| Chain sequence(s) |
A: SSTAVGFDERMLLHSEFEVKAQPHPERPDRLRAIAASLATAGVFPGRCLPINAREITKQELQMVHTSEHVDAVDTTSQLLYSYFTSDTYANEYSARAARLAAGLCADLATDIFTGRVKNGFALVRPPGHHAGVRHAMGFCLHNNAAVAALVAQAAGAKKVLIVDWDVHHGNGTQEIFEQNKSVLYISLHRHEGGNFYPGTGAADEVGSNGGEGYCVNVPWSCGGVGDKDYIFAFQHVVLPIASAFSPDFVIISAGFDAARGDPLGCCDVTPAGYSRMTQMLGDLCGGKMLVILEGGYNLRSISASATAVIKVLLGELPIATTPSVAGLQTVLDVLNIQLEFWPSLAISYSKLL
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:03:43)
[INFO] Main: Simulation completed successfully. (00:03:45)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 148 | S | A | -0.9310 | |
| 149 | S | A | -0.7870 | |
| 150 | T | A | 0.0000 | |
| 151 | A | A | 0.0000 | |
| 152 | V | A | 0.0000 | |
| 153 | G | A | 0.0000 | |
| 154 | F | A | -0.5986 | |
| 155 | D | A | -1.5263 | |
| 156 | E | A | -2.3731 | |
| 157 | R | A | -1.7168 | |
| 158 | M | A | 0.0000 | |
| 159 | L | A | -0.8380 | |
| 160 | L | A | 0.1240 | |
| 161 | H | A | 0.0000 | |
| 162 | S | A | 0.2779 | |
| 163 | E | A | 0.4816 | |
| 164 | F | A | 1.9154 | |
| 165 | E | A | 0.8668 | |
| 166 | V | A | 0.9947 | |
| 167 | K | A | -0.8446 | |
| 168 | A | A | -0.9164 | |
| 169 | Q | A | -1.4924 | |
| 170 | P | A | -1.0539 | |
| 171 | H | A | -1.0245 | |
| 172 | P | A | -0.6273 | |
| 173 | E | A | 0.0000 | |
| 174 | R | A | -1.0422 | |
| 175 | P | A | -1.3384 | |
| 176 | D | A | -1.9084 | |
| 177 | R | A | 0.0000 | |
| 178 | L | A | 0.0000 | |
| 179 | R | A | -2.4615 | |
| 180 | A | A | -1.4488 | |
| 181 | I | A | 0.0000 | |
| 182 | A | A | -0.9167 | |
| 183 | A | A | -0.4889 | |
| 184 | S | A | -0.5221 | |
| 185 | L | A | 0.0000 | |
| 186 | A | A | -0.3734 | |
| 187 | T | A | -0.1660 | |
| 188 | A | A | -0.4453 | |
| 189 | G | A | -0.7702 | |
| 190 | V | A | 0.0000 | |
| 191 | F | A | 0.0000 | |
| 192 | P | A | -0.8776 | |
| 193 | G | A | -1.4290 | |
| 194 | R | A | -2.0415 | |
| 195 | C | A | 0.0000 | |
| 196 | L | A | 0.0350 | |
| 197 | P | A | -0.3408 | |
| 198 | I | A | -0.4179 | |
| 199 | N | A | -1.3263 | |
| 200 | A | A | -1.3672 | |
| 201 | R | A | -1.4760 | |
| 202 | E | A | -1.3890 | |
| 203 | I | A | 0.0000 | |
| 204 | T | A | -1.2801 | |
| 205 | K | A | -2.1164 | |
| 206 | Q | A | -1.8913 | |
| 207 | E | A | -1.1824 | |
| 208 | L | A | 0.0000 | |
| 209 | Q | A | -1.1621 | |
| 210 | M | A | -0.1173 | |
| 211 | V | A | 0.0000 | |
| 212 | H | A | 0.0000 | |
| 213 | T | A | -1.4839 | |
| 214 | S | A | -1.9765 | |
| 215 | E | A | -2.8999 | |
| 216 | H | A | 0.0000 | |
| 217 | V | A | 0.0000 | |
| 218 | D | A | -2.6898 | |
| 219 | A | A | -1.5198 | |
| 220 | V | A | 0.0000 | |
| 221 | D | A | -1.9737 | |
| 222 | T | A | -1.1251 | |
| 223 | T | A | 0.0000 | |
| 224 | S | A | -0.7680 | |
| 225 | Q | A | -0.7070 | |
| 226 | L | A | 0.8918 | |
| 227 | L | A | 1.9208 | |
| 228 | Y | A | 1.5576 | |
| 229 | S | A | 0.8517 | |
| 230 | Y | A | 0.4548 | |
| 231 | F | A | 0.4301 | |
| 232 | T | A | -0.0307 | |
| 233 | S | A | -0.3312 | |
| 234 | D | A | -0.6831 | |
| 235 | T | A | 0.0000 | |
| 236 | Y | A | 0.0000 | |
| 237 | A | A | 0.0000 | |
| 238 | N | A | 0.0000 | |
| 239 | E | A | -0.0743 | |
| 240 | Y | A | 0.1120 | |
| 241 | S | A | 0.0000 | |
| 242 | A | A | 0.0000 | |
| 243 | R | A | -2.1044 | |
| 244 | A | A | 0.0000 | |
| 245 | A | A | 0.0000 | |
| 246 | R | A | -1.3939 | |
| 247 | L | A | 0.0000 | |
| 248 | A | A | 0.0000 | |
| 249 | A | A | 0.0000 | |
| 250 | G | A | 0.0000 | |
| 251 | L | A | 0.0000 | |
| 252 | C | A | 0.0000 | |
| 253 | A | A | 0.0000 | |
| 254 | D | A | -0.6590 | |
| 255 | L | A | 0.0000 | |
| 256 | A | A | 0.0000 | |
| 257 | T | A | -0.5363 | |
| 258 | D | A | -1.1628 | |
| 259 | I | A | 0.0000 | |
| 260 | F | A | -0.5975 | |
| 261 | T | A | -0.7823 | |
| 262 | G | A | -1.6036 | |
| 263 | R | A | -2.3077 | |
| 264 | V | A | 0.0000 | |
| 265 | K | A | -1.4576 | |
| 266 | N | A | 0.0000 | |
| 267 | G | A | 0.0000 | |
| 268 | F | A | 0.0000 | |
| 269 | A | A | 0.0000 | |
| 270 | L | A | 0.0000 | |
| 271 | V | A | 0.0000 | |
| 272 | R | A | 0.0000 | |
| 273 | P | A | 0.0000 | |
| 274 | P | A | 0.0000 | |
| 275 | G | A | 0.0000 | |
| 276 | H | A | 0.0000 | |
| 277 | H | A | 0.0000 | |
| 278 | A | A | 0.0000 | |
| 279 | G | A | 0.0000 | |
| 280 | V | A | -0.6069 | |
| 281 | R | A | -2.2711 | |
| 282 | H | A | -1.6769 | |
| 283 | A | A | 0.0000 | |
| 284 | M | A | -0.1547 | |
| 285 | G | A | 0.0000 | |
| 286 | F | A | 0.1585 | |
| 287 | C | A | 0.0000 | |
| 288 | L | A | 0.0000 | |
| 289 | H | A | 0.0000 | |
| 290 | N | A | 0.0000 | |
| 291 | N | A | 0.0000 | |
| 292 | A | A | 0.0000 | |
| 293 | A | A | 0.0000 | |
| 294 | V | A | 0.0000 | |
| 295 | A | A | 0.0000 | |
| 296 | A | A | 0.0000 | |
| 297 | L | A | -0.0007 | |
| 298 | V | A | 0.0000 | |
| 299 | A | A | 0.0000 | |
| 300 | Q | A | -0.9900 | |
| 301 | A | A | -0.2699 | |
| 302 | A | A | -0.2741 | |
| 303 | G | A | -0.8713 | |
| 304 | A | A | 0.0000 | |
| 305 | K | A | -2.4315 | |
| 306 | K | A | -2.2771 | |
| 307 | V | A | 0.0000 | |
| 308 | L | A | 0.0000 | |
| 309 | I | A | 0.0000 | |
| 310 | V | A | 0.0000 | |
| 311 | D | A | 0.0000 | |
| 312 | W | A | 0.0000 | |
| 313 | D | A | 0.0000 | |
| 314 | V | A | 0.0000 | |
| 315 | H | A | 0.0000 | |
| 316 | H | A | 0.0000 | |
| 317 | G | A | 0.0000 | |
| 318 | N | A | 0.0000 | |
| 319 | G | A | 0.0000 | |
| 320 | T | A | 0.0000 | |
| 321 | Q | A | 0.0000 | |
| 322 | E | A | -2.0422 | |
| 323 | I | A | -0.9235 | |
| 324 | F | A | 0.0000 | |
| 325 | E | A | -2.3737 | |
| 326 | Q | A | -2.9092 | |
| 327 | N | A | -2.5400 | |
| 328 | K | A | -2.7534 | |
| 329 | S | A | -1.8465 | |
| 330 | V | A | 0.0000 | |
| 331 | L | A | 0.0000 | |
| 332 | Y | A | 0.0000 | |
| 333 | I | A | 0.0000 | |
| 334 | S | A | 0.0000 | |
| 335 | L | A | 0.0000 | |
| 336 | H | A | 0.0000 | |
| 337 | R | A | -0.4318 | |
| 338 | H | A | 0.0000 | |
| 339 | E | A | -1.1040 | |
| 340 | G | A | -1.2092 | |
| 341 | G | A | -1.1352 | |
| 342 | N | A | -1.4755 | |
| 343 | F | A | -0.3817 | |
| 344 | Y | A | 0.4729 | |
| 345 | P | A | 0.1603 | |
| 346 | G | A | -0.4799 | |
| 347 | T | A | -0.3443 | |
| 348 | G | A | 0.0000 | |
| 349 | A | A | -1.0301 | |
| 350 | A | A | -1.4810 | |
| 351 | D | A | -2.4807 | |
| 352 | E | A | -1.8163 | |
| 353 | V | A | -1.2755 | |
| 354 | G | A | -2.2675 | |
| 355 | S | A | -2.0631 | |
| 356 | N | A | -2.4794 | |
| 357 | G | A | -2.3658 | |
| 358 | G | A | 0.0000 | |
| 359 | E | A | -2.4610 | |
| 360 | G | A | 0.0000 | |
| 361 | Y | A | -1.0376 | |
| 362 | C | A | 0.0000 | |
| 363 | V | A | 0.0000 | |
| 364 | N | A | 0.0000 | |
| 365 | V | A | 0.0000 | |
| 366 | P | A | -0.6273 | |
| 367 | W | A | 0.0000 | |
| 368 | S | A | -0.7871 | |
| 369 | C | A | -0.1342 | |
| 370 | G | A | -0.2086 | |
| 371 | G | A | -0.7170 | |
| 372 | V | A | 0.0000 | |
| 373 | G | A | -0.9824 | |
| 374 | D | A | -0.9121 | |
| 375 | K | A | -0.7542 | |
| 376 | D | A | 0.0000 | |
| 377 | Y | A | 0.0000 | |
| 378 | I | A | -0.5271 | |
| 379 | F | A | -0.3281 | |
| 380 | A | A | 0.0000 | |
| 381 | F | A | 0.0000 | |
| 382 | Q | A | -1.0695 | |
| 383 | H | A | -0.3937 | |
| 384 | V | A | 0.0000 | |
| 385 | V | A | 0.0000 | |
| 386 | L | A | -0.3705 | |
| 387 | P | A | -0.1009 | |
| 388 | I | A | 0.0000 | |
| 389 | A | A | 0.0000 | |
| 390 | S | A | -0.3263 | |
| 391 | A | A | -0.1660 | |
| 392 | F | A | 0.0000 | |
| 393 | S | A | -0.5717 | |
| 394 | P | A | 0.0000 | |
| 395 | D | A | -1.8271 | |
| 396 | F | A | 0.0000 | |
| 397 | V | A | 0.0000 | |
| 398 | I | A | 0.0000 | |
| 399 | I | A | 0.0000 | |
| 400 | S | A | 0.0000 | |
| 401 | A | A | 0.0000 | |
| 402 | G | A | 0.0000 | |
| 403 | F | A | 0.0000 | |
| 404 | D | A | 0.0000 | |
| 405 | A | A | 0.0000 | |
| 406 | A | A | 0.0000 | |
| 407 | R | A | -2.5767 | |
| 408 | G | A | -1.6485 | |
| 409 | D | A | 0.0000 | |
| 410 | P | A | -0.3160 | |
| 411 | L | A | 0.4372 | |
| 412 | G | A | 0.0000 | |
| 413 | C | A | -0.0772 | |
| 414 | C | A | 0.0000 | |
| 415 | D | A | -1.6813 | |
| 416 | V | A | 0.0000 | |
| 417 | T | A | -0.7937 | |
| 418 | P | A | -0.6071 | |
| 419 | A | A | -0.2230 | |
| 420 | G | A | 0.0000 | |
| 421 | Y | A | 0.0000 | |
| 422 | S | A | -1.1954 | |
| 423 | R | A | -1.5329 | |
| 424 | M | A | 0.0000 | |
| 425 | T | A | 0.0000 | |
| 426 | Q | A | -1.7347 | |
| 427 | M | A | -1.1619 | |
| 428 | L | A | 0.0000 | |
| 429 | G | A | -1.4295 | |
| 430 | D | A | -1.9905 | |
| 431 | L | A | -1.0149 | |
| 432 | C | A | -0.9708 | |
| 433 | G | A | -1.2041 | |
| 434 | G | A | -1.1741 | |
| 435 | K | A | -1.1969 | |
| 436 | M | A | 0.0000 | |
| 437 | L | A | 0.0000 | |
| 438 | V | A | 0.0000 | |
| 439 | I | A | 0.0000 | |
| 440 | L | A | 0.0000 | |
| 441 | E | A | 0.0000 | |
| 442 | G | A | 0.0000 | |
| 443 | G | A | 0.0000 | |
| 444 | Y | A | 0.0000 | |
| 445 | N | A | -1.2190 | |
| 446 | L | A | -1.1094 | |
| 447 | R | A | -1.9927 | |
| 448 | S | A | -1.4331 | |
| 449 | I | A | 0.0000 | |
| 450 | S | A | 0.0000 | |
| 451 | A | A | -0.4300 | |
| 452 | S | A | 0.0000 | |
| 453 | A | A | 0.0000 | |
| 454 | T | A | -0.2242 | |
| 455 | A | A | -0.6564 | |
| 456 | V | A | 0.0000 | |
| 457 | I | A | 0.0000 | |
| 458 | K | A | -1.5695 | |
| 459 | V | A | -1.3992 | |
| 460 | L | A | 0.0000 | |
| 461 | L | A | -0.9370 | |
| 462 | G | A | -1.3456 | |
| 463 | E | A | -2.2097 | |
| 469 | L | A | 1.5089 | |
| 470 | P | A | 0.5907 | |
| 471 | I | A | 0.1578 | |
| 472 | A | A | 0.0599 | |
| 473 | T | A | -0.1869 | |
| 474 | T | A | 0.0928 | |
| 475 | P | A | 0.1495 | |
| 476 | S | A | 0.6059 | |
| 477 | V | A | 1.5874 | |
| 478 | A | A | 0.6148 | |
| 479 | G | A | 0.0000 | |
| 480 | L | A | 0.4591 | |
| 481 | Q | A | -0.6569 | |
| 482 | T | A | 0.0000 | |
| 483 | V | A | 0.0000 | |
| 484 | L | A | -0.8513 | |
| 485 | D | A | -1.8892 | |
| 486 | V | A | 0.0000 | |
| 487 | L | A | 0.0000 | |
| 488 | N | A | -1.7964 | |
| 489 | I | A | -1.2931 | |
| 490 | Q | A | 0.0000 | |
| 491 | L | A | -0.6512 | |
| 492 | E | A | -1.7133 | |
| 493 | F | A | -0.4830 | |
| 494 | W | A | 0.0000 | |
| 495 | P | A | -0.2442 | |
| 496 | S | A | 0.1514 | |
| 497 | L | A | 0.0000 | |
| 498 | A | A | 0.7598 | |
| 499 | I | A | 1.8436 | |
| 500 | S | A | 0.8470 | |
| 501 | Y | A | 0.7784 | |
| 502 | S | A | 1.1554 | |
| 503 | K | A | 1.1809 | |
| 504 | L | A | 2.0918 | |
| 505 | L | A | 2.1631 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine