Project name: acfc7c6975d2783

Chain sequence(s)	A: QVQLVQSGVEVKKPGASVKVSCKASGYTFTNYYMYWVRQAPGQGLEWMGGINPSNGGTNFNEKFKNRVTLTTDSSTTTAYMELKSLQFDDTAVYYCARRDYRFDMGFDYWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK; C: EIVLTQSPATLSLSPGERATLSCRASKGVSTSGYSYLHWYQQKPGQAPRLLIYLASYLESGVPARFSGSGSGTDFTLTISSLEPEDFAVYYCQHSRDLPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC; B: QVQLVQSGVEVKKPGASVKVSCKASGYTFTNYYMYWVRQAPGQGLEWMGGINPSNGGTNFNEKFKNRVTLTTDSSTTTAYMELKSLQFDDTAVYYCARRDYRFDMGFDYWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK; D: EIVLTQSPATLSLSPGERATLSCRASKGVSTSGYSYLHWYQQKPGQAPRLLIYLASYLESGVPARFSGSGSGTDFTLTISSLEPEDFAVYYCQHSRDLPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
Selected Chain(s)	A,C,B,D
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:00)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:00)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:00)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:00)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:01)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:17:28)
[INFO]       Main:     Simulation completed successfully.                                          (00:17:46)

• Minimal score value: -4.061
• Maximal score value: 2.0155
• Average score: -0.741
• Total score value: -985.5553

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	Q	A	-1.5094
2	V	A	-0.9602
3	Q	A	-1.2909
4	L	A	0.0000
5	V	A	0.0497
6	Q	A	0.0000
7	S	A	-0.2388
8	G	A	0.2353
9	V	A	1.4828
10	E	A	0.3638
11	V	A	0.3623
12	K	A	-1.0157
13	K	A	-1.9067
14	P	A	-1.5484
15	G	A	-1.3551
16	A	A	-1.2938
17	S	A	-1.6087
18	V	A	0.0000
19	K	A	-1.9661
20	V	A	0.0000
21	S	A	-0.4925
22	C	A	0.0000
23	K	A	-0.9615
24	A	A	0.0000
25	S	A	-0.8430
26	G	A	-1.0294
27	Y	A	-0.4635
28	T	A	-0.2234
29	F	A	0.0000
30	T	A	-0.4282
31	N	A	-0.6722
32	Y	A	-0.0582
33	Y	A	0.0519
34	M	A	0.0000
35	Y	A	0.0000
36	W	A	0.0000
37	V	A	0.0000
38	R	A	0.0000
39	Q	A	-0.5970
40	A	A	-1.0052
41	P	A	-1.0225
42	G	A	-1.2445
43	Q	A	-1.7459
44	G	A	-1.0808
45	L	A	0.0000
46	E	A	-0.6044
47	W	A	0.0000
48	M	A	0.0000
49	G	A	0.0000
50	G	A	0.0000
51	I	A	0.0000
52	N	A	-0.7568
53	P	A	-0.8554
54	S	A	-1.0241
55	N	A	-1.7074
56	G	A	-1.3330
57	G	A	-1.1604
58	T	A	-0.8919
59	N	A	-1.4078
60	F	A	-1.5964
61	N	A	-2.1518
62	E	A	-3.5330
63	K	A	-3.2920
64	F	A	0.0000
65	K	A	-3.6384
66	N	A	-2.9884
67	R	A	-2.3798
68	V	A	0.0000
69	T	A	-0.9754
70	L	A	0.0000
71	T	A	-0.3102
72	T	A	-0.7985
73	D	A	-1.1080
74	S	A	-0.7728
75	S	A	-0.5895
76	T	A	-0.6654
77	T	A	-0.7274
78	T	A	0.0000
79	A	A	0.0000
80	Y	A	-0.3747
81	M	A	0.0000
82	E	A	-1.2832
83	L	A	0.0000
84	K	A	-2.0360
85	S	A	-1.6245
86	L	A	0.0000
87	Q	A	-1.4688
88	F	A	0.1103
89	D	A	-1.2719
90	D	A	0.0000
91	T	A	-0.2332
92	A	A	0.0000
93	V	A	0.3503
94	Y	A	0.0000
95	Y	A	0.0000
96	C	A	0.0000
97	A	A	0.0000
98	R	A	0.0000
99	R	A	-0.0430
100	D	A	-0.1662
101	Y	A	0.1472
102	R	A	-1.1537
103	F	A	0.0177
104	D	A	0.0000
105	M	A	0.4526
106	G	A	0.0000
107	F	A	0.0000
108	D	A	-0.3872
109	Y	A	-0.1198
110	W	A	-0.3694
111	G	A	0.0000
112	Q	A	-1.2812
113	G	A	-0.4140
114	T	A	0.0000
115	T	A	0.4671
116	V	A	0.0000
117	T	A	0.0000
118	V	A	0.0000
119	S	A	0.0000
120	S	A	-0.5903
121	A	A	-0.5955
122	S	A	-0.6692
123	T	A	-0.5859
124	K	A	-1.1910
125	G	A	-1.4477
126	P	A	0.0000
127	S	A	-0.4663
128	V	A	0.0000
129	F	A	0.0000
130	P	A	-1.2724
131	L	A	0.0000
132	A	A	-0.6250
133	P	A	-0.4794
134	C	A	0.0000
135	S	A	-0.8320
136	R	A	-0.7241
137	S	A	-0.6830
138	T	A	-0.6991
139	S	A	-0.9323
140	E	A	-1.4566
141	S	A	-1.0015
142	T	A	-0.6890
143	A	A	0.0000
144	A	A	0.0000
145	L	A	0.0000
146	G	A	0.0000
147	C	A	0.0000
148	L	A	0.0000
149	V	A	0.0000
150	K	A	0.0000
151	D	A	-0.4276
152	Y	A	0.0000
153	F	A	0.0000
154	P	A	0.0000
155	E	A	-0.4410
156	P	A	-0.9545
157	V	A	-0.9543
158	T	A	-0.8409
159	V	A	-0.3682
160	S	A	-0.5641
161	W	A	0.0000
162	N	A	-0.9341
163	S	A	-0.7390
164	G	A	-0.5411
165	A	A	-0.2301
166	L	A	-0.0646
167	T	A	-0.1779
168	S	A	-0.1907
169	G	A	-0.2303
170	V	A	0.1428
171	H	A	-0.3351
172	T	A	0.0077
173	F	A	0.0000
174	P	A	-0.3568
175	A	A	0.1254
176	V	A	0.2982
177	L	A	0.9981
178	Q	A	0.1204
179	S	A	-0.0702
180	S	A	-0.2130
181	G	A	0.2439
182	L	A	0.0458
183	Y	A	0.3096
184	S	A	0.0000
185	L	A	0.0000
186	S	A	0.0000
187	S	A	0.0000
188	V	A	0.0000
189	V	A	0.0000
190	T	A	-0.1171
191	V	A	0.0000
192	P	A	-0.5519
193	S	A	0.0000
194	S	A	-0.7371
195	S	A	-0.9568
196	L	A	0.0000
197	G	A	-1.8651
198	T	A	-1.5472
199	K	A	-1.8556
200	T	A	-1.5133
201	Y	A	0.0000
202	T	A	-1.9523
203	C	A	0.0000
204	N	A	-1.8267
205	V	A	0.0000
206	D	A	-2.5932
207	H	A	0.0000
208	K	A	-2.9227
209	P	A	-1.7146
210	S	A	-1.9110
211	N	A	-2.6824
212	T	A	-2.2402
213	K	A	-2.9826
214	V	A	-1.8992
215	D	A	-2.8718
216	K	A	-2.5396
217	R	A	-2.9338
218	V	A	0.0000
219	E	A	-2.9986
220	S	A	-1.9003
221	K	A	-2.5477
222	Y	A	0.0000
223	G	A	0.0000
224	P	A	-0.5554
225	P	A	-0.5914
226	C	A	-0.4290
227	P	A	-0.3760
228	P	A	-0.4342
229	C	A	-0.0491
230	P	A	-0.4746
231	A	A	-0.2404
232	P	A	-0.0294
233	E	A	-0.3007
234	F	A	1.5205
235	L	A	1.9330
236	G	A	0.4899
237	G	A	0.3353
238	P	A	0.0000
239	S	A	0.2446
240	V	A	0.0000
241	F	A	1.3326
242	L	A	0.9532
243	F	A	1.2485
244	P	A	-0.1131
245	P	A	0.0000
246	K	A	-2.2398
247	P	A	-1.3839
248	K	A	-1.1944
249	D	A	-1.3292
250	T	A	0.0000
251	L	A	0.0000
252	M	A	0.2423
253	I	A	1.2364
254	S	A	0.0318
255	R	A	-1.3129
256	T	A	-0.8395
257	P	A	0.0000
258	E	A	-1.3054
259	V	A	0.0000
260	T	A	0.2396
261	C	A	0.0000
262	V	A	0.0000
263	V	A	0.0000
264	V	A	-0.7937
265	D	A	-0.9832
266	V	A	0.0000
267	S	A	-2.0550
268	Q	A	-2.5365
269	E	A	-3.0036
270	D	A	-2.7104
271	P	A	-2.7179
272	E	A	-3.0669
273	V	A	-1.8300
274	Q	A	-1.7292
275	F	A	-0.9171
276	N	A	-1.0357
277	W	A	0.0000
278	Y	A	-0.6627
279	V	A	-0.9481
280	D	A	-2.1438
281	G	A	-0.8972
282	V	A	0.5864
283	E	A	-0.6467
284	V	A	-0.5481
285	H	A	-1.8882
286	N	A	-2.1561
287	A	A	-1.8684
288	K	A	-2.3996
289	T	A	-1.9292
290	K	A	-2.4723
291	P	A	-2.6042
292	R	A	-3.9270
293	E	A	-4.0610
294	E	A	-3.2821
295	Q	A	-1.3150
296	F	A	0.9847
297	N	A	-0.3074
298	S	A	-1.0024
299	T	A	-1.8397
300	Y	A	-2.5449
301	R	A	-2.5148
302	V	A	0.0000
303	V	A	0.0000
304	S	A	0.0000
305	V	A	-0.8761
306	L	A	0.0000
307	T	A	-0.7754
308	V	A	0.0000
309	L	A	0.2999
310	H	A	-0.3723
311	Q	A	-1.3045
312	D	A	-1.6561
313	W	A	0.0000
314	L	A	-1.0537
315	N	A	-2.1794
316	G	A	-2.1796
317	K	A	-2.4451
318	E	A	-2.5571
319	Y	A	0.0000
320	K	A	-1.6917
321	C	A	0.0000
322	K	A	-1.3558
323	V	A	0.0000
324	S	A	-1.2898
325	N	A	0.0000
326	K	A	-2.6003
327	G	A	-1.6866
328	L	A	-0.6807
329	P	A	-0.7919
330	S	A	-0.6665
331	S	A	-0.8450
332	I	A	-0.5266
333	E	A	-1.7842
334	K	A	-1.1039
335	T	A	-1.1082
336	I	A	-0.3616
337	S	A	-1.3333
338	K	A	-1.3979
339	A	A	-1.1976
340	K	A	-2.3380
341	G	A	-1.9717
342	Q	A	-2.1307
343	P	A	-1.7831
344	R	A	-2.1237
345	E	A	-2.6555
346	P	A	0.0000
347	Q	A	-1.3861
348	V	A	0.0000
349	Y	A	0.0000
350	T	A	-0.7267
351	L	A	0.0000
352	P	A	-0.3265
353	P	A	-0.7862
354	S	A	-1.2705
355	Q	A	-2.2807
356	E	A	-2.5764
357	E	A	0.0000
358	M	A	-1.7876
359	T	A	-1.6242
360	K	A	-2.4402
361	N	A	-2.6737
362	Q	A	-2.6699
363	V	A	0.0000
364	S	A	0.0000
365	L	A	0.0000
366	T	A	0.0000
367	C	A	0.0000
368	L	A	0.0000
369	V	A	0.0000
370	K	A	-0.5789
371	G	A	-1.0780
372	F	A	0.0000
373	Y	A	-1.0718
374	P	A	0.0000
375	S	A	-0.2106
376	D	A	-1.1499
377	I	A	-0.6094
378	A	A	-0.5825
379	V	A	0.0000
380	E	A	-1.1840
381	W	A	0.0000
382	E	A	-1.7230
383	S	A	0.0000
384	N	A	-1.8725
385	G	A	-1.7603
386	Q	A	-2.2662
387	P	A	-1.9259
388	E	A	-1.8406
389	N	A	-2.0839
390	N	A	-1.4908
391	Y	A	-1.0342
392	K	A	-0.8364
393	T	A	-0.2909
394	T	A	0.0000
395	P	A	-0.0483
396	P	A	0.1590
397	V	A	0.5416
398	L	A	0.8798
399	D	A	-0.5054
400	S	A	-1.1198
401	D	A	-1.8758
402	G	A	-0.8175
403	S	A	0.0000
404	F	A	0.1688
405	F	A	0.0000
406	L	A	0.0000
407	Y	A	0.0000
408	S	A	0.0000
409	R	A	0.0000
410	L	A	0.0000
411	T	A	-1.0233
412	V	A	0.0000
413	D	A	-2.8108
414	K	A	-2.8071
415	S	A	-2.4803
416	R	A	-2.4359
417	W	A	0.0000
418	Q	A	-2.5282
419	E	A	-2.7150
420	G	A	-1.3239
421	N	A	-1.1226
422	V	A	0.1850
423	F	A	0.0000
424	S	A	0.0000
425	C	A	0.0000
426	S	A	0.0000
427	V	A	0.0000
428	M	A	0.0000
429	H	A	0.0000
430	E	A	-1.0810
431	A	A	-1.5041
432	L	A	-1.3954
433	H	A	-1.7255
434	N	A	-1.4249
435	H	A	-0.8819
436	Y	A	-0.3306
437	T	A	-0.6661
438	Q	A	-1.0311
439	K	A	-1.0238
440	S	A	-0.2105
441	L	A	0.0000
442	S	A	0.0000
443	L	A	-0.3197
444	S	A	-0.0104
445	L	A	0.7368
446	G	A	-0.7109
447	K	A	-1.7855
1	Q	B	-1.4964
2	V	B	-0.9290
3	Q	B	-1.2657
4	L	B	0.0000
5	V	B	-0.0443
6	Q	B	0.0000
7	S	B	-0.2967
8	G	B	0.1849
9	V	B	1.3708
10	E	B	0.1689
11	V	B	0.1392
12	K	B	-1.0994
13	K	B	-1.9274
14	P	B	-1.5093
15	G	B	-1.3181
16	A	B	-1.2415
17	S	B	-1.5038
18	V	B	0.0000
19	K	B	-1.8879
20	V	B	0.0000
21	S	B	-0.5920
22	C	B	0.0000
23	K	B	-1.1192
24	A	B	0.0000
25	S	B	-0.9042
26	G	B	-1.0311
27	Y	B	-0.4667
28	T	B	-0.2328
29	F	B	0.0000
30	T	B	-0.4576
31	N	B	-0.7125
32	Y	B	-0.1191
33	Y	B	-0.0408
34	M	B	0.0000
35	Y	B	0.0000
36	W	B	0.0000
37	V	B	0.0000
38	R	B	0.0000
39	Q	B	-0.5838
40	A	B	-0.9996
41	P	B	-1.0207
42	G	B	-1.2439
43	Q	B	-1.7424
44	G	B	-1.0923
45	L	B	0.0000
46	E	B	-0.5894
47	W	B	0.0000
48	M	B	0.0000
49	G	B	0.0000
50	G	B	0.0000
51	I	B	0.0000
52	N	B	-0.7707
53	P	B	-0.9544
54	S	B	-1.0426
55	N	B	-1.7050
56	G	B	-1.3226
57	G	B	-1.1305
58	T	B	-0.8227
59	N	B	-1.2267
60	F	B	-1.4438
61	N	B	-2.0472
62	E	B	-3.4203
63	K	B	-3.2213
64	F	B	0.0000
65	K	B	-3.3753
66	N	B	-2.8135
67	R	B	-2.2041
68	V	B	0.0000
69	T	B	-0.9553
70	L	B	0.0000
71	T	B	-0.3793
72	T	B	-0.8163
73	D	B	-1.0619
74	S	B	-0.7316
75	S	B	-0.5634
76	T	B	-0.6694
77	T	B	-0.7485
78	T	B	0.0000
79	A	B	0.0000
80	Y	B	-0.5611
81	M	B	0.0000
82	E	B	-1.4013
83	L	B	0.0000
84	K	B	-1.7694
85	S	B	-1.4849
86	L	B	0.0000
87	Q	B	-1.3723
88	F	B	0.1432
89	D	B	-1.2525
90	D	B	0.0000
91	T	B	-0.2519
92	A	B	0.0000
93	V	B	0.3596
94	Y	B	0.0000
95	Y	B	0.0000
96	C	B	0.0000
97	A	B	0.0000
98	R	B	0.0000
99	R	B	-0.1155
100	D	B	-0.2925
101	Y	B	-0.0370
102	R	B	-1.2746
103	F	B	-0.1523
104	D	B	-0.0891
105	M	B	0.3189
106	G	B	0.0000
107	F	B	0.0000
108	D	B	-0.3834
109	Y	B	-0.0721
110	W	B	-0.3659
111	G	B	0.0000
112	Q	B	-1.3269
113	G	B	-0.4558
114	T	B	0.0000
115	T	B	0.3981
116	V	B	0.0000
117	T	B	0.0000
118	V	B	0.0000
119	S	B	0.0000
120	S	B	-0.6533
121	A	B	-0.6079
122	S	B	-0.6835
123	T	B	-0.6000
124	K	B	-1.1674
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126	D	D	-2.9867
127	E	D	-3.2360
128	Q	D	0.0000
129	L	D	-2.3077
130	K	D	-2.9192
131	S	D	-1.8073
132	G	D	-1.2618
133	T	D	-0.9634
134	A	D	0.0000
135	S	D	0.0000
136	V	D	0.0000
137	V	D	0.0000
138	C	D	0.0000
139	L	D	0.0000
140	L	D	0.0000
141	N	D	0.0000
142	N	D	-0.7760
143	F	D	0.0000
144	Y	D	0.0000
145	P	D	-1.1658
146	R	D	-1.7964
147	E	D	-2.6247
148	A	D	-1.9582
149	K	D	-2.1830
150	V	D	-1.0358
151	Q	D	-0.6658
152	W	D	0.0000
153	K	D	-0.7464
154	V	D	0.0000
155	D	D	-1.9445
156	N	D	-1.6349
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158	L	D	0.1736
159	Q	D	-0.5457
160	S	D	-0.7670
161	G	D	-1.2541
162	N	D	-1.5505
163	S	D	-1.4705
164	Q	D	-1.5668
165	E	D	-1.8257
166	S	D	-0.8918
167	V	D	-0.4296
168	T	D	0.0000
169	E	D	-2.0568
170	Q	D	-1.5825
171	D	D	-1.7725
172	S	D	-1.6179
173	K	D	-2.1403
174	D	D	-1.5248
175	S	D	0.0000
176	T	D	0.0000
177	Y	D	0.0000
178	S	D	0.0000
179	L	D	0.0000
180	S	D	0.0000
181	S	D	0.0000
182	T	D	-0.7399
183	L	D	0.0000
184	T	D	-0.5955
185	L	D	-0.6502
186	S	D	-0.8448
187	K	D	-1.8339
188	A	D	-1.5894
189	D	D	-2.0321
190	Y	D	0.0000
191	E	D	-3.1707
192	K	D	-3.3856
193	H	D	-2.8922
194	K	D	-3.2148
195	V	D	-1.4232
196	Y	D	0.0000
197	A	D	0.0000
198	C	D	0.0000
199	E	D	-0.7389
200	V	D	0.0000
201	T	D	-1.1582
202	H	D	0.0000
203	Q	D	-1.6198
204	G	D	-0.4161
205	L	D	-0.2299
206	S	D	-0.4494
207	S	D	-0.4087
208	P	D	-0.4991
209	V	D	0.0259
210	T	D	-0.4744
211	K	D	-0.7655
212	S	D	-0.6498
213	F	D	0.0000
214	N	D	-1.7713
215	R	D	-2.2401
216	G	D	-2.0507
217	E	D	-2.5299
218	C	D	-1.4324