Chain sequence(s) |
C: EVQLVESGGGLVQPGGSLRLSCAASDFTFRSYEMSWVRQAPGKGLEWVSAISGSGGSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAIYYCARLRDGFNKGFDYWGQGTLVTVSS
input PDB |
Selected Chain(s) | C |
Distance of aggregation | 10 Å |
FoldX usage | Yes |
Dynamic mode | No |
Automated mutations | No |
Mutated residues | TK117C,VH116C,SC119C,VG118C |
Energy difference between WT (input) and mutated protein (by FoldX) | 5.95791 kcal/mol
CAUTION: Your mutation/s can destabilize the protein structure |
Downloads | Download all the data |
Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00) [WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow to prevent this behavior) (00:00:00) [INFO] runJob: Starting aggrescan3d job on: input.pdb with C chain(s) selected (00:00:00) [INFO] runJob: Creating pdb object from: input.pdb (00:00:00) [INFO] FoldX: Starting FoldX energy minimalization (00:00:00) [INFO] FoldX: Building mutant model (00:00:26) [INFO] FoldX: Starting FoldX energy minimalization (00:00:48) [INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:01:16) [INFO] Main: Simulation completed successfully. (00:01:16) |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
residue index | residue name | chain | Aggrescan3D score | mutation |
---|---|---|---|---|
residue index | residue name | chain | Aggrescan3D score | |
1 | E | C | -2.0063 | |
2 | V | C | -0.9165 | |
3 | Q | C | -1.2443 | |
4 | L | C | 0.0000 | |
5 | V | C | 0.5648 | |
6 | E | C | 0.1591 | |
7 | S | C | -0.4748 | |
8 | G | C | -0.8874 | |
9 | G | C | -0.2738 | |
10 | G | C | 0.5619 | |
11 | L | C | 1.2002 | |
12 | V | C | -0.1017 | |
13 | Q | C | -1.2337 | |
14 | P | C | -1.4142 | |
15 | G | C | -1.4231 | |
16 | G | C | -0.9741 | |
17 | S | C | -1.2279 | |
18 | L | C | -0.9453 | |
19 | R | C | -2.1382 | |
20 | L | C | 0.0000 | |
21 | S | C | -0.5418 | |
22 | C | C | 0.0000 | |
23 | A | C | -0.2017 | |
24 | A | C | 0.0000 | |
25 | S | C | -0.2017 | |
26 | D | C | 0.0000 | |
27 | F | C | 1.5458 | |
28 | T | C | 0.2525 | |
29 | F | C | 0.0000 | |
30 | R | C | -2.0325 | |
31 | S | C | -0.8863 | |
32 | Y | C | -1.2160 | |
33 | E | C | -1.1454 | |
34 | M | C | 0.0000 | |
35 | S | C | 0.0000 | |
36 | W | C | 0.0000 | |
37 | V | C | 0.0000 | |
38 | R | C | 0.0000 | |
39 | Q | C | -0.3597 | |
40 | A | C | -1.1188 | |
41 | P | C | -1.2890 | |
42 | G | C | -1.4347 | |
43 | K | C | -2.1380 | |
44 | G | C | -1.0643 | |
45 | L | C | 0.3880 | |
46 | E | C | -0.4122 | |
47 | W | C | 0.3302 | |
48 | V | C | 0.0000 | |
49 | S | C | 0.0000 | |
50 | A | C | 0.0000 | |
51 | I | C | 0.0000 | |
52 | S | C | -0.5831 | |
53 | G | C | -1.2447 | |
54 | S | C | -1.2286 | |
55 | G | C | -1.0817 | |
56 | G | C | -0.7345 | |
57 | S | C | -0.3025 | |
58 | T | C | 0.1989 | |
59 | Y | C | 0.6077 | |
60 | Y | C | -0.3564 | |
61 | A | C | -1.1425 | |
62 | D | C | -2.3460 | |
63 | S | C | -1.7184 | |
64 | V | C | 0.0000 | |
65 | K | C | -2.3856 | |
66 | G | C | -1.6180 | |
67 | R | C | 0.0000 | |
68 | F | C | 0.0000 | |
69 | T | C | -0.6722 | |
70 | I | C | 0.0000 | |
71 | S | C | -0.5624 | |
72 | R | C | -1.3626 | |
73 | D | C | -1.9805 | |
74 | N | C | -2.1901 | |
75 | S | C | -1.7905 | |
76 | K | C | -2.3163 | |
77 | N | C | -1.6491 | |
78 | T | C | 0.0000 | |
79 | L | C | 0.0000 | |
80 | Y | C | -0.6696 | |
81 | L | C | 0.0000 | |
82 | Q | C | -1.2301 | |
83 | M | C | 0.0000 | |
84 | N | C | -1.3288 | |
85 | S | C | -1.2305 | |
86 | L | C | 0.0000 | |
87 | R | C | -2.4689 | |
88 | A | C | -1.8396 | |
89 | E | C | -2.3623 | |
90 | D | C | 0.0000 | |
91 | T | C | -0.7192 | |
92 | A | C | 0.0000 | |
93 | I | C | 0.7556 | |
94 | Y | C | 0.0000 | |
95 | Y | C | 0.5792 | |
96 | C | C | 0.0000 | |
97 | A | C | 0.0000 | |
98 | R | C | 0.0000 | |
99 | L | C | 0.0000 | |
100 | R | C | -3.1907 | |
101 | D | C | -3.3333 | |
102 | G | C | -2.0866 | |
103 | F | C | -1.2310 | |
104 | N | C | -2.4286 | |
105 | K | C | -3.1848 | |
106 | G | C | -1.9076 | |
107 | F | C | -0.9859 | |
108 | D | C | -1.0994 | |
109 | Y | C | -0.2104 | |
110 | W | C | 0.5562 | |
111 | G | C | -0.0702 | |
112 | Q | C | -0.8760 | |
113 | G | C | -0.0110 | |
114 | T | C | 0.3247 | |
115 | L | C | 1.0450 | |
116 | H | C | 0.0000 | mutated: VH116C |
117 | K | C | -0.3929 | mutated: TK117C |
118 | G | C | -0.8907 | mutated: VG118C |
119 | C | C | -0.2147 | mutated: SC119C |
120 | S | C | -0.7908 |