Project name: ae35f962f08644e

Chain sequence(s)	H: QIQLVQSGPELKKPGETVKISCKASGYTFTTYGMSWVKQAPGKGLKWMGWIYTYSGVPTYADDLEGRFAFSLETSASTAYLQINNLKNEDTATYFCARVRDGYYRYAMDYWGQGTSVTVSS; L: DIHMTQSPSSLSASLGGKVTITCKASQDINRYIAWYQHKPGKGPRLLIHFTSTLQSGIPSRFSGSGSGRDYSFSISNLEPEDIATYYCLQYDDLRTFGGGTKLEIK
Selected Chain(s)	H,L
Distance of aggregation	10 Å
FoldX usage	Yes
Dynamic mode	No
Automated mutations	No

Simulation log

[INFO]       Logger:   Verbosity set to: 2 - [INFO]                                                (00:00:01)
[WARNING]    runJob:   Working directory already exists (possibly overwriting previous results -ow 
                       to prevent this behavior)                                                   (00:00:01)
[INFO]       runJob:   Starting aggrescan3d job on: input.pdb with all chain(s) selected           (00:00:01)
[INFO]       runJob:   Creating pdb object from: input.pdb                                         (00:00:01)
[INFO]       FoldX:    Starting FoldX energy minimalization                                        (00:00:01)
[INFO]       Analysis: Starting Aggrescan3D on folded.pdb                                          (00:01:40)
[INFO]       Main:     Simulation completed successfully.                                          (00:01:41)

• Minimal score value: -4.0953
• Maximal score value: 2.029
• Average score: -0.6892
• Total score value: -156.4478

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	Q	H	-1.4094
2	I	H	-0.7695
3	Q	H	-0.8854
4	L	H	0.0000
5	V	H	0.4694
6	Q	H	0.0000
7	S	H	-0.5526
8	G	H	-0.7665
9	P	H	-0.4978
11	E	H	-0.2792
12	L	H	0.5592
13	K	H	-1.1993
14	K	H	-2.6186
15	P	H	-2.7990
16	G	H	-2.5542
17	E	H	-2.3448
18	T	H	-1.8572
19	V	H	0.0000
20	K	H	-1.2999
21	I	H	0.0000
22	S	H	-0.3336
23	C	H	0.0000
24	K	H	-0.4957
25	A	H	0.0000
26	S	H	-0.6619
27	G	H	-0.9424
28	Y	H	-0.3361
29	T	H	-0.0715
30	F	H	0.0000
35	T	H	0.5780
36	T	H	0.0119
37	Y	H	-0.1461
38	G	H	0.0000
39	M	H	0.0000
40	S	H	0.0000
41	W	H	0.0000
42	V	H	0.0000
43	K	H	-0.8726
44	Q	H	-1.1539
45	A	H	-1.4273
46	P	H	-1.3069
47	G	H	-1.4570
48	K	H	-2.3452
49	G	H	-1.5421
50	L	H	0.0000
51	K	H	-1.5698
52	W	H	0.0000
53	M	H	0.0000
54	G	H	0.0000
55	W	H	0.7013
56	I	H	0.0000
57	Y	H	1.4880
58	T	H	0.0000
59	Y	H	1.6499
62	S	H	1.0965
63	G	H	1.1253
64	V	H	2.0290
65	P	H	1.0179
66	T	H	0.6140
67	Y	H	-0.3044
68	A	H	0.0000
69	D	H	-3.1342
70	D	H	-3.2538
71	L	H	0.0000
72	E	H	-2.9098
74	G	H	-1.8203
75	R	H	-1.4863
76	F	H	0.0000
77	A	H	-0.2994
78	F	H	0.0000
79	S	H	0.1776
80	L	H	0.2206
81	E	H	-0.5642
82	T	H	-0.2668
83	S	H	-0.3609
84	A	H	-0.4104
85	S	H	-0.5042
86	T	H	0.0000
87	A	H	0.0000
88	Y	H	-0.2317
89	L	H	0.0000
90	Q	H	-0.8331
91	I	H	0.0000
92	N	H	-1.6993
93	N	H	-2.4568
94	L	H	0.0000
95	K	H	-3.1222
96	N	H	-3.0141
97	E	H	-2.7968
98	D	H	0.0000
99	T	H	-1.2067
100	A	H	0.0000
101	T	H	-0.5211
102	Y	H	0.0000
103	F	H	0.0000
104	C	H	0.0000
105	A	H	0.0000
106	R	H	0.0000
107	V	H	0.0000
108	R	H	-1.0717
109	D	H	-1.6857
110	G	H	-0.5571
111	Y	H	0.8027
112A	Y	H	0.5900
112	R	H	-0.1679
113	Y	H	-0.0955
114	A	H	0.0000
115	M	H	0.0000
116	D	H	0.0000
117	Y	H	0.0268
118	W	H	0.0000
119	G	H	0.0000
120	Q	H	-1.5195
121	G	H	-0.9883
122	T	H	0.0000
123	S	H	-0.4602
124	V	H	0.0000
125	T	H	-0.6229
126	V	H	0.0000
127	S	H	-1.1458
128	S	H	-1.0078
1	D	L	-2.8394
2	I	L	0.0000
3	H	L	-1.7974
4	M	L	0.0000
5	T	L	-1.0083
6	Q	L	-0.7006
7	S	L	-0.4748
8	P	L	-0.5737
9	S	L	-0.8725
10	S	L	-1.1757
11	L	L	-0.7248
12	S	L	-0.9894
13	A	L	-0.9909
14	S	L	-1.2192
15	L	L	-0.4011
16	G	L	-1.2671
17	G	L	-1.5937
18	K	L	-2.2044
19	V	L	0.0000
20	T	L	-0.4289
21	I	L	0.0000
22	T	L	-0.7273
23	C	L	0.0000
24	K	L	-2.6144
25	A	L	0.0000
26	S	L	-2.2142
27	Q	L	-3.0790
28	D	L	-3.5232
29	I	L	0.0000
36	N	L	-2.5451
37	R	L	-2.4018
38	Y	L	-1.1130
39	I	L	0.0000
40	A	L	0.0000
41	W	L	0.0000
42	Y	L	0.0000
43	Q	L	0.0000
44	H	L	-1.0589
45	K	L	-1.4616
46	P	L	-1.0467
47	G	L	-1.7246
48	K	L	-2.6017
49	G	L	-1.7021
50	P	L	0.0000
51	R	L	-1.0515
52	L	L	0.0000
53	L	L	0.0000
54	I	L	0.0000
55	H	L	0.0000
56	F	L	-0.1122
57	T	L	0.0000
65	S	L	-0.2302
66	T	L	0.1283
67	L	L	0.2562
68	Q	L	-0.2038
69	S	L	-0.3323
70	G	L	-0.4736
71	I	L	-0.2411
72	P	L	-0.2919
74	S	L	-0.5035
75	R	L	-1.0997
76	F	L	0.0000
77	S	L	-0.3185
78	G	L	-0.2054
79	S	L	-0.7556
80	G	L	-1.6441
83	S	L	-2.1820
84	G	L	-2.9553
85	R	L	-4.0953
86	D	L	-3.5380
87	Y	L	0.0000
88	S	L	-0.7367
89	F	L	0.0000
90	S	L	-0.6942
91	I	L	0.0000
92	S	L	-1.7670
93	N	L	-2.1747
94	L	L	0.0000
95	E	L	-1.5194
96	P	L	-1.2571
97	E	L	-1.7697
98	D	L	0.0000
99	I	L	-0.1601
100	A	L	0.0000
101	T	L	-0.9411
102	Y	L	0.0000
103	Y	L	0.0000
104	C	L	0.0000
105	L	L	0.0000
106	Q	L	0.0000
107	Y	L	0.0000
108	D	L	-1.8890
114	D	L	-2.3118
115	L	L	-1.2048
116	R	L	-0.9204
117	T	L	-1.0568
118	F	L	-0.3885
119	G	L	0.0000
120	G	L	-0.9715
121	G	L	-1.0493
122	T	L	0.0000
123	K	L	-2.0481
124	L	L	0.0000
125	E	L	-2.0219
126	I	L	-1.0512
127	K	L	-1.7332