| Chain sequence(s) |
A: MNGSPHVVRPVLALLLALSLAAGVAEAQTKVNPGWNMFSPQQDVEIGAQSAAAAERQLPILNDREVENYVNTIGQRLARNAGGPQFQYRFRVVNASDINAFALPGGYIYLNRGIIDNARNEGEVAGVLAHEIAHSALRHGTHQASKAYAAQAGLQILGGLLGGKVGGNTAQILNTVGGVGLNALFLKFSRELETQADVRGAQILAASGYTPADMVSFFNQLAKVDTSRKTTWLSHHPAPPDRIARIEKERQLLREPATPTQNVARLNSVQSRLRGYGAAPTMSQIAQGATANNPPMTSSGTSGIGRVEAPSRSWRQYTNRTGSYALSYPSNWRVYESGGFGVTLAPEGGVGTVRGRSEVVYGAIVNHYEPQSGGRATMQSATTDLLNQIRQASPHLRVISGSTQQLRTSSGGTAMAASLRGRNPNTNIDERVTVVTRALPDGHLMYMVFVTPEADARNYSSVLNQMVNTLQVASNARH
input PDB |
| Selected Chain(s) | A |
| Distance of aggregation | 10 Å |
| FoldX usage | Yes |
| Dynamic mode | No |
| Automated mutations | No |
| Downloads | Download all the data |
| Simulation log |
[INFO] Logger: Verbosity set to: 2 - [INFO] (00:00:01)
[WARNING] runJob: Working directory already exists (possibly overwriting previous results -ow
to prevent this behavior) (00:00:01)
[INFO] runJob: Starting aggrescan3d job on: input.pdb with A chain(s) selected (00:00:01)
[INFO] runJob: Creating pdb object from: input.pdb (00:00:01)
[INFO] FoldX: Starting FoldX energy minimalization (00:00:01)
[INFO] Analysis: Starting Aggrescan3D on folded.pdb (00:06:54)
[INFO] Main: Simulation completed successfully. (00:06:58)
|
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | M | A | 0.3001 | |
| 2 | N | A | -1.0707 | |
| 3 | G | A | -1.1037 | |
| 4 | S | A | -0.8083 | |
| 5 | P | A | -0.5309 | |
| 6 | H | A | -0.3733 | |
| 7 | V | A | 1.8468 | |
| 8 | V | A | 2.0379 | |
| 9 | R | A | 0.1891 | |
| 10 | P | A | 1.5005 | |
| 11 | V | A | 3.2323 | |
| 12 | L | A | 3.6586 | |
| 13 | A | A | 2.7922 | |
| 14 | L | A | 3.7672 | |
| 15 | L | A | 4.5421 | |
| 16 | L | A | 4.1699 | |
| 17 | A | A | 3.4068 | |
| 18 | L | A | 3.5884 | |
| 19 | S | A | 2.4170 | |
| 20 | L | A | 2.6931 | |
| 21 | A | A | 1.5968 | |
| 22 | A | A | 1.0703 | |
| 23 | G | A | 0.5115 | |
| 24 | V | A | 1.2295 | |
| 25 | A | A | -0.1421 | |
| 26 | E | A | -1.5668 | |
| 27 | A | A | -1.1625 | |
| 28 | Q | A | -2.0562 | |
| 29 | T | A | -1.7857 | |
| 30 | K | A | -2.1814 | |
| 31 | V | A | -1.4569 | |
| 32 | N | A | -1.7194 | |
| 33 | P | A | -0.7880 | |
| 34 | G | A | -0.5035 | |
| 35 | W | A | -0.0208 | |
| 36 | N | A | -0.2901 | |
| 37 | M | A | 0.1709 | |
| 38 | F | A | 0.0000 | |
| 39 | S | A | -0.8221 | |
| 40 | P | A | -1.2281 | |
| 41 | Q | A | -1.7070 | |
| 42 | Q | A | -1.4334 | |
| 43 | D | A | 0.0000 | |
| 44 | V | A | -1.2689 | |
| 45 | E | A | -2.3305 | |
| 46 | I | A | 0.0000 | |
| 47 | G | A | 0.0000 | |
| 48 | A | A | -1.0519 | |
| 49 | Q | A | -1.6680 | |
| 50 | S | A | 0.0000 | |
| 51 | A | A | 0.0000 | |
| 52 | A | A | -1.2800 | |
| 53 | A | A | -1.4337 | |
| 54 | A | A | 0.0000 | |
| 55 | E | A | -2.1237 | |
| 56 | R | A | -2.7551 | |
| 57 | Q | A | -2.1842 | |
| 58 | L | A | -1.0577 | |
| 59 | P | A | -0.7170 | |
| 60 | I | A | -0.7996 | |
| 61 | L | A | 0.0000 | |
| 62 | N | A | -1.8567 | |
| 63 | D | A | 0.0000 | |
| 64 | R | A | -2.8654 | |
| 65 | E | A | -2.3028 | |
| 66 | V | A | 0.0000 | |
| 67 | E | A | 0.0000 | |
| 68 | N | A | -2.2217 | |
| 69 | Y | A | 0.0000 | |
| 70 | V | A | 0.0000 | |
| 71 | N | A | -1.5801 | |
| 72 | T | A | -1.0446 | |
| 73 | I | A | 0.0000 | |
| 74 | G | A | 0.0000 | |
| 75 | Q | A | -2.0236 | |
| 76 | R | A | -1.8994 | |
| 77 | L | A | 0.0000 | |
| 78 | A | A | -1.9121 | |
| 79 | R | A | -2.5949 | |
| 80 | N | A | -1.5237 | |
| 81 | A | A | 0.0000 | |
| 82 | G | A | -1.2407 | |
| 83 | G | A | -1.1611 | |
| 84 | P | A | -1.2241 | |
| 85 | Q | A | -1.8249 | |
| 86 | F | A | -1.2060 | |
| 87 | Q | A | -1.4942 | |
| 88 | Y | A | 0.0000 | |
| 89 | R | A | -0.9859 | |
| 90 | F | A | 0.0000 | |
| 91 | R | A | -1.2620 | |
| 92 | V | A | 0.0000 | |
| 93 | V | A | 0.0000 | |
| 94 | N | A | -0.1925 | |
| 95 | A | A | 0.0000 | |
| 96 | S | A | -0.5715 | |
| 97 | D | A | 0.0000 | |
| 98 | I | A | 0.0000 | |
| 99 | N | A | 0.0000 | |
| 100 | A | A | 0.0000 | |
| 101 | F | A | 0.0000 | |
| 102 | A | A | 0.0000 | |
| 103 | L | A | 0.0000 | |
| 104 | P | A | 0.0000 | |
| 105 | G | A | 0.0000 | |
| 106 | G | A | 0.0000 | |
| 107 | Y | A | -0.2358 | |
| 108 | I | A | 0.0000 | |
| 109 | Y | A | 0.0000 | |
| 110 | L | A | 0.0000 | |
| 111 | N | A | 0.0000 | |
| 112 | R | A | 0.0000 | |
| 113 | G | A | 0.0000 | |
| 114 | I | A | 0.0000 | |
| 115 | I | A | 0.0000 | |
| 116 | D | A | -2.1725 | |
| 117 | N | A | -2.0461 | |
| 118 | A | A | 0.0000 | |
| 119 | R | A | -2.3218 | |
| 120 | N | A | -1.2263 | |
| 121 | E | A | 0.0000 | |
| 122 | G | A | 0.0000 | |
| 123 | E | A | 0.0000 | |
| 124 | V | A | 0.0000 | |
| 125 | A | A | 0.0000 | |
| 126 | G | A | 0.0000 | |
| 127 | V | A | 0.0000 | |
| 128 | L | A | 0.0000 | |
| 129 | A | A | 0.0000 | |
| 130 | H | A | 0.0000 | |
| 131 | E | A | 0.0000 | |
| 132 | I | A | 0.0000 | |
| 133 | A | A | 0.0000 | |
| 134 | H | A | 0.0000 | |
| 135 | S | A | 0.0000 | |
| 136 | A | A | 0.0000 | |
| 137 | L | A | 0.0000 | |
| 138 | R | A | -0.3703 | |
| 139 | H | A | 0.0000 | |
| 140 | G | A | 0.0000 | |
| 141 | T | A | 0.0000 | |
| 142 | H | A | 0.0000 | |
| 143 | Q | A | -0.8360 | |
| 144 | A | A | 0.0000 | |
| 145 | S | A | 0.0000 | |
| 146 | K | A | -1.6835 | |
| 147 | A | A | -0.9178 | |
| 148 | Y | A | -0.4724 | |
| 149 | A | A | -0.4232 | |
| 150 | A | A | -0.5220 | |
| 151 | Q | A | -1.0930 | |
| 152 | A | A | -0.6033 | |
| 153 | G | A | 0.0939 | |
| 154 | L | A | 0.9405 | |
| 155 | Q | A | -0.5363 | |
| 156 | I | A | 0.3527 | |
| 157 | L | A | 0.8783 | |
| 158 | G | A | 0.0371 | |
| 159 | G | A | -0.4062 | |
| 160 | L | A | 0.4940 | |
| 161 | L | A | 1.2100 | |
| 162 | G | A | -0.2675 | |
| 163 | G | A | -0.9235 | |
| 164 | K | A | -1.7493 | |
| 165 | V | A | -0.5409 | |
| 166 | G | A | -1.1023 | |
| 167 | G | A | -0.9743 | |
| 168 | N | A | -0.6023 | |
| 169 | T | A | -0.4683 | |
| 170 | A | A | -0.4350 | |
| 171 | Q | A | 0.0000 | |
| 172 | I | A | 0.0000 | |
| 173 | L | A | 0.0854 | |
| 174 | N | A | -0.2777 | |
| 175 | T | A | -0.2571 | |
| 176 | V | A | -0.0748 | |
| 177 | G | A | 0.2154 | |
| 178 | G | A | 0.1366 | |
| 179 | V | A | 1.1270 | |
| 180 | G | A | 0.2075 | |
| 181 | L | A | 0.4212 | |
| 182 | N | A | -0.1494 | |
| 183 | A | A | 0.0783 | |
| 184 | L | A | -0.0511 | |
| 185 | F | A | 0.0000 | |
| 186 | L | A | -0.3414 | |
| 187 | K | A | -1.1620 | |
| 188 | F | A | 0.0000 | |
| 189 | S | A | -1.7780 | |
| 190 | R | A | -2.8285 | |
| 191 | E | A | -2.7556 | |
| 192 | L | A | 0.0000 | |
| 193 | E | A | 0.0000 | |
| 194 | T | A | -1.7025 | |
| 195 | Q | A | -1.4391 | |
| 196 | A | A | 0.0000 | |
| 197 | D | A | 0.0000 | |
| 198 | V | A | 0.0000 | |
| 199 | R | A | -0.9538 | |
| 200 | G | A | 0.0000 | |
| 201 | A | A | 0.0000 | |
| 202 | Q | A | -0.7127 | |
| 203 | I | A | 0.0000 | |
| 204 | L | A | 0.0000 | |
| 205 | A | A | 0.0000 | |
| 206 | A | A | -0.7194 | |
| 207 | S | A | 0.0000 | |
| 208 | G | A | -0.5215 | |
| 209 | Y | A | 0.0000 | |
| 210 | T | A | -0.4601 | |
| 211 | P | A | 0.0000 | |
| 212 | A | A | -0.2689 | |
| 213 | D | A | 0.0000 | |
| 214 | M | A | 0.0000 | |
| 215 | V | A | -0.1901 | |
| 216 | S | A | -0.3267 | |
| 217 | F | A | 0.0000 | |
| 218 | F | A | 0.0000 | |
| 219 | N | A | -0.8200 | |
| 220 | Q | A | -1.0814 | |
| 221 | L | A | 0.0000 | |
| 222 | A | A | -1.1343 | |
| 223 | K | A | -2.1573 | |
| 224 | V | A | -1.9162 | |
| 225 | D | A | -2.7640 | |
| 226 | T | A | -1.9474 | |
| 227 | S | A | -1.8911 | |
| 228 | R | A | -2.8769 | |
| 229 | K | A | -2.3711 | |
| 230 | T | A | -1.2003 | |
| 231 | T | A | -0.5280 | |
| 232 | W | A | 0.0000 | |
| 233 | L | A | 0.0471 | |
| 234 | S | A | -0.2645 | |
| 235 | H | A | -0.4884 | |
| 236 | H | A | 0.0000 | |
| 237 | P | A | -0.8360 | |
| 238 | A | A | -0.7819 | |
| 239 | P | A | 0.0000 | |
| 240 | P | A | -1.4410 | |
| 241 | D | A | -2.1490 | |
| 242 | R | A | 0.0000 | |
| 243 | I | A | -0.9750 | |
| 244 | A | A | -1.8463 | |
| 245 | R | A | -2.5458 | |
| 246 | I | A | 0.0000 | |
| 247 | E | A | -2.9776 | |
| 248 | K | A | -3.1883 | |
| 249 | E | A | 0.0000 | |
| 250 | R | A | -2.7870 | |
| 251 | Q | A | -2.8944 | |
| 252 | L | A | -2.1781 | |
| 253 | L | A | -2.0840 | |
| 254 | R | A | -2.2547 | |
| 255 | E | A | -1.4057 | |
| 256 | P | A | -0.6310 | |
| 257 | A | A | -0.3350 | |
| 258 | T | A | -0.2037 | |
| 259 | P | A | -0.3781 | |
| 260 | T | A | -0.3497 | |
| 261 | Q | A | -0.7679 | |
| 262 | N | A | -0.8480 | |
| 263 | V | A | -0.0203 | |
| 264 | A | A | -0.3026 | |
| 265 | R | A | -0.8474 | |
| 266 | L | A | 0.0000 | |
| 267 | N | A | -1.7529 | |
| 268 | S | A | -1.2868 | |
| 269 | V | A | 0.0000 | |
| 270 | Q | A | -2.0130 | |
| 271 | S | A | -1.8781 | |
| 272 | R | A | -2.0263 | |
| 273 | L | A | 0.0000 | |
| 274 | R | A | -2.3660 | |
| 275 | G | A | -1.3216 | |
| 276 | Y | A | -0.1230 | |
| 277 | G | A | -0.6409 | |
| 278 | A | A | -0.3490 | |
| 279 | A | A | -0.3968 | |
| 280 | P | A | -0.4857 | |
| 281 | T | A | -0.9457 | |
| 282 | M | A | -0.5640 | |
| 283 | S | A | -1.2815 | |
| 284 | Q | A | -1.6421 | |
| 285 | I | A | -0.9572 | |
| 286 | A | A | -1.0339 | |
| 287 | Q | A | -1.8320 | |
| 288 | G | A | -1.5475 | |
| 289 | A | A | -1.3866 | |
| 290 | T | A | -1.4315 | |
| 291 | A | A | -1.4812 | |
| 292 | N | A | -2.1938 | |
| 293 | N | A | -1.9780 | |
| 294 | P | A | -1.0850 | |
| 295 | P | A | -0.4282 | |
| 296 | M | A | 0.5944 | |
| 297 | T | A | 0.1203 | |
| 298 | S | A | -0.5093 | |
| 299 | S | A | -0.4911 | |
| 300 | G | A | -0.7743 | |
| 301 | T | A | -0.5979 | |
| 302 | S | A | -0.7635 | |
| 303 | G | A | -0.9645 | |
| 304 | I | A | -0.5105 | |
| 305 | G | A | -1.7072 | |
| 306 | R | A | -2.5997 | |
| 307 | V | A | -1.9099 | |
| 308 | E | A | -2.5766 | |
| 309 | A | A | -1.4875 | |
| 310 | P | A | -1.1379 | |
| 311 | S | A | -1.5011 | |
| 312 | R | A | -1.9280 | |
| 313 | S | A | -1.3691 | |
| 314 | W | A | -1.4251 | |
| 315 | R | A | -2.2728 | |
| 316 | Q | A | -1.9919 | |
| 317 | Y | A | 0.0000 | |
| 318 | T | A | -1.1638 | |
| 319 | N | A | 0.0000 | |
| 320 | R | A | -2.3531 | |
| 321 | T | A | -1.5488 | |
| 322 | G | A | -1.2900 | |
| 323 | S | A | 0.0000 | |
| 324 | Y | A | 0.0000 | |
| 325 | A | A | -0.8005 | |
| 326 | L | A | 0.0000 | |
| 327 | S | A | 0.0000 | |
| 328 | Y | A | 0.0000 | |
| 329 | P | A | 0.0000 | |
| 330 | S | A | -1.4530 | |
| 331 | N | A | -1.6846 | |
| 332 | W | A | 0.0000 | |
| 333 | R | A | -1.4597 | |
| 334 | V | A | -0.3036 | |
| 335 | Y | A | -0.3803 | |
| 336 | E | A | -1.9669 | |
| 337 | S | A | -0.9539 | |
| 338 | G | A | -1.5111 | |
| 339 | G | A | -1.4266 | |
| 340 | F | A | 0.0000 | |
| 341 | G | A | 0.0000 | |
| 342 | V | A | 0.0000 | |
| 343 | T | A | -0.0516 | |
| 344 | L | A | 0.0000 | |
| 345 | A | A | 0.0000 | |
| 346 | P | A | 0.0000 | |
| 347 | E | A | -2.6466 | |
| 348 | G | A | -1.4593 | |
| 349 | G | A | 0.0000 | |
| 350 | V | A | 0.2054 | |
| 351 | G | A | -0.6222 | |
| 352 | T | A | -1.2131 | |
| 353 | V | A | -1.6335 | |
| 354 | R | A | -2.7367 | |
| 355 | G | A | -2.2802 | |
| 356 | R | A | -2.4352 | |
| 357 | S | A | -0.9579 | |
| 358 | E | A | -0.6247 | |
| 359 | V | A | 0.4052 | |
| 360 | V | A | 0.0000 | |
| 361 | Y | A | 0.1280 | |
| 362 | G | A | 0.0000 | |
| 363 | A | A | 0.0000 | |
| 364 | I | A | 0.3994 | |
| 365 | V | A | 0.0000 | |
| 366 | N | A | 0.0000 | |
| 367 | H | A | 0.0000 | |
| 368 | Y | A | -0.6959 | |
| 369 | E | A | -1.5848 | |
| 370 | P | A | 0.0000 | |
| 371 | Q | A | -2.0579 | |
| 372 | S | A | -1.6643 | |
| 373 | G | A | -1.7645 | |
| 374 | G | A | -2.0130 | |
| 375 | R | A | -2.3655 | |
| 376 | A | A | -1.7184 | |
| 377 | T | A | -0.9394 | |
| 378 | M | A | -0.8074 | |
| 379 | Q | A | -1.2832 | |
| 380 | S | A | -1.0236 | |
| 381 | A | A | 0.0000 | |
| 382 | T | A | 0.0000 | |
| 383 | T | A | -0.6704 | |
| 384 | D | A | -1.1196 | |
| 385 | L | A | 0.0000 | |
| 386 | L | A | 0.0000 | |
| 387 | N | A | -1.2796 | |
| 388 | Q | A | -1.4453 | |
| 389 | I | A | -1.0729 | |
| 390 | R | A | -1.9053 | |
| 391 | Q | A | -1.9667 | |
| 392 | A | A | -1.0833 | |
| 393 | S | A | -1.3491 | |
| 394 | P | A | -1.5874 | |
| 395 | H | A | -1.9702 | |
| 396 | L | A | 0.0000 | |
| 397 | R | A | -2.2362 | |
| 398 | V | A | -0.5332 | |
| 399 | I | A | -0.2599 | |
| 400 | S | A | -0.2946 | |
| 401 | G | A | -0.5804 | |
| 402 | S | A | -0.4853 | |
| 403 | T | A | -0.9225 | |
| 404 | Q | A | -1.7995 | |
| 405 | Q | A | -2.0723 | |
| 406 | L | A | -1.5353 | |
| 407 | R | A | -2.2461 | |
| 408 | T | A | 0.0000 | |
| 409 | S | A | -1.2154 | |
| 410 | S | A | -1.1221 | |
| 411 | G | A | -1.2788 | |
| 412 | G | A | -0.9719 | |
| 413 | T | A | -1.0518 | |
| 414 | A | A | 0.0000 | |
| 415 | M | A | 0.0000 | |
| 416 | A | A | 0.0000 | |
| 417 | A | A | 0.0000 | |
| 418 | S | A | -0.5122 | |
| 419 | L | A | 0.0000 | |
| 420 | R | A | -2.4798 | |
| 421 | G | A | -2.6919 | |
| 422 | R | A | -3.4582 | |
| 423 | N | A | 0.0000 | |
| 424 | P | A | -1.5357 | |
| 425 | N | A | -1.7663 | |
| 426 | T | A | -1.4339 | |
| 427 | N | A | -2.0595 | |
| 428 | I | A | -1.5879 | |
| 429 | D | A | -2.8507 | |
| 430 | E | A | 0.0000 | |
| 431 | R | A | -1.6664 | |
| 432 | V | A | 0.0000 | |
| 433 | T | A | 0.0000 | |
| 434 | V | A | 0.0000 | |
| 435 | V | A | 0.0000 | |
| 436 | T | A | 0.0000 | |
| 437 | R | A | -0.0447 | |
| 438 | A | A | -0.2145 | |
| 439 | L | A | 0.0000 | |
| 440 | P | A | -1.5185 | |
| 441 | D | A | -1.9868 | |
| 442 | G | A | -1.7397 | |
| 443 | H | A | -1.3730 | |
| 444 | L | A | 0.0000 | |
| 445 | M | A | 0.0000 | |
| 446 | Y | A | 0.2784 | |
| 447 | M | A | 0.0000 | |
| 448 | V | A | 0.4576 | |
| 449 | F | A | 0.0000 | |
| 450 | V | A | 0.0000 | |
| 451 | T | A | 0.0000 | |
| 452 | P | A | 0.0000 | |
| 453 | E | A | -1.7096 | |
| 454 | A | A | -1.0929 | |
| 455 | D | A | -1.5471 | |
| 456 | A | A | -1.6729 | |
| 457 | R | A | -2.6778 | |
| 458 | N | A | -2.3357 | |
| 459 | Y | A | 0.0000 | |
| 460 | S | A | -1.5608 | |
| 461 | S | A | -1.3316 | |
| 462 | V | A | 0.0000 | |
| 463 | L | A | -0.8778 | |
| 464 | N | A | -1.7115 | |
| 465 | Q | A | -1.3318 | |
| 466 | M | A | 0.0000 | |
| 467 | V | A | 0.0000 | |
| 468 | N | A | -1.7514 | |
| 469 | T | A | -1.1165 | |
| 470 | L | A | 0.0000 | |
| 471 | Q | A | -1.0588 | |
| 472 | V | A | -0.7346 | |
| 473 | A | A | -0.9659 | |
| 474 | S | A | -1.2310 | |
| 475 | N | A | -2.0946 | |
| 476 | A | A | 0.0000 | |
| 477 | R | A | -2.9677 | |
| 478 | H | A | -2.3387 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine