| Chain sequence(s) |
A: GPLPLNPEPPLRSTDEFVTPTDLLYYAETDLITETGHPTKDIVVNGKVVIPRVSSTDYKVFKLTLPDPNTLPLPSSDFVDFSTEILIWRLRAFRIKRFGPLGKGTYGHPNFNALGDVDNPTAPLHPGPDMTQALSWTPKLKQLYIIGDEPPIGKYITPAAPAPGLPPGAVPPLETKHTIIEHGDRADIGFGAKDYAALEPRKDDVPDDILNTTTKVPDLEGMKAEPYGNRLFTYDEYEKSADSRRLVLNGPDPVPLPSRDPPSKLYTPPPPGSPYWVLPPRRLFTLPDAGEITEEDLLFNKPIYLEKTEGLNNGVLWHNRLYITILDNTRAEIETITTQKSTPEPNVYDPSNYVTSKRYTEELQLELIVQLCRIPLTPETLEYLRRLDPRILVEANLPFIPPEERPDPYAGLKFREIDLTDKLSSDLSSSELGREYLNR
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:05)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | G | A | -0.2275 | |
| 2 | P | A | 0.4592 | |
| 3 | L | A | 1.3466 | |
| 4 | P | A | 0.3666 | |
| 5 | L | A | 0.9170 | |
| 6 | N | A | -1.0396 | |
| 7 | P | A | -1.3238 | |
| 8 | E | A | -2.2568 | |
| 9 | P | A | -1.7175 | |
| 10 | P | A | -0.7335 | |
| 11 | L | A | -0.0928 | |
| 12 | R | A | -0.9693 | |
| 13 | S | A | -1.1521 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.8659 | |
| 16 | E | A | -2.7700 | |
| 17 | F | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | T | A | -0.9941 | |
| 20 | P | A | -0.9313 | |
| 21 | T | A | 0.0000 | |
| 22 | D | A | -1.6131 | |
| 23 | L | A | -0.4786 | |
| 24 | L | A | -0.3266 | |
| 25 | Y | A | -0.4163 | |
| 26 | Y | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | E | A | -1.6755 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -1.4434 | |
| 31 | L | A | 0.0773 | |
| 32 | I | A | 0.0000 | |
| 33 | T | A | -0.2961 | |
| 34 | E | A | -0.4697 | |
| 35 | T | A | -0.4450 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -1.4814 | |
| 38 | P | A | 0.0000 | |
| 39 | T | A | -1.4842 | |
| 40 | K | A | -2.0463 | |
| 41 | D | A | -0.8155 | |
| 42 | I | A | 1.2261 | |
| 43 | V | A | 2.2370 | |
| 44 | V | A | 1.6759 | |
| 45 | N | A | -0.5295 | |
| 46 | G | A | -0.3628 | |
| 47 | K | A | -0.1097 | |
| 48 | V | A | 2.0095 | |
| 49 | V | A | 2.5137 | |
| 50 | I | A | 1.2573 | |
| 51 | P | A | -0.0791 | |
| 52 | R | A | -1.1162 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | S | A | 0.0000 | |
| 56 | T | A | 0.0000 | |
| 57 | D | A | 0.0000 | |
| 58 | Y | A | 0.0000 | |
| 59 | K | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | K | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | T | A | -1.4384 | |
| 65 | L | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -0.7627 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -0.5198 | |
| 70 | T | A | -0.2006 | |
| 71 | L | A | 0.0243 | |
| 72 | P | A | -0.0683 | |
| 73 | L | A | -0.0414 | |
| 74 | P | A | -0.3408 | |
| 75 | S | A | -0.7322 | |
| 76 | S | A | -1.2655 | |
| 77 | D | A | -2.0448 | |
| 78 | F | A | -0.9345 | |
| 79 | V | A | 0.0000 | |
| 80 | D | A | -1.7568 | |
| 81 | F | A | -0.2869 | |
| 82 | S | A | -0.4093 | |
| 83 | T | A | -0.5503 | |
| 84 | E | A | -0.7327 | |
| 85 | I | A | 0.0000 | |
| 86 | L | A | 0.0000 | |
| 87 | I | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.6710 | |
| 92 | A | A | 0.0000 | |
| 93 | F | A | 0.0000 | |
| 94 | R | A | 0.0000 | |
| 95 | I | A | 0.0000 | |
| 96 | K | A | -0.6181 | |
| 97 | R | A | 0.0000 | |
| 98 | F | A | 0.3695 | |
| 99 | G | A | -0.4472 | |
| 100 | P | A | -0.4605 | |
| 101 | L | A | -0.4384 | |
| 102 | G | A | -1.0198 | |
| 103 | K | A | -1.5390 | |
| 104 | G | A | 0.0000 | |
| 105 | T | A | -0.5570 | |
| 106 | Y | A | 0.0000 | |
| 107 | G | A | -0.5787 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | -1.2247 | |
| 110 | N | A | -2.2788 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | 0.0000 | |
| 113 | A | A | 0.0000 | |
| 114 | L | A | 0.0000 | |
| 115 | G | A | 0.0000 | |
| 116 | D | A | -1.3344 | |
| 117 | V | A | -1.1441 | |
| 118 | D | A | -2.7320 | |
| 119 | N | A | -2.0944 | |
| 120 | P | A | -1.1310 | |
| 121 | T | A | -0.6780 | |
| 122 | A | A | -0.6579 | |
| 123 | P | A | -0.4968 | |
| 124 | L | A | -0.2089 | |
| 125 | H | A | -1.0838 | |
| 126 | P | A | -1.0023 | |
| 127 | G | A | -1.0621 | |
| 128 | P | A | -1.2837 | |
| 129 | D | A | -2.2258 | |
| 130 | M | A | -1.2265 | |
| 131 | T | A | -1.4340 | |
| 132 | Q | A | -1.5623 | |
| 133 | A | A | -0.9568 | |
| 134 | L | A | -0.4671 | |
| 135 | S | A | -0.3555 | |
| 136 | W | A | 0.0000 | |
| 137 | T | A | -0.6011 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.0000 | |
| 140 | L | A | 0.0000 | |
| 141 | K | A | -1.2523 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | Y | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | I | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | D | A | 0.0000 | |
| 149 | E | A | -0.4847 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | I | A | -0.1675 | |
| 153 | G | A | 0.0000 | |
| 154 | K | A | -0.9389 | |
| 155 | Y | A | -0.5875 | |
| 156 | I | A | 0.2935 | |
| 157 | T | A | 0.0491 | |
| 158 | P | A | 0.3428 | |
| 159 | A | A | -0.0749 | |
| 160 | A | A | -0.1035 | |
| 161 | P | A | 0.0972 | |
| 162 | A | A | -0.1607 | |
| 163 | P | A | -0.3415 | |
| 164 | G | A | -0.3314 | |
| 165 | L | A | 0.4475 | |
| 166 | P | A | -0.0408 | |
| 167 | P | A | -0.2249 | |
| 168 | G | A | -0.1352 | |
| 169 | A | A | 0.5955 | |
| 170 | V | A | 1.8431 | |
| 171 | P | A | 0.9806 | |
| 172 | P | A | 0.6898 | |
| 173 | L | A | 1.0020 | |
| 174 | E | A | -0.7815 | |
| 175 | T | A | -0.9254 | |
| 176 | K | A | -1.7189 | |
| 177 | H | A | -1.5260 | |
| 178 | T | A | -0.6930 | |
| 179 | I | A | -0.1446 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | -0.9299 | |
| 182 | H | A | -1.2066 | |
| 183 | G | A | -0.9062 | |
| 184 | D | A | -0.8685 | |
| 185 | R | A | -0.5070 | |
| 186 | A | A | 0.0000 | |
| 187 | D | A | 0.0000 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | -0.2990 | |
| 190 | F | A | -0.0125 | |
| 191 | G | A | -0.0562 | |
| 192 | A | A | -0.0312 | |
| 193 | K | A | -0.1505 | |
| 194 | D | A | -0.4283 | |
| 195 | Y | A | 0.0000 | |
| 196 | A | A | -1.0165 | |
| 197 | A | A | -0.3413 | |
| 198 | L | A | 0.1599 | |
| 199 | E | A | -1.3215 | |
| 200 | P | A | -1.4360 | |
| 201 | R | A | -2.0448 | |
| 202 | K | A | -2.8392 | |
| 203 | D | A | -2.0958 | |
| 204 | D | A | -1.3622 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | D | A | -1.6232 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | L | A | -1.2503 | |
| 211 | N | A | -1.7303 | |
| 212 | T | A | -0.8391 | |
| 213 | T | A | -0.4155 | |
| 214 | T | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | V | A | -0.0215 | |
| 217 | P | A | -0.3094 | |
| 218 | D | A | -0.9514 | |
| 219 | L | A | -1.0405 | |
| 220 | E | A | -2.2030 | |
| 221 | G | A | -1.5430 | |
| 222 | M | A | 0.0000 | |
| 223 | K | A | -1.9422 | |
| 224 | A | A | -1.2761 | |
| 225 | E | A | -0.9814 | |
| 226 | P | A | -0.3039 | |
| 227 | Y | A | -0.1522 | |
| 228 | G | A | 0.0000 | |
| 229 | N | A | 0.0000 | |
| 230 | R | A | -0.6347 | |
| 231 | L | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | T | A | -0.8150 | |
| 234 | Y | A | -0.7722 | |
| 235 | D | A | -1.4352 | |
| 236 | E | A | -2.3256 | |
| 237 | Y | A | -1.6642 | |
| 238 | E | A | -2.4744 | |
| 239 | K | A | -1.8768 | |
| 240 | S | A | -1.6933 | |
| 241 | A | A | -1.7073 | |
| 242 | D | A | -2.6331 | |
| 243 | S | A | -2.0885 | |
| 244 | R | A | -2.9509 | |
| 245 | R | A | -2.1755 | |
| 246 | L | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | L | A | -0.1291 | |
| 249 | N | A | -0.7788 | |
| 250 | G | A | -0.7822 | |
| 251 | P | A | -1.0079 | |
| 252 | D | A | -1.2732 | |
| 253 | P | A | 0.0737 | |
| 254 | V | A | 1.2430 | |
| 255 | P | A | 0.4256 | |
| 256 | L | A | 0.7889 | |
| 257 | P | A | -0.1751 | |
| 258 | S | A | -1.0833 | |
| 259 | R | A | -1.3280 | |
| 260 | D | A | -2.2956 | |
| 261 | P | A | -1.8440 | |
| 262 | P | A | -1.3483 | |
| 263 | S | A | -0.8987 | |
| 264 | K | A | -1.0475 | |
| 265 | L | A | 0.7574 | |
| 266 | Y | A | 0.3098 | |
| 267 | T | A | -0.1259 | |
| 268 | P | A | 0.1045 | |
| 269 | P | A | 0.2751 | |
| 270 | P | A | -0.3096 | |
| 271 | P | A | -0.3841 | |
| 272 | G | A | -0.2115 | |
| 273 | S | A | 0.4006 | |
| 274 | P | A | 0.7768 | |
| 275 | Y | A | 1.9264 | |
| 276 | W | A | 1.7181 | |
| 277 | V | A | 2.4356 | |
| 278 | L | A | 1.2415 | |
| 279 | P | A | 0.1134 | |
| 280 | P | A | -0.8937 | |
| 281 | R | A | -1.7706 | |
| 282 | R | A | -0.7451 | |
| 283 | L | A | 0.7597 | |
| 284 | F | A | 0.3368 | |
| 285 | T | A | -0.8583 | |
| 286 | L | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | D | A | -1.6482 | |
| 289 | A | A | 0.0000 | |
| 290 | G | A | -1.5608 | |
| 291 | E | A | -2.0061 | |
| 292 | I | A | -1.5265 | |
| 293 | T | A | -1.8465 | |
| 294 | E | A | -2.6282 | |
| 295 | E | A | -2.7682 | |
| 296 | D | A | -2.0680 | |
| 297 | L | A | -1.1670 | |
| 298 | L | A | -1.1178 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.3735 | |
| 301 | K | A | -1.9168 | |
| 302 | P | A | -1.0944 | |
| 303 | I | A | -0.3006 | |
| 304 | Y | A | -0.4751 | |
| 305 | L | A | 0.0000 | |
| 306 | E | A | -2.6150 | |
| 307 | K | A | -3.0983 | |
| 308 | T | A | 0.0000 | |
| 309 | E | A | -2.0937 | |
| 310 | G | A | -1.2161 | |
| 311 | L | A | -0.7357 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | L | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.7842 | |
| 319 | N | A | -0.7134 | |
| 320 | R | A | -0.8822 | |
| 321 | L | A | 0.0000 | |
| 322 | Y | A | 0.0000 | |
| 323 | I | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | I | A | 0.0000 | |
| 326 | L | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.7503 | |
| 331 | A | A | 0.0000 | |
| 332 | E | A | -2.4323 | |
| 333 | I | A | -1.7800 | |
| 334 | E | A | -1.9713 | |
| 335 | T | A | -0.9446 | |
| 336 | I | A | 0.4467 | |
| 337 | T | A | 0.0463 | |
| 338 | T | A | -0.3940 | |
| 339 | Q | A | -1.6987 | |
| 340 | K | A | -1.9991 | |
| 341 | S | A | -1.3855 | |
| 342 | T | A | -1.1491 | |
| 343 | P | A | -1.2549 | |
| 344 | E | A | -1.6785 | |
| 345 | P | A | -1.0556 | |
| 346 | N | A | -0.7679 | |
| 347 | V | A | 0.9066 | |
| 348 | Y | A | 1.0621 | |
| 349 | D | A | -0.1670 | |
| 350 | P | A | -0.1894 | |
| 351 | S | A | -0.5008 | |
| 352 | N | A | -1.0042 | |
| 353 | Y | A | -0.2254 | |
| 354 | V | A | 0.5661 | |
| 355 | T | A | 0.0799 | |
| 356 | S | A | -0.3261 | |
| 357 | K | A | -1.5060 | |
| 358 | R | A | -1.4362 | |
| 359 | Y | A | 0.0000 | |
| 360 | T | A | -0.9235 | |
| 361 | E | A | 0.0000 | |
| 362 | E | A | -0.3346 | |
| 363 | L | A | 0.0000 | |
| 364 | Q | A | -0.5540 | |
| 365 | L | A | 0.0000 | |
| 366 | E | A | 0.0000 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | V | A | 0.0000 | |
| 370 | Q | A | -0.3475 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | R | A | -0.6822 | |
| 374 | I | A | 0.0000 | |
| 375 | P | A | -0.5885 | |
| 376 | L | A | -0.3622 | |
| 377 | T | A | -0.8108 | |
| 378 | P | A | -1.2657 | |
| 379 | E | A | -2.3342 | |
| 380 | T | A | 0.0000 | |
| 381 | L | A | -1.2919 | |
| 382 | E | A | -2.1153 | |
| 383 | Y | A | 0.0000 | |
| 384 | L | A | 0.0000 | |
| 385 | R | A | -2.4083 | |
| 386 | R | A | -1.4299 | |
| 387 | L | A | -0.7928 | |
| 388 | D | A | -0.9487 | |
| 389 | P | A | -1.5285 | |
| 390 | R | A | -1.7550 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | 0.0000 | |
| 393 | V | A | -1.6016 | |
| 394 | E | A | -1.9785 | |
| 395 | A | A | -1.0957 | |
| 396 | N | A | -1.3700 | |
| 397 | L | A | 0.0000 | |
| 398 | P | A | 0.4004 | |
| 399 | F | A | 1.7281 | |
| 400 | I | A | 0.4148 | |
| 401 | P | A | -0.6376 | |
| 402 | P | A | -1.8805 | |
| 403 | E | A | -3.2628 | |
| 404 | E | A | -3.5335 | |
| 405 | R | A | -2.7366 | |
| 406 | P | A | -1.7090 | |
| 407 | D | A | -1.1896 | |
| 408 | P | A | -0.5990 | |
| 409 | Y | A | -0.3331 | |
| 410 | A | A | -0.4488 | |
| 411 | G | A | -0.6240 | |
| 412 | L | A | -0.5347 | |
| 413 | K | A | -1.9425 | |
| 414 | F | A | -1.3748 | |
| 415 | R | A | -1.7522 | |
| 416 | E | A | -2.5031 | |
| 417 | I | A | -1.8608 | |
| 418 | D | A | -2.7985 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -1.9419 | |
| 421 | D | A | -2.8860 | |
| 422 | K | A | -2.9606 | |
| 423 | L | A | -1.4778 | |
| 424 | S | A | -1.2735 | |
| 425 | S | A | -0.7607 | |
| 426 | D | A | -1.7930 | |
| 427 | L | A | 0.0000 | |
| 428 | S | A | -1.4827 | |
| 429 | S | A | -1.4161 | |
| 430 | S | A | 0.0000 | |
| 431 | E | A | -2.0821 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -2.7672 | |
| 435 | E | A | -2.1399 | |
| 436 | Y | A | -1.0838 | |
| 437 | L | A | -0.5355 | |
| 438 | N | A | -2.0332 | |
| 439 | R | A | -2.2834 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine