| Chain sequence(s) |
A: GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSL
B: GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLS input PDB |
| Selected Chain(s) | A,B |
| Distance of aggregation | 10 Å |
| FoldX usage | No |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:00)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:00)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with all chain(s) selected (00:00:00)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:00)
[INFO] runJob: FoldX not utilized. Treating input pdb file as it was already optimized. (00:00:00)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:00:01)
[INFO] Main: Simulation completed successfully. (00:00:06)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 237 | G | A | -0.9776 | |
| 238 | P | A | 0.0000 | |
| 239 | S | A | -0.0626 | |
| 240 | V | A | 0.0000 | |
| 241 | F | A | 1.8745 | |
| 242 | L | A | 1.3719 | |
| 243 | F | A | 1.5738 | |
| 244 | P | A | -0.0192 | |
| 245 | P | A | 0.0000 | |
| 246 | K | A | -2.0395 | |
| 247 | P | A | -1.4116 | |
| 248 | K | A | -1.0706 | |
| 249 | D | A | -1.1745 | |
| 250 | T | A | 0.0000 | |
| 251 | L | A | 0.0000 | |
| 252 | M | A | 0.4332 | |
| 253 | I | A | 1.5880 | |
| 254 | S | A | 0.2802 | |
| 255 | R | A | -0.7628 | |
| 256 | T | A | -0.5724 | |
| 257 | P | A | 0.0000 | |
| 258 | E | A | -0.9821 | |
| 259 | V | A | 0.0000 | |
| 260 | T | A | 0.5060 | |
| 261 | C | A | 0.0000 | |
| 262 | V | A | 0.0000 | |
| 263 | V | A | 0.0000 | |
| 264 | V | A | -0.7311 | |
| 265 | D | A | -2.0199 | |
| 266 | V | A | 0.0000 | |
| 267 | S | A | -2.2821 | |
| 268 | H | A | -2.4218 | |
| 269 | E | A | -2.8814 | |
| 270 | D | A | -2.6408 | |
| 271 | P | A | -2.5496 | |
| 272 | E | A | -3.0671 | |
| 273 | V | A | -2.0040 | |
| 274 | K | A | -2.1587 | |
| 275 | F | A | -1.1005 | |
| 276 | N | A | -1.0918 | |
| 277 | W | A | 0.0000 | |
| 278 | Y | A | -0.6137 | |
| 279 | V | A | -1.0112 | |
| 280 | D | A | -2.2742 | |
| 281 | G | A | -0.9131 | |
| 282 | V | A | 0.5938 | |
| 283 | E | A | -0.5335 | |
| 284 | V | A | -0.3840 | |
| 285 | H | A | -1.8200 | |
| 286 | N | A | -2.1461 | |
| 287 | A | A | -1.8755 | |
| 288 | K | A | -2.4568 | |
| 289 | T | A | -2.1566 | |
| 290 | K | A | -2.8567 | |
| 291 | P | A | -2.4627 | |
| 292 | R | A | -3.6786 | |
| 293 | E | A | -3.8537 | |
| 294 | E | A | -3.5129 | |
| 295 | Q | A | -1.9563 | |
| 296 | Y | A | -0.1095 | |
| 297 | N | A | -1.3134 | |
| 298 | S | A | -1.5660 | |
| 299 | T | A | -2.0305 | |
| 300 | Y | A | -2.7658 | |
| 301 | R | A | -2.5679 | |
| 302 | V | A | 0.0000 | |
| 303 | V | A | -0.9029 | |
| 304 | S | A | 0.0000 | |
| 305 | V | A | -0.7861 | |
| 306 | L | A | 0.0000 | |
| 307 | T | A | -0.5490 | |
| 308 | V | A | 0.0000 | |
| 309 | L | A | 0.8750 | |
| 310 | H | A | -0.1404 | |
| 311 | Q | A | -1.1498 | |
| 312 | D | A | -1.4514 | |
| 313 | W | A | 0.0000 | |
| 314 | L | A | -1.0986 | |
| 315 | N | A | -1.9883 | |
| 316 | G | A | -2.2268 | |
| 317 | K | A | -2.3898 | |
| 318 | E | A | -2.5558 | |
| 319 | Y | A | 0.0000 | |
| 320 | K | A | -1.7599 | |
| 321 | C | A | 0.0000 | |
| 322 | K | A | -1.4950 | |
| 323 | V | A | 0.0000 | |
| 324 | S | A | -1.4004 | |
| 325 | N | A | 0.0000 | |
| 326 | K | A | -2.6002 | |
| 327 | A | A | -1.5194 | |
| 328 | L | A | -0.5999 | |
| 329 | P | A | -0.4754 | |
| 330 | A | A | -0.3916 | |
| 331 | P | A | -0.8085 | |
| 332 | I | A | -0.7183 | |
| 333 | E | A | -1.8626 | |
| 334 | K | A | -1.1591 | |
| 335 | T | A | -1.0558 | |
| 336 | I | A | -0.3260 | |
| 337 | S | A | -1.0833 | |
| 338 | K | A | -1.4036 | |
| 339 | A | A | -1.2587 | |
| 340 | K | A | -2.2311 | |
| 341 | G | A | -1.9431 | |
| 342 | Q | A | -1.9783 | |
| 343 | P | A | -1.8340 | |
| 344 | R | A | -1.9993 | |
| 345 | E | A | -2.2857 | |
| 346 | P | A | 0.0000 | |
| 347 | Q | A | -1.0860 | |
| 348 | V | A | 0.0000 | |
| 349 | Y | A | 0.0000 | |
| 350 | T | A | -0.7149 | |
| 351 | L | A | 0.0000 | |
| 352 | P | A | -0.2290 | |
| 353 | P | A | -0.6938 | |
| 354 | S | A | -1.4309 | |
| 355 | R | A | -2.5107 | |
| 356 | D | A | -2.4858 | |
| 357 | E | A | 0.0000 | |
| 358 | L | A | -1.4666 | |
| 359 | T | A | -1.3480 | |
| 360 | K | A | -1.9668 | |
| 361 | N | A | -2.3889 | |
| 362 | Q | A | -2.2046 | |
| 363 | V | A | 0.0000 | |
| 364 | S | A | 0.0000 | |
| 365 | L | A | 0.0000 | |
| 366 | T | A | 0.0000 | |
| 367 | C | A | 0.0000 | |
| 368 | L | A | 0.0000 | |
| 369 | V | A | 0.0000 | |
| 370 | K | A | -0.4943 | |
| 371 | G | A | -0.9031 | |
| 372 | F | A | 0.0000 | |
| 373 | Y | A | -1.0118 | |
| 374 | P | A | 0.0000 | |
| 375 | S | A | -0.2413 | |
| 376 | D | A | -1.2379 | |
| 377 | I | A | -0.5410 | |
| 378 | A | A | -0.3554 | |
| 379 | V | A | -0.1518 | |
| 380 | E | A | -0.9831 | |
| 381 | W | A | 0.0000 | |
| 382 | E | A | -1.7487 | |
| 383 | S | A | 0.0000 | |
| 384 | N | A | -1.8570 | |
| 385 | G | A | -1.8956 | |
| 386 | Q | A | -2.3372 | |
| 387 | P | A | -1.9857 | |
| 388 | E | A | -1.8392 | |
| 389 | N | A | -1.9362 | |
| 390 | N | A | -1.1932 | |
| 391 | Y | A | -0.7632 | |
| 392 | K | A | -0.5967 | |
| 393 | T | A | -0.1764 | |
| 394 | T | A | 0.0000 | |
| 395 | P | A | -0.0609 | |
| 396 | P | A | 0.1401 | |
| 397 | V | A | 0.6688 | |
| 398 | L | A | 1.0831 | |
| 399 | D | A | -0.3725 | |
| 400 | S | A | -1.1096 | |
| 401 | D | A | -1.7961 | |
| 402 | G | A | -0.7042 | |
| 403 | S | A | 0.0000 | |
| 404 | F | A | 0.2714 | |
| 405 | F | A | 0.0000 | |
| 406 | L | A | 0.0000 | |
| 407 | Y | A | 0.0000 | |
| 408 | S | A | 0.0000 | |
| 409 | K | A | 0.0000 | |
| 410 | L | A | 0.0000 | |
| 411 | T | A | -0.8332 | |
| 412 | V | A | 0.0000 | |
| 413 | D | A | -2.4784 | |
| 414 | K | A | -2.4374 | |
| 415 | S | A | -2.1417 | |
| 416 | R | A | -1.8029 | |
| 417 | W | A | 0.0000 | |
| 418 | Q | A | -1.8668 | |
| 419 | Q | A | -1.8531 | |
| 420 | G | A | -0.7635 | |
| 421 | N | A | -0.5528 | |
| 422 | V | A | 0.8170 | |
| 423 | F | A | 0.0000 | |
| 424 | S | A | -0.6332 | |
| 425 | C | A | 0.0000 | |
| 426 | S | A | 0.0000 | |
| 427 | V | A | 0.0000 | |
| 428 | M | A | 0.0000 | |
| 429 | H | A | 0.0000 | |
| 430 | E | A | -1.1177 | |
| 431 | A | A | -1.4977 | |
| 432 | L | A | 0.0000 | |
| 433 | H | A | -1.7786 | |
| 434 | N | A | -1.6632 | |
| 435 | H | A | -1.1008 | |
| 436 | Y | A | -0.2422 | |
| 437 | T | A | -0.5071 | |
| 438 | Q | A | -0.7508 | |
| 439 | K | A | -0.8584 | |
| 440 | S | A | -0.3261 | |
| 441 | L | A | 0.0000 | |
| 442 | S | A | 0.5542 | |
| 443 | L | A | 1.0322 | |
| 237 | G | B | -0.6936 | |
| 238 | P | B | 0.0000 | |
| 239 | S | B | -0.0340 | |
| 240 | V | B | 0.0000 | |
| 241 | F | B | 1.7961 | |
| 242 | L | B | 1.2861 | |
| 243 | F | B | 1.6030 | |
| 244 | P | B | -0.0012 | |
| 245 | P | B | 0.0000 | |
| 246 | K | B | -2.1004 | |
| 247 | P | B | -1.2722 | |
| 248 | K | B | -0.9167 | |
| 249 | D | B | -1.0417 | |
| 250 | T | B | 0.0000 | |
| 251 | L | B | 0.0000 | |
| 252 | M | B | 0.7854 | |
| 253 | I | B | 1.7303 | |
| 254 | S | B | 0.4037 | |
| 255 | R | B | -0.7171 | |
| 256 | T | B | -0.5184 | |
| 257 | P | B | 0.0000 | |
| 258 | E | B | -1.0638 | |
| 259 | V | B | 0.0000 | |
| 260 | T | B | 0.4376 | |
| 261 | C | B | 0.0000 | |
| 262 | V | B | 0.0000 | |
| 263 | V | B | 0.0000 | |
| 264 | V | B | -0.7512 | |
| 265 | D | B | -1.8818 | |
| 266 | V | B | 0.0000 | |
| 267 | S | B | -2.1287 | |
| 268 | H | B | -2.2943 | |
| 269 | E | B | -2.7446 | |
| 270 | D | B | -2.4637 | |
| 271 | P | B | -2.3424 | |
| 272 | E | B | -2.9749 | |
| 273 | V | B | -1.9033 | |
| 274 | K | B | -2.2148 | |
| 275 | F | B | -1.2178 | |
| 276 | N | B | -1.0817 | |
| 277 | W | B | 0.0000 | |
| 278 | Y | B | -0.5594 | |
| 279 | V | B | -0.9085 | |
| 280 | D | B | -2.2161 | |
| 281 | G | B | -0.8616 | |
| 282 | V | B | 0.8061 | |
| 283 | E | B | -0.4201 | |
| 284 | V | B | -0.3365 | |
| 285 | H | B | -1.7913 | |
| 286 | N | B | -2.1170 | |
| 287 | A | B | -1.7170 | |
| 288 | K | B | -2.4803 | |
| 289 | T | B | -2.0419 | |
| 290 | K | B | -2.6616 | |
| 291 | P | B | -2.3075 | |
| 292 | R | B | -2.9932 | |
| 293 | E | B | -3.4358 | |
| 294 | E | B | -3.3137 | |
| 295 | Q | B | -1.8889 | |
| 296 | Y | B | -0.1371 | |
| 297 | N | B | -1.2937 | |
| 298 | S | B | -1.2922 | |
| 299 | T | B | -2.0289 | |
| 300 | Y | B | -2.4704 | |
| 301 | R | B | -2.3184 | |
| 302 | V | B | 0.0000 | |
| 303 | V | B | -0.8547 | |
| 304 | S | B | 0.0000 | |
| 305 | V | B | -0.8860 | |
| 306 | L | B | 0.0000 | |
| 307 | T | B | -0.6079 | |
| 308 | V | B | 0.0000 | |
| 309 | L | B | 0.9136 | |
| 310 | H | B | 0.0070 | |
| 311 | Q | B | -1.0926 | |
| 312 | D | B | -1.3825 | |
| 313 | W | B | 0.0000 | |
| 314 | L | B | -1.2401 | |
| 315 | N | B | -1.9721 | |
| 316 | G | B | -2.2355 | |
| 317 | K | B | -2.3411 | |
| 318 | E | B | -2.4867 | |
| 319 | Y | B | 0.0000 | |
| 320 | K | B | -1.7626 | |
| 321 | C | B | 0.0000 | |
| 322 | K | B | -1.4748 | |
| 323 | V | B | 0.0000 | |
| 324 | S | B | -1.4283 | |
| 325 | N | B | 0.0000 | |
| 326 | K | B | -2.5510 | |
| 327 | A | B | -1.4319 | |
| 328 | L | B | -0.5434 | |
| 329 | P | B | -0.4925 | |
| 330 | A | B | -0.3847 | |
| 331 | P | B | -0.8895 | |
| 332 | I | B | -0.7305 | |
| 333 | E | B | -1.8194 | |
| 334 | K | B | -1.1793 | |
| 335 | T | B | -1.0023 | |
| 336 | I | B | -0.2652 | |
| 337 | S | B | -1.2088 | |
| 338 | K | B | -1.3466 | |
| 339 | A | B | -1.0539 | |
| 340 | K | B | -2.1636 | |
| 341 | G | B | -1.8569 | |
| 342 | Q | B | -1.9475 | |
| 343 | P | B | -1.9427 | |
| 344 | R | B | -2.1743 | |
| 345 | E | B | -2.5710 | |
| 346 | P | B | 0.0000 | |
| 347 | Q | B | -1.1733 | |
| 348 | V | B | 0.0000 | |
| 349 | Y | B | 0.0000 | |
| 350 | T | B | -0.7432 | |
| 351 | L | B | 0.0000 | |
| 352 | P | B | -0.3344 | |
| 353 | P | B | -0.7575 | |
| 354 | S | B | -1.4346 | |
| 355 | R | B | -2.4906 | |
| 356 | D | B | -2.4321 | |
| 357 | E | B | 0.0000 | |
| 358 | L | B | -1.4687 | |
| 359 | T | B | -1.3090 | |
| 360 | K | B | -1.9332 | |
| 361 | N | B | -2.3655 | |
| 362 | Q | B | -2.1957 | |
| 363 | V | B | 0.0000 | |
| 364 | S | B | 0.0000 | |
| 365 | L | B | 0.0000 | |
| 366 | T | B | 0.0000 | |
| 367 | C | B | 0.0000 | |
| 368 | L | B | 0.0000 | |
| 369 | V | B | 0.0000 | |
| 370 | K | B | -0.4267 | |
| 371 | G | B | 0.0000 | |
| 372 | F | B | 0.0000 | |
| 373 | Y | B | -0.9582 | |
| 374 | P | B | 0.0000 | |
| 375 | S | B | -0.2848 | |
| 376 | D | B | -0.8387 | |
| 377 | I | B | -0.4224 | |
| 378 | A | B | -0.4039 | |
| 379 | V | B | 0.0000 | |
| 380 | E | B | -1.0485 | |
| 381 | W | B | 0.0000 | |
| 382 | E | B | -1.6901 | |
| 383 | S | B | -1.2142 | |
| 384 | N | B | -1.7950 | |
| 385 | G | B | -1.7239 | |
| 386 | Q | B | -2.2929 | |
| 387 | P | B | -2.0475 | |
| 388 | E | B | -2.0371 | |
| 389 | N | B | -2.3729 | |
| 390 | N | B | -1.9674 | |
| 391 | Y | B | -1.2673 | |
| 392 | K | B | -0.9119 | |
| 393 | T | B | -0.2569 | |
| 394 | T | B | 0.0000 | |
| 395 | P | B | -0.0641 | |
| 396 | P | B | 0.2133 | |
| 397 | V | B | 0.6918 | |
| 398 | L | B | 1.1274 | |
| 399 | D | B | -0.2463 | |
| 400 | S | B | -0.9888 | |
| 401 | D | B | -1.7918 | |
| 402 | G | B | -0.7037 | |
| 403 | S | B | 0.0000 | |
| 404 | F | B | 0.3761 | |
| 405 | F | B | 0.0000 | |
| 406 | L | B | 0.0000 | |
| 407 | Y | B | 0.0000 | |
| 408 | S | B | 0.0000 | |
| 409 | K | B | 0.0000 | |
| 410 | L | B | 0.0000 | |
| 411 | T | B | -1.0410 | |
| 412 | V | B | 0.0000 | |
| 413 | D | B | -2.5114 | |
| 414 | K | B | -2.3803 | |
| 415 | S | B | -2.0665 | |
| 416 | R | B | -1.8411 | |
| 417 | W | B | 0.0000 | |
| 418 | Q | B | -2.0510 | |
| 419 | Q | B | -1.9409 | |
| 420 | G | B | -0.9181 | |
| 421 | N | B | -0.6910 | |
| 422 | V | B | 0.6531 | |
| 423 | F | B | 0.0000 | |
| 424 | S | B | 0.0000 | |
| 425 | C | B | 0.0000 | |
| 426 | S | B | 0.0000 | |
| 427 | V | B | 0.0000 | |
| 428 | M | B | 0.0000 | |
| 429 | H | B | 0.0000 | |
| 430 | E | B | -1.0867 | |
| 431 | A | B | -1.5706 | |
| 432 | L | B | 0.0000 | |
| 433 | H | B | -1.7820 | |
| 434 | N | B | -1.5860 | |
| 435 | H | B | -0.8246 | |
| 436 | Y | B | -0.0793 | |
| 437 | T | B | -0.4998 | |
| 438 | Q | B | -0.8482 | |
| 439 | K | B | -0.9701 | |
| 440 | S | B | -0.3670 | |
| 441 | L | B | 0.0000 | |
| 442 | S | B | 0.2111 | |
| 443 | L | B | 0.3048 | |
| 444 | S | B | -0.1486 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine