 | D | A | -2.8859 | |
| 296 | D | A | -2.2089 | |
| 297 | L | A | -1.4142 | |
| 298 | L | A | -0.7688 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.4807 | |
| 301 | Q | A | -1.6059 | |
| 302 | P | A | -1.0598 | |
| 303 | R | A | -0.7251 | |
| 304 | F | A | -0.8627 | |
| 305 | F | A | 0.0000 | |
| 306 | E | A | -2.6438 | |
| 307 | K | A | -2.7531 | |
| 308 | T | A | 0.0000 | |
| 309 | A | A | -0.6923 | |
| 310 | G | A | -0.6873 | |
| 311 | L | A | -0.4470 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | I | A | 0.0000 | |
| 316 | L | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | G | A | -1.0327 | |
| 319 | N | A | -0.8879 | |
| 320 | Q | A | -0.8802 | |
| 321 | L | A | 0.0000 | |
| 322 | Y | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | I | A | 0.0000 | |
| 326 | L | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.9288 | |
| 331 | A | A | 0.0000 | |
| 332 | E | A | -2.3575 | |
| 333 | I | A | -1.5814 | |
| 334 | Q | A | -1.8343 | |
| 335 | T | A | -1.2243 | |
| 336 | I | A | -0.1447 | |
| 337 | E | A | -0.9932 | |
| 338 | T | A | 0.1096 | |
| 339 | Q | A | 0.1424 | |
| 340 | I | A | 1.7882 | |
| 341 | S | A | 0.3813 | |
| 342 | T | A | -0.3117 | |
| 343 | P | A | -1.0862 | |
| 344 | E | A | -1.9095 | |
| 345 | V | A | -0.4492 | |
| 346 | N | A | -0.5147 | |
| 347 | V | A | 1.4510 | |
| 348 | Y | A | 1.5112 | |
| 349 | D | A | -0.0229 | |
| 350 | P | A | 0.1665 | |
| 351 | S | A | 0.1085 | |
| 352 | N | A | 0.5844 | |
| 353 | Y | A | 0.8998 | |
| 354 | V | A | 1.5935 | |
| 355 | T | A | -0.0876 | |
| 356 | S | A | -0.7983 | |
| 357 | K | A | -1.8877 | |
| 358 | L | A | -0.9311 | |
| 359 | Y | A | 0.0000 | |
| 360 | T | A | -0.7255 | |
| 361 | E | A | 0.0000 | |
| 362 | E | A | -0.5442 | |
| 363 | Y | A | 0.0000 | |
| 364 | Q | A | -0.5968 | |
| 365 | L | A | 0.0000 | |
| 366 | E | A | 0.0000 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | L | A | 0.0000 | |
| 370 | Q | A | -0.4834 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | R | A | -1.1897 | |
| 374 | I | A | 0.0000 | |
| 375 | P | A | -0.7920 | |
| 376 | L | A | -0.4413 | |
| 377 | T | A | -0.9113 | |
| 378 | P | A | -1.5141 | |
| 379 | E | A | -2.4628 | |
| 380 | T | A | 0.0000 | |
| 381 | L | A | -2.0038 | |
| 382 | E | A | -3.3397 | |
| 383 | E | A | 0.0000 | |
| 384 | L | A | 0.0000 | |
| 385 | R | A | -3.4370 | |
| 386 | R | A | -2.3409 | |
| 387 | L | A | -1.5566 | |
| 388 | D | A | -1.8659 | |
| 389 | D | A | -3.1122 | |
| 390 | S | A | -1.6315 | |
| 391 | F | A | 0.0000 | |
| 392 | L | A | 0.0000 | |
| 393 | V | A | -1.7924 | |
| 394 | D | A | -2.2346 | |
| 395 | A | A | -1.6131 | |
| 396 | N | A | -2.1122 | |
| 397 | L | A | -1.3529 | |
| 398 | P | A | -1.3115 | |
| 399 | D | A | -1.9197 | |
| 400 | I | A | -0.8025 | |
| 401 | P | A | -0.5012 | |
| 402 | P | A | -0.6635 | |
| 403 | V | A | 0.3523 | |
| 404 | E | A | -1.7143 | |
| 405 | R | A | -1.8423 | |
| 406 | P | A | -1.6880 | |
| 407 | D | A | -2.2660 | |
| 408 | P | A | -1.2389 | |
| 409 | L | A | -1.0185 | |
| 410 | A | A | -1.1756 | |
| 411 | G | A | -1.3660 | |
| 412 | K | A | -1.8184 | |
| 413 | K | A | -2.3941 | |
| 414 | F | A | -1.4220 | |
| 415 | I | A | -1.1606 | |
| 416 | E | A | -2.2635 | |
| 417 | I | A | -1.7073 | |
| 418 | D | A | -2.5460 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.5905 | |
| 421 | D | A | -2.3297 | |
| 422 | K | A | -1.9450 | |
| 423 | L | A | -0.8238 | |
| 424 | S | A | -1.0148 | |
| 425 | T | A | -1.0099 | |
| 426 | N | A | -2.4547 | |
| 427 | L | A | 0.0000 | |
| 428 | E | A | -3.5705 | |
| 429 | E | A | -3.5635 | |
| 430 | T | A | -2.6659 | |
| 431 | E | A | -2.3023 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -3.0985 | |
| 435 | E | A | -2.0392 | |
| 436 | Y | A | -1.2228 | |
| 437 | L | A | -0.7156 | |
| 438 | N | A | -2.0019 | |
| 439 | R | A | -2.2321 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine