| Chain sequence(s) |
A: YLPPTTPVAKVQSTDEYVYPTSLFCHAHTDRLLTVGHPFKDIVKNGKVVVPKVSGWQWRVFRLKFPDPNKFALPQKDFYDPEKERLVWRLRGLEIGRGGPLGKGTVGHPLFNKLGDTENPTEPVHEGADVRVSFSFDPKQTQLFIVGCEPPTGEHWDLAPPCPGLPPGACPPIQLVNSVIEDGDMCDIGFGNMNFKELQQDRSGVPLDIVSTRCKWPDFLKMTNEAYGDKMFFFGRREQVYARHFYVRAGPEGHPLPSAPPPSPLYVPPPPSSPYAVPPSTDYFGTPSGSLVSSDGQLFNRPFWLQRAQGNNNGVCWHNELFVTVVDNTRNTNFTISQQLSTPENNVYDPSNFKNYLRHVEQFELSLIAQLCKVPLDPGVLAHINTMNPTILENWNLGFVPPKEREDPYKGLIFWEVDLTERFSQDLDQFALGRKFLYQ
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:04)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Y | A | 1.9482 | |
| 2 | L | A | 1.9758 | |
| 3 | P | A | 0.7073 | |
| 4 | P | A | 0.1202 | |
| 5 | T | A | 0.1997 | |
| 6 | T | A | 0.1566 | |
| 7 | P | A | 0.2599 | |
| 8 | V | A | 1.2526 | |
| 9 | A | A | 0.0442 | |
| 10 | K | A | -1.1352 | |
| 11 | V | A | -0.3647 | |
| 12 | Q | A | -1.5051 | |
| 13 | S | A | -1.6724 | |
| 14 | T | A | 0.0000 | |
| 15 | D | A | -2.7015 | |
| 16 | E | A | -2.6042 | |
| 17 | Y | A | 0.0000 | |
| 18 | V | A | 0.0000 | |
| 19 | Y | A | 0.4137 | |
| 20 | P | A | 0.0261 | |
| 21 | T | A | 0.1004 | |
| 22 | S | A | -0.1814 | |
| 23 | L | A | 0.0000 | |
| 24 | F | A | -0.0889 | |
| 25 | C | A | 0.0000 | |
| 26 | H | A | 0.0000 | |
| 27 | A | A | 0.0000 | |
| 28 | H | A | -1.2262 | |
| 29 | T | A | 0.0000 | |
| 30 | D | A | -2.7313 | |
| 31 | R | A | -2.7003 | |
| 32 | L | A | -0.8569 | |
| 33 | L | A | 1.0405 | |
| 34 | T | A | 1.3353 | |
| 35 | V | A | 1.9023 | |
| 36 | G | A | 0.0000 | |
| 37 | H | A | -0.1948 | |
| 38 | P | A | 0.0000 | |
| 39 | F | A | -0.6505 | |
| 40 | K | A | -1.8253 | |
| 41 | D | A | -0.9428 | |
| 42 | I | A | 0.8955 | |
| 43 | V | A | 1.0505 | |
| 44 | K | A | -1.1879 | |
| 45 | N | A | -1.9475 | |
| 46 | G | A | -1.2543 | |
| 47 | K | A | -1.0051 | |
| 48 | V | A | 1.6022 | |
| 49 | V | A | 2.0388 | |
| 50 | V | A | 1.2846 | |
| 51 | P | A | 0.4713 | |
| 52 | K | A | -0.6144 | |
| 53 | V | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | G | A | 0.0000 | |
| 56 | W | A | 0.0000 | |
| 57 | Q | A | 0.0000 | |
| 58 | W | A | 0.0000 | |
| 59 | R | A | 0.0000 | |
| 60 | V | A | 0.0000 | |
| 61 | F | A | 0.0000 | |
| 62 | R | A | 0.0000 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.2222 | |
| 65 | F | A | 0.0000 | |
| 66 | P | A | 0.0000 | |
| 67 | D | A | -1.6461 | |
| 68 | P | A | 0.0000 | |
| 69 | N | A | -1.3379 | |
| 70 | K | A | -1.8733 | |
| 71 | F | A | -0.9287 | |
| 72 | A | A | -0.5809 | |
| 73 | L | A | -0.9096 | |
| 74 | P | A | -1.2403 | |
| 75 | Q | A | -2.4781 | |
| 76 | K | A | -3.0905 | |
| 77 | D | A | -2.9807 | |
| 78 | F | A | -1.6377 | |
| 79 | Y | A | -1.9017 | |
| 80 | D | A | -2.6895 | |
| 81 | P | A | -2.3152 | |
| 82 | E | A | -3.0210 | |
| 83 | K | A | -3.3796 | |
| 84 | E | A | -2.4431 | |
| 85 | R | A | -1.2759 | |
| 86 | L | A | 0.0000 | |
| 87 | V | A | 0.0000 | |
| 88 | W | A | 0.0000 | |
| 89 | R | A | 0.0000 | |
| 90 | L | A | 0.0000 | |
| 91 | R | A | -0.5159 | |
| 92 | G | A | 0.0000 | |
| 93 | L | A | 0.0000 | |
| 94 | E | A | -1.0329 | |
| 95 | I | A | 0.0000 | |
| 96 | G | A | -1.3942 | |
| 97 | R | A | 0.0000 | |
| 98 | G | A | -0.8230 | |
| 99 | G | A | -0.6361 | |
| 100 | P | A | -0.4189 | |
| 101 | L | A | 0.0020 | |
| 102 | G | A | -0.4298 | |
| 103 | K | A | -0.7254 | |
| 104 | G | A | 0.0000 | |
| 105 | T | A | -0.4233 | |
| 106 | V | A | 0.0000 | |
| 107 | G | A | 0.1096 | |
| 108 | H | A | 0.0000 | |
| 109 | P | A | 0.3313 | |
| 110 | L | A | 0.3443 | |
| 111 | F | A | 0.0000 | |
| 112 | N | A | -0.9651 | |
| 113 | K | A | -0.0661 | |
| 114 | L | A | -0.6803 | |
| 115 | G | A | -0.8877 | |
| 116 | D | A | -1.2810 | |
| 117 | T | A | -1.0054 | |
| 118 | E | A | -2.2497 | |
| 119 | N | A | -2.5157 | |
| 120 | P | A | -1.8809 | |
| 121 | T | A | -1.6592 | |
| 122 | E | A | -2.2484 | |
| 123 | P | A | -1.2006 | |
| 124 | V | A | -0.5476 | |
| 125 | H | A | -1.8849 | |
| 126 | E | A | -2.4252 | |
| 127 | G | A | -1.9865 | |
| 128 | A | A | -1.5018 | |
| 129 | D | A | -2.1827 | |
| 130 | V | A | -1.3025 | |
| 131 | R | A | -0.7104 | |
| 132 | V | A | 0.3931 | |
| 133 | S | A | 0.2399 | |
| 134 | F | A | 0.2100 | |
| 135 | S | A | -0.1020 | |
| 136 | F | A | 0.0000 | |
| 137 | D | A | -0.7292 | |
| 138 | P | A | 0.0000 | |
| 139 | K | A | 0.1556 | |
| 140 | Q | A | -0.1671 | |
| 141 | T | A | 0.0000 | |
| 142 | Q | A | 0.0000 | |
| 143 | L | A | 0.0000 | |
| 144 | F | A | 0.0000 | |
| 145 | I | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | G | A | 0.0000 | |
| 148 | C | A | 0.0000 | |
| 149 | E | A | -0.5472 | |
| 150 | P | A | 0.0000 | |
| 151 | P | A | 0.0000 | |
| 152 | T | A | 0.0000 | |
| 153 | G | A | 0.0000 | |
| 154 | E | A | -0.2105 | |
| 155 | H | A | 0.0000 | |
| 156 | W | A | 1.1031 | |
| 157 | D | A | 0.4397 | |
| 158 | L | A | 0.9416 | |
| 159 | A | A | 0.7529 | |
| 160 | P | A | 0.0016 | |
| 161 | P | A | 0.3476 | |
| 162 | C | A | 0.4796 | |
| 163 | P | A | -0.0302 | |
| 164 | G | A | -0.1468 | |
| 165 | L | A | 0.4600 | |
| 166 | P | A | -0.1784 | |
| 167 | P | A | -0.3681 | |
| 168 | G | A | -0.4672 | |
| 169 | A | A | -0.0449 | |
| 170 | C | A | 0.6183 | |
| 171 | P | A | 0.7162 | |
| 172 | P | A | 0.9690 | |
| 173 | I | A | 1.9330 | |
| 174 | Q | A | 1.0237 | |
| 175 | L | A | 1.4005 | |
| 176 | V | A | 0.8306 | |
| 177 | N | A | -0.3030 | |
| 178 | S | A | -0.0109 | |
| 179 | V | A | 0.3216 | |
| 180 | I | A | 0.0000 | |
| 181 | E | A | 0.3659 | |
| 182 | D | A | 0.2533 | |
| 183 | G | A | -0.1814 | |
| 184 | D | A | -0.5490 | |
| 185 | M | A | 0.0000 | |
| 186 | C | A | 0.0000 | |
| 187 | D | A | -0.4352 | |
| 188 | I | A | 0.0000 | |
| 189 | G | A | 0.1027 | |
| 190 | F | A | 0.0603 | |
| 191 | G | A | -0.0846 | |
| 192 | N | A | -0.2705 | |
| 193 | M | A | -0.1049 | |
| 194 | N | A | 0.0000 | |
| 195 | F | A | 0.0000 | |
| 196 | K | A | -3.2707 | |
| 197 | E | A | -2.3987 | |
| 198 | L | A | -1.1617 | |
| 199 | Q | A | -2.4458 | |
| 200 | Q | A | -3.2373 | |
| 201 | D | A | -3.4802 | |
| 202 | R | A | -3.3079 | |
| 203 | S | A | 0.0000 | |
| 204 | G | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | P | A | 0.0000 | |
| 207 | L | A | 0.0738 | |
| 208 | D | A | 0.0000 | |
| 209 | I | A | 0.0000 | |
| 210 | V | A | 0.0000 | |
| 211 | S | A | -1.9072 | |
| 212 | T | A | -1.4147 | |
| 213 | R | A | -1.9219 | |
| 214 | C | A | 0.0000 | |
| 215 | K | A | 0.0000 | |
| 216 | W | A | -0.2029 | |
| 217 | P | A | 0.0000 | |
| 218 | D | A | 0.0000 | |
| 219 | F | A | 0.3320 | |
| 220 | L | A | 0.5542 | |
| 221 | K | A | -1.2112 | |
| 222 | M | A | 0.0000 | |
| 223 | T | A | -0.8967 | |
| 224 | N | A | -1.6335 | |
| 225 | E | A | -1.2652 | |
| 226 | A | A | -0.6625 | |
| 227 | Y | A | -0.4067 | |
| 228 | G | A | 0.0000 | |
| 229 | D | A | 0.0000 | |
| 230 | K | A | -0.6332 | |
| 231 | M | A | 0.0000 | |
| 232 | F | A | 0.0000 | |
| 233 | F | A | -0.0832 | |
| 234 | F | A | 0.1478 | |
| 235 | G | A | -0.7269 | |
| 236 | R | A | -2.2122 | |
| 237 | R | A | -2.6221 | |
| 238 | E | A | -1.6179 | |
| 239 | Q | A | 0.0743 | |
| 240 | V | A | 1.5093 | |
| 241 | Y | A | 0.9986 | |
| 242 | A | A | 0.0463 | |
| 243 | R | A | -1.4273 | |
| 244 | H | A | -1.0233 | |
| 245 | F | A | 0.0107 | |
| 246 | Y | A | 0.0000 | |
| 247 | V | A | 0.0000 | |
| 248 | R | A | -0.6046 | |
| 249 | A | A | -1.1192 | |
| 250 | G | A | -0.8906 | |
| 251 | P | A | -1.1334 | |
| 252 | E | A | -1.4081 | |
| 253 | G | A | -1.2869 | |
| 254 | H | A | -1.4191 | |
| 255 | P | A | -1.0002 | |
| 256 | L | A | 0.3348 | |
| 257 | P | A | -0.0276 | |
| 258 | S | A | -0.0979 | |
| 259 | A | A | 0.1897 | |
| 260 | P | A | -0.3451 | |
| 261 | P | A | -0.0513 | |
| 262 | P | A | 0.0539 | |
| 263 | S | A | 0.5888 | |
| 264 | P | A | 0.6952 | |
| 265 | L | A | 1.8997 | |
| 266 | Y | A | 1.7712 | |
| 267 | V | A | 1.9511 | |
| 268 | P | A | 1.1157 | |
| 269 | P | A | 0.6000 | |
| 270 | P | A | -0.1625 | |
| 271 | P | A | -0.1324 | |
| 272 | S | A | -0.3013 | |
| 273 | S | A | 0.2789 | |
| 274 | P | A | 0.5606 | |
| 275 | Y | A | 1.5880 | |
| 276 | A | A | 1.1496 | |
| 277 | V | A | 2.0369 | |
| 278 | P | A | 1.0094 | |
| 279 | P | A | 0.3688 | |
| 280 | S | A | -0.2281 | |
| 281 | T | A | -0.3210 | |
| 282 | D | A | -0.7555 | |
| 283 | Y | A | 1.0092 | |
| 284 | F | A | 0.8025 | |
| 285 | G | A | 0.1938 | |
| 286 | T | A | 0.0000 | |
| 287 | P | A | 0.0000 | |
| 288 | S | A | 0.0000 | |
| 289 | G | A | 0.0000 | |
| 290 | S | A | 0.7803 | |
| 291 | L | A | 1.5933 | |
| 292 | V | A | 0.5319 | |
| 293 | S | A | -0.1866 | |
| 294 | S | A | -0.8220 | |
| 295 | D | A | -1.8772 | |
| 296 | G | A | 0.0000 | |
| 297 | Q | A | 0.0000 | |
| 298 | L | A | -1.0904 | |
| 299 | F | A | 0.0000 | |
| 300 | N | A | -1.7102 | |
| 301 | R | A | -2.0438 | |
| 302 | P | A | -1.0465 | |
| 303 | F | A | -0.1840 | |
| 304 | W | A | -0.3587 | |
| 305 | L | A | 0.0000 | |
| 306 | Q | A | -2.1582 | |
| 307 | R | A | -2.8927 | |
| 308 | A | A | 0.0000 | |
| 309 | Q | A | -1.6913 | |
| 310 | G | A | -1.3377 | |
| 311 | N | A | -1.3915 | |
| 312 | N | A | 0.0000 | |
| 313 | N | A | 0.0000 | |
| 314 | G | A | 0.0000 | |
| 315 | V | A | 0.0000 | |
| 316 | C | A | 0.0000 | |
| 317 | W | A | 0.0000 | |
| 318 | H | A | -0.7941 | |
| 319 | N | A | -0.8667 | |
| 320 | E | A | -1.0271 | |
| 321 | L | A | 0.0000 | |
| 322 | F | A | 0.0000 | |
| 323 | V | A | 0.0000 | |
| 324 | T | A | 0.0000 | |
| 325 | V | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | D | A | 0.0000 | |
| 328 | N | A | 0.0000 | |
| 329 | T | A | 0.0000 | |
| 330 | R | A | -0.4202 | |
| 331 | N | A | 0.0000 | |
| 332 | T | A | -0.2024 | |
| 333 | N | A | 0.3982 | |
| 334 | F | A | 1.4553 | |
| 335 | T | A | 0.8020 | |
| 336 | I | A | 0.4456 | |
| 337 | S | A | -0.8618 | |
| 338 | Q | A | -1.5959 | |
| 339 | Q | A | -1.0851 | |
| 340 | L | A | 0.4428 | |
| 341 | S | A | -0.1466 | |
| 342 | T | A | -0.8766 | |
| 343 | P | A | -1.3410 | |
| 344 | E | A | -2.5666 | |
| 345 | N | A | -2.0070 | |
| 346 | N | A | -1.3324 | |
| 347 | V | A | 0.8398 | |
| 348 | Y | A | 1.2289 | |
| 349 | D | A | -0.0472 | |
| 350 | P | A | -0.7604 | |
| 351 | S | A | -0.4744 | |
| 352 | N | A | -0.5087 | |
| 353 | F | A | -0.7565 | |
| 354 | K | A | -1.7987 | |
| 355 | N | A | -1.6099 | |
| 356 | Y | A | 0.1078 | |
| 357 | L | A | 0.7992 | |
| 358 | R | A | 0.9901 | |
| 359 | H | A | 0.0000 | |
| 360 | V | A | 1.1385 | |
| 361 | E | A | 0.0000 | |
| 362 | Q | A | -0.4020 | |
| 363 | F | A | 0.0000 | |
| 364 | E | A | -1.9698 | |
| 365 | L | A | 0.0000 | |
| 366 | S | A | -0.6555 | |
| 367 | L | A | 0.0000 | |
| 368 | I | A | 0.0000 | |
| 369 | A | A | 0.0000 | |
| 370 | Q | A | 0.0000 | |
| 371 | L | A | 0.0000 | |
| 372 | C | A | 0.0000 | |
| 373 | K | A | -0.2743 | |
| 374 | V | A | 0.0000 | |
| 375 | P | A | -1.3266 | |
| 376 | L | A | -1.7272 | |
| 377 | D | A | -2.0305 | |
| 378 | P | A | -1.0870 | |
| 379 | G | A | -1.0945 | |
| 380 | V | A | 0.0000 | |
| 381 | L | A | -0.6064 | |
| 382 | A | A | -0.7057 | |
| 383 | H | A | -0.8932 | |
| 384 | I | A | 0.0000 | |
| 385 | N | A | -1.4180 | |
| 386 | T | A | -0.5851 | |
| 387 | M | A | -0.3845 | |
| 388 | N | A | -0.8778 | |
| 389 | P | A | -1.2522 | |
| 390 | T | A | -1.4967 | |
| 391 | I | A | 0.0000 | |
| 392 | L | A | -1.4692 | |
| 393 | E | A | -2.8384 | |
| 394 | N | A | -2.3789 | |
| 395 | W | A | -1.4965 | |
| 396 | N | A | -1.2910 | |
| 397 | L | A | -0.2063 | |
| 398 | G | A | 0.5913 | |
| 399 | F | A | 2.3774 | |
| 400 | V | A | 1.7538 | |
| 401 | P | A | 0.0428 | |
| 402 | P | A | -1.8959 | |
| 403 | K | A | -3.3681 | |
| 404 | E | A | -3.8149 | |
| 405 | R | A | -4.0392 | |
| 406 | E | A | -3.8016 | |
| 407 | D | A | -2.8444 | |
| 408 | P | A | -1.7502 | |
| 409 | Y | A | -0.9915 | |
| 410 | K | A | -2.1048 | |
| 411 | G | A | -0.6314 | |
| 412 | L | A | 0.6552 | |
| 413 | I | A | 1.6264 | |
| 414 | F | A | 0.6749 | |
| 415 | W | A | -0.3272 | |
| 416 | E | A | -1.7073 | |
| 417 | V | A | 0.0000 | |
| 418 | D | A | -2.9723 | |
| 419 | L | A | 0.0000 | |
| 420 | T | A | -2.0844 | |
| 421 | E | A | -2.7684 | |
| 422 | R | A | -2.2583 | |
| 423 | F | A | -1.2399 | |
| 424 | S | A | -1.5016 | |
| 425 | Q | A | -1.8370 | |
| 426 | D | A | -3.0320 | |
| 427 | L | A | 0.0000 | |
| 428 | D | A | -2.9222 | |
| 429 | Q | A | -2.6816 | |
| 430 | F | A | -1.5493 | |
| 431 | A | A | -0.9158 | |
| 432 | L | A | 0.0000 | |
| 433 | G | A | 0.0000 | |
| 434 | R | A | -1.6801 | |
| 435 | K | A | -0.8357 | |
| 436 | F | A | 0.1152 | |
| 437 | L | A | 0.9450 | |
| 438 | Y | A | 0.7969 | |
| 439 | Q | A | -0.3178 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine