| Chain sequence(s) |
A: SLPLNMPALEMPAFIATKVSQYSCQRKTTLNNYNKKFTDAFEVMAENYEFKENEIFCLEFLRAASLLKSLPFSVTRMKDIQGLPCVGDQVRDIIEEIIEEGESSRVNEVLNDERYKAFKQFTSVFGVGVKTSEKWYRMGLRTVEEVKADKTLKLSKMQKAGLLYYEDLVSCVSKAEADAVSLIVKNTVCTFLPDALVTITGGFRRGKNIGHDIDFLITNPGPREDDELLHKVIDLWKKQGLLLYCDIIESTFVKEQLPSRKVDAMDHFQKCFAILKLYQPRVDNSTCNTSEQLEMAEVKDWKAIRVDLVITPFEQYPYALLGWTGSRQFGRDLRRYAAHERKMILDNHGLYDRRKRIFLKAGSEEEIFAHLGLDYVEPWERNA
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:09:41)
[INFO] Main: Simulation completed successfully. (00:09:44)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 131 | S | A | 0.6890 | |
| 132 | L | A | 1.5992 | |
| 133 | P | A | 0.9183 | |
| 134 | L | A | 1.2939 | |
| 135 | N | A | -0.0820 | |
| 136 | M | A | 0.8270 | |
| 137 | P | A | 0.1692 | |
| 138 | A | A | 0.3369 | |
| 139 | L | A | 0.9441 | |
| 140 | E | A | -0.7525 | |
| 141 | M | A | 0.4327 | |
| 142 | P | A | 0.4078 | |
| 143 | A | A | 0.7940 | |
| 144 | F | A | 1.6154 | |
| 145 | I | A | 1.7135 | |
| 146 | A | A | 0.2394 | |
| 147 | T | A | -0.3606 | |
| 148 | K | A | -1.0712 | |
| 149 | V | A | -0.5100 | |
| 150 | S | A | -0.9289 | |
| 151 | Q | A | -1.0296 | |
| 152 | Y | A | 0.0000 | |
| 153 | S | A | 0.0000 | |
| 154 | C | A | 0.0000 | |
| 155 | Q | A | -1.5198 | |
| 156 | R | A | 0.0000 | |
| 157 | K | A | -1.9202 | |
| 158 | T | A | 0.0000 | |
| 159 | T | A | -0.6277 | |
| 160 | L | A | 0.0264 | |
| 161 | N | A | -1.1441 | |
| 162 | N | A | -1.1028 | |
| 163 | Y | A | -0.2237 | |
| 164 | N | A | 0.0000 | |
| 165 | K | A | -2.9092 | |
| 166 | K | A | -3.0498 | |
| 167 | F | A | 0.0000 | |
| 168 | T | A | 0.0000 | |
| 169 | D | A | -2.7427 | |
| 170 | A | A | 0.0000 | |
| 171 | F | A | 0.0000 | |
| 172 | E | A | -2.1037 | |
| 173 | V | A | -1.0862 | |
| 174 | M | A | 0.0000 | |
| 175 | A | A | 0.0000 | |
| 176 | E | A | -1.8127 | |
| 177 | N | A | 0.0000 | |
| 178 | Y | A | -1.9295 | |
| 179 | E | A | -2.8430 | |
| 180 | F | A | 0.0000 | |
| 181 | K | A | -3.1988 | |
| 182 | E | A | -3.5811 | |
| 183 | N | A | -2.1682 | |
| 184 | E | A | -1.8610 | |
| 185 | I | A | 1.0155 | |
| 186 | F | A | 0.4759 | |
| 187 | C | A | 0.0000 | |
| 188 | L | A | 0.1568 | |
| 189 | E | A | 0.1768 | |
| 190 | F | A | 0.0000 | |
| 191 | L | A | -0.3524 | |
| 192 | R | A | -0.4219 | |
| 193 | A | A | 0.0000 | |
| 194 | A | A | 0.0000 | |
| 195 | S | A | 0.0000 | |
| 196 | L | A | 0.0000 | |
| 197 | L | A | 0.0000 | |
| 198 | K | A | -0.9177 | |
| 199 | S | A | -0.6329 | |
| 200 | L | A | 0.0000 | |
| 201 | P | A | -0.2574 | |
| 202 | F | A | 0.4803 | |
| 203 | S | A | -0.4294 | |
| 204 | V | A | 0.0000 | |
| 205 | T | A | -1.3000 | |
| 206 | R | A | -2.6259 | |
| 207 | M | A | -2.2645 | |
| 208 | K | A | -2.8186 | |
| 209 | D | A | -1.9661 | |
| 210 | I | A | 0.0000 | |
| 211 | Q | A | -2.1482 | |
| 212 | G | A | -1.1871 | |
| 213 | L | A | 0.0000 | |
| 214 | P | A | -0.6321 | |
| 215 | C | A | -0.4990 | |
| 216 | V | A | -1.0985 | |
| 217 | G | A | -1.5545 | |
| 218 | D | A | -2.7752 | |
| 219 | Q | A | -1.9656 | |
| 220 | V | A | 0.0000 | |
| 221 | R | A | -2.9749 | |
| 222 | D | A | -3.1781 | |
| 223 | I | A | 0.0000 | |
| 224 | I | A | 0.0000 | |
| 225 | E | A | -2.7452 | |
| 226 | E | A | -2.9207 | |
| 227 | I | A | 0.0000 | |
| 228 | I | A | -2.3368 | |
| 229 | E | A | -3.3105 | |
| 230 | E | A | -3.4536 | |
| 231 | G | A | -2.7139 | |
| 232 | E | A | -3.3075 | |
| 233 | S | A | 0.0000 | |
| 234 | S | A | -1.7862 | |
| 235 | R | A | -1.9806 | |
| 236 | V | A | 0.0000 | |
| 237 | N | A | -2.0419 | |
| 238 | E | A | -2.8650 | |
| 239 | V | A | -1.8841 | |
| 240 | L | A | -1.5613 | |
| 241 | N | A | -2.8035 | |
| 242 | D | A | -2.9392 | |
| 243 | E | A | -3.2126 | |
| 244 | R | A | -2.2880 | |
| 245 | Y | A | 0.0000 | |
| 246 | K | A | -2.5458 | |
| 247 | A | A | 0.0000 | |
| 248 | F | A | 0.0000 | |
| 249 | K | A | -1.8607 | |
| 250 | Q | A | -1.4413 | |
| 251 | F | A | 0.0000 | |
| 252 | T | A | -0.7574 | |
| 253 | S | A | -0.2994 | |
| 254 | V | A | 0.0000 | |
| 255 | F | A | 0.1562 | |
| 256 | G | A | -0.6281 | |
| 257 | V | A | 0.0000 | |
| 258 | G | A | -0.8866 | |
| 259 | V | A | -1.8615 | |
| 260 | K | A | -2.3732 | |
| 261 | T | A | -1.6996 | |
| 262 | S | A | 0.0000 | |
| 263 | E | A | -2.1289 | |
| 264 | K | A | -2.5561 | |
| 265 | W | A | 0.0000 | |
| 266 | Y | A | -1.6187 | |
| 267 | R | A | -2.0601 | |
| 268 | M | A | -0.4847 | |
| 269 | G | A | -0.8626 | |
| 270 | L | A | -1.0448 | |
| 271 | R | A | -1.5861 | |
| 272 | T | A | -1.6036 | |
| 273 | V | A | 0.0000 | |
| 274 | E | A | -2.7229 | |
| 275 | E | A | -2.4855 | |
| 276 | V | A | 0.0000 | |
| 277 | K | A | -2.1851 | |
| 278 | A | A | -1.8563 | |
| 279 | D | A | -2.2019 | |
| 280 | K | A | -2.4085 | |
| 281 | T | A | -1.3456 | |
| 282 | L | A | -1.4133 | |
| 283 | K | A | -2.2427 | |
| 284 | L | A | -1.6472 | |
| 285 | S | A | -1.6123 | |
| 286 | K | A | -2.4765 | |
| 287 | M | A | -1.1116 | |
| 288 | Q | A | -1.2088 | |
| 289 | K | A | -1.9173 | |
| 290 | A | A | 0.0000 | |
| 291 | G | A | 0.0000 | |
| 292 | L | A | 0.0000 | |
| 293 | L | A | 0.8634 | |
| 294 | Y | A | 0.3417 | |
| 295 | Y | A | -0.1541 | |
| 296 | E | A | -1.3240 | |
| 297 | D | A | -0.5588 | |
| 298 | L | A | 0.0000 | |
| 299 | V | A | 0.2499 | |
| 300 | S | A | 0.1019 | |
| 301 | C | A | 0.4539 | |
| 302 | V | A | 0.0000 | |
| 303 | S | A | -0.8869 | |
| 304 | K | A | -1.7847 | |
| 305 | A | A | -1.0705 | |
| 306 | E | A | -0.7499 | |
| 307 | A | A | 0.0000 | |
| 308 | D | A | -1.0268 | |
| 309 | A | A | -0.1283 | |
| 310 | V | A | 0.0000 | |
| 311 | S | A | -0.0388 | |
| 312 | L | A | 0.6931 | |
| 313 | I | A | 0.2336 | |
| 314 | V | A | 0.0000 | |
| 315 | K | A | -0.8733 | |
| 316 | N | A | -1.1325 | |
| 317 | T | A | 0.0000 | |
| 318 | V | A | 0.0000 | |
| 319 | C | A | -0.6728 | |
| 320 | T | A | -0.4565 | |
| 321 | F | A | -0.1257 | |
| 322 | L | A | 0.0000 | |
| 323 | P | A | -1.0703 | |
| 324 | D | A | -1.9039 | |
| 325 | A | A | -0.5597 | |
| 326 | L | A | 0.2666 | |
| 327 | V | A | 0.0000 | |
| 328 | T | A | 0.1559 | |
| 329 | I | A | -0.0031 | |
| 330 | T | A | 0.0000 | |
| 331 | G | A | -0.7052 | |
| 332 | G | A | -0.7183 | |
| 333 | F | A | 0.0000 | |
| 334 | R | A | -0.6601 | |
| 335 | R | A | -0.5751 | |
| 336 | G | A | -0.9241 | |
| 337 | K | A | -1.3116 | |
| 338 | N | A | -1.7067 | |
| 339 | I | A | -0.4312 | |
| 340 | G | A | -0.5572 | |
| 341 | H | A | -0.3561 | |
| 342 | D | A | -0.6240 | |
| 343 | I | A | 0.0000 | |
| 344 | D | A | -0.3404 | |
| 345 | F | A | 0.0000 | |
| 346 | L | A | 0.0000 | |
| 347 | I | A | 0.0000 | |
| 348 | T | A | 0.0000 | |
| 349 | N | A | -1.0971 | |
| 350 | P | A | -0.8793 | |
| 351 | G | A | -1.4763 | |
| 352 | P | A | -1.5959 | |
| 353 | R | A | -3.4459 | |
| 354 | E | A | -3.6009 | |
| 355 | D | A | -3.1867 | |
| 356 | D | A | -3.8471 | |
| 357 | E | A | -3.2606 | |
| 358 | L | A | 0.0000 | |
| 359 | L | A | 0.0000 | |
| 360 | H | A | -1.8982 | |
| 361 | K | A | -1.9403 | |
| 362 | V | A | 0.0000 | |
| 363 | I | A | 0.0000 | |
| 364 | D | A | -2.7558 | |
| 365 | L | A | -1.9902 | |
| 366 | W | A | 0.0000 | |
| 367 | K | A | -3.2857 | |
| 368 | K | A | -3.4001 | |
| 369 | Q | A | -2.7773 | |
| 370 | G | A | -2.0570 | |
| 371 | L | A | -0.8507 | |
| 372 | L | A | -0.9317 | |
| 373 | L | A | 0.1271 | |
| 374 | Y | A | 0.0000 | |
| 375 | C | A | -0.2217 | |
| 376 | D | A | -0.6535 | |
| 377 | I | A | 0.0226 | |
| 378 | I | A | -0.0077 | |
| 379 | E | A | -1.4834 | |
| 380 | S | A | -0.8668 | |
| 381 | T | A | -0.4178 | |
| 382 | F | A | -0.5557 | |
| 383 | V | A | -0.5251 | |
| 384 | K | A | -2.3531 | |
| 385 | E | A | -2.5793 | |
| 386 | Q | A | -1.8002 | |
| 387 | L | A | -0.4109 | |
| 388 | P | A | 0.0000 | |
| 389 | S | A | -1.3099 | |
| 390 | R | A | -2.5253 | |
| 391 | K | A | -2.3450 | |
| 392 | V | A | -1.1450 | |
| 393 | D | A | -1.0818 | |
| 394 | A | A | -0.4972 | |
| 395 | M | A | 0.5841 | |
| 396 | D | A | 0.0000 | |
| 397 | H | A | -0.3308 | |
| 398 | F | A | 0.0000 | |
| 399 | Q | A | 0.0000 | |
| 400 | K | A | 0.0000 | |
| 401 | C | A | 0.0000 | |
| 402 | F | A | 0.2032 | |
| 403 | A | A | 0.0000 | |
| 404 | I | A | 0.0000 | |
| 405 | L | A | 0.0000 | |
| 406 | K | A | -0.1340 | |
| 407 | L | A | 0.0000 | |
| 408 | Y | A | -0.3762 | |
| 409 | Q | A | -1.4489 | |
| 410 | P | A | -1.3377 | |
| 411 | R | A | -2.2101 | |
| 412 | V | A | -0.5876 | |
| 413 | D | A | -2.2005 | |
| 414 | N | A | -1.8514 | |
| 415 | S | A | -1.2081 | |
| 416 | T | A | -0.8060 | |
| 417 | C | A | -0.3016 | |
| 418 | N | A | -1.2574 | |
| 419 | T | A | -1.2320 | |
| 420 | S | A | -1.4596 | |
| 421 | E | A | -2.4456 | |
| 422 | Q | A | -1.7033 | |
| 423 | L | A | -0.1773 | |
| 424 | E | A | -1.2916 | |
| 425 | M | A | 0.2066 | |
| 426 | A | A | -0.3118 | |
| 427 | E | A | -1.5758 | |
| 428 | V | A | -0.1904 | |
| 429 | K | A | -2.1576 | |
| 430 | D | A | -2.7075 | |
| 431 | W | A | -1.1889 | |
| 432 | K | A | -1.0329 | |
| 433 | A | A | 0.0000 | |
| 434 | I | A | 0.0000 | |
| 435 | R | A | 0.0000 | |
| 436 | V | A | 0.0000 | |
| 437 | D | A | 0.0000 | |
| 438 | L | A | 0.0000 | |
| 439 | V | A | 0.0000 | |
| 440 | I | A | 0.0160 | |
| 441 | T | A | 0.0000 | |
| 442 | P | A | -0.3146 | |
| 443 | F | A | 0.3445 | |
| 444 | E | A | -1.6879 | |
| 445 | Q | A | 0.0000 | |
| 446 | Y | A | 0.1009 | |
| 447 | P | A | 0.0000 | |
| 448 | Y | A | 0.0000 | |
| 449 | A | A | 0.0000 | |
| 450 | L | A | 0.0000 | |
| 451 | L | A | 0.0000 | |
| 452 | G | A | -0.4580 | |
| 453 | W | A | -0.2859 | |
| 454 | T | A | 0.0000 | |
| 455 | G | A | -0.8987 | |
| 456 | S | A | 0.0000 | |
| 457 | R | A | -1.9786 | |
| 458 | Q | A | 0.0000 | |
| 459 | F | A | 0.0000 | |
| 460 | G | A | -0.9343 | |
| 461 | R | A | -1.0695 | |
| 462 | D | A | 0.0000 | |
| 463 | L | A | 0.0000 | |
| 464 | R | A | -1.0619 | |
| 465 | R | A | -1.3049 | |
| 466 | Y | A | -1.4911 | |
| 467 | A | A | 0.0000 | |
| 468 | A | A | -2.1075 | |
| 469 | H | A | -2.4250 | |
| 470 | E | A | -2.8021 | |
| 471 | R | A | -2.7026 | |
| 472 | K | A | -3.0739 | |
| 473 | M | A | 0.0000 | |
| 474 | I | A | 0.0000 | |
| 475 | L | A | 0.0000 | |
| 476 | D | A | 0.0000 | |
| 477 | N | A | 0.0000 | |
| 478 | H | A | 0.0000 | |
| 479 | G | A | 0.0000 | |
| 480 | L | A | 0.0000 | |
| 481 | Y | A | 0.0000 | |
| 482 | D | A | 0.0000 | |
| 483 | R | A | -3.0966 | |
| 484 | R | A | -3.8338 | |
| 485 | K | A | -3.3066 | |
| 486 | R | A | -2.9042 | |
| 487 | I | A | -0.6579 | |
| 488 | F | A | -0.3747 | |
| 489 | L | A | -0.7312 | |
| 490 | K | A | -2.0172 | |
| 491 | A | A | -1.9876 | |
| 492 | G | A | -1.5708 | |
| 493 | S | A | -1.6455 | |
| 494 | E | A | 0.0000 | |
| 495 | E | A | -2.8111 | |
| 496 | E | A | -2.5300 | |
| 497 | I | A | 0.0000 | |
| 498 | F | A | 0.0000 | |
| 499 | A | A | -1.4742 | |
| 500 | H | A | -1.1954 | |
| 501 | L | A | 0.0000 | |
| 502 | G | A | -1.2009 | |
| 503 | L | A | -1.4297 | |
| 504 | D | A | -2.2020 | |
| 505 | Y | A | -1.8191 | |
| 506 | V | A | 0.0000 | |
| 507 | E | A | -1.2929 | |
| 508 | P | A | -0.4325 | |
| 509 | W | A | 0.1835 | |
| 510 | E | A | 0.0000 | |
| 511 | R | A | 0.0000 | |
| 512 | N | A | 0.0000 | |
| 513 | A | A | 0.0000 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine